ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Thin-layer chromatography
;
Reversed phase
;
2-benzoylbenzoic acids
;
Anionic and cationic counter ions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The 2-benzoylbenzoic acid series was investigated by reversed-phase, high-performance, thin-layer and column chromatography using various alkylammonium salts and di(2-ethylhexyl)orthophosphoric acid as polar associating reagents. The effects of the individual substituents on retention were quantified by Δlog k′ and ΔRM values. The compounds investigated differing in molecular structure (hydrophilic and hydrophobic substituents) commonly occurring groups in drugs and biologically active substances provide information on molecular interaction in these ion-pair systems. The combined effects on retention of organic modifier and ion-pair reagent concentration were investigated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02269912
