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  • English  (53)
  • 2020-2024  (45)
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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    DDC: 571.978
    Language: English
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  • 2
    Call number: RIFS 23.95604
    Type of Medium: Monograph available for loan
    Pages: VI, 342 Seiten , Illustrationen , 21 cm x 14.8 cm, 460 g
    ISBN: 9783658416829 , 3658416823
    Language: English
    Branch Library: RIFS Library
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  • 3
    Keywords: hydrodynamics ; hydrology ; mechanical engineering
    Description / Table of Contents: The phenomena related to the flow of fluids are generally complex, and difficult to quantify. New approaches, considering points of view still not explored, may introduce useful tools in the study of Hydrodynamics and the related transport phenomena. The details of the flows and the properties of the fluids must be considered on a very small scale perspective. Consequently, new concepts and tools are generated to better describe the fluids and their properties. This volume presents conclusions about advanced topics of calculated and observed flows. It contains twenty chapters, organized in five sections: 1) Mathematical Models in Fluid Mechanics 2) Biological Applications and Biohydrodynamics 3) Detailed Experimental Analyses of Fluids and Flows 4) Radiation-, Electro-, Magnetohydrodynamics, and Magnetorheology 5) Special Topics on Simulations and Experimental Data. These chapters present new points of view about methods and tools used in Hydrodynamics.
    Pages: Online-Ressource (286 Seiten)
    ISBN: 9789533078939
    Language: English
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  • 4
    Keywords: hydrodynamics ; hydrology ; mechanical engineering
    Description / Table of Contents: The phenomena related to the flow of fluids are generally complex, and difficult to quantify. New approaches - considering points of view still not explored - may introduce useful tools in the study of Hydrodynamics and the related transport phenomena. The details of the flows and the properties of the fluids must be considered on a very small scale perspective. Consequently, new concepts and tools are generated to better describe the fluids and their properties. This volume presents conclusions about advanced topics of calculated and observed flows. It contains eighteen chapters, organized in five sections: 1) Mathematical Models in Fluid Mechanics, 2) Biological Applications and Biohydrodynamics, 3) Detailed Experimental Analyses of Fluids and Flows, 4) Radiation-, Electro-, Magnetohydrodynamics, and Magnetorheology, 5) Special Topics on Simulations and Experimental Data. These chapters present new points of view about methods and tools used in Hydrodynamics.
    Pages: Online-Ressource (442 Seiten)
    ISBN: 9789533075969
    Language: English
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  • 5
    Keywords: hydrodynamics ; hydrology ; mechanical engineering
    Description / Table of Contents: The constant evolution of the calculation capacity of the modern computers implies in a permanent effort to adjust the existing numerical codes, or to create new codes following new points of view, aiming to adequately simulate fluid flows and the related transport of physical properties. Additionally, the continuous improving of laboratory devices and equipment, which allow to record and measure fluid flows with a higher degree of details, induces to elaborate specific experiments, in order to shed light in unsolved aspects of the phenomena related to these flows. This volume presents conclusions about different aspects of calculated and observed flows, discussing the tools used in the analyses. It contains eighteen chapters, organized in four sections: 1) Smoothed Spheres, 2) Models and Codes in Fluid Dynamics, 3) Complex Hydraulic Engineering Applications, 4) Hydrodynamics and Heat/Mass Transfer. The chapters present results directed to the optimization of the methods and tools of Hydrodynamics.
    Pages: Online-Ressource (424 Seiten)
    ISBN: 9789533077123
    Language: English
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  • 6
    Publication Date: 2024-04-05
    Description: The interaction of light with matter has triggered the interest of scientists for a long time. The area of plasmonics emerges in this context through the interaction of light with valence electrons in metals. The random phase approximation in the long wavelength limit is used for analytical investigation of plasmons in three‐dimensional metals, in a two‐dimensional electron gas, and finally in the most famous two‐dimensional semi‐metal, namely graphene. We show that plasmons in bulk metals as well as in a two‐dimensional electron gas originate from classical laws, whereas quantum effects appear as non‐local corrections. On the other hand, graphene plasmons are purely quantum modes, and thus, they would not exist in a “classical world.” Furthermore, under certain circumstances, light is able to couple with plasmons on metallic surfaces, forming a surface plasmon polariton, which is very important in nanoplasmonics due to its subwavelength nature. In addition, we outline two applications that complete our theoretical investigation. First, we examine how the presence of gain (active) dielectrics affects surface plasmon polariton properties and we find that there is a gain value for which the metallic losses are completely eliminated resulting in lossless plasmon propagation. Second, we combine monolayers of graphene in a periodic order and construct a plasmonic metamaterial that provides tunable wave propagation properties, such as epsilon‐near‐zero behavior, normal, and negative refraction.
    Keywords: random phase approximation, graphene, gain dielectrics, plasmonic metamaterial ; thema EDItEUR::P Mathematics and Science::PH Physics::PHF Materials / States of matter::PHFC Condensed matter physics (liquid state and solid state physics)
    Language: English
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  • 7
    Publication Date: 2023-07-04
    Description: Extensional tectonics in the Late Paleozoic Central Europe was accompanied by rift magmatism that triggered voluminous intracontinental caldera-forming eruptions. Among these, the Lower Permian Rochlitz Volcanic System (RVS) in the North Saxon Volcanic Complex (Eastern Germany, Saxony) represents a supereruption (VEI 8, estimated volume of 1056 km3) of monotonous rhyolites followed by monotonous intermediates. Mapping, petrography, whole-rock geochemistry along with mineral chemistry and oxygen isotopes in zircon display its complex eruption history and magma evolution. Crystal-rich (〉 35 vol%), rhyolitic Rochlitz-α Ignimbrite with strong to moderate welding compaction erupted in the climactic stage after reheating of the magma by basaltic injections. Due to magma mixing, low-volume trachydacitic-to-rhyolitic Rochlitz-β Ignimbrite succeeded, characterized by high Ti and Zr-values and zircon with mantle δ18O. Randomly oriented, sub-horizontally bedded fiamme, and NW–SE striking subvolcanic bodies and faults suggest pyroclastic fountaining along NW–SE-oriented fissures as the dominant eruption style. Intrusion of the Leisnig and the Grimma Laccoliths caused resurgence of the Rochlitz caldera forming several peripheral subbasins. In the post-climactic stage, these were filled with lava complexes, ignimbrites and alluvial to lacustrine sediments. Significant Nb and Ta anomalies and high Nb/Ta ratios (11.8–17.9) display a high degree of crustal contamination for the melts of the RVS. Based on homogenous petrographic and geochemical composition along with a narrow range of δ18O in zircon Rochlitz-α Ignimbrite were classified as monotonous rhyolites. For the Rochlitz-β Ignimbrites, underplating and mixing with basic melts are indicated by Mg-rich annite–siderophyllite and δ18O 〈 6.0 in zircon. The wide spectrum of δ18O on zircon suggests an incomplete mixing process during the formation of monotonous intermediates in the RVS.
    Description: Technische Universität Bergakademie Freiberg (3135)
    Keywords: ddc:552.2 ; Monotonous rhyolites ; Monotonous intermediates ; Magma mixing ; Ti-in-biotite thermobarometer ; δ18O in zircon ; VEI 8 fissure eruption
    Language: English
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  • 8
    Publication Date: 2023-07-20
    Description: New whole-rock geochemical and coupled U–Pb and Lu–Hf LA-ICP-MS zircon data of metasedimentary rocks of the Austroalpine, South Alpine and Penninic basement domains are presented, to disentangle the pre-Variscan tectonic evolution of the proto-Alps. The studied units seem to record distinct stages of protracted Late Ediacaran to Carboniferous tectonosedimentary processes prior to the Variscan collision. In the case of Austroalpine and South Alpine units, nevertheless, no major differences in terms of provenance are observed, since most detrital zircon samples are characterized by a major Pan-African peak. Their detrital zircon spectra record a provenance from the northeastern Saharan Metacraton and the Sinai basement at the northern Arabian-Nubian Shield, being thus located along the eastern Early Paleozoic northern Gondwana margin, whereas sources located further west are inferred for the Penninic Unit, which might have been placed close to the Moldanubian Unit of the Bohemian Massif. In any case, it is thus clear that the Alpine basement remained in a close position to the Gondwana mainland at least during the Early Paleozoic. The Late Ediacaran to Silurian tectonic evolution, which includes Cadomian and Cenerian tectonometamorphic and magmatic processes, seem thus to record a continuum related to a retreating-mode accretionary orogen, with diachronous back-arc basin opening and possibly discrete compressional/transpressional pulses linked to changes in subduction zone dynamics. On the other hand, it is inferred that the Alpine basement essentially comprises Pan-African metasedimentary and subordinate metaigneous rocks, possibly with very few Early Neoproterozoic relics. This basement was significantly reworked during the protracted Paleozoic orogenic evolution, due to anatexis and/or assimilation by mantle-derived juvenile magmatism.
    Description: Georg-August-Universität Göttingen (1018)
    Keywords: ddc:551 ; Alpine basement ; Cadomian orogeny ; Cenerian orogeny ; Retreating-mode accretionary orogen ; Sedimentary provenance ; Detrital zircons
    Language: English
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  • 9
    Publication Date: 2023-08-08
    Description: Nitrate reduction constitutes an important natural mechanism to mitigate the widespread and persistent nitrate contamination of groundwater resources. In fractured aquifers, however, the abundance and accessibility of electron donors and their spatial correlation with groundwater flow paths are often poorly understood. In this study, the nitrate reduction potential of a fractured carbonate aquifer in the Upper Muschelkalk of SW Germany was investigated, where denitrification is due to the oxidation of ferrous iron and reduced sulfur. Petrographical analyses of rock samples revealed concentrations of syn-sedimentary and diagenetically formed pyrite ranging from 1 to 4 wt.% with only small differences between different facies types. Additional ferrous iron is available in saddle dolomites (up to 2.6 wt.%), which probably were formed by tectonically induced percolation of low-temperature hydrothermal fluids. Borehole logging at groundwater wells (flowmeter, video, gamma) indicates that most groundwater flow occurs along karstified bedding planes partly located within dolomites of the shoal and backshoal facies. The high porosity (15–30%) of these facies facilitates molecular diffusive exchange of solutes between flow paths in the fractures and the reactive minerals in the pore matrix. The high-porosity facies together with hydraulically active fractures featuring pyrite or saddle dolomite precipitates constitute the zones of highest nitrate reduction potential within the aquifer. Model-based estimates of electron acceptor/donor balances indicate that the nitrate reduction potential protecting water supply wells increases with increasing porosity of the rock matrix and decreases with increasing hydraulic conductivity (or effective fracture aperture) and spacing of the fracture network.
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Description: Eberhard Karls Universität Tübingen (1020)
    Keywords: ddc:551.49 ; Fractured rocks ; Groundwater protection ; Nitrate ; Carbonate facies ; Germany
    Language: English
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  • 10
    Publication Date: 2023-11-13
    Description: We assessed the spatial and temporal variability of the Arctic Boundary Current (ABC) using seven oceanographic moorings, deployed across the continental slope north of Severnaya Zemlya in 2015–2018. Transports and individual water masses were quantified based on temperature and salinity recorders and current profilers. Our results were compared with observations from the northeast Svalbard and the central Laptev Sea continental slopes to evaluate the hydrographic transformation along the ABC pathway. The highest velocities (〉0.30 m s〈sup〉−1〈/sup〉) of the ABC occurred at the upper continental slope and decreased offshore to below 0.03 m s〈sup〉−1〈/sup〉 in the deep basin. The ABC showed seasonal variability with velocities two times higher in winter than in summer. Compared to upstream conditions in Svalbard, water mass distribution changed significantly within 20 km of the shelf edge due to mixing with‐ and intrusion of shelf waters. The ABC transported 4.15 ± 0.3 Sv in the depth range 50–1,000 m, where 0.88 ± 0.1, 1.5 ± 0.2, 0.61 ± 0.1 and 1.0 ± 0.15 Sv corresponded to Atlantic Water (AW), Dense Atlantic Water (DAW), Barents Sea Branch Water (BSBW) and Transformed Atlantic Water (TAW). 62–70% of transport was constrained to within 30–40 km of the shelf edge, and beyond 84 km, transport increases were estimated to be 0.54 Sv. Seasonality of TAW derived from local shelf‐processes and advection of seasonal‐variable Fram Strait waters, while BSBW transport variability was dominated by temperature changes with maximum transport coinciding with minimum temperatures. Further Barents Sea warming will likely reduce TAW and BSBW transport leading to warmer conditions along the ABC pathway.
    Description: Plain Language Summary: We assessed the structure and seasonal variability of the flow and water masses of the Arctic Boundary Current (ABC) in the region north of Severnaya Zemlya. This current is important in the Arctic Ocean as it transports relatively warm and saline waters along the Eurasian Arctic continental slope. We quantified the flow, transport and hydrographic variability of the ABC. Compared to observations from upstream, our results indicate that the water masses away from the shelf break maintained the hydrographic characteristics from upstream. In contrast, the water masses near the shelf break were significantly cooled and freshened due to intrusion of‐ and mixing with shelf waters. The water masses near the shelf break showed a seasonal signal in volume transport and temperature which derives from local shelf processes, advection of seasonal‐variable waters along the ABC pathway and the seasonal cooling of the Barents Sea. If the warming trend in the Barents Sea continues, warmer waters are expected to be advected eastward along the Eurasian continental slope by the ABC.
    Description: Key Points: We quantify the Arctic Boundary Current (ABC) transport north of Severnaya Zemlya with a 2015–2018 mooring array. Hydrographic changes along the ABC pathway are most prominent at the continental slope due to the interaction with shelf water. Seasonality of water masses from the shelf sea was observed in transport, temperature and off‐shelf excursions within the ABC.
    Description: Bundesministerium für Bildung und Forschung http://dx.doi.org/10.13039/501100002347
    Description: EC Horizon 2020 Framework Programme http://dx.doi.org/10.13039/100010661
    Description: Russian Science Foundation http://dx.doi.org/10.13039/501100006769
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Description: https://doi.pangaea.de/10.1594/PANGAEA.951363
    Description: https://doi.pangaea.de/10.1594/PANGAEA.951394
    Description: https://doi.pangaea.de/10.1594/PANGAEA.951394
    Description: https://doi.pangaea.de/10.1594/PANGAEA.954244
    Description: https://doi.pangaea.de/10.1594/PANGAEA.954249
    Description: https://doi.pangaea.de/10.1594/PANGAEA.954299
    Description: https://doi.pangaea.de/10.1594/PANGAEA.954352
    Keywords: ddc:551.48 ; Arctic Boundary Current ; seasonal transport variability ; water mass transport ; along‐slope current
    Language: English
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