Publication Date:
1990-03-09
Description:
The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Redondo, J M -- Hata, S -- Brocklehurst, C -- Krangel, M S -- R01-GM41052/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Mar 9;247(4947):1225-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2156339" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
Binding Sites
;
Cell Line
;
Chloramphenicol O-Acetyltransferase/genetics
;
DNA Restriction Enzymes
;
Deoxyribonuclease I
;
Enhancer Elements, Genetic/*genetics
;
Gene Rearrangement
;
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
;
Humans
;
Molecular Sequence Data
;
Mutation
;
Nuclear Proteins/metabolism
;
Plasmids
;
Promoter Regions, Genetic/genetics
;
Receptors, Antigen, T-Cell/*genetics
;
Repetitive Sequences, Nucleic Acid
;
*Transcription, Genetic
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
