ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The mass spectra of twenty one C-19 modified cholesteryl derivatives have been determined and compared with results for related systems. In the case when the hydrogen(s) of the C-19 group have been replaced by other groups the metastable evidence shows that in those molecules with a C-3 hydroxyl group the loss of water followed by the loss of the C-19 group gives rise to an intense ion at m/e 353, whereas the loss of the C-19 group with hydrogen transfer to the ion, followed by the loss of water gives rise to the large ion at m/e 354. In contrast in the case of the C-3 acetates the main fragmentation is the loss of acetic acid followed by the loss of the C-19 group to give the ion at m/e 353. This is rationalised on the basis of results observed in other systems. In the case of the C-3 tosylates evidence for pyrolysis before electron impact fragmentation is presented. The subsequent fragmentation of the large ions at m/e 354, 353 and other m/e values in the high mass region is shown to be in line with earlier work.
Additional Material:
22 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210010411
