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Effect of sodium 4-phenylbutyrate on Clenbuterol-mediated muscle growth (2018)

Public Library of Science (PLoS)

In: PLoS ONE

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Publication Date: 2018-07-28

Description: by David M. Brown, Sarah Jones, Zoe C. T. R. Daniel, Madelaine C. Brearley, Jo E. Lewis, Francis J. P. Ebling, Tim Parr, John M. Brameld Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), would inhibit Clenbuterol-mediated muscle growth and reduce expression of genes that are known indicators of an ISR in mice. Clenbuterol (1mg/kg/day) administered to C57BL6/J mice for 21 days increased body weight ( p

Electronic ISSN: 1932-6203

Topics: Medicine , Natural Sciences in General

Published by Public Library of Science (PLoS)

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