ISSN:
1435-1536
Keywords:
Key words HCO-10
;
vesicles
;
encapsulation
;
stability
;
solubilization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract The characteristics of poly(oxyethylene) hydrogenated caster oil ether (HCO-10) vesicles were studied for the standpoints of encapsulation efficiency, stability, solubilization and permeability or barrier efficiency. The vesicles of 5% HCO-10 had 6.24% of calcein-entrapment efficiency and 240 nm of mean diameter. The stability of HCO-10 vesicle suspensions was dependent on their concentrations. In the vesicle suspensions of 10% HCO-10 or more, both the size of the vesicles and the fluidity of the suspensions obviously varied with incubation time, indicating that a flocculation occurred; whereas, the vesicle suspension of 5% HCO-10 was relatively stable. The solubilization process of HCO-10 vesicles by SDS was similar to that of EggPC liposomes. The rate constants for permeation of Cl ion and calcein were 2.46×10-3 s-1 and 5.79×10-5 s-1, respectively, suggesting that HCO-10 vesicles possessed some barrier potential for Cl ion and calcein although they were smaller than those of liposomes. Furthermore, the efflux of the solute such as calcein from HCO-10 vesicles was maximum at 37 °C, where the vesicle membrane was presumably destabilized by dehydration of EOs in HCO-10 molecules.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003960050065
