Publikationsdatum:
1991-04-19
Beschreibung:
A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lubin, I -- Faktorowich, Y -- Lapidot, T -- Gan, Y -- Eshhar, Z -- Gazit, E -- Levite, M -- Reisner, Y -- New York, N.Y. -- Science. 1991 Apr 19;252(5004):427-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1826797" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Antibodies/analysis
;
Antibodies, Monoclonal/immunology
;
Antigens, CD3
;
Antigens, Differentiation, T-Lymphocyte/immunology
;
B-Lymphocytes/*cytology/immunology
;
*Bone Marrow Cells
;
*Bone Marrow Transplantation
;
Cell Differentiation
;
Chimera
;
Hematopoietic Stem Cells/cytology
;
Hemocyanin/immunology
;
Humans
;
Immunization
;
Immunoglobulins/analysis
;
Immunologic Deficiency Syndromes
;
Immunophenotyping
;
Mice
;
Mice, Inbred BALB C
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocytes/*cytology/immunology
;
*Transplantation, Heterologous
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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