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1

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Genetic degeneration of old and young Y chromosomes in the flowering plant Rumex hastatulus (2014)

Hough, J. ; Hollister, J. D. ; Wang, W. ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(21): 7713-7718. Published 2014 May 13. doi: 10.1073/pnas.1319227111.

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Publikationsdatum: 2014-05-13

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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2

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Climate negotiations under scientific uncertainty (2012)

Barrett, S. ; Dannenberg, A.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(43): 17372-17376. Published 2012 Oct 08. doi: 10.1073/pnas.1208417109.

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Publikationsdatum: 2012-10-08

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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3

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Avoiding disastrous climate change is possible but not inevitable (2011)

Barrett, S.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(29): 11733-11734. Published 2011 Jul 07. doi: 10.1073/pnas.1108775108.

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Publikationsdatum: 2011-07-07

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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4

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Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing (2012)

Frey, M. A. ; Michaud, M. ; VanHouten, J. N. ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(14): 5190-5195. Published 2012 Mar 19. doi: 10.1073/pnas.1117293109.

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Publikationsdatum: 2012-03-19

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Avoiding disastrous climate change is possible but not inevitable [Commentary] (2011)

Barrett, S.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2011-07-20

Beschreibung: What the world does or does not do about climate change will have profound implications. If the world fails to act, we may cross a climate tipping point, with disastrous consequences all around. No country by itself can prevent this, but a substantial number of countries working together can avert disaster. Collectively, we know what we need to do. However, can we agree on what each of us should do? Can we be assured that, if we act, others will fulfill their pledges? An experimental paper in PNAS (1) provides reasons for optimism and despair, optimism because, with communication, outcomes...

Schlagwort(e): Sustainability Science

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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6

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Aquaculture and resilience [Sustainability Science] (2014)

Troell, M., Naylor, R. L., Metian, M., Beveridge, M., Tyedmers, P. H., Folke, C., Arrow, K. J., Barrett, S., Crepin, A.–S., Ehrlich, P. R., Gren, A., Kautsky, N., Levin, S. A., Nyborg, K., Osterblom, H., Polasky, S., Scheffer, M., Walker, B. H., Xepapadeas, T., de Zeeuw, A.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2014-09-17

Beschreibung: Aquaculture is the fastest growing food sector and continues to expand alongside terrestrial crop and livestock production. Using portfolio theory as a conceptual framework, we explore how current interconnections between the aquaculture, crop, livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilience in the...

Schlagwort(e): Sustainability Science

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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7

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Interaction of human telomeric DNA with N-methyl mesoporphyrin IX (2012)

Nicoludis, J. M., Barrett, S. P., Mergny, J.-L., Yatsunyk, L. A.

Oxford University Press

In: Nucleic Acids Research

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Publikationsdatum: 2012-06-28

Beschreibung: The remarkable selectivity of N -methyl mesoporphyrin IX (NMM) for G-quadruplexes (GQs) is long known, however its ability to stabilize and bind GQs has not been investigated in detail. Through the use of circular dichroism, UV-visible spectroscopy and fluorescence resonance energy transfer (FRET) melting assay we have shown that NMM stabilizes human telomeric DNA dAG 3 (TTAG 3 ) 3 (Tel22) and is selective for its parallel conformation to which it binds in 1:1 stoichiometry with a binding constant of ~1.0 x 10 5 M –1 . NMM does not interact with an antiparallel conformation of Tel22 in sodium buffer and is the second example in the literature, after TOxaPy, of a ligand with an excellent selectivity for a specific GQ structure. NMM's stabilizing ability toward predominantly parallel GQ conformation is universal: it stabilizes a variety of biologically relevant G-rich sequences including telomeres and oncogene promoters. The N -methyl group is integral for selectivity and stabilization, as the unmethylated analogue, mesoporphyrin IX, does not stabilize GQ DNA in FRET melting assays. Finally, NMM induces the isomerization of Tel22 into a structure with increased parallel component in K + but not in Na + buffer. The ability of NMM to cause structural rearrangement and efficient stabilization of Tel22 may bear biological significance.

Print ISSN: 0305-1048

Digitale ISSN: 1362-4962

Thema: Biologie

Publiziert von Oxford University Press

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8

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P-31 MRI of solids using the quadratic echo [Applied Biological Sciences] (2012)

Frey, M. A., Michaud, M., Van; Houten, J. N., Insogna, K. L., Madri, J. A., Barrett, S. E.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2012-04-04

Beschreibung: Magnetic resonance imaging (MRI) of solids is rarely attempted. One of the main reasons is that the broader MR linewidths, compared to the narrow resonance of the hydrogen (1H) in free water, limit both the attainable spatial resolution and the signal-to-noise ratio. Basic physics research, stimulated by the quest to build a quantum computer, gave rise to a unique MR pulse sequence that offers a solution to this long-standing problem. The “quadratic echo” significantly narrows the broad MR spectrum of solids. Applying field gradients in sync with this line-narrowing sequence offers a fresh approach to carry out MRI of hard and soft solids with high spatial resolution and with a wide range of potential uses. Here we demonstrate that this method can be used to carry out three-dimensional MRI of the phosphorus (31P) in ex vivo bone and soft tissue samples.

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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9

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Y-chromosome degeneration in a flowering plant [Evolution] (2014)

Hough, J., Hollister, J. D., Wang, W., Barrett, S. C. H., Wright, S. I.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2014-05-28

Beschreibung: Heteromorphic sex chromosomes have originated independently in many species, and a common feature of their evolution is the degeneration of the Y chromosome, characterized by a loss of gene content and function. Despite being of broad significance to our understanding of sex chromosome evolution, the genetic changes that occur during...

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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10

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Climate negotiations under scientific uncertainty [Sustainability Science] (2012)

Barrett, S., Dannenberg, A.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2012-10-24

Beschreibung: How does uncertainty about “dangerous” climate change affect the prospects for international cooperation? Climate negotiations usually are depicted as a prisoners’ dilemma game; collectively, countries are better off reducing their emissions, but self-interest impels them to keep on emitting. We provide experimental evidence, grounded in an analytical framework, showing that...

Schlagwort(e): Sustainability Science

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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