ISSN:
0941-1216
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Organic Syntheses Based on 2-Oxoglutaric Acid. II. On the Synthesis of Heterocycles by Reactions of Dimethyl 3-bromo-2-oxoglutarate with BinucleophilesReactions of dimethyl 3-bromo-2-oxoglutarate 2 with binucleophiles to form heterocycles proceed on two different pathways depending on the type of reactant. Thus, strong S-nucleophiles like thioureas and thiocarbohydrazide substitute initially the bromine atom and form 2-aminothiazoles 3-7 and the 1,3,4-thiadiazine 8. However, o-phenylendiamines reacted to form the brominated quinoxaline-2(1H)-one derivatives 9 and 10, resp.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19933350210