Publication Date:
1998-09-25
Description:
The development of the Drosophila eye has served as a model system for investigations of tissue patterning and cell-cell communication; however, early eye development has not been well understood. The results presented here indicate that specialized cells are established along the dorsal-ventral midline of the developing eye by Notch-mediated signaling between dorsal and ventral cells, and that Notch activation at the midline plays an essential role both in promoting the growth of the eye primordia and in regulating eye patterning. These observations imply that the developmental homology between Drosophila wings and vertebrate limbs extends to Drosophila eyes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Papayannopoulos, V -- Tomlinson, A -- Panin, V M -- Rauskolb, C -- Irvine, K D -- GM-R01-54594/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Sep 25;281(5385):2031-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, NJ 08854, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9748163" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Patterning
;
Calcium-Binding Proteins
;
Drosophila/genetics/*growth & development/metabolism
;
*Drosophila Proteins
;
Eye Proteins/genetics
;
Gene Expression Regulation, Developmental
;
Genes, Insect
;
Homeodomain Proteins
;
Insect Proteins/genetics/physiology
;
Intercellular Signaling Peptides and Proteins
;
Intracellular Signaling Peptides and Proteins
;
Larva/growth & development
;
Ligands
;
Membrane Proteins/genetics/*physiology
;
Morphogenesis
;
Mutation
;
*N-Acetylglucosaminyltransferases
;
Photoreceptor Cells, Invertebrate/cytology/*growth & development
;
Receptors, Notch
;
Signal Transduction
;
*Transcription Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
