ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
A biocompatible glue consisting of human serum albumin (HSA) and citric acidderivative (CAD), named CAD-A glue was developed. CAD was successfully synthesized by thereaction between citric acid and N-hydroxysuccinimide in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride. When the CAD-A glue was applied to the collagenbasedcasings, it took 7 min to obtain half of maximum bonding strength (760 g/cm2). The bondingstrength of this glue to collagen-based casings increased with increasing of HSA concentration.Thebonding strength of CAD-A glue increased with increasing CAD concentration up to 200 mM, andthen decreased with increasing CAD concentration under the fixed HSA concentration (50 w/w%).The CAD-A glue showed excellent wound closure ability rather than fibrin glue when applied to themouse skin. These results suggested that this developed glue had both tissue compatibility andbonding strength for use in clinical field
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1339.pdf
