Publication Date:
1983-06-03
Description:
Growth of vesicular stomatitis virus (VSV) in HeLa cells results in progeny containing non-VSV antigens with a molecular weight around 75,000. The non-VSV antigens were detected by antiserums to HeLa cell determinants. These antiserums precipitate whole virions but do not neutralize them. Because one of the antiserums is directed to a tumor-specific surface antigen of HeLa cells, it appears that VSV specifically acquires such antigens during its passage through human tumor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Little, L M -- Zavada, J -- Der, C J -- Huang, A S -- AI 16625/AI/NIAID NIH HHS/ -- CA 09031/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1069-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302845" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Neoplasm/*immunology
;
Antigens, Viral/immunology
;
Electrophoresis, Polyacrylamide Gel
;
HeLa Cells/*microbiology
;
Humans
;
Immune Sera/immunology
;
Melanoma/immunology
;
Molecular Weight
;
Rabbits/immunology
;
Sheep/immunology
;
Vesicular stomatitis Indiana virus/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
