Publication Date:
2007-03-10
Description:
Sleep facilitates memory consolidation. A widely held model assumes that this is because newly encoded memories undergo covert reactivation during sleep. We cued new memories in humans during sleep by presenting an odor that had been presented as context during prior learning, and so showed that reactivation indeed causes memory consolidation during sleep. Re-exposure to the odor during slow-wave sleep (SWS) improved the retention of hippocampus-dependent declarative memories but not of hippocampus-independent procedural memories. Odor re-exposure was ineffective during rapid eye movement sleep or wakefulness or when the odor had been omitted during prior learning. Concurring with these findings, functional magnetic resonance imaging revealed significant hippocampal activation in response to odor re-exposure during SWS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rasch, Bjorn -- Buchel, Christian -- Gais, Steffen -- Born, Jan -- New York, N.Y. -- Science. 2007 Mar 9;315(5817):1426-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160/23a, 23538 Lubeck, Germany. rasch@kfg.uni-luebeck.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17347444" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Brain/physiology
;
Brain Mapping
;
*Cues
;
Electroencephalography
;
Female
;
Hippocampus/*physiology
;
Humans
;
*Learning
;
Magnetic Resonance Imaging
;
Male
;
Memory/*physiology
;
*Odors
;
Sleep/*physiology
;
Sleep, REM/physiology
;
Wakefulness
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
