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  • 1
    Schriftenreihen ausleihbar
    Schriftenreihen ausleihbar
    The precipitation regime of Long Island, New York (1969)
    Washington, DC : United States Gov. Print. Off.
    Dazugehörige Bände
    Details Verfügbarkeit
    Signatur: SR 90.0002(627-A)
    In: Professional paper
    Materialart: Schriftenreihen ausleihbar
    Seiten: VI, A-21 S. + 1 pl.
    Serie: U.S. Geological Survey professional paper 627-A
    Sprache: Englisch
    Standort: Kompaktmagazin unten
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Asymmetric Context-Dependent Mutation Patterns Revealed through Mutation-Accumulation Experiments (2015)
    Oxford University Press
    Details
    Publikationsdatum: 2015-06-22
    Beschreibung: Despite the general assumption that site-specific mutation rates are independent of the local sequence context, a growing body of evidence suggests otherwise. To further examine context-dependent patterns of mutation, we amassed 5,645 spontaneous mutations in wild- type (WT) and mismatch-repair deficient (MMR – ) mutation–accumulation (MA) lines of the gram-positive model organism Bacillus subtilis . We then analyzed〉7,500 spontaneous base-substitution mutations across B. subtilis , Escherichia coli , and Mesoplasma florum WT and MMR – MA lines, finding a context-dependent mutation pattern that is asymmetric around the origin of replication. Different neighboring nucleotides can alter site-specific mutation rates by as much as 75-fold, with sites neighboring G:C base pairs or dimers involving alternating pyrimidine–purine and purine–pyrimidine nucleotides having significantly elevated mutation rates. The influence of context-dependent mutation on genome architecture is strongest in M. florum , consistent with the reduced efficiency of selection in organisms with low effective population size. If not properly accounted for, the disparities arising from patterns of context-dependent mutation can significantly influence interpretations of positive and purifying selection.
    Print ISSN: 0737-4038
    Digitale ISSN: 1537-1719
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-16
    Beschreibung: Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase-mediated process that introduces nucleotide substitutions at defined locations within mtd. This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Minghsun -- Deora, Rajendar -- Doulatov, Sergei R -- Gingery, Mari -- Eiserling, Frederick A -- Preston, Andrew -- Maskell, Duncan J -- Simons, Robert W -- Cotter, Peggy A -- Parkhill, Julian -- Miller, Jeff F -- AI38417/AI/NIAID NIH HHS/ -- AI43986/AI/NIAID NIH HHS/ -- GM-08042/GM/NIGMS NIH HHS/ -- T32A107323/PHS HHS/ -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2091-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896279" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bacteriophages/enzymology/*genetics/*physiology/ultrastructure ; Bordetella bronchiseptica/genetics/metabolism/*virology ; *Genes, Viral ; Genetic Variation ; Genome, Viral ; Mutation ; RNA-Directed DNA Polymerase/genetics/*metabolism ; Receptors, Virus/metabolism ; Repetitive Sequences, Nucleic Acid ; Templates, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Coordinate regulation and sensory transduction in the control of bacterial virulence (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1989-02-17
    Beschreibung: Genes and operons that encode bacterial virulence factors are often subject to coordinate regulation. These regulatory systems are capable of responding to various environmental signals that may be encountered during the infectious cycle. For some pathogens, proteins that mediate sensory transduction and virulence control are similar to components of other bacterial information processing systems. Understanding the molecular mechanisms governing global regulation of pathogenicity is essential for understanding bacterial infectious diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, J F -- Mekalanos, J J -- Falkow, S -- AI23945/AI/NIAID NIH HHS/ -- AI26195/AI/NIAID NIH HHS/ -- AI26289/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1989 Feb 17;243(4893):916-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2537530" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bacteria/*pathogenicity ; Bacterial Infections/microbiology ; Bordetella pertussis/pathogenicity ; Humans ; Rhizobium/pathogenicity ; Vibrio cholerae/pathogenicity ; Virulence
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Public health and biosecurity. Adaptations of avian flu virus are a cause for concern (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2012-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berns, Kenneth I -- Casadevall, Arturo -- Cohen, Murray L -- Ehrlich, Susan A -- Enquist, Lynn W -- Fitch, J Patrick -- Franz, David R -- Fraser-Liggett, Claire M -- Grant, Christine M -- Imperiale, Michael J -- Kanabrocki, Joseph -- Keim, Paul S -- Lemon, Stanley M -- Levy, Stuart B -- Lumpkin, John R -- Miller, Jeffery F -- Murch, Randall -- Nance, Mark E -- Osterholm, Michael T -- Relman, David A -- Roth, James A -- Vidaver, Anne K -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):660-1. doi: 10.1126/science.1217994. Epub 2012 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics Institute, University of Florida, Gainesville, FL 32611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22294736" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptation, Biological ; Advisory Committees ; Animals ; Biological Warfare Agents ; Containment of Biohazards ; Humans ; Influenza A Virus, H5N1 Subtype/*pathogenicity ; Influenza, Human/epidemiology/transmission/*virology ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; *Public Health ; *Publishing ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Policy: Adaptations of avian flu virus are a cause for concern (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berns, Kenneth I -- Casadevall, Arturo -- Cohen, Murray L -- Ehrlich, Susan A -- Enquist, Lynn W -- Fitch, J Patrick -- Franz, David R -- Fraser-Liggett, Claire M -- Grant, Christine M -- Imperiale, Michael J -- Kanabrocki, Joseph -- Keim, Paul S -- Lemon, Stanley M -- Levy, Stuart B -- Lumpkin, John R -- Miller, Jeffery F -- Murch, Randall -- Nance, Mark E -- Osterholm, Michael T -- Relman, David A -- Roth, James A -- Vidaver, Anne K -- England -- Nature. 2012 Jan 31;482(7384):153-4. doi: 10.1038/482153a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉US National Science Advisory Board for Biosecurity, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22294204" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bioterrorism/prevention & control/*trends ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity/physiology ; Influenza, Human/*transmission/*virology ; Public Health ; Risk Assessment ; Zoonoses/transmission/virology
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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  • 7
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    Induction of autoimmune diabetes by oral administration of autoantigen (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-06
    Beschreibung: An antigen administered orally can induce immunological tolerance to a subsequent challenge with the same antigen. Evidence has been provided for the efficacy of this approach in the treatment of human autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. However, oral administration of autoantigen in mice was found to induce a cytotoxic T lymphocyte response that could lead to the onset of autoimmune diabetes. Thus, feeding autoantigen can cause autoimmunity, which suggests that caution should be used when applying this approach to the treatment of human autoimmune diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blanas, E -- Carbone, F R -- Allison, J -- Miller, J F -- Heath, W R -- AI-29385/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1707-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939860" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administration, Oral ; Animals ; Autoantigens/administration & dosage/*immunology ; Autoimmune Diseases/*immunology ; CD4-Positive T-Lymphocytes/immunology ; Chimera ; Diabetes Mellitus/*immunology ; Dose-Response Relationship, Immunologic ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Ovalbumin/administration & dosage/*immunology ; T-Lymphocytes, Cytotoxic/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Triggering bacterial virulence (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cotter, P A -- Miller, J F -- New York, N.Y. -- Science. 1996 Aug 30;273(5279):1183-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of California at Los Angeles School of Medicine, 90095-1747, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8787124" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Bacterial Adhesion ; Bacterial Outer Membrane Proteins/*genetics/secretion ; Bacterial Proteins/genetics ; Calcium/metabolism ; Escherichia coli/genetics/*pathogenicity ; *Escherichia coli Proteins ; Gene Expression Regulation, Bacterial ; HeLa Cells ; Humans ; Membrane Proteins/genetics ; *Phosphotransferases ; *Virulence/genetics ; Yersinia/genetics/*pathogenicity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Investigating a second thymus in mice (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2006-06-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, J F A P -- New York, N.Y. -- Science. 2006 Jun 16;312(5780):1597-8; author reply 1597-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16778037" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Choristoma ; Leukemia/etiology/prevention & control ; Mice ; Mice, Inbred Strains ; *Neck ; T-Lymphocytes/physiology ; Thymectomy ; *Thymus Gland/cytology/immunology/physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Neural activity in human hippocampal formation reveals the spatial context of retrieved memories (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-11-30
    Beschreibung: In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669102/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669102/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Jonathan F -- Neufang, Markus -- Solway, Alec -- Brandt, Armin -- Trippel, Michael -- Mader, Irina -- Hefft, Stefan -- Merkow, Max -- Polyn, Sean M -- Jacobs, Joshua -- Kahana, Michael J -- Schulze-Bonhage, Andreas -- MH-061975/MH/NIMH NIH HHS/ -- R01 MH055687/MH/NIMH NIH HHS/ -- R01 MH061975/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1111-4. doi: 10.1126/science.1244056.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Drexel University, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288336" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Separation ; Electrodes, Implanted ; Epilepsy ; Hippocampus/cytology/*physiology ; Humans ; *Memory, Episodic ; Neurons/*physiology ; Space Perception/*physiology ; Temporal Lobe/cytology/physiology ; User-Computer Interface
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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