Publication Date:
1995-11-10
Description:
The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell blasts with up-regulated activation markers. These blast cells also infiltrated liver, heart, lung, and pancreas tissue, and amounts of serum immunoglobulin were elevated. The mice invariably became moribund by 3 to 4 weeks of age. Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation. Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waterhouse, P -- Penninger, J M -- Timms, E -- Wakeham, A -- Shahinian, A -- Lee, K P -- Thompson, C B -- Griesser, H -- Mak, T W -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):985-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, University of Toronto, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481803" target="_blank"〉PubMed〈/a〉
Keywords:
Abatacept
;
Animals
;
Antigens, CD/analysis
;
Antigens, CD95/metabolism
;
Antigens, Differentiation/genetics/*physiology
;
Apoptosis
;
B-Lymphocytes/immunology
;
CTLA-4 Antigen
;
Cells, Cultured
;
Concanavalin A/pharmacology
;
Female
;
Gamma Rays
;
Gene Targeting
;
Homeostasis
;
*Immunoconjugates
;
Immunoglobulins/blood
;
Immunophenotyping
;
Lymph Nodes/immunology/pathology
;
*Lymphocyte Activation
;
Lymphoproliferative Disorders/*immunology/pathology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Spleen/immunology/pathology
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
