ALBERT

Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.

Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.

Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.

Description / Table of Contents: Preface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects. .

Description / Table of Contents: 1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells -- 2. Na+-K+-2Cl- Cotransporter -- 3. Thiazide-sensitive NaCl Cotransporter -- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia -- 5. Na+/H+ Exchangers in Epithelia -- 6. Sugar Transport Across Epithelia -- 7. Amino Acid Transporters of Epithelia -- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX) -- 9. Urea Transporters in Health and Disease -- 10. H,K-ATPases in Epithelia -- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells -- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters -- 13. ClC-2 Chloride Channels -- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology -- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine -- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator -- 17. TMEM16 Proteins (Anoctamins) in Epithelia -- 18. Epithelial Sodium Channels (ENaC) -- 19. ROMK and Bartter Syndrome Type 2 -- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron -- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels -- 22. KCa3.1 in Epithelia -- 23. BK Channels in Epithelia -- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels -- 25. KCNE regulation of KCNQ channels -- 26. Orai Channels -- 27. Trp Channels in Renal Epithelia -- 28. P2X receptors in Epithelia -- 29. The Polycystins and Polycystic Kidney Disease -- 30. Renal Aquaporins in Health and Disease.

Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.

Description / Table of Contents: Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.

Description / Table of Contents: Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index.

Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.

Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.

Description / Table of Contents: An introduction to reproducibility in the context of animal research -- Rodent Genetics -- Animal and environmental factors that influence reproducibility -- Microbiology and Microbiome -- Effects of untreated pain, anesthesia and analgesia in animal experimentation -- Why do we need a statistical experiment design -- Statistical tests and Sample size calculations -- Design of experiments -- Scholarly Publishing and Scientific Reproducibility -- Systematic reviews -- Planning animal experiments.

Description / Table of Contents: Chapter 1. Literature review -- Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology -- Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology -- Conclusion.

Description / Table of Contents: Part I. What Is Wrong with Health? What Should the Future of Health Be? -- INNOVATION DESIGN for the FUTURE of HEALTH -- Health Innovations from an Innovators’ Perspective -- From SICKCARE to HEALTHCARE to HEALTH -- Future Look on Health: Opportunities -- Navigating Towards a Future of “One Health” -- Part II. Exponential Medicine + Technologies + Mindset -- Exponential Technologies for an Exponential Medicine -- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study -- Healthy Longevity -- The Science of Health Longevity -- Space Healthtech: Innovation Base for Longevity -- Part III. Future Health Value Propositions -- Healthcare the Melting Pot of Technology, Humanity, and Confusion -- Democratize Health Delivery -- Health Innovation Process: Definitions and Short Methodology Introductions -- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health -- Digital Health Business Models: Transformation Is on the Horizon -- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable -- (Digital) Patient Journey and Empowerment: Digital Twin -- Part IV. Innovation Methodology Basics -- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver -- Purpose Launchpad Methodology: Introduction -- Design Thinking for Innovations in Healthcare -- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling -- Innovation Methodology I3 EME: Awareness for Biomedical Engineers -- Part V. Ethics + Health Innovation -- Integrating Ethical Considerations into Innovation Design -- Part VI. Health Innovation Design -- Case Studies Used Throughout the Book: Innovation Categories Explained -- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities? -- Purpose Launchpad Health (PLH) Methodology Introduction -- Part VII. Purpose Launchpad Health -- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies -- Part VIII. Health Leadership, Skills and other Methodologies -- Soft Skills Needed for Problem Understanding and Innovation Generation -- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches -- Future Skills Framework in Healthcare -- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry -- Part IX. Health Entrepreneurship -- Global Health Markets and Their Different Needs -- Patient: Health Relation and Digital Health Entrepreneurship -- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs -- Regulatory Issues for Health Innovations -- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare -- A Primer on Patents and IP for Health Innovations -- Successfully Implementing Ambidexterity in the Medical Industry -- Reverse Innovation: Circumvent Digital Health Transformation Issues -- Part X. Health Innovation Education and Incubation -- Health Innovation Design: “CAMPing” for the Unmet Clinical Need -- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University -- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University -- Clinical Innovation at Acibadem Biodesign Center -- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program -- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology -- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator -- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe -- Leadership-Compass: “Networking and Synapting Empowered by Health Captains” -- Part XI. Purpose Launchpad Health: Toolset Templates and Principles -- PLH Templates and Principles.

Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.

Description / Table of Contents: Part 1: What is Salivary Bioscience, Why is it Important, and How Do We Study It? -- Chapter 1: Foundations of Interdisciplinary Salivary Bioscience: An Introduction (Granger et al.) -- Chapter 2: Salivary Gland Anatomy and Physiology (Hernández et al.) -- Chapter 3: Saliva Collection, Handing, Transport, and Storage: Special Considerations and Best Practices for Interdisciplinary Salivary Bioscience(Padilla et al.) -- Chapter 4: Analytical Strategies and Tactics in Salivary Bioscience (Riis et al.) -- Part 2: Physiology and Development Research and Applications (Part 2 Editor: Dr. Jenna Riis) -- Chapter 5: Salivary Bioscience, Human Stress, and the Hypothalamic Pituitary Adrenal Axis (Clow et al.) -- Chapter 6: The Use of Saliva for Genetics and Epigenetics Research (Nemoda et al.) -- Chapter 7: Saliva as a Window Into the Human Oral Microbiome and Metabolome(Whiteson et al.) -- Chapter 8: Salivaomics, saliva Exo-somics, and Saliva Liquid Biopsy (Wong et al.) -- Chapter 9: Salivary Bioscience, Immunity, and Inflammation (Riis et al.) -- Chapter 10:Salivary Bioscience and Human Development (Hibel et al.) -- Part 3: Biomedical Research and Related Applications (Part 3 Editor: Dr. Elizabeth Thomas) -- Chapter 11: Biomedical Research and Related Applications:Current Assay Methods and Quality Requirements in Oral Fluid Diagnostics Applications (Granger S. et al.) -- Chapter 12: Salivary Biomarkers and Neurodegenerative Conditions (Thomas et al.) -- Chapter 13: The Use of Antibodies in Saliva to Measure PathogenExposure and Infection(Heaney et al.) -- Chapter 14: Salivary Bioscience and Pain (Payne et al.) -- Chapter 15: Salivary Bioscience and Environmental Exposure Assessment (Panuwet et al.) -- Chapter 16: Saliva and Drugs of Abuse (Navazesh et al.) -- Chapter 17: Therapeutic Drug Monitoring in Saliva (Thomas) -- Chapter 18: Salivary Bioscience and Periodontal Medicine (Freire et al.) -- Chapter 19: Salivary Bioscience and Cancer (Navazesh et al.) -- Part 4: Psychosocial Research and Applications(Part 4 Editor: Dr. Kate Ryan Kuhlman) -- Chapter 20: Salivary Bioscience in Clinical Psychologyand Psychiatry(Kuhlman) -- Chapter 21: Salivary Bioscience Research in Health Psychology and Behavioral Medicine (Hoyt et al.) -- chapter 22: The Neuroscience of Human Social Behavior: A Review of How Testosterone and Cortisol Underpin Competition and Affiliation Dynamics (Kornienko et al.) -- chapter 23: Salivary Studies of the Social Neuroscience of Human-animal Interaction (Pendry et al.) -- Part 5: Population Health Research and Applications(Part 5 Editor: Dr. Marcus Taylor) -- Chapter 24: Salivary Bioscience and Military, Space, and OperationalResearch(Roma et al.) -- Chapter 25: Salivary Bioscience Research Related to Prenatal Adversity (Eiden et al.) -- Chapter 26: Salivary Bioscience and Pediatrics (Johnson et al.) -- Chapter 27: Use of saliva to better understand the experience of adulthood and aging(Almeida et al.) -- Chapter 28: Salivary Bioscience and Research on Animal Welfare and Conservation Science(Staley et al.) -- Part 6: The Way Forward: Future Directions for the Science and Practice of Salivary Bioscience -- Chapter 29:Applications of Salivary Bioscience to Precision Medicine (Kuhlman) -- Chapter 30:Public Health and IndustryApplications of Salivary Bioscience (Riis et al.) -- Chapter 31: Envisioning the Future of Interdisciplinary Salivary Bioscience (Granger et al.).

Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.

Description / Table of Contents: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.

Description / Table of Contents: Part I. Introduction: The Pathway to Publishing -- Part II. Most common errors -- 1. General research and writing practices -- 2. Content of quantitative papers -- 3. Mechanics of writing -- 4. Grammatical structures and stylistic strategies -- 5. Achieving clarity and conciseness -- 6. Recording scientific data -- 7. Approaching publication -- 8. Slide and poster presentations.

Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .

Description / Table of Contents: Preface -- Tissue-specific cell signaling: introduction -- Beyond the brain signaling -- Cell signaling within pituitary, the master gland of the endocrine system -- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands -- Signaling pathways governing activation of innate immune cells -- Cell activation and signaling in lymphocytes -- Signaling pathways involved in kidney and urinary tract physiology and pathology -- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis -- Testicular signaling: team work in sperm production -- Sperm signaling specificity: from sperm maturation until oocyte recognition -- Hormone signaling pathways in the postnatal mammary gland -- Oogenesis signaling: from development to environmental plasticity and aging -- Key signaling pathways in the cardiovascular system -- Growth factor signaling in the maintenance of adult lung homeostasis -- The signaling pathways involved in the regulation of skeletal muscle plasticity -- Adipocyte-specific signaling.

Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.

Description / Table of Contents: Introduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX.

Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.

Description / Table of Contents: Part 1 General and Principles of Toxicology -- A Historical Glimpse and Stalwarts -- General Toxicology -- Principles of Toxicology -- Mechanism of Toxicity -- Part 2 Disposition and Kinetics -- Disposition of Toxicants -- Toxicokinetic of Xenobiotics -- Part3 Organ Toxicity -- Target Organ Toxicity -- Part4 Non-Organ-Directed Toxicity -- chemical carcinogenesis -- Genetic Toxicology -- Developmental Toxicology -- Part5 Toxic Agents -- Pesticides -- Metals and Micronutrients -- Solvents. Gasses and Vapors -- Toxicology of Nanomaterial Particles -- Toxic Effects of Calories -- Part6 Plants, Biotoxins and Food Poisonings -- Plant Toxicity -- Biotoxins and Venomous Organisms -- Poisonous Foods and Food Poisonings -- Part7 Radioactive Materials -- Radiation and Radioactive Materials -- Part8 Applications of Toxicology -- Food Toxicology -- Ecotoxicology -- Environmental Toxicology -- Analytical and Clinical Toxicology -- Occupational Toxicology. .

Description / Table of Contents: 1. Current and Futuristic Roadmap of Ovarian Cancer Management: An Overview -- 2. Epithelial ovarian cancer and cancer stem cells -- 3. Ovarian Cancer: Therapeutic Strategies to Overcome Immune Suppression -- 4. Pharmacological effects of natural components against ovarian cancer and mechanisms -- 5. Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity -- 6. PAX8, an emerging player in Ovarian Cancer -- 7. Single Cell RNA Sequencing of Ovarian Cancer: Promises and Challenges.-8. Enforced expression of METCAM/MUC18 decreases in vitro motility and invasiveness and tumorigenesis and in vivo tumorigenesis of human ovarian cancer BG-1 cells -- 9. 3D Models for Ovarian Cancer -- 10. Ovarian Cancer Stem Cells: Characterization and Role in Tumorigenesis.

Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.

Description / Table of Contents: 1.Introduction to Drugs, Drug Targets and Drug Resistance -- 2.Drugs Resistance in Bacterial Diseases -- 3.Drugs Resistance Against Viral Diseases -- 4.Drug Resistance in Protozoal Infections -- 5.Antifungal Drugs: Mechanism of Action and Resistance -- 6.Drug Resistance in Ear, Nose, and Throat Infections -- 7.Drug Resistance in Skin Diseases -- 8.Drugs Resistance in Lungs Diseases -- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges -- 10.Drug Resistance in Kidney Diseases -- 11.Drugs resistance in Heart Diseases -- 12.Drugs Resistance in Liver Disease -- 13.Drug Resistance in Cancer -- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS -- 15.Drug Resistance in Reproductive Diseases -- 16.Drug Resistance in Diabetes -- 17.Drug Resistance in Rheumatological Diseases -- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response -- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization -- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat -- 21.Drugs Resistance Management.

Description / Table of Contents: 1. Can GPCRs be targeted to control inflammation in asthma? -- 2. Cellular and molecular processes in pulmonary hypertension -- 3. INFLAMMATORY PATHWAYS IN SARCOIDOSIS -- 4. Innate Immune Responses and Pulmonary Diseases -- 5. Interstitial Lung Disease associated with Connective Tissue Diseases -- 6. Molecular mechanisms of vascular damage during lung injury -- 7. Neurotrophin Regulation and Signaling in Airway Smooth Muscle -- 8. Novel Thoracic MRI approaches for the assessment of pulmonary physiology and inflammation -- 9. Overview on Interactive Role of Inflammation, Reactive Oxygen Species and Calcium signaling in Asthma, COPD and Pulmonary Hypertension -- 10. Protein S-palmitoylation and lung diseases -- 11. Redox role of ROS and inflammation in pulmonary diseases -- 12. Semaphorin3E/PlexinD1 axis in asthma: what we know so far -- 13. Serine protease inhibitors to treat lung inflammatory diseases -- 14. Sex and Gender Differences in Lung Disease -- 15. Sex hormones and lung inflammation -- 16. Synopsis of Clinical Acute Respiratory Distress Syndrome (ARDS).

Description / Table of Contents: Ch 1: Overview of Microbial NGS -- Ch 2: WGS for Bacterial Identification and Susceptibility Testing -- Ch 3: WGS for Bacterial Virulence Assessment -- Ch 4: Epidemiological Typing by WGS -- Ch 5: Bioinformatics Approaches for WGS Analysis -- Ch 6: WGS for Clinical Virology -- Ch 7: WGS for Clinical Mycology -- Ch 8: WGS for Clinical Parasitology -- Ch 9: Long Read Sequencing -- Ch 10: Aspects of WGS Integration -- Ch 11: Microbiome Analysis -- Ch 12: Metagenomics of Environmental Samples -- Ch 13: Clinical Metagenomics -- Ch 14: Metagenomics for Pathogen Discovery -- Ch 15: Advanced Applications for MALDI-TOF: Typing -- Ch 16: Advanced Applications for MALDI-TOF: Infectious Diseases and Antibiotic Susceptibility Testing (AST) -- Ch 17: Omics for Food and Water Microbiology -- Ch 18: Omics for Forensic and Post-Mortem Microbiology -- Ch 19: Omics for Antimicrobial Resistance Surveillance -- Ch 20: Total Laboratory Automation.

Description / Table of Contents: Graviola Fruit Extraction by Ionic Liquid Microwave-assisted Extraction (IL-MAE) -- Role of Ionic Liquids in the Enzyme Stabilization: A Case Study with Trichoderma ressie Cellulase -- Role of Ionic Liquids in the Processing of Lignocellulosic Biomass -- Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier -- Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative review -- Identification of Potential Biomarkers of Porcine Gelatin -- Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic Waste -- Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extract -- Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria -- Synthesis of chitosan-folic acid nanoparticles as a drug delivery system for propolis compounds.

Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.

Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.

Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.

Description / Table of Contents: Foreword - Peter Singer -- Introduction: Biomedical Research in One World: Current and Future Challenges -- Part I - Biomedical Research -- Section One - Genetic and Cell Research -- Chap 1: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics -- Chap 2: Bioethical Decision Making and Genome Editing -- Chap 3: Therapeutic Genome Editing -- Chap 4: Bioethical Decision-Making about Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study -- Chap 5: Gene Therapy and Germline Cells Research -- Chap 6: Bioethical Quandaries in Preimplantation Genetic Diagnosis -- Chap 7: Rare Disease Research -- Chap 8: Limits of Debate: Governance of Human Embryo Research and the Making of the Fourteen-Day Rule -- Chap 9 Human/Non-Human Chimeras -- Chap 10: Human Cloning: Recent Advances and Bioethical Issues -- Section Two - Enhancement Research -- Chap 11: The Evolutionary Optimality Challenge -- Chap 12: Mood Enhancement -- Chap 13: Superior Sport Performance: Ethical and Legal Issues -- Chap 14: Arguments over Life Extension in Contemporary Bioethics -- Section Three - Research with Human Biological Samples and Health Data -- Chap 15: Research with Human Biological Samples. Systematization of the Phases and Affected Rights -- Chap 16: Biobanks for Biomedical Research: Evolution and Future -- Chap 17: Biobanking in Global Health & Research -- Chap 18: Ethical and Legal Considerations in Genomic Data Sharing: Evolution of the Discourse and the Road Ahead -- Section Four - Biomedical Challenges in Research -- Chap 19: Human Challenge Trials in Pandemics: Risks and Benefits -- Chap 20: Ethical Considerations for Vaccine Research -- Chap 21: Global Health Partnerships and Emerging Infectious Disease -- Chap 22: Precision Medicine -- Chap 23: The Development, Implementation, and Oversight of Artificial -- Intelligence in Health Care: Legal and Ethical Issues -- Part II - Animals, Food and Environment -- Section One - Using Animals in Scientific Research -- Chap 24: The Use of Animals in Basic Biological Research -- Chap 25: The Use of Animals in the Study of Human Disease: Key Roles of General Ethical Principles -- Chap 26: Ethical Issues Concerning Genetically Modified Animals for the Study of Human Diseases -- Chap 27: Of Mice-Rats and Pig-Men: Ethical Issues in the Development of Human/Nonhuman Chimeras -- Chap 28: Animals in Research in Pharmaceutical Industry -- Chap 29: Animal Use in Toxicity Studies -- Chap 30: Ethical Issues from the Use of Animals in the Cosmetics and Fashion Industries -- Chap 31: Is it Time to Phase Out the Use of all Nonhuman Primates in Invasive Research? -- Chap 32: Growing Human Organs Inside Animals -- Chap 33: Animal Cloning -- Section Two - Decision Making and Alternatives to Animal Use in Research -- Chap 34: Replacement, Reduction and Refinement -- Chap 35: Integrating Human and Nonhuman Research Ethics -- Chap 36: Regulation of Animal Research -- Section Three - GMOs for Global Challenges -- Chap 37: Ethical Issues in Genetically Modified Foods: From Transgenesis to CRISPR-Cas9 Genome Editing Technology -- Chap 38: GMOs and Human and Environmental Safety -- Chap 39: GMOs and Sustainable Agriculture.

Description / Table of Contents: Senescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors.

Description / Table of Contents: 1. Alkanes, composition, constitution, and configuration -- 2. Functional groups -- 3. Electronic structure of organic molecules -- 4. Alkenes and alkynes -- 5. Substitutions on saturated carbon atom -- 6. Nucleophilic additions -- 7. Stereochemistry, symmetry, and molecular chirality -- 8. Derivatives of carboxylic acids -- 9. Electrophilic substitutions -- 10. Pericyclic reactions -- 11. Organic natural products -- 12. Organic supramolecular and supermolecular structures.

Description / Table of Contents: Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.

Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.

Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.

Description / Table of Contents: Foreword: On Handbooks -- Introduction -- Scientific Integrity and Institutional Ethics: Challenges and Perspectives -- Part I - Research Ethics -- Section One - Scientific Integrity and Research Misconduct -- Chap 1: Data Alteration -- Chap 2: Research Misconduct and Questionable Research Practices -- Chap 3: Ethics of Authorship -- Chap 4: Dissemination of Research Results -- Chap 5: Conflicts of Interest in Research -- Chap 6: A Priori Publication Agreements to Improve Adherence to Ethics in Research Publications -- Section Two - Conducting Ethical Research -- Chap 7: Freedom of Scientific Research and Primacy of Human Being: Practical and Epistemological Tensions -- Chap 8: Exploitation in Biomedical Research -- Chap 9: Selection of Research Subjects: Methodological and Ethical Issues -- Chap 10: Confidentiality and Privacy in Digital Clinical Trials -- Chap 11: Dematerialization and Intellectual Property in the Biosciences -- Part II - Institutional Ethics and Bioethics Committees -- Section One - Institutional Ethics -- Chap 12: Historical Development of Institutional Ethics and Bioethics -- Chap 13: Principles of Institutional Ethics -- Chap 14: Institutional Review Boards (IRB): US Perspectives -- Chap 15: Decision Making within Institutions -- Chap 16: Scientific Advances, Ethical Oversight and Legal Institutionality -- Section Two - Ethics and Bioethics Committees -- Chap 17: Members and Structure of Institutional Bioethics Committees -- Chap 18: Foundations of Bioethical Decision-Making in Bioethics and Biolaw -- Chap 19: Just Doing Bioethics': Policy, Principle, and Process -- Chap 20: Ethics Education and Institutional Ethics Committees -- Chap 21: Role of Ethics Committees in Emergency Use of Unproven Interventions Outside Research -- Chap 22: The Ethics of Resource Allocation in Pandemics: A Bayesian Model -- Section Three - Bioethical Issues in Institutional Ethics -- Chap 23: Scientific Knowledge and Social Responsibility -- Chap 24: Conscientious Objection -- Chap 25: Institutional Liability in Research -- Chap 26: Research Assessments Should Recognize Responsible Research Practices. Narrative Review of a Lively Debate and Promising Developments -- Chap 27: Coercion in Mental Health Treatment.

Description / Table of Contents: Chapter 1. WHO Critical Priority Escherichia coli in Latin America: A One Health Challenge for a PostPandemic World -- Chapter 2. Recent progress on enterotoxigenic E. coli (ETEC) and antibiotic resistance in pathogenic E. coli -- Chapter 3. New concepts on domestic and wild reservoirs, and transmission of E. coli and its environment -- Chapter 4. New molecular mechanisms of virulence and pathogenesis in E. coli.-Chapter 5. Bovine reservoir of STEC and EPEC: advances and new contributions -- Chapter 6. Phages and Escherichia coli -- Chapter 7. Insights into animal carriage and pathogen surveillance in Latin America: the case of STEC and APEC -- Chapter 8. Shiga Toxin and its effect on the Central Nervous System -- Chapter 9. Relevance of Escherichia coli in fresh produce safety -- Chapter 10. Quantitative Microbial Risk Assessment of Hemolytic Uremic Syndrome due to Beef Consumption: Impact of Interventions to Reduce the Presence of Shiga Toxin-Producing Escherichia coli -- Chapter 11. An Updated Overview on the Resistance and Virulence of UPEC -- Chapter 12. Interactions of pathogenic Escherichia coli with gut microbiota -- Chapter 13. Emergence of Hybrid Escherichia coli Strains -- Chapter 14. Genomic analysis of pathogenic E. coli strains in Latin America -- Chapter 15. Therapeutic options for diarrheagenic Escherichia coli.

Description / Table of Contents: Prologue: Many questions, no answers -- Part 1: Crisis, what crisis...? -- 1. Too Late -- 2. Don’t Rely on Your Prescription -- 3. Chronic Disease? -- 4. No Prevention -- 5. Male Plus Low Income = Double Whammy -- 6. False Incentives -- 7. The End of Big Pharma -- 8. Research Not for Patients -- 9. Organ-Based Medicine -- 10. Interjection 1: How Healthy Do You Want to Be?.-Part 2: The Medicine of the Future -- 11. Re-Discover the Whole Patient -- 12. Research for patients -- 13. Know Your Genes -- 14. Outnumbered -- 15. Your Exposome -- 16. Big Data Medicine -- 17. Healed -- 18. Well-Tech -- 19. Interjection 2: Superhumans -- Part 3: The Future has Begun... -- 20. Self-diagnosis -- 21. Self-therapy -- 22. Your Digital Twin. Epilogue: Nobody Is Sick Anymore -- Appendix 1: Special Page 1 -- Appendix 2: Special Page 2. .

Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.

Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .

Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.

Description / Table of Contents: Attenuation of Bnip3 Mediated Doxorubicin-Induced Cell Death in Cardiac Myocytes -- Sex Dependent Regulation of Circadian Rhythms in Health and Disease -- Circadian Pharmacological Approach to Treat Myocardial Infarct -- GPER Function as a Determinant of the Progression of Atherosclerotic Disease in Women -- Novel Therapeutic Approach to Treat Cardiac-Rheumatology in Females -- Correlation between Sex, Immigration Status, Ethnicity, and Long-term Outcomes of Ischemic Stroke -- Risk Assessment and Predictive Modelling for The Heart-Brain Interface in Women -- Insomnia Interventions for Female Cardiac Patients -- Aortic Stenosis Progression, Cardiac Damage, and Survival: Comparison Between Men and Women -- Treatment and Management of Valvular Heart Disease and Cost-Effectiveness Analysis -- Association of Mortality and Acute Aortic Events with Ascending Aortic Aneurysm -- Improving Diagnosis and Treatment for Patients Who Suffer Spontaneous Coronary Artery Dissection (SCAD) -- Preeclampsia and Future Cardiovascular Health -- Cardiovascular Disease in Women with a History of Pregnancy Complications -- Hormone Replacement Treatment for Cardiovascular Disease -- Cardiovascular Mortality Following Early-Stage Breast Cancer -- Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease in Women -- Sex Differences in Cardiac Rehabilitation Enrollment -- Promoting Exercise and Physical Activity in Female Patients with Heart Disease -- Sex and Gender Differences in the Diagnosis, Treatment, and Outcomes of Coronary Artery Disease -- Sex Differences in Arterial Aging and its Implications on Cardiovascular Diseases -- Impact of a Novel Community-Based Lifestyle Intervention Program on Type 2 Diabetes and Cardiovascular Risk -- Clinical Outcomes Related to Heart Failure and Pulmonary Hypertension -- Examination of Health-Related Quality of Life in Women with Coronary Artery Disease -- The Risks and Benefits of Implantable Cardioverter-Defibrillator Generator Replacement -- The Effects and Roles of Estrogen in Managing Hypertension in Menopausal Women -- The Effects of Menopausal Hormone Therapy on the Vascular System -- Influence of Sex Differences in Non-Obstructive Coronary Artery Disease -- Diet1 and Resistance to High Cholesterol Levels and Cardiovascular Disease -- Interventions to Improve Clinical Outcomes Following Hospitalization for Heart Failure -- Sex-Dependent Cardioprotective Effects of the Phytoestrogen Resveratrol -- Blood Pressure Across a Woman's Life Cycle -- Women’s Fitness Levels and Heart Rate Response to Exercise -- Supervised Exercise Therapy Through Cardiac Rehabilitation following Peripheral Arterial Disease -- Sex Differences in ANT2-Mediated ATP Import into Mitochondria for Protection Against Hypoxia Lethal Injury.

Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.

Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.

Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.

Description / Table of Contents: Targeted Drug Delivery from Titanium Implants: A Review of Challenges and Approaches -- Reliability of Magnetic Resonance Tractography in Predicting Early Clinical Improvements in Patients with Diffuse Axonal Injury -- Integrated Thermal Rehabilitation: a New Therapeutic Approach for Disabilities -- The Cat Pet as a Source Intensification of Atopic Dermatitis -- Clinical Course and Outcome of Community Acquired Bacterial Meningitis in Cancer Patients -- Influence of Coping Strategy on Perception of Anxiety and Depression in Patients with Non-Small Cell Lung Cancer -- Inflammatory Markers during Continuous High Cut-Off Hemodialysis in Patients with Septic Shock and Acute Kidney Injury -- Body Composition and Biochemical Markers of Nutrition in Non-Dialysis Dependent Chronic Kidney Disease -- Biocompatibility of hemodialysis -- Decreasing Vaccination Coverage Rates against Hepatitis B and Tuberculosis in Newborns -- Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/17 and 2017/18 in Poland -- Epidemic Influenza Seasons from 2008 to 2018 in Poland: A Focused Review of Virological Characteristics.

Description / Table of Contents: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.

Description / Table of Contents: Part I. Healthcare -- Chapter 1. Is It Time to FONA Friend? A Novel Mixed Reality Front of Neck Access Simulator -- Chapter 2. “Learning About Skin Breakdown” – Design, Development and Evaluation of an Augmented Reality Application to Inform about Pressure Ulcers (sores) and Moisture Lesions -- Chapter 3. The Use of 3D-Printing and Injection Moulding in the Development of a Low-Cost, Perfused Renal Malignancy Model for Training of Robot-Assisted Laparoscopic Partial Nephrectomy -- Chapter 4. The Co-IMMUNicate App: An Engaging and Entertaining Education Resource on Immunity to Respiratory Viruses -- Part II. Education -- Chapter 5. Application of AR and 3D Technology for Learning Neuroanatomy -- Chapter 6. Communicative Powers of Interactive Digital Mediums in the Field of Polyomics -- Chapter 7. SkilletonVR: Canine Skeleton VR -- Chapter 8. Using Holograms to Engage Young People with Anatomy -- Chapter 9. The Digital Dolphin: Are 3D Mobile Based and Interactive Models a Useful Aid to Volunteers on Stranding Schemes Learning the Basic Anatomy and Pathology of Cetaceans? -- Chapter 10. The Impact of the COVID Crisis on Anatomical Education: A Systematic Review.

Description / Table of Contents: Part 1: Setting the scene -- Chapter 1: Life after Academia: Launching your Pharma/Biotech Career -- Chapter 2: Competences for Pharmacists -- Chapter 3: Job and Career Opportunities in the Pharmaceutical Industry: An Overview -- Part 2: Opportunities along the drug/product life cycle -- Chapter 4: Career Opportunities in Toxicology -- Chapter 5: Job Possibilities in Clinical Research -- Chapter 6: How to Get and Develop a Career in a Market Access Role in the Medical Devices Industry -- Chapter 7: Job Opportunities in Pharmaceutical Marketing -- Chapter 8: Working in Medical Affairs and Clinical Operations: Life-Changing Careers -- Chapter 9: The Role of Medical Science Liaison -- Chapter 10: Career Development for Physicians in the Biopharmaceutical Industry -- Part 3: Opportunities in Supportive Functions -- Chapter 11: Job and Career Opportunities in Regulatory Affairs/Science -- Chapter 12: Job Opportunities in Clinical Research Quality Assurance -- Chapter 13: Job Opportunities in Quality Assurance Related to Manufacturing of Medicinal Products -- Part 4: Other Opportunities in the Pharmaceutical and Biomedical Sector -- Chapter 14: Careers Perspective in a Science and Technology Park -- Chapter 15: To be or not to be: Entrepreneurship and Enterprise Creation as a Way to Innovate in Life Sciences -- Chapter 16: How to Become a Successful Hospital and Community Pharmacist -- Part 5: Practical tips and tricks -- Chapter 17: A Successful Career in the Life Sciences Industry: How to Write your Strongest Resumé and Ace that Interview -- Chapter 18: Skill Building for Career Advancement: Public Speaking and Networking -- Chapter 19: Training Opportunities for a Career in the Pharmaceutical and Biomedical Industry/Sector.

Description / Table of Contents: 1. Introduction on Tuberculosis: Integrated Studies for a Complex Disease -- 2. Global Tuberculosis Epidemiology -- 3. Heterogeneity in Tuberculosis -- 4. The Unequivocal Relationship between Tuberculosis and Tobacco: Integration of Two Maladies -- 5. Relationship between Pre-existing Cancer and Tuberculosis -- 6. Laboratory Diagnosis of Tuberculosis -- 7. The Role of Diagnostic Microdevices in the Fight Against Tuberculosis -- 8. Immunodiagnostics of Tuberculosis: Recent Discoveries -- 9. Role of Bronchoscopy in Diagnostics and Treatment of Tuberculosis -- 10. Diagnosis of Childhood Tuberculosis in Low- and Middle-income Countries -- 11. Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis -- 12. A Multidisciplinary Approach Towards Finding and Treating All Tuberculosis Patients -- 13. Chemotherapy for Drug-Susceptible Tuberculosis -- 14. The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications -- 15. Immune Approaches In Tuberculosis Treatment -- 16. Inhalation Therapy in Pulmonary Tuberculosis -- 17. Role of Micronutrients in Tuberculosis Management -- 18. Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for An Integrated Approach -- 19. Resistance in Tuberculosis: Molecular Mechanisms and Modulation -- 20. Personalized Tuberculosis Care for Drug-Resistant Tuberculosis -- 21. Important Targets and Inhibitors of Mycobacterium Tuberculosis -- 22. P-type ATPases: A Relevant Component in Mycobacterium tuberculosis Viability -- 23. The Challenges of Antitubercular Drug Discovery -- 24. Exploring Decaprenylphosphoryl-β-D-ribose 2’-Epimerase 1 (DprE1): A Target for Anti-Tubercular Drugs -- 25. Energy Pathways in Mycobacterium Tuberculosis -- 26. Drug Discovery for Non-Tuberculous Mycobacteria: Recent Updates -- 27. Challenges for Contact Tracing and Tuberculosis Preventive Therapy Scale-up -- 28. Exploring Problematizations Underlying Tuberculosis Control Strategies: A Cross-Country Analysis of India and Kenya -- 29. Challenges in Prevention and Management of Tuberculosis -- 30. Tuberculosis in Contacts and Healthcare Workers -- 31. Tuberculosis Among People Who Use Drugs: Multilevel Considerations for Prevention, Diagnosis, and Treatment -- 32. Anti-Tumor Necrosis Factor-α Antagonists and Tuberculosis -- 33. Breast Tuberculosis -- 34. Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management -- 35. Pleural Tuberculosis -- 36. Ocular Tuberculosis -- 37. Ocular Tuberculosis: Biomarkers for Risk Stratification -- 38. Bone and Joint Tuberculosis -- 39. Abdominal Tuberculosis: Pathogenesis, Clinical Features, and Diagnosis -- 40. Bovine Tuberculosis at The Interface of Cattle, Wildlife, and Humans -- 41. Evolution and Molecular Characteristics of Mycobacterium Tuberculosis and Mycobacterium Bovis -- 42. Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis -- 43. Estimation of Microbial Mutation Rates in Tuberculosis Research -- 44. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance -- 45. Multiomics Integration of Tuberculosis Pathogenesis -- 46. Lung Microbiome in Tuberculosis -- 47. The Correlation of Microbiota and Host Epigenome in Tuberculosis -- 48. The Pathogenesis and Progression of Sarcoidosis from The Standpoint of Tuberculosis -- 49. Tuberculosis: A Historical and Global Bioethical Perspective -- 50. The Problem of Tuberculosis: Myths, Stigma, and Mimics -- 51. Tuberculosis: Integrated Studies for a Complex Disease 2050.

Description / Table of Contents: Overview of Freeze Drying -- Characterization and Determination of Freeze Drying Properties of Frozen Formulations – Case Studies -- Beyond pH: Acid/base relationships in frozen and freeze-dried pharmaceuticals -- Concepts and Strategies in the Design of Formulation for Freeze Drying -- Formulation Design for Freeze Drying - Case studies of Stabilization of Proteins -- Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product -- Freeze-drying of thermosensible pharmaceuticals with organic co-solvent + water formulations -- Primary container closure system selection for lyophilized drug products -- Vial Breakage During Lyophilization -- The Nucleation of Ice -- Stresses, Stabilization, and Recent Insights in Freezing of Biologics -- Lyophilization Process Understanding and Scale-up using ab initio Vial Heat Transfer Modeling -- Secondary drying: Challenges and Considerations -- Design and Process Considerations in Spray Freeze Drying -- LyoPRONTO: Deterministic and Probabilistic Modeling. Tutorial and Case Study -- Utilizing Solid-State NMR Spectroscopy to Assess Properties of Lyophilized Formulations -- Design of Moisture Studies for a Lyophilized Product -- Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Lyophilized Products -- Application of PAT in Real-time Monitoring and Controlling of Lyophilization Process -- Process Analytical Technology (PAT) for Lyophilization Process Monitoring and End Point Detection -- Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer -- Overview of Heat and Mass Transfer Modeling in Lyophilization to Create Design Spaces and Improve Process Analytical Tool (PAT) Capability -- Application of QbD elements in the Development and Manufacturing of a Lyophilized product -- Characterization of Freeze Dryer -- Scale-up and Technology Transfer of a Lyophilization Process -- Lyophilization Validation: Process Design and Modeling -- Lyophilization Validation: Process Qualification and Continued Process Verification -- Homogeneity Assessment of Lyohilized Biological Drug Products During Process Performance Qualification -- Informed Manufacturing through the use of Big Data Analytics for Freeze Drying Process & Equipment -- Multivariate Analysis for Process Understanding, Continuous Process Verification and Condition Monitoring of Lyophilization Processes -- Lyophilized Drug Product Cake Appearance: What Is Acceptable?.

Description / Table of Contents: Chapter 1. Management of Biobanks -- Chapter 2. Quality Management -- Chapter 3. Documentation and Records -- Chapter 4. Human Resources Management -- Chapter 5. Ethical and Legal Aspects -- Chapter 6. Supplies, Materials Management -- Chapter 7. Equipment -- Chapter 8. Traceability -- Chapter 9. Environmental and Staff Hygiene -- Chapter 10. Biobanking Processes and Quality Control -- Chapter 11. Deviations, Nonconforming Product/Data or Service -- Chapter 12. Audits -- Chapter 13. Improvement -- Chapter 14. Biobank Cooperation in the Scientific, Research and Development Area -- Chapter 15. Safety and Security.

Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.

Description / Table of Contents: Chapter 1. The tumor microenvironment -- Chapter 2. Methods of formulation of polymeric nanoparticles -- Chapter 3. Natural polymers based nanoparticles targeted to solid tumors -- Chapter 4. Optimization of physicochemical properties of polymeric nanoparticles for targeting solid tumors -- Chapter 5. Passive and active targeting approaches for solid tumors -- Chapter 6. Polymeric nanoparticles entrapping natural drugs for cancer therapy -- Chapter 7. Polymeric nanoparticles entrapping drug combinations targeted to solid tumors -- Chapter 8. Ligands specific to over-expressed receptors in solid tumors -- Chapter 9. Ligand targeted polymeric nanoparticles for cancer chemotherapy -- Chapter 10. Polymeric nanoparticles as theranostics for targeting solid tumors -- Chapter 11. Oral delivery of polymeric nanoparticles for solid tumors -- Chapter 12. Polymeric nanoparticles to target glioblastoma tumors -- Chapter 13. Polymeric nanoparticles to target lung cancer -- Chapter 14. Polymer based nanoplatforms for targeting breast cancer -- Chapter 15. PH-Sensitive polymeric nanoparticles for cancer treatment -- Chapter 16. Polymeric nanoplatforms for targeted treatment of prostate cancer -- Chapter 17. Cellular internalization and toxicity of polymeric nanoparticles -- Chapter 18. Prospects and challenges in the treatment of solid tumors.

Description / Table of Contents: Introduction on Integrated Science of Global Epidemics -- Emerging Viral Infections in Human Population -- One Health as An Integrated Approach: Perspectives from Public Services for Mitigation of Future Epidemics -- Multipronged Approach to Combat COVID-19: Lessons from Previous Pandemics for the Future -- Response to Disease Outbreaks in Africa: A Call to Build Resilient Health Systems -- Navigating Global Public Influenza Surveillance Systems for Reliable Forecasting -- Three Respiratory Syndrome Epidemics (SARS, MERS, COVID-19) in Two Decades: Clinical Epidemiological Considerations -- Epidemic in Complex Networks and Some Ideas About the Impact of Isolation Strategies in the Context of the COVID-19 Pandemic -- Optimal Control: Application and Applicability in Times of Pandemics -- Analysis of A COVID-19 Model Implementing SocialDistancing as An Optimal Control Strategy -- Impact of Policy Implementations on the Propagation of COVID-19 Before Vaccine -- Environmental Factors Associated with Global Pandemic Transmission and Morbidity -- Urbanization and the Epidemiology of Infectious Diseases: Towards the Social Framing of Global Responses -- Pandemics and Mass Casualties: Cornerstones of Management -- Social Marketing Contributions to Mitigate Global Epidemics -- The Significance of Super Intelligence of Artificial Intelligence Agencies in the Social Savageries of COVID-19: An Appraisal -- Integration of Sex and Gender Approaches in National Ethics Committees’ Mandate to Appraise COVID-19 Research Protocols: Lessons from West Africa -- Psychology, Law, Ethics, Telehealth, and the Global Pandemic -- Physical Inactivity, Sedentarism, and Low Fitness: A Worldwide Pandemic for Public Health -- The Global Epidemic of Diabesity: Are We Heading for An Unsustainable Future? -- Nutrition, Function, and Quality of Life in Older Adults Socially Isolated Due to the COVID-19 Pandemic: A Focus on Telehealth Interventions -- Africa’s Response to Pandemics -- Vaccine Hesitancy and Refusal: History, Causes, Mitigation Strategies -- Vaccine Compliance versus Trust in a Pandemic -- Child Development in A Crisis: A Pandemic -- HIV/AIDS Problems and Policies in Adolescent Population -- Addressing Needs of Foreign Schoolchildren to Combat a Global Epidemic of Dengue Virus Infection: Transnational and Trans-sectoral Initiatives -- Integrated Science of Global Epidemics 2050.

Description / Table of Contents: Section I – Introduction to Spermatology Symposium -- Chapter 1. The XIIIth International Symposium on Spermatology -- Chapter 2. Fifty Years of the Spermatology Symposium -- Chapter 3. Spermatology in Sweden -- Section II – Are Sperm at the Verge of Extinction? -- Chapter 4. Temporal trends in human sperm counts: Findings and implications -- `Chapter 5. Is Decreasing Sperm Concentrations a Sign of a General Decay in Fertility Potential? -- Chapter 6. Environmental toxicants and sperm production in men and animals -- Section III – Sperm DNA – protection and delivery of a complete and undamaged genome? -- Chapter 7. Post-testicular sperm DNA oxidation: what to be afraid of? -- Chapter 8. Sperm as a possible source of transgenerational epimutations and genetic instability -- Chapter 9. Complex population of chromatin-associated proteins identified in mature sperm of the European sea bass (Dicentrarchuslabrax) through high-throughput proteomic analysis -- Chapter 10. Does Cinnamtannin B-1 protects or destabilize sperm DNA? Contradictory results of SCSA® and TUNEL Invited presentations -- Chapter 11. Peripubertal serum dioxin concentrations and sperm methylome of young Russian adults -- Chapter 12. Sperm DNA fragmentation in human split ejaculates -- Section IV - Sperm Competition, Evolution and Sperm-Egg Interaction -- Chapter 13. The sexual cascade: evolutionary dynamics of sperm competition -- Chapter 14. Genotype-phenotype associations in relation to evolution of sperm form and function -- Chapter 15. From mouse to human: New aspects of sperm transport and fertilization using cutting edge technologies -- Chapter 16. First Snapshot of How Sperm Binds the Egg at the Molecular Level -- Chapter 17. The Typical and Atypical Centrioles and Their Potential Roles in the Sperm and Embryo -- Chapter 18. Adaptive modifications of the regulation of sperm motility in the diversification of reproductive modes of amphibians -- Section V - Genetic aspects of sperm production and performance and its effects on the offspring -- Chapter 19. When cilia go bad - the complex genetics of ciliopathies -- Chapter 20. Within-Ejaculate Sperm Selection and its Implications for Assisted Reproduction Technologies -- Chapter 21. Requirements for informative and robust computational measures of sperm motility -- Chapter 22. Effect of cryopreservation on the genome of sperm in animal and humans -- Chapter 23. Mutations in the CFAP-coding Genes Lead to Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella -- Chapter 24. The mouse-specific Gly-to-Cys mutation in mammalian acrosin is a cause of impairment in proteolytic activity -- Chapter 25. Chemical and genetic approaches to identify C. elegans spermiogenesis-related factors -- Section V -CASA - Advances and Challenges -- Chapter 26. CASA in the clinical andrology laboratory -- Chapter 27. Process and Data Management of Casa in Animal Spermatozoa -- Chapter 28. Relationship between flagellar movement and head trajectory at higher frame rates-is this still a valid approach for CASA? -- Chapter 29. CASA a Suitable tool for epidemiology and reprotox studies -- Section VI -Challenges for Sperm Function In Vitro -- Chapter 30. Common challenges for sperm in vitro- causes and consequences -- Chapter 31. Main effects of in vitro manipulation of spermatozoa -- Chapter 32. Effect of Melatonin on Capacitation and Ca2+ Distribution in Red Deer Spermatozoa -- Chapter 33. Unravelling the signal transduction pathways of novel mitochondrial peroxiporins in activated piscine spermatozoa -- Chapter 34. Prolonged chilled preservation and preliminary investigations of energy production of koala (Phascolarctos cinereus) spermatozoa -- Chapter 35. Sperm motion and metabolism in physiological conditions -- Chapter 36. Gametes collision in fresh water fish: evidences of guidance and selection -- Chapter 37. Lectin-binding pattern changes on the bovine sperm after differently induced process of capacitation -- Section VII -Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges -- Chapter 38. Have we conquered sperm morphology analysis in different mammalian species as analysed by CASMA? -- Chapter 39. Progress with sperm morphology evaluation after the strict criteria prognosis groups era due to the introduction of the new lower reference limit values for semen parameters of the 2010 WHO manual -- Chapter 40. A structured assessment for the assessment of human sperm morphology -- Chapter 41. On the Indispensability for Standardization of the Basic Examination of Human Semen -- Chapter 42. A simple but dramatic technical improvement in the Diff Quik stain protocol used for preparing specimens for sperm morphology evaluation (Improved Diff Quik stain protocol for preparation of sperm morphology evaluation specimens) -- Section VII - Fertility and Infertility -- Chapter 43. Intracellular Viruses Identification in Sperm Assay of Patients with Fertility problems -- Chapter 44. Association between vitamin D intake and vitamin D status with semen parameters among young men in Southern Spain -- Chapter 45. Single cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success -- Chapter 46. Sperm from a patient with a homozygous in-frame deletion in CATSPERE lack functional CatSper expression and fail to fertilise at IVF -- Chapter 47. Changes in pattern of protein phosphorylation in bull testicular and epididymal sperm -- Chapter 48. Proteomics and biomarker identification in improved sperm motility parameters after 4 h of ejaculatory abstinence -- Chapter 49. HSP90A may control spermatogenesis of Asian elephant (Elephas maximus) cryptorchid testes -- Chapter 50. Improved sperm function in human sperm subpopulations: a model for studying subfertility -- Chapter 51. Absence of BSP protein have not important effect on male infertility. .

Description / Table of Contents: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .

Description / Table of Contents: Overload of Medical Documentation: A Disincentive for Healthcare Professionals -- Epidemiologic Benefits of Pneumococcal Vaccine Introduction into Preventive Vaccination Programs -- Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly -- Influenza A (H1N1) and Respiratory Syncytial Virus (RSV) Coinfection in a Newborn Child: A Case Report -- Thoracic Manifestation of Granulomatosis with Polyangiitis: A Case Report -- The Natural Course of Impaired Fasting Glucose -- Oleosins: A Short Allergy Review -- Shortage of Physicians: A Critical Review -- Fluid Therapy in Patients Undergoing Abdominal Surgery: A Bumpy Road Towards Individualized Management -- Manual Pressure Release and Low-Grade Electrical Peripheral Receptor Stimulation in Nonspecific Low Back Pain: A Randomized Controlled Trial -- Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate. Cognitive Function After Lung Transplantation.

Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .

Description / Table of Contents: Chapter 1. The historical studies underpinning the concept of hair follicle neogenesis (Higgins C, Jahoda C) -- Chapter 2. Hair regeneration and rejuvenation: pipeline of medical and technical strategies (Limbu S, Kemp P) -- Chapter 3. Cells and structures involved in hair follicle regeneration: an introduction (Tsai J, Garza LA) -- Chapter 4. The dermal papilla and hair follicle regeneration: Engineering strategies to improve dermal papilla inductivity (Pantelireis N, Clavel C) -- Chapter 5. Dermal sheath and hair follicle regeneration (Yoshida Y, Tsuboi K, Kishimoto J) -- Chapter 6. Epithelial-mesenchymal interactions between hair follicles and dermal adipose tissue (Ramos R, Plikus MV) -- Chapter 7. Lymphatic vasculature and hair follicle regeneration (Cazorla A, Perez-Moreno M) -- Chapter 8. In vitro and ex vivo hair follicle models to explore therapeutic options for hair regeneration (Bertolini M, Piccini I, McElwee KJ) -- Chapter 9. Extracellular vesicles including exosomes for hair follicle regeneration (Aberdam E, le Riche A, Bordes S, Closs B, Park BS, Aberdam D) -- Chapter 10. Stem cell-based therapies for hair loss: what is the evidence from a clinical perspective? (Park BS, Choi HI) -- Chapter 11. Induced pluripotent stem cell approach for hair follicle regeneration (Pinto A, Terskikh AV) -- Chapter 12. Biofabrication technologies in hair neoformation (Abreu CM, Gasperini L, Marques AP) -- Chapter 13. Wound healing induced hair follicle regeneration (Jiang Y, Myung P) -- Chapter 14. Hair follicles in wound healing and skin remodeling (Plotczyk M, Jimenez F) .

Description / Table of Contents: Western blotting: How it began -- 2. Basics of Western Blotting -- 3.Basic Calculations in Western Blotting -- 4.Choosing The Right Antibody For Western Blotting -- 5. Sample Preparation -- 6. Blocking membranes at places that do not have transferred proteins -- 7. A Basic Method for Western Blotting -- 8. Trouble Shooting Western Blotting -- 9. Using Biotin to demonstrate western and dot blotting in University Practical Classes- A Guide To Instructors -- 10. Nitrocellulose Membrane Art -- 11. The Use Of A Harmless Invisible Ink To Send Secret Messages On Nitrocellulose Membranes And As A Substitute For The Harmful Radioactive Ink Used As A Marker In ECL Membrane Assays -- 12. Fingerprinting On Nitrocellulose And Polyvinylidene Difluoride Membrane -- 13. Spectrometric Determination Of Protein For Electrophoresis -- 14. Concentrating Proteins For Western Blotting -- 15. Dissolving Proteins Using Lysis Buffer -- 16. Blotting And Detecting Glycosaminoglycans -- 17. Passive Blotting From Tissue Slices -- 18. Localizing Proteins by Tissue Printing -- 19. Ultrasound Blotting -- 20. Obtaining Several Blots From A Single SDS-PAGE Gel By Passive Transfer -- 21. Diffusion Blotting From SDS-PAGE Gels Supported By Solid Plastic -- 22. Dot-Immunobinding -- 23. Simultaneous Immunoblotting Analysis With Activity Gel Electrophoresis -- 24. Protein Blotting By Centrifugation -- 25. Blotting And Immunostaining Of Multiple Antigenic Peptides -- 26. High Molecular Weight Protein Blotting Using Agarose Gel Electrophoresis -- 27. Cetyltrimethylammonium bromide PAGE And Eastern Blotting -- 28. Purification Of Autoantibodies Bound To An Autoantigen Immobilized On A Membrane Strip -- 29. Miniaturized Blotting -- 30. Affinity Immunoblotting -- 31. Transferring Coomassie Blue Stained Proteins from Polyacrylamide Gels To Transparencies -- 32. Protein Transfer From Immobilized pH Gradient Gels -- 33. SDS PAGE To Immunoblotting In Sixty Minutes -- 34. Western Blot Analysis Of Protein-DNA Complexes Formed DuringGel Shift Experiments -- 35. Electrophoretic Transfer Of High And Low Molecular Weight Proteins To Membranes Using Heat -- 36. Grid-immunoblotting -- 37. Far-western Blotting -- 38. Native Electrophoresis And Western Blot Analysis -- 39. Efficient Electroblotting Of Low Molecular Weight Protein After Staining With Coomassie -- 40. Avoiding Non-specific Binding Of Secondary Antibodies In Immunoblotting By Double-blotting -- 41.A Brief Introduction To Other Protein Blotting Methods -- 42. Quantitative Computerized Western Blotting In Detail -- 43. Common Problems In Electrophoresis.

Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.

Description / Table of Contents: Part One: Basic Concepts in Precision Oncology -- Chapter 1. Design and Implementation of a precision oncology workflow -- Chapter 2. An overview of cancer genome sequencing -- Chapter 3. Software infrastructures for precision medicine workflows -- Part Two: Current Computational Methods and Tools in Precision Oncology -- Chapter 4. Somatic and germline variant calling from next-generation sequencing data -- Chapter 5. Identification of copy number alterations from next-generation sequencing data -- Chapter 6. Genome-wide discovery of large-scale structural variants from next-generation sequencing data -- Chapter 7. Assessment of microsatellite instability from next-generation sequencing data -- Chapter 8. Computational approaches for the investigation of intra-tumor heterogeneity and clonal evolution from bulk sequencing data -- Chapter 9. Analysis of the transcriptome for precision oncology applications -- Chapter 10. Computational methods for drug repurposing -- Chapter 11. Pathway for analysis for precision oncology applications -- Chapter 12. Identification of fusion transcripts from RNA-seq -- Chapter 13. Computational resources for the interpretation of variations in cancer -- Chapter 14. Analysis of electronic health records for precision oncology -- Chapter 15. Network approaches for precision oncology -- Chapter 16. Experimental validation of genomic alterations -- Part Three: Advanced Concepts - The Future of Precision Oncology -- Chapter 17. Molecular profiling of liquid biopsies for precision oncology -- Chapter 18. Artificial intelligence for precision oncology -- Chapter 19. Single-cell technologies in precision oncology -- Chapter 20. Computational approaches for precision immuno-oncology -- Chapter 21. Multi-pmics profiling of the tumor microenvironment -- Chapter 22. Epigenetic and precision oncology -- Chapter 23. Next generation knowledge bases to support precision oncology. .

Description / Table of Contents: Foreword -- Preface -- Chapter 1. The Year 1975 -- Chapter 2. The Effects of the Social and Behavioral Sciences -- Chapter 3. Little Biology and Biology of the Little -- Chapter 4. The Big End of the Spectrum -- Chapter 5. A Second “Time of Tumult” and A New Home for Biology -- Chapter 6. Technology and the “Fearless Biologists” -- Chapter 7. Genes and Beyond -- Chapter 8. Integrating Biology -- Chapter 9. Expanding Big Bio -- Epilogue -- Index.

Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.

Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.

Description / Table of Contents: Constituents of Cannabis Sativa -- Synthetic and Natural Derivatives of Cannabidiol -- Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions -- Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues -- Sleep-Wake Neurobiology -- Cannabinoids and Sleep/Wake Control -- Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals -- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence -- Natural Cannabinoids as Templates for Sleep Disturbances Treatment -- The Effect of Cannabinoids on the Brain´s Circadian Clock -- Effects of Cannabis Consumption on Sleep -- Addiction and Sleep Disorders -- Cannabis for Restless Legs Syndrome.

Description / Table of Contents: 1. Potential role of mast cells in regulating corticosteroid insensitivity in severe asthma -- 2. Galectin-3 Promotes ROS, Inflammation and Vascular Fibrosis in Pulmonary Arterial Hypertension -- 3. Anti-Inflammatory Effects of Statins in Lung Vascular Pathology: From Basic Science to Clinical Trials -- 4. Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension -- 5. Pulmonary Inflammation and KRAS Mutation in Lung Cancer -- 6. microRNA Targets for Asthma Therapy -- 7. Roles of genetic predisposition in the sex-bias of pulmonary pathophysiology, as a function of estrogens -- 8. Hypercapnic respiratory failure-driven skeletal muscle dysfunction: It is time for animal mod-els-based mechanistic research -- 9. Role of airway smooth muscle in inflammation related to asthma and COPD -- 10. Systemic Sclerosis and Pulmonary Disease -- 11. Innate Lymphoid Cells in airway inflammation -- 12. Sjogren’s Syndrome and pulmonary disease -- 13. Redox Regulation, Oxidative Stress and Inflammation in Group 3 Pulmonary Hypertension -- 14. Sex-Steroid Signaling in Lung Diseases and Inflammation -- 15. Cytokines, Chemokines and Inflammation in Pulmonary Arterial Hypertension -- 16. Interactive roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases -- 17. Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis -- 18. Crosstalk between Lung and Extrapulmonary Organs in Infection and Inflammation -- 19. Inflammation in Pulmonary Arterial Hypertension -- 20. Lysophospholids in Lung Inflammatory Diseases.

Description / Table of Contents: Introduction on Integrated Science: Science without Borders -- The Human Person as an Integrated System -- On the Nature of Qualitative Research in Process Transformations: The Changing Man in the Changing World.-Integrated Science: Ambitions, Practicalities, Misunderstandings -- The Integration of the Sciences and Integral Human Knowledge -- The Indelible Stamp of Lowly Origins: An Epistemic Architecture between the Sciences and Humanities -- Transdisciplinary Science: Integration or Systematic, Strategic and Catalytic Knowledge -- Models and Integration -- Unlaws: the Missing “Dark Matter” in the Philosophy of Science -- Life - Stabilization of the Unstable through Controlling Influence of Quantum Information -- The Sustainable Humanist Concept in Art and Science Synergies -- From Being One to Being Many. Understanding the Diversity of Bio‐Life: Human, Nonhuman and Liminal Beings in the in Bio Art and Body Art -- Composite Bodies in Times of Catastrophe. On Socio‐Material Assemblies, Affective Contagions and the Biodegradable -- Life, Complexity, Communication: Integrating Social Systems Theory and Consciousness -- Rethinking the Reverse Side of Artificial Intelligence -- The Question of Transdisciplinarity between Modern Science and Critical Thought -- Adaptive Networks at the Crossroad of Artificial Intelligence and Formal, Biological, Medical and Social Sciences -- Are We Ready for "Them" Now? The Relationship between Human and Humanoid Robots -- Integrating Computer Simulation and Social Theory for Planning and Managing Complex Problems -- Rethinking Managerial Control in the Contemporary Context -- Innovation and Altruism: A New Paradigm Defining the Survival of Corporations -- Integrated Science 2050: Science without Borders.

Description / Table of Contents: Chapter 1: “Carving Your Own Path” – shaping your scientific identity -- Chapter 2: The Two Cornerstones of Academic Research: Writing Grant Applications and Publications -- Chapter 3: Setting up a Successful Research Group -- Chapter 4: Leading Your Research Group as a Principal Investigator -- Chapter 5: The Daily Work of Principal Investigators -- Chapter 6: Dealing with Failure and Stress in Academic Research -- Chapter 7: Thoughts of Principal Investigators about Work, Science, and Themselves -- Chapter 8: Under the Hood – Common Thinking Patterns of Principal Investigators -- Chapter 9: Epilogue -- Chapter 10: Methods.

Description / Table of Contents: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.

Description / Table of Contents: Advances in translational science to identify new therapies for systemic lupus erythematosus -- Hallmark of systemic lupus erythematosus: Role of B Cell Hyperactivity. Fabien B Vincent, William A Figgett and Margaret L Hibbs -- B cell targeted therapies in systemic lupus erythematosus -- Type I Interferons and the perpetuation of a loss of tolerance -- Therapeutic Modulation of the Interferon Pathway in Systemic Lupus Erythematosus -- The concept of co-stimulatory blockade in SLE -- Cytokines: their role in amplifying SLE pathogenesis -- Intracellular targets in SLE -- Regulatory T cells in SLE -- Balancing strategies: GC and GILZ Axis.

Description / Table of Contents: Artificial Intelligence in the Health Care System: An Overview -- Complex interaction among immune, inflammatory, and carcinogenic mechanisms in the head and neck squamous cell carcinoma -- Outcomes of Repeat Pulmonary Metastasectomy: An Evidence Review -- Quality of Life of Patients after Laparoscopic Pyeloplasty Due to Ureteropelvic Junction Obstruction: A Long-Term Observation -- Causes and Effects of Introducing Surgery Safety Checklist: A review -- Benefit of Biological Drugs for Quality of Life in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis of Clinical Trials -- Changes of Motile Ciliary Phenotype in Patients with Primary Ciliopathies -- Effects of Inhalation of STIM-Orai Antagonist SKF 96365 on Ovalbumin-Induced Airway Remodeling in Guinea Pigs -- In Silico Analysis of Bone Tension during Fixation of the Medial Malleolus Fracture after Ankle Joint Endoprosthesis -- Effects of Physical Activity at High Altitude on Hormonal Profiles in Foreign Trekkers and Indigenous Nepalese Porters -- Influence of Parathyroidectomy on Sleep Quality in Primary Hyperparathyroidism -- Mini Craniotomy in the Management of Supra-Tentorial Spontaneous Intracranial Hemorrhage; a Single-Center Outcome of the Minimally Invasive Treatment.

Description / Table of Contents: Introduction. --Part 1 -- Chapter 1. Role of Par-4 in lung cancer -- Chapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinoma -- Chapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancers -- Chapter 4. Regulation of Par-4 and role in GI tumors -- Chapter 5. Role of Par-4 in prostate cancer -- Chapter 6. Activation of apoptosis by Par-4 in pancreatic cancer -- Chapter 7. Role of Par-4 and GRP78 in Glioblastoma -- Chapter 8. Role of Par-4 in breast cancer recurrence -- Chapter 9. Involvement of Par-4 in breast cancer -- Chapter 10. Role of endogenous Par-4 in CLL -- Chapter 11. Role of Par-4 in inhibition of TCL1 induced growth -- Chapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cells -- Chapter 13. Par-4 expression in cholangiocarcinoma -- Chapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cells -- Chapter 15. PAWR as direct SRC-1/HOXC11 suppression target -- Chapter 16. Par-4 cleavage is required for TNF induced apoptosis -- Chapter 17. Par-4 secretagogues -- Chapter 18. Recombinant production and characterization of SAC -- Chapter 19. Anti-tumor effects of plant derived Par-4 -- Chapter 20. Par-4 in Mycobacterium tuberculosis Infected Macrophages -- Part 2 - Role in other Diseases -- Chapter 21. Role of Par-4 in ceramide inducible effects in neurons -- Chapter 22. Role of Par-4 in Alzheimers disease -- Chapter 23. Dopamine signaling in association with induction of Par-4 protein expression -- Chapter 24. Par-4 (PAWR) in major depressive disorder -- Chapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetes -- Chapter 26. Par-4 in cardiac fibroblast senescence -- Chapter 27. Par-4 in ocular development and disease -- Chapter 28. Par-4 in apoptosis during human salivary gland development -- Chapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosis -- Chapter 30. Lessons from knockout mice -- Part 3 - From Bench to Bedside -- Chapter 31. Par-4 secretagogues in clinical trials -- Chapter 32. Potential of Par-4 as a therapeutic target for cancer.

Description / Table of Contents: Chapter 1: Outline Of Anatomy/Physiology Of Skeletal Tissues -- Chapter 2: Tumors Of The Musculoskeletal System -- Chapter 3: Tumor-Like Lesions Of The Musculoskeletal System -- Chapter 4: General Considerations About Bone Tumors -- Chapter 5: Appendix: Manual For Histological Preparation And Examination Of Tissues Containing Bone And Cartilage.

Description / Table of Contents: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression -- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening -- Ion channels in Lung Cancer -- Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer -- Transportome Malfunctions and the Hallmarks of Pancreatic Cancer -- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer -- Ion Channels in Glioma Malignancy -- Membrane Transporters and Channels in Melanoma -- Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.

Description / Table of Contents: 1. Inflammatory components of the thyroid cancer microenvironment - an avenue for identification of novel biomarkers -- 2. Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity -- 3. Exosomes in the Healthy and Malignant Bone Marrow Microenvironment -- 4. Structural Biology of the Tumor Microenvironment -- 5. Metabolic interactions between tumor and stromal cells in the Tumor Microenvironment -- 6. Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy -- 7. Non-coding RNAs in Papillary Thyroid Cancer: Interaction with cancer associated fibroblasts (CAFs) in the Tumor Microenvironment (TME) and regulators of differentiation and Lymph Node Metastasis.

Description / Table of Contents: Compliance with the Surgery Safety Checklist: An Update on the Status -- Surgical Safety Checklist: Polychromatic or Achromatic Design -- Surgical Strategy and Clinical Outcome in Patients with Bronchial Carcinoids -- Frozen Section or Intraoperative Cytology: Are We Ready for a Paradigm Shift in Thoracic Surgery? -- Clinical Outcome in Patients with Nosocomial COVID-19 Infection After Thoracic Surgery -- Cytological Diagnostic Procedures in Malignant Mesothelioma -- Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions -- Cytokines in Renal Cell Carcinoma: A Step Towards Earlier Detection and Targeted Therapy -- Primary Hyperparathyroidism Secondary to Ectopic Parathyroid Adenoma: A Case Report -- Perception of Well-Being and Quality of Life in Obese Patients After Bariatric Surgery -- Do Multiple Brain Lesions Always Connote Worse Outcomes? Appraisal Evidence from a Tertiary Care Center in Koshi/Purbanchal Province of Nepal -- Radioimaging and Demographic Profiles of Patients with Spontaneous Intracerebral Hemorrhage: A Need for the Pragmatic Referral System -- Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report.

Description / Table of Contents: Chapter 1: The Structure And Function Of Living Organisms -- Chapter 2: Energy In Biology – Demand And Use -- Chapter 3: Information – Its Role And Meaning In Organism -- Chapter 4: Regulation In Biological Systems -- Chapter 5: Interrelationship In Organized Biological Systems. .

Description / Table of Contents: 1 Introduction: Hot and Cold Theory, the Path Towards Personalized Medicine -- Part I Definitions and Beliefs -- 2 Principle of Hot and Cold and Its Clinical Application in Traditional Chinese Medicine -- 3 Principle of Hot and Cold and Its Clinical Application in Persian Medicine -- 4 Principle of Hot (Ushna) and Cold (Sheeta) and Its Clinical Application in Ayurvedic Medicine -- 5 Principle of Hot and Cold and Its Clinical Application in Latin American and Caribbean Medicines -- Part II Scientific Evidence -- 6 Hot and Cold Theory: Evidence in Nutrition -- 7 Hot and Cold Theory: Evidence in Pharmacology -- 8 Hot and Cold Theory: Evidence in Physiology -- 9 Hot and Cold Theory: Evidence in Systems Biology -- Part III Perspective -- 10 Hot and Cold Theory: A Personalized Medicine Approach -- 11 Hot and Cold Theory: Future Perspective.

Description / Table of Contents: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.

Description / Table of Contents: Biopharmaceuticals Produced from Cultivated Mammalian Cells -- Remote Control of Mammalian Therapeutic Designer Cells -- Next generation cell engineering using microRNAs -- An Omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production -- Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations -- Monoclonal antibody glycoengineering for biopharmaceutical quality assurance -- Next-generation cell engineering platform for improving recombinant protein production in mammalian cells -- Manufacturing human pluripotent stem cells and differentiated progenitors -- Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications -- Process Design for hMSC Products in Stirred Tank Bioreactors -- Bio-production of Adeno-associated virus for gene therapy -- Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale -- Intensified and Continuous mAb Production with Single-Use Systems -- Mathematical modelling of cell culture processes -- Model-assisted design concepts for mammalian cell culture processes -- Bioprocess monitoring and control -- Industrial Monitoring of Cell Culture.

Description / Table of Contents: Part 1: Getting started -- Chapter 1: The why and the what of scientific research and publishing -- Chapter 2: Understanding research ethics -- Chapter 3: How to structure a scientific article, conference poster and presentation -- Part 2: The Hidden Bumps -- Chapter 4: Who gets authorship status? -- Chapter 5: The art of journal selection -- Chapter 6: Understanding the editor’s perspectives -- Part 3: The Destination -- Chapter 7: Converting a scientific article for the media -- Chapter 8: What are research metrics and why should I care? -- Chapter 9: Beyond your scientific publication -- Chapter 10: The Editor’s Perspective – Full-Length Interviews.

Description / Table of Contents: Artificial Intelligence and Precision Medicine: A Perspective -- Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge -- Quantum Medicine: A Role of Extremely Low-Frequency Magnetic Fields in the Management of Chronic Pain -- Manual Therapy Approach to the Extraocular Muscles in Migraine Treatment: A Preliminary Study -- Capacitive and Resistive Electric Transfer Therapy: A Comparison of Operating Methods in Non-specific Chronic Low Back Pain -- Serum Impedance in Children with Recurrent Respiratory Infections -- Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek -- The Impact of Change in Hospital Admissions When Primary Care Is Provided by a Single Primary Care Physician: A Cohort Study Among HMO Patients in Israel -- Risk of Falls in Patients Aged Over 65 in the Context of the Treatment Facility -- Anthropometric Indices as Long-Term Predictors of Diabetes in Impaired Fasting Glucose Metabolism: Findings in the PURE Study in Poland -- Cardiovascular Risk Factors Drive Impaired Fasting Glucose to Type 2 Diabetes: Findings After a 9-Year Follow-Up in the PURE Study in Poland -- Sleep-Disordered Breathing in Pregnancy.

Description / Table of Contents: Chapter 1. Creating Interactive Three-Dimensional Applications to Visualise Novel Stent Grafts That Aid in the Treatment of Aortic Aneurysms -- Chapter 2. Using Confocal Microscopy to Generate an Accurate Vascular Model for Use in Patient Education Animation -- Chapter 3. Methods and applications of 3D Patient-Specific Virtual Reconstructions in Surgery -- Chapter 4. Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients -- Chapter 5. Virtual Wards: A Rapid Adaptation to Clinical Attachments in MBChB During the COVID-19 Pandemic -- Chapter 6. Artificial Intelligence: Innovation to Assist in the Identification of Sono-anatomy for Ultrasound-Guided Regional Anaesthesia -- Chapter 7. A Systematic Review of Randomised Control Trials Evaluating the Efficacy and Safety of Open and Endoscopic Carpal Tunnel Release -- Chapter 8. Exploring Visualisation for Embryology Education: A Twenty-First-Century Perspective -- Chapter 9. How Artificial Intelligence and Machine Learning Is Assisting Us to Extract Meaning from Data on Bone Mechanics? -- Chapter 10. Visual Communication and Creative Processes Within the Primary Care Consultation -- Chapter 11. Digital 2D, 2.5D and 3D Methods for Adding Photo-Realistic Textures to 3D Facial Depictions of People from the Past -- Chapter 12. Teaching with Cadavers Outside of the Dissection Room Using Cadaveric Videos -- Chapter 13. A Novel Cadaveric Embalming Technique for Enhancing Visualisation of Human Anatomy -- Chapter 14. Assessing the Impact of Interactive Educational Videos and Screencasts Within Pre-clinical Microanatomy and Medical Physiology Teaching.

Description / Table of Contents: Part I. The History and Philosophy of Medical Imaging -- Chapter 1. Re:Viewing Observation. The Philosophy of Medical Imaging -- Part II. Innovation in Imaging Technologies -- Chapter 2. Emerging Imaging Techniques in Anatomy: For Teaching, Research and Clinical Practice -- Chapter 3. Mapping of Orthopaedic Fractures for Optimal Surgical Guidance -- Chapter 4. Visualising the Dural Venous Sinuses Using Volume Tracing, a Novel Approach -- Chapter 5. Placental Morphology and Morphometry: Is It a Prerequisite for Future Pathological Investigations? -- Part III. Art-Based Practice and Body Science -- Chapter 6. Drawing: A Dialogue across Disciplines -- Chapter 7. Visualizing the Human Body Using an Artistic Approach -- Chapter 8. Construction of Facial Composites from Eyewitness Memory.