Publication Date:
2006-12-16
Description:
Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide receptors. Neutrophils rapidly hydrolyze released ATP to adenosine that then acts via A3-type adenosine receptors, which are recruited to the leading edge, to promote cell migration. Thus, ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Yu -- Corriden, Ross -- Inoue, Yoshiaki -- Yip, Linda -- Hashiguchi, Naoyuki -- Zinkernagel, Annelies -- Nizet, Victor -- Insel, Paul A -- Junger, Wolfgang G -- GM-60475/GM/NIGMS NIH HHS/ -- GM-66232/GM/NIGMS NIH HHS/ -- PR043034/PR/OCPHP CDC HHS/ -- R01 GM-51477/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Dec 15;314(5806):1792-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17170310" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine/metabolism/pharmacology
;
Adenosine A3 Receptor Agonists
;
Adenosine A3 Receptor Antagonists
;
Adenosine Triphosphate/analogs & derivatives/*metabolism/pharmacology
;
Animals
;
*Autocrine Communication
;
Cell Membrane/metabolism
;
*Chemotaxis, Leukocyte/drug effects
;
Cytoplasmic Granules/metabolism
;
HL-60 Cells
;
Humans
;
Hydrolysis
;
Mice
;
Mice, Knockout
;
Neutrophils/drug effects/metabolism/*physiology
;
Purinergic P2 Receptor Antagonists
;
Receptor, Adenosine A3/*metabolism
;
Receptors, Purinergic P2/*metabolism
;
Receptors, Purinergic P2Y2
;
Signal Transduction
;
Suramin/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
