ISSN:
0941-1216
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
New Pyoverdin Siderophores from Pseudomonas putida CFour new pyoverdins (C 2A, C 2B, C 3A, C 3B) were isolated from cultures of Pseudomonas putida C. Their structures were elucidated by chemical and spectroscopic methods. The compounds consist of a chromophore - (1S)-5-amino-2,3-dihydro-8,9-dihydroxy-1H-pyrimido [1,2-a]quinoline-1-carboxylic acid - substituted at the amino group with a dicarboxylic acid or its amide. The carboxyl group of the chromophore is amidically bound to the N-terminus of L-Asp-D-[N5-hydroxy-N5-(D-β-hydroxybutyryl)] Orn-D-Dab-L-Thr-Gly-D-Ser-L-Ser-L-threo-β-hydroxy-Asp-L-Thr. The four pyoverdins differ only in the nature of the dicarboxylic acid (amide), viz. L-malamoyl- (C 2A), succinamoyl- (C 2B), L-3-carboxy-2-hydroxypropanoyl- (C 3A) or 3-carboxypropanoyl (C 3B) residue. The hydroxamate function consists of N5-hydroxy-Orn and β-hydroxybutyric acid, a structural unit which has been encountered for the first time in a pyoverdin.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19933350208
