Publication Date:
1999-11-05
Description:
The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt. Inactivation of the heterochronic gene lin-42 causes hypodermal terminal differentiation to occur precociously, during the third molt. LIN-42 most closely resembles the Period family of proteins from Drosophila and other organisms, proteins that function in another type of biological timing mechanism: the timing of circadian rhythms. Per mRNA levels oscillate with an approximately 24-hour periodicity. lin-42 mRNA levels also oscillate, but with a faster rhythm; the oscillation occurs relative to the approximately 6-hour molting cycles of postembryonic development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeon, M -- Gardner, H F -- Miller, E A -- Deshler, J -- Rougvie, A E -- GM50227/GM/NIGMS NIH HHS/ -- HD007480/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1999 Nov 5;286(5442):1141-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, MN 55108, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10550049" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Amino Acid Sequence
;
Animals
;
Caenorhabditis elegans/*chemistry/genetics/growth & development
;
*Caenorhabditis elegans Proteins
;
Cell Cycle Proteins
;
Cell Differentiation
;
*Circadian Rhythm
;
Cloning, Molecular
;
*Drosophila Proteins
;
Evolution, Molecular
;
Exons
;
Genes, Helminth
;
Helminth Proteins/*chemistry/*genetics/physiology
;
Humans
;
Insect Proteins/chemistry/genetics
;
Intracellular Signaling Peptides and Proteins
;
Molecular Sequence Data
;
Molting
;
Mutation
;
Nuclear Proteins/chemistry/genetics/physiology
;
Period Circadian Proteins
;
RNA, Helminth/genetics/metabolism
;
RNA, Messenger/genetics/metabolism
;
Repetitive Sequences, Amino Acid
;
Sequence Alignment
;
Transcription Factors/chemistry/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
