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An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer (2020)

Wang, Jia-Bin ; Li, Ping ; Liu, Xiao-Long ; [weitere]

Springer Nature

In: Nature Communications. 2020; 11(1): 6352. Published 2020 Dec 01. doi: 10.1038/s41467-020-20260-7.

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Publikationsdatum: 2020-12-01

Beschreibung: Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of different immunosuppressive molecules makes it very difficult to accurately predict clinical outcomes based only on a single immunosuppressive molecule. Here, we establish a comprehensive immune scoring system (ISSGC) based on 6 immunosuppressive ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using the LASSO method to improve prognostic accuracy and provide an additional selection strategy for adjuvant chemotherapy of gastric cancer (GC). The results show that ISSGC is an independent prognostic factor and a supplement of TNM stage for GC patients, and it can improve their prognosis prediction accuracy; in addition, it can distinguish GC patients with better prognosis from those with high prognostic nutritional index score; furthermore, ISSGC can also be used as a tool to select GC patients who would benefit from adjuvant chemotherapy independent of their TNM stages, MSI status and EBV status.

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Three-dimensionally bonded spongy graphene material with super compressive elasticity and near-zero Poisson’s ratio (2015)

Yingpeng Wu; Ningbo Yi; Lu Huang; Tengfei Zhang; Shaoli Fang; Huicong Chang; Na Li; Jiyoung Oh; Jae Ah Lee; Mikhail Kozlov; Alin C. Chipara; Humberto Terrones; Peishuang Xiao; Guankui Long; Yi Huang; Fan Zhang; Long Zhang; Xavier LepróCarter Haines; Márcio Dias Lima; Nestor Perea Lopez; Lakshmy P. Rajukumar; Ana L. Elias; Simin Feng; Seon Jeong Kim; N. T. Narayanan; Pulickel M. Ajayan; Mauricio Terrones; Ali Aliev; Pengfei Chu; Zhong Zhang; Ray H. Baughman; Yongsheng Chen

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-01-22

Beschreibung: Article The incorporation of the desirable properties of graphene into three-dimensional materials remains challenging. Here, the authors report the scalable self-assembly of graphene sheets into spongy materials with very low densities, and near-zero and largely strain-independent Poisson's ratios in all directions. Nature Communications doi: 10.1038/ncomms7141 Authors: Yingpeng Wu, Ningbo Yi, Lu Huang, Tengfei Zhang, Shaoli Fang, Huicong Chang, Na Li, Jiyoung Oh, Jae Ah Lee, Mikhail Kozlov, Alin C. Chipara, Humberto Terrones, Peishuang Xiao, Guankui Long, Yi Huang, Fan Zhang, Long Zhang, Xavier Lepró, Carter Haines, Márcio Dias Lima, Nestor Perea Lopez, Lakshmy P. Rajukumar, Ana L. Elias, Simin Feng, Seon Jeong Kim, N. T. Narayanan, Pulickel M. Ajayan, Mauricio Terrones, Ali Aliev, Pengfei Chu, Zhong Zhang, Ray H. Baughman, Yongsheng Chen

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls (2015)

Zezhang Zhu; Nelson Leung-Sang Tang; Leilei Xu; Xiaodong Qin; Saihu Mao; Yueming Song; Limin Liu; Fangcai Li; Peng Liu; Long Yi; Jiang Chang; Long Jiang; Bobby Kin-Wah Ng; Benlong Shi; Wen Zhang; Jun Qiao; Xu Sun; Xusheng Qiu; Zhou Wang; Fei Wang; Dingding Xie; Ling Chen; Zhonghui Chen; Mengran Jin; Xiao Han; Zongshan Hu; Zhen Zhang; Zhen Liu; Feng Zhu; Bang-ping Qian; Yang Yu; Bing Wang; K. M. Lee; Wayne Y.W. Lee; T. P. Lam; Yong Qiu; Jack Chun-Yiu Cheng

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-09-24

Beschreibung: Article The authors perform a genome-wide association study of adolescent idiopathic scoliosis patients of Han Chinese descent, and identify 3 new loci for disease susceptibility. Nature Communications doi: 10.1038/ncomms9355 Authors: Zezhang Zhu, Nelson Leung-Sang Tang, Leilei Xu, Xiaodong Qin, Saihu Mao, Yueming Song, Limin Liu, Fangcai Li, Peng Liu, Long Yi, Jiang Chang, Long Jiang, Bobby Kin-Wah Ng, Benlong Shi, Wen Zhang, Jun Qiao, Xu Sun, Xusheng Qiu, Zhou Wang, Fei Wang, Dingding Xie, Ling Chen, Zhonghui Chen, Mengran Jin, Xiao Han, Zongshan Hu, Zhen Zhang, Zhen Liu, Feng Zhu, Bang-ping Qian, Yang Yu, Bing Wang, K. M. Lee, Wayne Y.W. Lee, T. P. Lam, Yong Qiu, Jack Chun-Yiu Cheng

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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