Publication Date:
1996-12-06
Description:
An antigen administered orally can induce immunological tolerance to a subsequent challenge with the same antigen. Evidence has been provided for the efficacy of this approach in the treatment of human autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. However, oral administration of autoantigen in mice was found to induce a cytotoxic T lymphocyte response that could lead to the onset of autoimmune diabetes. Thus, feeding autoantigen can cause autoimmunity, which suggests that caution should be used when applying this approach to the treatment of human autoimmune diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blanas, E -- Carbone, F R -- Allison, J -- Miller, J F -- Heath, W R -- AI-29385/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1707-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939860" target="_blank"〉PubMed〈/a〉
Keywords:
Administration, Oral
;
Animals
;
Autoantigens/administration & dosage/*immunology
;
Autoimmune Diseases/*immunology
;
CD4-Positive T-Lymphocytes/immunology
;
Chimera
;
Diabetes Mellitus/*immunology
;
Dose-Response Relationship, Immunologic
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Ovalbumin/administration & dosage/*immunology
;
T-Lymphocytes, Cytotoxic/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
