Publication Date:
1996-04-12
Description:
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human primary macrophages. Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naldini, L -- Blomer, U -- Gallay, P -- Ory, D -- Mulligan, R -- Gage, F H -- Verma, I M -- Trono, D -- AG08514/AG/NIA NIH HHS/ -- AG10435/AG/NIA NIH HHS/ -- AI37510/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Apr 12;272(5259):263-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Salk Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8602510" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Brain/cytology/virology
;
Cell Division
;
Cells, Cultured
;
Female
;
*Gene Transfer Techniques
;
Genetic Therapy
;
*Genetic Vectors
;
HIV/*genetics/physiology
;
HeLa Cells
;
Humans
;
Macrophages/cytology/virology
;
Molecular Sequence Data
;
Neurons/cytology/virology
;
Plasmids
;
Rats
;
Transfection
;
Virus Integration
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
