ISSN:
1573-5044
Keywords:
Calystegine
;
tropane alkaloid
;
tropinone reductase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Calystegines are a new group of polyhydroxy alkaloids with a nortropane skeleton. They were detected in Atropa belladonna root cultures by chromatographic methods (TLC, GC) and identified by NMR and mass spectroscopy. Their occurrence was examined in several species of the Solanaceae. The biosynthesis of these compounds is suggested to proceed via the tropane alkaloid pathway, the first metabolite being pseudotropine. A pseudotropine-forming tropinone reductase was isolated and characterized from Atropa belladonna root cultures. Further evidence is given for the significance of tropinone and pseudotropine in calystegine formation by feeding experiments that increased calystegine formation. 15N-tropinone was shown to be incorporated into calystegines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00033882
