Publication Date:
2016-01-23
Description:
Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as latent tumour-initiating seeds and eventually breaking out to replace the host tissue. They make metastasis a highly inefficient process. However, once metastases have been established, current treatments frequently fail to provide durable responses. An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Massague, Joan -- Obenauf, Anna C -- CA129243/CA/NCI NIH HHS/ -- CA163167/CA/NCI NIH HHS/ -- P30 CA008748/CA/NCI NIH HHS/ -- England -- Nature. 2016 Jan 21;529(7586):298-306. doi: 10.1038/nature17038.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA. ; Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26791720" target="_blank"〉PubMed〈/a〉
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
