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  • 1
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    Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Day, M -- Morris, R G -- New York, N.Y. -- Science. 2001 Aug 3;293(5531):755.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK. Mark@cfn.ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11486056" target="_blank"〉PubMed〈/a〉
    Keywords: 2-Amino-5-phosphonovalerate/pharmacology ; Animals ; Doxycycline/pharmacology ; Gene Deletion ; Hippocampus/*physiology ; Memory/drug effects/*physiology ; Mice ; Rats ; Receptors, N-Methyl-D-Aspartate/*genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Schemas and memory consolidation (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-04-07
    Description: Memory encoding occurs rapidly, but the consolidation of memory in the neocortex has long been held to be a more gradual process. We now report, however, that systems consolidation can occur extremely quickly if an associative "schema" into which new information is incorporated has previously been created. In experiments using a hippocampal-dependent paired-associate task for rats, the memory of flavor-place associations became persistent over time as a putative neocortical schema gradually developed. New traces, trained for only one trial, then became assimilated and rapidly hippocampal-independent. Schemas also played a causal role in the creation of lasting associative memory representations during one-trial learning. The concept of neocortical schemas may unite psychological accounts of knowledge structures with neurobiological theories of systems memory consolidation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tse, Dorothy -- Langston, Rosamund F -- Kakeyama, Masaki -- Bethus, Ingrid -- Spooner, Patrick A -- Wood, Emma R -- Witter, Menno P -- Morris, Richard G M -- G9200370/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2007 Apr 6;316(5821):76-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, and Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17412951" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning ; Cues ; Hippocampus/*physiology ; Male ; *Memory ; Mental Recall ; Neocortex/*physiology ; Rats ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Schema-dependent gene activation and memory encoding in neocortex (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-09
    Description: When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tse, Dorothy -- Takeuchi, Tomonori -- Kakeyama, Masaki -- Kajii, Yasushi -- Okuno, Hiroyuki -- Tohyama, Chiharu -- Bito, Haruhiko -- Morris, Richard G M -- G0700447/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):891-5. doi: 10.1126/science.1205274. Epub 2011 Jul 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh EH8 9JZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21737703" target="_blank"〉PubMed〈/a〉
    Keywords: 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology ; Animals ; Cues ; Cytoskeletal Proteins/genetics ; Early Growth Response Protein 1/genetics ; *Genes, Immediate-Early ; Hippocampus/*physiology ; Learning ; Male ; *Memory ; *Mental Recall ; Neocortex/*physiology ; Nerve Tissue Proteins/genetics ; Prefrontal Cortex/*physiology ; Rats ; Receptors, AMPA/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Synaptic Transmission/drug effects ; *Transcriptional Activation ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Baryons at the edge of the X-ray-brightest galaxy cluster (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-26
    Description: Studies of the diffuse x-ray-emitting gas in galaxy clusters have provided powerful constraints on cosmological parameters and insights into plasma astrophysics. However, measurements of the faint cluster outskirts have become possible only recently. Using data from the Suzaku x-ray telescope, we determined an accurate, spatially resolved census of the gas, metals, and dark matter out to the edge of the Perseus Cluster. Contrary to previous results, our measurements of the cluster baryon fraction are consistent with the expected universal value at half of the virial radius. The apparent baryon fraction exceeds the cosmic mean at larger radii, suggesting a clumpy distribution of the gas, which is important for understanding the ongoing growth of clusters from the surrounding cosmic web.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simionescu, Aurora -- Allen, Steven W -- Mantz, Adam -- Werner, Norbert -- Takei, Yoh -- Morris, R Glenn -- Fabian, Andrew C -- Sanders, Jeremy S -- Nulsen, Paul E J -- George, Matthew R -- Taylor, Gregory B -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1576-9. doi: 10.1126/science.1200331.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 452 Lomita Mall, Stanford, CA 94305, USA. asimi@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436446" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Neuroscience. The imaginary mind of a mouse (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, Richard G M -- Takeuchi, Tomonori -- G0700447/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Mar 23;335(6075):1455-6. doi: 10.1126/science.1220824.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cognitive and Neural Systems, University. of Edinburgh, Edinburgh EH8 9JZ, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22442473" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; *Fear ; *Memory ; Neurons/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Impaired spatial learning after saturation of long-term potentiation (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-25
    Description: If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naive test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (〈10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moser, E I -- Krobert, K A -- Moser, M B -- Morris, R G -- New York, N.Y. -- Science. 1998 Sep 25;281(5385):2038-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Norwegian University of Science and Technology, 7034 Trondheim, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9748165" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dentate Gyrus/physiology ; Electric Stimulation ; Electrodes, Implanted ; Evoked Potentials ; Excitatory Postsynaptic Potentials ; Hippocampus/*physiology ; Long-Term Potentiation/*physiology ; Male ; Maze Learning/*physiology ; Perforant Pathway ; Rats ; Synapses/physiology ; Tetany
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Neuroscience: Shedding light on a change of mind (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeuchi, Tomonori -- Morris, Richard G M -- England -- Nature. 2014 Sep 18;513(7518):323-4. doi: 10.1038/nature13745. Epub 2014 Aug 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh EH8 9JZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25162529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Hippocampus/*physiology ; Male ; Memory/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Transport on Coupled Spatial Networks (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-09-19
    Description: Author(s): R. G. Morris and M. Barthelemy Transport processes on spatial networks are representative of a broad class of real world systems which, rather than being independent, are typically interdependent. We propose a measure of utility to capture key features that arise when such systems are coupled together. The coupling is defined in ... [Phys. Rev. Lett. 109, 128703] Published Tue Sep 18, 2012
    Keywords: Soft Matter, Biological, and Interdisciplinary Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
    Electronic Resource
    Electronic Resource
    Interference from digoxin-like immunoreactive substance(s) in commercial digoxin kit assay methods (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 359-363 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; immunoassay ; analytical interference ; therapeutic drug monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have examined the current state of interference by digoxin-like immunoreactive substance(s) (DLIS) in 10 commercially available digoxin assay methods, ie 5 radioimmunoassays (RIA) and 5 non-radioactive immunoassays. Fifty-five specimens of maternal venous blood (30 from third trimester pregnancy and 25 at delivery) and 32 cord samples from their offspring were tested (none of the subjects being medicated with digoxin). The results demonstrated a wide range of DLIS interference with values up to 1.1 μg·l−1 being obtained in the cord blood specimens. Of the methods tested the “Coat-a Count” RIA (Diagnostic Products Corporation) and the EMIT column method (Syva) run on the Cobas MIRA (Roche) consistently showed the least interference with respect to all 3 sources of specimens. The Delfia Method (LKB/Wallac) consistently showed the greatest crossreactivity with DLIS. The present study thus demonstrates that DLIS interference persists in several commercial digoxin methods and suggests that the use of data obtained from such methods may compromise patient management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315410
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  • 10
    Electronic Resource
    Electronic Resource
    Disposition of epirubicin and metabolites with repeated courses to cancer patients (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 481-487 
    Details
    ISSN: 1432-1041
    Keywords: Epirubicin ; pharmacokinetics ; plasma concentrations ; cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thirteen cancer patients were studied following a total of 41 courses of epirubicin (EPI) (38–50 mg·m−2, mean 49.2 mg·m−2, administered by a 60 min infusion), together with other cancer chemotherapeutic agents. The aim was to consider the disposition of EPI and metabolites following subsequent courses as it has been reported that doxorubicin (the 4′-epimer parent of EPI) clearance is increased following the first administration. We have observed that EPI-glucuronide accounted for a mean 78.0%, epirubicinol 0.2% and epirubicinol-glucuronide 19.3% and that parent EPI accounted for only 2.4% of the EPI-compounds measured (mean of all patients and courses) for the 3 h period immediately following the infusion. These data confirm the rapid metabolism of EPI and the dominance of the glucuronidation metabolite pathway (which is not available to doxorubicin) and are compared with the metabolite profile observed in other reports. Large inter- and intra-individual variability in area under the plasma concentration/time curve were observed with no clear evidence of any consistent directional trend for such fluctuations, suggesting that factors contributing to EPI disposition are multivariate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315227
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