Publikationsdatum:
2012-10-16
Beschreibung:
Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and pathological brain functions related to reward and motivation. However, it is unknown whether subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures, and whether inputs to the VTA differentially modulate such circuits. Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (gamma-aminobutyric-acid-containing) neurons in the rostromedial tegmental nucleus. These results establish that distinct VTA circuits generate reward and aversion, and thereby provide a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493743/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493743/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lammel, Stephan -- Lim, Byung Kook -- Ran, Chen -- Huang, Kee Wui -- Betley, Michael J -- Tye, Kay M -- Deisseroth, Karl -- Malenka, Robert C -- NS069375/NS/NINDS NIH HHS/ -- P50 MH086403/MH/NIMH NIH HHS/ -- England -- Nature. 2012 Nov 8;491(7423):212-7. doi: 10.1038/nature11527. Epub 2012 Oct 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23064228" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Avoidance Learning/drug effects/*physiology
;
Axons/metabolism
;
Dopamine/metabolism
;
Dopamine Antagonists/pharmacology
;
Dopaminergic Neurons/metabolism
;
GABAergic Neurons/metabolism
;
Habenula/cytology/physiology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Models, Neurological
;
Neural Pathways/*physiology
;
Receptors, Dopamine/metabolism
;
*Reward
;
Synapses/metabolism
;
Ventral Tegmental Area/cytology/*physiology
Print ISSN:
0028-0836
Digitale ISSN:
1476-4687
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
