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  • 1
    Online Resource
    Online Resource
    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    URL: https://doi.org/10.1007/978-3-030-79511-5
    DOI: 10.1007/978-3-030-79511-5
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Satellite Precipitation Measurement : Volume 1 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Atmospheric science. ; Water. ; Hydrology. ; Climatology. ; Measurement. ; Measuring instruments. ; Atmospheric Science. ; Water. ; Climate Sciences. ; Measurement Science and Instrumentation.
    Description / Table of Contents: SECTION 1 Status of Observations and Satellite Programs: Chapter 1. The Global Precipitation Measurement (GPM) mission -- Chapter 2. Status of the CloudSat mission -- Chapter 3. The Megha-Tropiques mission after seven years in space -- Chapter 4. Microwave sensors, imagers and sounders -- Chapter 5. Microwave and sub-mm wave sensors: A European perspective -- Chapter 6. Plans for future missions -- SECTION 2 Retrieval Techniques, Algorithms and Sensors: Chapter 7. Introduction to passive microwave retrieval methods -- Chapter 8. The Goddard Profiling (GPROF) precipitation retrieval algorithm -- Chapter 9. Precipitation estimation from the Microwave Integrated Retrieval System (MiRS) -- Chapter 10. Introduction to radar rain retrieval methods -- Chapter 11. Dual-frequency Precipitation Radar (DPR) on the Global Precipitation Measurements (GPM) mission’s Core Observatory -- Chapter 12. DPR dual-frequency precipitation classification -- Chapter 13. Triple-frequency radar retrievals -- Chapter 14. Precipitation retrievals from satellite combined radar and radiometer observations -- Chapter 15. Scattering of hydrometeors -- Chapter 16. Radar snowfall measurement -- Chapter 17. A 1DVar-based snowfall rate algorithm for passive microwave radiometers -- Chapter 18. X-band synthetic aperture radar methods -- SECTION 3 Merged Precipitation Products: Chapter 19. Integrated Multi-satellitE Retrievals for the Global Precipitation Measurement (GPM) mission (IMERG) -- Chapter 20. Global Satellite Mapping of Precipitation (GSMaP) products in the GPM era -- Chapter 21. Improving PERSIANN-CCS using passive microwave rainfall estimation -- Chapter 22. TAMSAT -- Chapter 23. Algorithm and data improvements for version 2.1 of the Climate Hazards Center’s Infrared Precipitation with Stations Data Set -- Chapter 24. Merging the infrared fleet and the microwave constellation for tropical hydrometeorology (TAPEER) and global climate monitoring (GIRAFE) applications -- SECTION 4 Validation: Chapter 25. The IPWG satellite precipitation validation effort -- Chapter 26. The GPM Ground Validation Program -- Chapter 27. The GPM DPR Validation Program -- Chapter 28. Error and uncertainty characterization -- Chapter 29. Multiscale evaluation of satellite precipitation products: Effective resolution of IMERG -- Chapter 30. Remote sensing of orographic precipitation -- Chapter 31. Integrated multi-satellite evaluation for the Global Precipitation Measurement: Impact of precipitation types on spaceborne precipitation estimation -- Chapter 32. Hydrologic validation and flood analysis -- Chapter 33. Global-scale evaluation of 22 precipitation datasets using gauge observations and hydrological modeling -- Chapter 34. OceanRAIN – The global ocean surface-reference dataset for characterization, validation and evaluation of the water cycle -- SECTION 5 Observed Characteristics of Precipitation: Chapter 35. GPCP and the global characteristics of precipitation -- Chapter 36. Global snowfall detection and measurement -- Chapter 37. Snowfall detection by spaceborne radars -- Chapter 38. On the duration and lifecyle of precipitation systems in the tropics -- Chapter 39. Observational characteristics of warm-type heavy rainfall -- Chapter 40. Satellite precipitation measurement and extreme rainfall -- Chapter 41. Rainfall trends in East Africa from an ensemble of IR-based satellite products -- Chapter 42. Heavy precipitation systems in the Mediterranean area: The role of GPM -- Chapter 43. Dryland precipitation climatology from satellite observations -- Chapter 44. Haifall detection -- Chapter 45. Improving high-latitude and cold region precipitation analysis -- Chapter 46. Latent heating retrievals from satellite observations -- SECTION 6 Applications: Chapter 47. Operational applications of Global Precipitation Measurement observations -- Chapter 48. Assimilation of precipitation observations from space into numerical weather prediction (NWP) -- Chapter 49. Precipitation ensemble data assimilation in NWP models -- Chapter 50. PERSIANN-CDR for hydrology and hydro-climatic applications -- Chapter 51. Soil moisture and precipitation: The SM2RAIN algorithm for rainfall retrieval from satellite soil moisture -- Chapter 52. Drought risk management using satellite-based rainfall estimates -- Chapter 53. Two decades of urban hydroclimatological studies have yielded discovery and societal benefits -- Chapter 54. Validation of climate models -- Chapter 55. Extreme precipitation in the Himalayan landslide hotspot -- Chapter 56. The value of satellite rainfall estimates in agriculture and food security -- Chapter 57. Using satellite estimates of precipitation for fire danger rating -- Chapter 58. Variability of satellite sea surface salinity under rainfall.
    Abstract: This book offers a complete overview of the measurement of precipitation from space, which has made considerable advancements during the last two decades. This is mainly due to the Tropical Rainfall Measuring Mission (TRMM), the Global Precipitation Measurement (GPM) mission, CloudSat and a carefully maintained constellation of satellites hosting passive microwave sensors. The book revisits a previous book, Measuring Precipitation from Space, edited by V. Levizzani, P. Bauer and F. J. Turk, published with Springer in 2007. The current content has been completely renewed to incorporate the advancements of science and technology in the field since then. This book provides unique contributions from field experts and from the International Precipitation Working Group (IPWG). The book will be of interest to meteorologists, hydrologists, climatologists, water management authorities, students at various levels and many other parties interested in making use of satellite precipitation data sets. Chapter “TAMSAT” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: LXXI, 450 p. 108 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030245689
    Series Statement: Advances in Global Change Research, 67
    URL: https://doi.org/10.1007/978-3-030-24568-9
    DOI: 10.1007/978-3-030-24568-9
    DDC: 551.5
    Language: English
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  • 3
    Online Resource
    Online Resource
    Machine Learning Techniques for Smart City Applications: Trends and Solutions (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Machine learning. ; Artificial intelligence. ; Medical policy. ; Transportation engineering. ; Traffic engineering. ; Business logistics. ; Machine Learning. ; Artificial Intelligence. ; Intelligence Infrastructure. ; Health Policy. ; Transportation Technology and Traffic Engineering. ; Logistics.
    Description / Table of Contents: Applying Deep Learning to Predict Civic Purpose Development: Within the Smart City Context -- Convolution Neural Network Scheme for Detection of Electricity Theft in Smart Grids -- Helping Hand: A GMM Based Real time Assistive Device for Disabled Using Hand Gestures -- A Review on Hand Gesture and Sign Language Techniques for Hearing Impaired Person -- DriveSense: Adaptive System for Driving Behaviour Analysis and Ranking -- Classification and Tracking of Vehicles Using Videos Captured by Unmanned Aerial Vehicles -- Tracking Everyone and Everything in Smart Cities with an ANN Driven Smart Antenna -- Wavelet based Saliency and Ensemble Classifier for Pedestrian Detection in Infrared Images -- A Survey of Emerging Applications of Machine Learning in the Diagnosis and Management of Sleep Hygiene and Health in the Elderly Population -- Smart City Traffic Patterns Prediction Using Machine Learning.
    Abstract: This book discusses the application of different machine learning techniques to the sub-concepts of smart cities such as smart energy, transportation, waste management, health, infrastructure, etc. The focus of this book is to come up with innovative solutions in the above-mentioned issues with the purpose of alleviating the pressing needs of human society. This book includes content with practical examples which are easy to understand for readers. It also covers a multi-disciplinary field and, consequently, it benefits a wide readership including academics, researchers, and practitioners.
    Type of Medium: Online Resource
    Pages: VIII, 226 p. 179 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031088599
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    URL: https://doi.org/10.1007/978-3-031-08859-9
    DOI: 10.1007/978-3-031-08859-9
    DDC: 006.31
    Language: English
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  • 4
    Online Resource
    Online Resource
    The Science and Business of Drug Discovery : Demystifying the Jargon (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacovigilance. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Drug Safety and Pharmacovigilance. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: Introduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline – discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline – clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters.
    Abstract: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .
    Type of Medium: Online Resource
    Pages: XVII, 402 p. 102 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030578145
    URL: https://doi.org/10.1007/978-3-030-57814-5
    DOI: 10.1007/978-3-030-57814-5
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Satellite Precipitation Measurement : Volume 2 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Atmospheric science. ; Climatology. ; Measurement. ; Measuring instruments. ; Water. ; Hydrology. ; Atmospheric Science. ; Climate Sciences. ; Measurement Science and Instrumentation. ; Water.
    Description / Table of Contents: SECTION 4 Validation: Chapter 25. The IPWG satellite precipitation validation effort -- Chapter 26. The GPM Ground Validation Program -- Chapter 27. The GPM DPR Validation Program -- Chapter 28. Error and uncertainty characterization -- Chapter 29. Multiscale evaluation of satellite precipitation products: Effective resolution of IMERG -- Chapter 30. Remote sensing of orographic precipitation -- Chapter 31. Integrated multi-satellite evaluation for the Global Precipitation Measurement: Impact of precipitation types on spaceborne precipitation estimation -- Chapter 32. Hydrologic validation and flood analysis -- Chapter 33. Global-scale evaluation of 22 precipitation datasets using gauge observations and hydrological modeling -- Chapter 34. OceanRAIN – The global ocean surface-reference dataset for characterization, validation and evaluation of the water cycle -- SECTION 5 Observed Characteristics of Precipitation: Chapter 35. GPCP and the global characteristics of precipitation -- Chapter 36. Global snowfall detection and measurement -- Chapter 37. Snowfall detection by spaceborne radars -- Chapter 38. On the duration and lifecyle of precipitation systems in the tropics -- Chapter 39. Observational characteristics of warm-type heavy rainfall -- Chapter 40. Satellite precipitation measurement and extreme rainfall -- Chapter 41. Rainfall trends in East Africa from an ensemble of IR-based satellite products -- Chapter 42. Heavy precipitation systems in the Mediterranean area: The role of GPM -- Chapter 43. Dryland precipitation climatology from satellite observations -- Chapter 44. Haifall detection -- Chapter 45. Improving high-latitude and cold region precipitation analysis -- Chapter 46. Latent heating retrievals from satellite observations -- SECTION 6 Applications: Chapter 47. Operational applications of Global Precipitation Measurement observations -- Chapter 48. Assimilation of precipitation observations from space into numerical weather prediction (NWP) -- Chapter 49. Precipitation ensemble data assimilation in NWP models -- Chapter 50. PERSIANN-CDR for hydrology and hydro-climatic applications -- Chapter 51. Soil moisture and precipitation: The SM2RAIN algorithm for rainfall retrieval from satellite soil moisture -- Chapter 52. Drought risk management using satellite-based rainfall estimates -- Chapter 53. Two decades of urban hydroclimatological studies have yielded discovery and societal benefits -- Chapter 54. Validation of climate models -- Chapter 55. Extreme precipitation in the Himalayan landslide hotspot -- Chapter 56. The value of satellite rainfall estimates in agriculture and food security -- Chapter 57. Using satellite estimates of precipitation for fire danger rating -- Chapter 58. Variability of satellite sea surface salinity under rainfall.
    Abstract: This book offers a complete overview of the measurement of precipitation from space, which has made considerable advancements during the last two decades. This is mainly due to the Tropical Rainfall Measuring Mission (TRMM), the Global Precipitation Measurement (GPM) mission, CloudSat and a carefully maintained constellation of satellites hosting passive microwave sensors. The book revisits a previous book, Measuring Precipitation from Space, edited by V. Levizzani, P. Bauer and F. J. Turk, published with Springer in 2007. The current content has been completely renewed to incorporate the advancements of science and technology in the field since then. This book provides unique contributions from field experts and from the International Precipitation Working Group (IPWG). The book will be of interest to meteorologists, hydrologists, climatologists, water management authorities, students at various levels and many other parties interested in making use of satellite precipitation data sets.
    Type of Medium: Online Resource
    Pages: XCIII, 725 p. 300 illus., 251 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357986
    Series Statement: Advances in Global Change Research, 69
    URL: https://doi.org/10.1007/978-3-030-35798-6
    DOI: 10.1007/978-3-030-35798-6
    DDC: 551.5
    Language: English
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