Publication Date:
2017-01-20
Description:
〈i〉SMARCA4〈/i〉-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers Nature Communications, Published online: 19 January 2017; doi:10.1038/ncomms14098 Lung cancers often harbour loss-of-function mutations in SMARCA4 . Here, the authors demonstrate a vulnerability of SMARCA4 -deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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