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  • thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology  (1,259)
  • bic Book Industry Communication::M Medicine  (1,140)
  • FID-GEO-DE-7
  • English  (2,372)
  • Portuguese  (155)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the fascination with shape memory alloys (SMAs) has grown across industries such as aerospace, automotive, naval, civil, and biology. SMAs possess unique properties, including the ability to recover from deformation when heated, exhibit pseudoelastic stress-strain behavior for large deformations, and exceptional biocompatibility for bioengineering applications. However, a comprehensive understanding of critical characteristics like transformation temperature and stress values is necessary to fully utilize SMAs. The shape memory effect, where SMAs regain their original shape after deformation under specific thermal conditions, has driven innovative applications in various sectors. In aerospace, SMAs are used in wing structures and actuation systems, enabling morphing and improving aerodynamics. In healthcare, they are integrated into orthopedic devices, simplifying surgical procedures and providing necessary support. The automotive industry also benefits from SMAs, using them in seatbelts and vibration damping systems for enhanced safety and comfort. Accurate knowledge of critical characteristics is essential for effective utilization of SMAs, unlocking their potential in different fields. The remarkable versatility of SMAs, with their deformation recovery, pseudoelasticity, and biocompatibility, positions them as a material of immense interest. As research and development continue, SMAs are poised to drive future innovations, shaping various industries.
    Keywords: shape memory alloy (SMAs) ; shape memory effect (SME) ; superelasticity ; smart materials ; constitutive models ; simulation and modeling ; smart devices ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mg alloy is the lightest metallic structural material and possesses the advantages of high specific strength, high specific stiffness, good electromagnetism shield, good damping capacity, good machinability, and easy recycling, etc. Therefore, it has extremely broad application prospects and has drawn considerable interest in the fields of automobile, electronics, electrical appliances, transportation, aerospace, and aviation. In addition, Mg alloys are gradually showing application potential in emerging industries, serving as biodegradable metals in the biomedical field, functional material for hydrogen storage, and so on. This Special Issue (SI), entitled “Research Progress in High-Performance Magnesium Alloy and Its Applications”, presents recent developments and excellent results in the field of Mg alloys, and includes 10 articles and one editorial covering some interesting aspects of the topic.
    Keywords: grain refinement ; high strength and toughness ; {10–12} twin ; Mg-Gd-Y alloy ; multidirectional impact forging ; Mg-Zn-Mn-Ca ; Ca2Mg6Zn3 phase ; corrosion behaviors ; SKPFM ; boride ; MgB2 ; mechanical alloying ; ignition ; combustion ; flame temperature ; magnesium alloy ; biocompatibility ; surface coating modification ; corrosion resistance ; implantable bio-metal materials ; filler material ; welding ; scandium ; microstructure modification ; mechanical properties ; microstructure ; texture ; stretch formability ; high temperature cross-rolling ; annealing ; wire arc additive manufacturing ; cold metal transfer ; Al-Mg alloys ; orthogonal experiment ; Mg-Bi-Ca alloy ; hot deformation ; constitutive model ; dynamic recrystallization kinetics ; Mg alloy ; twinning ; random orientation ; compression ; room temperature ; backward extrusion ; tensile strength ; failure mechanism ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 6
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Metalliferous minerals play a central role in the global economy. They will continue to provide the raw materials we need for industrial processes. Significant challenges will likely emerge if the climate-driven green and low-carbon development transition of metalliferous mineral exploitation is not managed responsibly and sustainably. Green low-carbon technology is vital to promote the development of metalliferous mineral resources shifting from extensive and destructive mining to clean and energy-saving mining in future decades. Global mining scientists and engineers have conducted a lot of research in related fields, such as green mining, ecological mining, energy-saving mining, and mining solid waste recycling, and have achieved a great deal of innovative progress and achievements. This Special Issue intends to collect the latest developments in the green low-carbon mining field, written by well-known researchers who have contributed to the innovation of new technologies, process optimization methods, or energy-saving techniques in metalliferous minerals development.
    Keywords: metallurgical slag-based binders ; solidification/stabilisation ; As(III) ; As(V) ; calcium hydroxide ; sublevel caving ; numerical simulation ; physical model ; structural parameter ; green mining ; limestone ; high temperature ; confining pressure ; SHPB ; constitutive model ; open-pit mine ; PLAXIS 3D ; dynamic load ; safety factor ; acceleration ; particle sedimentation ; filling mining ; degree of influence ; pipeline transportation ; solid waste utilization ; tailings ; reclamation risk ; hazard identification ; complex network ; hazard management ; digital mine ; mine short-term production planning ; haulage equipment dispatch plan ; ABCA ; NSGA ; settlement velocity measurement ; K-means ; tailings backfill ; unsupervised learning ; cemented paste backfill ; ESEM ; picture processing ; floc networks ; pumping agent ; fractal dimension ; backfill slurry ; strength of cemented backfill ; inhomogeneity of cemented backfill ; cemented tailings backfill ; copper ; zinc ; recovery ; sulfide concentrate ; artificial microbial community ; granular backfill ; bearing characteristics ; numerical model ; particle size ; surface subsidence ; blasting dust movement ; dust concentration ; particle size distribution ; blasting dust reduction ; backfill ; metal mine ; log-sigmoid ; tailings pond ; regional distribution ; dam break ; accident statistics ; causation analysis ; backfilling ; increasing resistance and reducing pressure ; computational fluid dynamics ; spiral pipe ; stowing gradient ; coal-based solid waste ; orthogonal experiment ; strength development ; regression analysis ; engineering performance ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTU Mining technology and engineering
    Language: English
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  • 9
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Elastomer materials are characterized by their high elongation and (entropy) elasticity, which makes them indispensable for widespread applications in various engineering and medical areas as well as consumer goods. This book focuses on the state-of-the-art of elastomers covering all aspects from their properties to applications. The development and testing of advanced elastomers is of particular interest. Attention is given to various aspects of elastomers, such as ever-increasing environmental concepts dealing with recyclability and reusability, incorporation of functional groups or additives to obtain novel functionality or bioelastomers, analytical description of mechanisms and structure relations of the fracture behavior of elastomers, and their external stimuli-responsive character. The scope of the book encompasses contributions at the frontier of science in polymer network synthesis, experimental and theoretical physics of polymer networks, and new structures and functionalities incorporated into elastomers leading to enhanced properties of crosslinked elastomeric materials, among others.
    Keywords: magnetorheological elastomer ; filler ; hetero-aggregation ; nanosized Ni-Mg cobalt ferrites ; electrical resistance ; resistivity ; rheological properties ; elastomers ; in-situ silica ; friction ; abrasion ; tear fatigue test ; buffing dust collagen (BDC) ; styrene–butadiene rubber (SBR) ; polymer composites ; biodegradation ; bio-oil ; bio-based plasticizer ; eco-friendly plasticizer ; acrylonitrile-butadiene rubber ; NBR ; mechanical testing ; thermo-oxidative aging ; vulcanized rubber ; rubber compounds ; carbon black ; vibration damping ; viscoelasticity ; magnetorheological ; elastomer ; magnetic particle ; viscoelastic ; rheological ; smart materials ; coating ; particle coating ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In this Special Issue, we have several papers related to fuel-cell-based cogeneration systems; the management and control of fuel cell systems; the analysis, simulation, and operation of different types of fuel cells; modelling and online experimental validation; and the environment assessment of cathode materials in lithium-ion battery energy generation systems. A paper which gives a comprehensive review with technical guidelines for the design and operation of fuel cells, especially in a cogeneration system setup, which can be an important source of references for the optimal design and operation of various types of fuel cells in cogeneration systems, can also be found in this Special Issue.
    Keywords: LIBs ; environmental sustainability ; cathode material ; LCA ; wind energy ; fuel cell ; IM ; induction generator ; hybrid system ; mine blast optimizer ; solid oxide fuel cell ; robust model predictive control ; off-line calculation ; control synthesis ; review ; cogeneration ; optimal design ; guidelines ; SOFC ; simulation ; internal reforming ; anode oxidation ; carbon formation ; direct methanol fuel cell ; methanol crossover ; power density ; catalyst ; membrane electrode assembly ; Colebrook equation ; fuel cells ; flow friction factor ; open-cathode ; pressure drop ; symbolic regression ; numerically stabile solution ; roughness ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 15
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Smart materials and structures are capable of active or passive changes in terms of shapes, properties, and mechanical or electromagnetic responses in reaction to an external stimulus, such as light, temperature, stress, moisture, pH, and electric or magnetic fields. They have attracted increasing interest for their enhanced performance and efficiency over a wide range of industrial applications, especially for aerospace. These require novel engineering approaches and design philosophies in order to integrate the actions of sensors, actuators, and control circuit elements into a single system that can respond adaptively to its surroundings. This reprint has collected cutting-edge research and recent advances in smart materials and structures, including seven original research papers and three review articles, co-authored by 65 scientists and engineers from 18 institutions and 3 industries. The research topics mainly cover advanced materials, applications of smart materials and structures, as well as recent development in sensing techniques. We hope this reprint will contribute to disseminating the latest progress in smart materials and structures, as well as stimulate the interest of its audience to work in this important and vibrant area to promote and benefit the multidisciplinary scientific communities.
    Keywords: textile-based mechanical sensors ; mechanism ; preparation ; advantages ; applications ; Artificial Neural Network (ANN) ; guided waves ; Structural Health Monitoring (SHM) ; Finite Element Analysis (FEA) ; damage detection ; metals ; composites ; aeroelastic stability ; bladed disk ; intentional mistuning ; piezoelectric material ; topological optimization ; microstructure ; high-entropy alloy ; mechanical property ; bipedal robot ; dynamics simulation ; MRE isolator ; vibration reduction control algorithms ; no-core fiber ; polyaniline ; polyacrylic acid ; pH sensor ; multimode interference ; gas foil bearing ; Inconel alloy ; sensing foil ; strain field ; temperature field ; thermomechanical coupling ; thermomechanical characterization ; rotor dynamics ; turbomachinery ; cholesteric liquid crystals ; electro-optic response ; polymer stabilization ; ion-trapping mechanism ; liquid metal ; stretchable conductor ; 3D printing ; high dynamic stability ; wearable devices ; biomimetic ; Venus flytrap ; smart ; composite ; mechanics ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Non-Newtonian (non-linear) fluids are common in nature, for example, in mud and honey, but also in many chemical, biological, food, pharmaceutical, and personal care processing industries. This Special Issue of Fluids is dedicated to the recent advances in the mathematical and physical modeling of non-linear fluids with industrial applications, especially those concerned with CFD studies. These fluids include traditional non-Newtonian fluid models, electro- or magneto-rheological fluids, granular materials, slurries, drilling fluids, polymers, blood and other biofluids, mixtures of fluids and particles, etc.
    Keywords: TA1-2040 ; T1-995 ; Poiseuille–Couette flow ; membrane ; viscous fluid ; channel flow ; existence theorem ; yield stress ; hemoglobe capacitor ; creeping flows ; viscoplastic fluids ; projection method ; power-law fluid ; first- and second-order slip ; Mittag–Leffler ; lubrication ; viscoplastic fluid ; rupture ; convection ; Re numbers ; enhanced oil recovery (EOR) ; SPH-FEM ; Gamma densitometer ; oil recovery ; non-newtonian fluids ; marginal function ; particle interaction ; computational fluid dynamics ; non-isothermal flows ; suspensions ; Brinkman equation ; lubrication approximation (76A05 ; lid-driven cavity ; smoothed particle hydrodynamics (SPH) ; 76D08 ; Phan-Thien–Tanner (PTT) model ; bubble suspension ; porous media ; non-equilibrium thermodynamics ; porous medium ; suspension viscosity ; hemoglobin ; convection-diffusion ; slug translational velocity ; closure relationship ; non-linear fluids ; wormlike micellar solutions (WMS) ; high viscosity oil ; viscoelastic surfactants (VES) ; 76A20) ; meshless ; Bingham fluid ; Reynolds equation ; generalised simplified PTT ; dense suspension ; chemical EOR (cEOR) ; buoyancy force ; viscosity ratio ; aspect ratio ; rheology ; lubrication approximation ; fluid-solid interaction (FSI) ; optimal control ; natural convection ; biofluids ; shear-dependent viscosity ; thermodynamic capacitor ; shear-thinning ; stokesian dynamics ; weak solution ; biological capacitor ; cement ; variable viscosity ; Couette flow ; pressure boundary conditions ; inhomogeneous fluids ; boundary control ; similarity transformation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The development of solid state gas sensors based on microtransducers and nanostructured sensing materials is the key point in the design of portable measurement systems able to reach sensing and identification performance comparable with analytical ones. In such a context several efforts must be spent of course in the development of the sensing material, but also in the choice of the transducer mechanism and its structure, in the electrical characterization of the performance and in the design of suitable measurement setups. This call for papers invites researchers worldwide to report about their novel results on the most recent advances and overview in design and measurements for applications in gas sensors, along with their relevant features and technological aspects. Original research papers are welcome (but not limited) on all aspects that focus on the most recent advances in: (i) basic principles and modeling of gas and VOCs sensors; (ii) new gas sensor principles and technologies; (iii) Characterization and measurements methodologies; (iv) transduction and sampling systems; (vi) package optimization; (vi) gas sensor based systems and applications.
    Keywords: TA1-2040 ; T1-995 ; indium oxide ; n/a ; environmental monitoring ; semiconductor ; gas sensor ; packed gas chromatographic column ; ultrathin carbon layer ; metal-oxide-semiconductor array sensor ; halitosis ; laser ablation ; capacitive micromachined ultrasonic transducers (CMUT) ; LTCC side via ; MEMS ; indirect packaging ; gas sensing ; efficiency ; bad breath ; electrospray ; array optimization ; low temperature co-fired ceramic (LTCC) ; electronic nose ; UV irradiation ; core/shell nanostructure ; combinatorial and high-throughput technique ; sensitive material ; hydrogen sulfide ; CO detection ; ZnO ; amperometric ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The use of concentrated solar technologies has grown significantly worldwide in the last decade but the research and development of this renewable energy technology still needs to be advanced to guarantee its competitiveness with other energy sources. Challenges remain with reducing costs, optimizing the systems design, and increasing the performance and durability of the systems.This Special Issue on research on solar collectors presents some recent developments and studies on tracking-solar collectors for medium- to high-temperature applications, both line- and point-focus systems, conceived for the supply of heat in industrial processes, to provide thermal energy to a power block for electricity production, or even to combine heat and electricity generation in a solar collector unit (CPV/T). The articles included in this Special Issue cover theoretical or practical issues on geometrics optics, thermal–hydraulic modelling, and performance analysis, focusing on the following topics:• Solar towers: heliostat fields analysis and optimization• Solar towers: heat transfer media studies• Parabolic troughs: evacuated solar receivers analysis and thermal–hydraulic modelling• Fresnel reflectors: geometrics optics and manufacturing issues• Fresnel lens in CPV• Energy losses in solar collectors systems
    Keywords: thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue was intended as a forum to advance research and apply machine-learning and data-mining methods to facilitate the development of modern electric power systems, grids and devices, and smart grids and protection devices, as well as to develop tools for more accurate and efficient power system analysis. Conventional signal processing is no longer adequate to extract all the relevant information from distorted signals through filtering, estimation, and detection to facilitate decision-making and control actions. Machine learning algorithms, optimization techniques and efficient numerical algorithms, distributed signal processing, machine learning, data-mining statistical signal detection, and estimation may help to solve contemporary challenges in modern power systems. The increased use of digital information and control technology can improve the grid’s reliability, security, and efficiency; the dynamic optimization of grid operations; demand response; the incorporation of demand-side resources and integration of energy-efficient resources; distribution automation; and the integration of smart appliances and consumer devices. Signal processing offers the tools needed to convert measurement data to information, and to transform information into actionable intelligence. This Special Issue includes fifteen articles, authored by international research teams from several countries.
    Keywords: virtual power plant (VPP) ; power quality (PQ) ; global index ; distributed energy resources (DER) ; energy storage systems (ESS) ; power systems ; long-term assessment ; battery energy storage systems (BESS) ; smart grids ; conducted disturbances ; power quality ; supraharmonics ; 2–150 kHz ; Power Line Communications (PLC) ; intentional emission ; non-intentional emission ; mains signalling ; virtual power plant ; data mining ; clustering ; distributed energy resources ; energy storage systems ; short term conditions ; cluster analysis (CA) ; nonlinear loads ; harmonics, cancellation, and attenuation of harmonics ; waveform distortion ; THDi ; low-voltage networks ; optimization techniques ; different batteries ; off-grid microgrid ; integrated renewable energy system ; cluster analysis ; K-means ; agglomerative ; ANFIS ; fuzzy logic ; induction generator ; MPPT ; neural network ; renewable energy ; variable speed WECS ; wind energy conversion system ; wind energy ; frequency estimation ; spectrum interpolation ; power network disturbances ; COVID-19 ; time-varying reproduction number ; social distancing ; load profile ; demographic characteristic ; household energy consumption ; demand-side management ; energy management ; time series ; Hidden Markov Model ; short-term forecast ; sparse signal decomposition ; supervised dictionary learning ; dictionary impulsion ; singular value decomposition ; discrete cosine transform ; discrete Haar transform ; discrete wavelet transform ; transient stability assessment ; home energy management ; binary-coded genetic algorithms ; optimal power scheduling ; demand response ; Data Injection Attack ; machine learning ; critical infrastructure ; smart grid ; water treatment plant ; power system ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The Special Issue “Assessment and Nonlinear Modeling of Wave, Tidal, and Wind Energy Converters and Turbines” contributes original research to stimulate the continuing progress of the offshore renewable energy (ORE) field, with a focus on state-of-the-art numerical approaches developed for the design and analysis of ORE devices. Particularly, this collection provides new methodologies, analytical/numerical tools, and theoretical methods that deal with engineering problems in the ORE field of wave, wind, and current structures. This Special Issue covers a wide range of multidisciplinary aspects, such as the 1) study of generalized interaction wake model systems with elm variation for offshore wind farms; 2) a flower pollination method based on global maximum power point tracking strategy for point-absorbing type wave energy converters; 3) performance optimization of a Kirsten–Boeing turbine using a metamodel based on neural networks coupled with CFD; 4) proposal of a novel semi-submersible floating wind turbine platform composed of inclined columns and multi-segmented mooring lines; 5) reduction of tower fatigue through blade back twist and active pitch-to-stall control strategy for a semi-submersible floating offshore wind turbine; 6) assessment of primary energy conversion of a closed-circuit OWC wave energy converter; 7) development and validation of a wave-to-wire model for two types of OWC wave energy converters; 8) assessment of a hydrokinetic energy converter based on vortex-induced angular oscillations of a cylinder; 9) application of wave-turbulence decomposition methods on a tidal energy site assessment; 10) parametric study for an oscillating water column wave energy conversion system installed on a breakwater; 11) optimal dimensions of a semisubmersible floating platform for a 10 MW wind turbine; 12) fatigue life assessment for power cables floating in offshore wind turbines.
    Keywords: off-shore wind farms (OSWFs) ; wake model ; wind turbine (WT) ; Extreme Learning Machine (ELM) ; wind power (WP) ; large-eddy simulation (LES) ; point-absorbing ; wave energy converter (WEC) ; maximum power point tracking (MPPT) ; flower pollination algorithm (FPA) ; power take-off (PTO) ; hill-climbing method ; Kirsten–Boeing ; vertical axis turbine ; optimization ; neural nets ; Tensorflow ; ANSYS CFX ; metamodeling ; FOWT ; multi-segmented mooring line ; inclined columns ; semi-submersible ; AFWT ; floating offshore wind turbine (FOWT) ; pitch-to-stall ; blade back twist ; tower fore–aft moments ; negative damping ; blade flapwise moment ; tower axial fatigue life ; wave energy ; oscillating water column ; tank testing ; valves ; air compressibility ; air turbine ; wave-to-wire model ; energy harnessing ; energy converter ; flow-induced oscillations ; vortex-induced vibration ; flow–structure interaction ; hydrodynamics ; vortex shedding ; cylinder wake ; tidal energy ; site assessment ; wave-current interaction ; turbulence ; integral length scales ; wave-turbulence decomposition ; OWC ; wave power converting system ; parametric study ; caisson breakwater application ; floating offshore wind turbines ; frequency domain model ; semisubmersible platform ; 10 MW wind turbines ; large floating platform ; platform optimization ; wind energy ; floating offshore wind turbine ; dynamic analysis ; fatigue life assessment ; flexible power cables ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 25
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The fundamentals of mechanical system dynamics were established before the beginning of the industrial era. The 18th century was a very important time for science and was characterized by the development of classical mechanics. This development progressed in the 19th century, and new, important applications related to industrialization were found and studied. The development of computers in the 20th century revolutionized mechanical system dynamics owing to the development of numerical simulation. We are now in the presence of the fourth industrial revolution. Mechanical systems are increasingly integrated with electrical, fluidic, and electronic systems, and the industrial environment has become characterized by the cyber-physical systems of industry 4.0. Within this framework, the status-of-the-art has become represented by integrated mechanical systems and supported by accurate dynamic models able to predict their dynamic behavior. Therefore, mechanical systems dynamics will play a central role in forthcoming years. This Special Issue aims to disseminate the latest research findings and ideas in the field of mechanical systems dynamics, with particular emphasis on novel trends and applications.
    Keywords: tire model ; tire temperature ; FSAE vehicle ; rolling bearing ; rigid rotor ; internal radial clearance ; number of rolling elements ; vibration ; varying compliance vibration ; ball passage frequency ; load ; trucks ; handling stability ; lightweight ; taper-leaf spring ; suspension ; step steer ; motorcycle tires ; thermal modeling ; performance optimization ; real-time simulations ; conveyor ; friction ; rolling ; non-linear simulation ; fractal derivative ; viscoelastic models ; polymers ; bicycle ; mountain bike ; tire tread pattern ; force and moment ; e-bike ; tyre ; dynamics ; active rear axle independent steering (ARIS) system ; hierarchical synchronization control ; virtual coupling control ; linear active disturbance rejection control (LADRC) ; computational fluid dynamics ; fluid sloshing ; table cart method ; zero moment point ; rider ; body segment inertial parameters ; biomechanics ; human body ; motorcycle ; multibody ; robot ; compliance ; machining ; modes of vibration ; impulsive testing ; dynamic parameter identification ; dynamic parameters ; parallel kinematics ; parallel robot ; parallel manipulator ; varying friction ; valve train ; coupled approach ; NVH ; vibration energy control ; multi-physics mechanism theory ; non-linear stiffness ; isolation ; hydraulic system ; magnetic spring ; articulated vehicle ; hydraulic steering system ; directional stability ; deformable soil ; tracked vehicle ; contact model ; two-wheeler ; vehicle dynamic modelling ; wobble ; weave ; fork bending compliance ; rider influence ; ADAS ; driver model ; load cell ; steering wheel ; cable robots ; motion planning ; cable failure ; recovery strategy ; roller chain ; chain efficiency ; sliding friction ; lateral offset ; damping force ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Supply Chain 4.0 is designed, planned, managed and optimized using Industry 4.0 technologies. There are many research issues and challenges associated with Supply Chain 4.0, a data rich complex system. The available data can interpret what happened in the past, what is currently happening, what will happen in the future and what are the best actionable decisions. Digitalization, visibility, connectivity and interoperability are integrated in Supply Chain 4.0. The operational, tactical and strategic plans across the supply chain are digitally interlinked and real-time synchronized with a 360-degree view. The win–win partnerships are dynamic and sustainable, with agility, flexibility and responsiveness to uncertain business environments. New models and methods are advocated to implement Supply Chain 4.0 research and development. With the progress and implementation of Industry 4.0 technologies, it is anticipated that there will be more and more breakthroughs in the models and methods of Supply Chain 4.0. This Special Issue will serve as a helpful reference for Supply Chain 4.0 researchers and practitioners.
    Keywords: Industry 4.0 ; supply chain management and optimization ; Supply Chain 4.0 ; supply chain analytics ; supply chain visibility and connectivity ; supply chain synchronization and coordination ; sustainable supply chain management&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Additive manufacturing (AM) processes are gaining more and more attention from many industrial fields, mainly because they are revolutionizing the components’ designs and production lines. The complete industrialization of these processes has to be supported by the full understanding of correlation between AM building conditions and the final materials’ properties. Another critical aspect is that nowadays only a reduced number of materials processable by AM are available on the market. It is, therefore, fundamental to widen the materials’ portfolio, and to study and develop new materials that can take advantage of these unique building processes.
    Keywords: amorphous poly(lactide acid) ; poly(styrene-co-methyl methacrylate) ; polymer blends ; filament extrusion ; 3D printing ; additive manufacturing ; silicon nitride ; high performance ceramics ; photopolymerisation ; lithography-based ceramic manufacturing ; fused-deposition modeling ; mechanical properties ; thermal behavior ; polyetherimide ; fused filament modelling ; design of experiments ; directed energy deposition ; AISI 316L ; microstructure ; LPBF ; as-built ; as-cast ; microhardness ; tensile test ; Ni–Cu alloy ; materials development ; polymers ; metals ; ceramics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    Publication Date: 2024-04-11
    Description: This Special Issue covers symmetry and asymmetry phenomena occurring in real-life problems. We invited authors to submit their theoretical or experimental research presenting engineering and economic problem solution models dealing with the symmetry or asymmetry of different types of information. The issue gained interest in the research community and received many submissions. After rigorous scientific evaluation by editors and reviewers, nine papers were accepted and published. The authors proposed different MADM and MODM solution models as integrated tools to find a balance between the components of sustainable global development, to find a symmetry axis concerning goals, risks, and constraints to cope with the complicated problems. Most approaches suggested decision models under uncertainty, combining the usual decision-making methods with interval-valued fuzzy or rough sets theory, also Z numbers. The application fields of the proposed models involved both problems of technological sciences and social sciences. The papers cover three essential areas: engineering, economy, and management. We hope that a summary of the Special Issue as provided here will encourage a detailed analysis of the papers included in the Printed Edition.
    Keywords: TA1-2040 ; T1-995 ; rough sets ; interval type-2 fuzzy set (IT2FS) ; resources distribution ; the criteria of the weights ; public management ; Step-wise Weight Assessment Ratio Analysis (SWARA) ; multi-criteria decision-making (MCDM) ; symmetry of the method ; quadcopter ; transaction cost ; full fuzzy environment ; dual generalized geometric Bonferroni mean (DGGBM) operator ; data logger ; information theory ; control system ; salvage value ; nonlinear dynamics ; pattern formation ; oscillations ; stability ; Pythagorean fuzzy set ; FAHP ; fuzzy sets ; group decision-making ; generalized Bonferroni mean (GBM) operator ; probabilistic systems analysis ; economic decisions ; 2-tuple linguistic neutrosophic numbers set (2TLNNSs) ; evaluating the quality of distant courses ; subjective weights ; Z-numbers ; green supplier selection ; dual generalized Bonferroni mean (DGBM) operator ; normal cloud ; thrust ; sensor ; neutrosophic numbers ; MCDM ; Bayes’ theorem ; optimal dividend ; logistics ; measurement ; hybrid MCDM ; combining the weights ; data envelopment analysis ; criteria weights ; multiple attribute decision making (MADM) ; IDOCRIW ; excess-of-loss reinsurance ; fuzzy efficiency ; multiple-criteria decision-making (MCDM) ; MCGDM ; transport ; backward cloud transformation ; engineering problems ; rough ARAS ; capital injection ; performance ; Bonferroni mean (BM) operator ; green supply chain management ; population sizes ; hybrid problem solution models ; criteria weight assessment ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The proliferation of powerful but cheap devices, together with the availability of a plethora of wireless technologies, has pushed for the spread of the Wireless Internet of Things (WIoT), which is typically much more heterogeneous, dynamic, and general-purpose if compared with the traditional IoT. The WIoT is characterized by the dynamic interaction of traditional infrastructure-side devices, e.g., sensors and actuators, provided by municipalities in Smart City infrastructures, and other portable and more opportunistic ones, such as mobile smartphones, opportunistically integrated to dynamically extend and enhance the WIoT environment. A key enabler of this vision is the advancement of software and middleware technologies in various mobile-related sectors, ranging from the effective synergic management of wireless communications to mobility/adaptivity support in operating systems and differentiated integration and management of devices with heterogeneous capabilities in middleware, from horizontal support to crowdsourcing in different application domains to dynamic offloading to cloud resources, only to mention a few. The book presents state-of-the-art contributions in the articulated WIoT area by providing novel insights about the development and adoption of middleware solutions to enable the WIoT vision in a wide spectrum of heterogeneous scenarios, ranging from industrial environments to educational devices. The presented solutions provide readers with differentiated point of views, by demonstrating how the WIoT vision can be applied to several aspects of our daily life in a pervasive manner.
    Keywords: TA1-2040 ; T1-995 ; container ; fog computing ; virtual reality ; privacy and security ; software defined infrastructure ; intelligent medical service ; very long instruction word (VLIW) ; semantics ; privacy leakage detection ; context information ; post-copy ; ontology ; body area network ; DSP ; Internet-of-Things ; Mobile Device Management ; interoperability ; Android ; water consumption ; Processing-in-Memory ; performance analysis ; semantic ; mobility ; data management ; CRIU ; training simulator ; Industry 4.0 ; sensor networks ; experimental evaluation ; programming paradigm ; pre-copy ; microservice-oriented platform ; CubeSats ; middleware ; registry ; smart metering ; big data analytics ; nanosatellites ; medium access control ; Internet of Things ; heterogeneity ; web-of-things ; one-to-one computing educational program ; Web-of-Things ; internet of things ; instruction set extension ; microservices architecture ; migration ; behaviour ; wireless access networks ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 32
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Photoacoustic (or optoacoustic) imaging, including photoacoustic tomography (PAT) and photoacoustic microscopy (PAM), is an emerging imaging modality with great clinical potential. PAI’s deep tissue penetration and fine spatial resolution also hold great promise for visualizing physiology and pathology at the molecular level. PAI combines optical contrast with ultrasonic resolution, and is capable of imaging at depths of up to 7 cm with a real-time scalable spatial resolution of 10 to 500 µm. PAI has demonstrated applications in brain imaging and cancer imaging, such as breast cancer, prostate cancer, ovarian cancer etc. This Special Issue focuses on the novel technological developments and pre-clinical and clinical biomedical applications of PAI. Topics include but are not limited to: brain imaging; cancer imaging; image reconstruction; quantitative imaging; light source and delivery for PAI; photoacoustic detectors; nanoparticles designed for PAI; photoacoustic molecular imaging; photoacoustic spectroscopy.
    Keywords: photoacoustic imaging ; tomography ; thermoacoustic ; radio frequency ; image quality assessment ; image formation theory ; image reconstruction techniques ; sparsity ; signal processing ; deconvolution ; empirical mode decomposition ; signal deconvolution ; photoacoustics ; tissue characterization ; absorption ; Photoacoustic Computed Tomography (PACT) ; ring array ; fast imaging ; low cost ; photoacoustic tomography ; full-field detection ; wave equation ; final time inversion ; uniqueness ; stability ; iterative reconstruction ; 3D photoacoustic tomography ; full-view illumination and ultrasound detection ; photoacoustic coplanar ; quartz bowl ; correlation matrix filter ; time reversal operator ; photo-acoustic tomography ; reflection artifacts ; deep learning ; convolutional neural network ; time reversal ; Landweber algorithm ; U-net ; optoacoustic imaging ; respiratory gating ; motion artifacts ; full-ring illumination ; diffused-beam illumination ; point source illumination ; ultrasound tomography (UST) ; photoacoustic tomography (PAT) ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 33
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 34
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Research on radiation-tolerant electronics has increased rapidly over the past few years, resulting in many interesting approaches to modeling radiation effects and designing radiation-hardened integrated circuits and embedded systems. This research is strongly driven by the growing need for radiation-hardened electronics for space applications, high-energy physics experiments such as those on the Large Hadron Collider at CERN, and many terrestrial nuclear applications including nuclear energy and nuclear safety. With the progressive scaling of integrated circuit technologies and the growing complexity of electronic systems, their susceptibility to ionizing radiation has raised many exciting challenges, which are expected to drive research in the coming decade. In this book we highlight recent breakthroughs in the study of radiation effects in advanced semiconductor devices, as well as in high-performance analog, mixed signal, RF, and digital integrated circuits. We also focus on advances in embedded radiation hardening in both FPGA and microcontroller systems and apply radiation-hardened embedded systems for cryptography and image processing, targeting space applications.
    Keywords: TA1-2040 ; TK1-9971 ; T1-995 ; single event effects ; n/a ; radiation-hardening-by-design (RHBD) ; frequency divider by two ; single event upset ; Image processing ; CMOS analog integrated circuits ; FPGA ; total ionizing dose (TID) ; Impulse Sensitive Function ; soft error ; hardening by design ; radiation hardening by design ; X-rays ; Single-Event Upsets (SEUs) ; line buffer ; heavy ions ; VHDL ; FPGA-based digital controller ; radiation hardening by design (RHBD) ; radiation hardening ; SRAM-based FPGA ; proton irradiation ; ring oscillator ; sensor readout IC ; fault tolerance ; space application ; physical unclonable function ; voltage controlled oscillator (VCO) ; Ring Oscillators ; analog single-event transient (ASET) ; single event opset (SEU) ; SEB ; single event upsets ; bipolar transistor ; total ionizing dose ; protons ; triple modular redundancy (TMR) ; gain degradation ; space electronics ; saturation effect ; configuration memory ; Co-60 gamma radiation ; total ionization dose (TID) ; frequency synthesizers ; CMOS ; PLL ; TDC ; single-event upsets (SEUs) ; bandgap voltage reference (BGR) ; 4MR ; single-shot ; error rates ; Radiation Hardening by Design ; soft errors ; heavy-ions ; single-event effects (SEE) ; single event transient (SET) ; SEE testing ; proton irradiation effects ; RFIC ; single event upset (SEU) ; FMR ; ionization ; radiation tolerant ; triplex–duplex ; neutron irradiation effects ; digital integrated circuits ; single event gate rupture (SEGR) ; power MOSFETs ; ring-oscillator ; selective hardening ; voltage reference ; nuclear fusion ; TMR ; gamma-rays ; gamma ray ; instrumentation amplifier ; radiation effects ; reference circuits ; radiation-hardened ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 35
    Publication Date: 2024-04-11
    Description: Experiments to characterize the effects of moisture content and temperature on the mechanical properties of concrete were conducted. Based on these experiments, a new overall material model capable of predicting the mechanical behaviour of concrete subject to elevated temperatures up to 100 °C was developed. The material model estimates the time, temperature and moisture dependency of the compressive and tensile strength, creep and shrinkage of concrete.
    Keywords: TA1-2040 ; concrete ; Temperatur ; Beton ; Schwinden ; Temperature ; strength ; Kriechen ; creep ; Festigkeit ; shrinkage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 36
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Smart sensors are technologies designed to facilitate the monitoring operations. For instance, power consumption can be minimized through on-board processing and smart interrogation algorithms, and state detection enhanced through collaboration between sensor nodes. Applied to structural health monitoring, smart sensors are key enablers of sparse and dense sensor networks capable of monitoring full-scale structures and components. They are also critical in empowering operators with decision making capabilities. The objective of this Special Issue is to generate discussions on the latest advances in research on smart sensing technologies for structural health monitoring applications, with a focus on decision-enabling systems. This Special Issue covers a wide range of related topics such as innovative sensors and sensing technologies for crack, displacement, and sudden event monitoring, sensor optimization, and novel sensor data processing algorithms for damage and defect detection, operational modal analysis, and system identification of a wide variety of structures (bridges, transmission line towers, high-speed trains, masonry light houses, etc.).
    Keywords: TA1-2040 ; T1-995 ; NSGA-II ; wind force ; wavelet packet decomposition ; structural health monitoring ; amplitude spectrum ; environmental noise ; patch antenna ; damage identification ; event-triggered sensing ; Particle Swarm Optimization (PSO) algorithm ; high-speed train ; low-velocity impacts ; concrete structures ; sensors distribution optimization ; acceleration ; digital sampling moiré ; crack ; displacement sensor ; length effect ; FBG sensor array ; SHM ; space window ; Bayesian blind source separation ; feature selection ; stress detection ; wheel minor defect ; strain ; uniaxial stress measurement ; turbine ; impact identification ; helical antenna ; energy analysis of wavelet band ; strain wave ; time window ; structural steel members ; steel frame ; acoustoelastic effect ; demand-based nodes ; online wayside detection ; sensor ; bridge ; sensitivity ; acoustic emission ; bending stiffness ; wireless smart sensors ; distributed dense sensor network ; mapping construction ; data fusion ; fuzzy classification ; shear-wave birefringence ; normal mode ; piezoelectric wafer active sensors ; resonant frequency ; electromagnetic oscillation ; settlement ; sensor optimization ; modal frequencies ; perturbation theory ; feature extraction ; Virtual Distortion Method (VDM) ; reflective optical sensor ; fibre bundle ; smartphones ; crack identification ; active sensing ; test vehicle ; calibration ; stretching method ; model updating ; rotary ultrasonic array ; 2D crack growth ; data processing ; damage detection ; impactor stiffness ; tip clearance ; transmission tower ; phase spectrum ; concrete crack ; structural impact monitoring ; shaking table tests ; optical crack growth sensor ; steel strand ; passive sensing ; sudden event monitoring ; aero engine ; principal component analysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 37
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 38
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 39
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mobile robotics is a challenging field with great potential. It covers disciplines including electrical engineering, mechanical engineering, computer science, cognitive science, and social science. It is essential to the design of automated robots, in combination with artificial intelligence, vision, and sensor technologies. Mobile robots are widely used for surveillance, guidance, transportation and entertainment tasks, as well as medical applications. This Special Issue intends to concentrate on recent developments concerning mobile robots and the research surrounding them to enhance studies on the fundamental problems observed in the robots. Various multidisciplinary approaches and integrative contributions including navigation, learning and adaptation, networked system, biologically inspired robots and cognitive methods are welcome contributions to this Special Issue, both from a research and an application perspective.
    Keywords: TA1-2040 ; T1-995 ; similarity measure ; swarm-robotics ; drag-based system ; PID algorithm ; human–robot interaction ; behaviour dynamics ; state constraints ; fair optimisation ; micro mobile robot ; robot ; actuators ; high-gain observer ; turning model LIP ; space robot ; manipulation action sequences ; subgoal graphs ; remotely operated vehicle ; constrained motion ; joint limit avoidance ; curvilinear obstacle ; rehabilitation system ; stability criterion ; system design ; quad-tilt rotor ; iterative learning ; spiral curve ; cable detection ; SEA ; douglas–peuker polygonal approximation ; predictable trajectory planning ; ATEX ; obstacle avoidance system ; kinematic singularity ; collision avoidance ; biologically-inspired ; jumping robot ; differential wheeled robot ; design and modeling ; control efficacy ; robotics ; extremum-seeking ; object-oriented ; non-holonomic mobile robot ; magneto-rheological fluids ; rendezvous consensus ; altitude controller ; master-slave ; switching control ; deep reinforcement learning ; mechanism ; expansion logic strategy ; negative buoyancy ; action generation ; radial basis function neural networks ; unmanned aerial vehicles ; extend procedure ; glass façade cleaning robot ; convolutional neural network ; climbing robot ; micro air vehicle ; car-like kinematics ; variable speed ; machine learning ; dynamical model ; transportation ; geodesic ; unmanned surface vessel ; medical devices ; stopper ; extended state observer (ESO) ; high efficiency ; object mapping ; multi-objective optimization ; hybrid robot ; robot learning ; auto-tuning ; cable disturbance modeling ; manipulation planning ; pesticide application ; high-speed target ; sparse pose adjustment (SPA) ; service robot ; lumped parameter method ; Geometric Algebra ; dynamic coupling analysis ; Thau observer ; tri-tilt-rotor ; industrial robotic manipulator ; hardware-in-the-loop simulation ; robotic drilling ; muscle activities ; small size ; chameleon ; continuous hopping ; wall climbing robot ; hover mode ; 3D-SLAM ; curvature constraints ; PSO ; drilling end-effector ; Rodrigues parameters ; gait adaptation ; static environments ; position/force cooperative control ; snake-like robot ; shape-fitting ; powered exoskeleton ; input saturation ; kinematic identification ; methane ; human–machine interactive navigation ; q-learning ; path following ; hopping robot ; mobile manipulation ; high step-up ratio ; actuatorless ; monocular vision ; stability analysis ; compact driving unit ; snake robot ; non-holonomic robot ; curvature constraint ; phase-shifting ; dialytic elimination ; gesture recognition ; snake robots ; series elastic actuator ; flapping ; servo valve ; motion camouflage control ; biomimetic robot ; minimally invasive surgery robot ; centralized architecture ; trajectory planning ; computing time ; adaptive control law ; kinematics ; facial and gender recognition ; single actuator ; victim-detection ; shape memory alloys ; undiscovered sensor values ; discomfort ; Differential Evolution ; numerical evaluation ; quadruped robot ; coverage path planning ; localization ; MPC ; n/a ; fault diagnosis ; neural networks ; disturbance-rejection control ; sample gathering problem ; cart ; bio-inspired robot ; opposite angle-based exact cell decomposition ; optimization ; safety ; goal exchange ; hierarchical planning ; ocean current ; robot motion ; nonlinear differentiator ; mapping ; finite-time currents observer ; Newton iteration ; inverse kinematics ; deposition uniformity ; spatial pyramid pooling ; hierarchical path planning ; end effector ; head-raising ; fault recovery ; LOS ; path tracking ; non-inertial reference frame ; step climbing ; obstacle avoidance ; sliding mode control ; symmetrical adaptive variable impedance ; lane change ; quadcopter UAV ; singularity analysis ; biped mechanism ; fault-tolerant control ; dynamic neural networks ; mobile robots ; data association ; UAV ; enemy avoidance ; reinforcement learning ; grip optimization ; safety recovery mechanism ; exoskeleton ; dynamic environment ; uncertain environments ; hybrid bionic robot ; potential field ; robot navigation ; cleaning robot ; unmanned aerial vehicle ; non-singular fast-terminal sliding-mode control ; contact planning ; Lyapunov-like function ; piezoelectric actuator ; transition mode ; non-prehensile manipulation ; multiple mobile robots ; Tetris-inspired ; real-time action recognition ; integral line-of-sight ; topological map ; alpine ski ; target tracking ; closed-loop detection ; working efficiency ; mathematical modeling ; curve fitting ; force control ; biped robots ; NSGA-II ; mobile robot ; load carriage ; prescription map translation ; artificial fish swarm algorithm ; Q-networks ; self-reconfigurable robot ; G3-continuity ; autonomous vehicle ; loop closure detection ; excellent driver model ; robots ; graph representation ; regional growth ; target assignment ; evolutionary operators ; intelligent mobile robot ; motion sensor ; exploration ; droplets penetrability ; dynamic uncertainty ; simultaneous localization and mapping (SLAM) ; area decomposition ; multi-criteria decision making ; 4WS4WD vehicle ; biped climbing robots ; skiing robot ; ROS ; decision making ; smart materials ; centrifugal force ; missile control system ; formation of robots ; electro-rheological fluids ; pneumatics ; variable spray ; inertial measurement unit (IMU) ; Robot Operating System ; trajectory interpolation ; formation control ; immersion and invariance ; dragonfly ; parallel navigation ; harmonic potential field ; pallet transportation ; mobile robot navigation ; negative-buoyancy ; grip planning ; manipulator ; position control ; external disturbance ; legged robot ; passive skiing turn ; autonomous underwater vehicle (AUV) ; gait cycle ; path planning ; sliding mode observer ; dynamic gait ; self-learning ; polyomino tiling theory ; coalmine ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 40
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 41
    Publication Date: 2024-04-11
    Description: The subject of this PhD-thesis is the transferability of Facility Management (FM) by using the example of hospitals in Germany and Iran. The intention is to determine the status and significance of facility management in the project countries, to analyse similarities, semblances and differences in order to develop a system transferability model.
    Keywords: TA1-2040 ; health system ; facility management ; system transferability ; hospital ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 42
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue gathers research from different branches of science and engineering disciplines working on experiments and modelling of nanocomposites into one volume. The Guest Editor welcomes papers dedicated to experimental, computational, and theoretical aspects dealing with many important state-of-the-art technologies and methodologies regarding the synthesis, fabrication, characterization, properties, design, and applications, and both finite element analysis and molecular dynamic simulations, of nanocomposite materials and structures. Full papers covering novel topics, extending the frontiers of the science and technology of nanoreinforced composites are encouraged. Reviews covering topics of major interest will be also considered.
    Keywords: TA1-2040 ; T1-995 ; ab initio ; critical yield strength ; carbon nanotube ; impact buckling ; elasticity ; molecular dynamics simulation ; magnetism ; coarse-grained model ; 3D fiber-metal laminates ; mechanical property ; interface ; nanocomposites ; interface force fields ; YN ; graphene/Fe composite ; cohesive element ; stability ; ScN ; delamination propagation ; interfaces ; graphene nanoplatelets ; nanoindentation ; pressure ; molecular dynamics ; piezoelectric property ; temperature effect ; Fe-Al ; hardness ; equivalent fiber ; disorder ; Fe3Al ; elastic modulus ; delamination buckling ; CNT agglomeration ; CNTs/epoxy nanocomposites ; boron nitride honeycomb ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The ongoing deployment of 5G networks is a key enabler for realizing upcoming services at scale, including the massive deployment of the Internet of Things, providing communications to support autonomous vehicles, and supporting the realization of smart cities. However, as the limitations of existing approaches become apparent, the need for next-generation technologies is growing, in terms of improving spectral efficiency, increasing network data rates and densification, supporting local/wide area wireless coordination, and more. In this Special Issue, we present some technologies to meet these demanding requirements and facilitate coordinating wireless networks to support future Beyond 5G networks.
    Keywords: 5G fiber optic networks ; data-driven service assurance ; next generation networks ; predictive analytics ; live-video delivery ; 5G networks ; virtualized content delivery networks ; network function virtualization ; service function chain deployment ; deep reinforcement learning ; MAC classification ; vehicular networks ; VANETs ; distributed MAC ; centralized MAC ; multi-channel MAC ; single-channel MAC ; spectrum allocation ; private 5G ; mmWave RAN ; modulation and coding schemes ; spectral efficiency ; self-organization ; self-optimization ; self-healing ; SON applications and architecture ; SON design and dimensioning ; machine learning (ML) and artificial intelligence (AI) for SON ; massive Machine-Type Communication (mMTC) ; IoT ; URLLC ; backhauling ; SON for 3G/4G ; 5G and B5G networks ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 46
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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  • 47
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    Maven Publishers
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
    Language: English
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  • 48
    Publication Date: 2024-04-11
    Description: The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.
    Keywords: TA1-2040 ; fling-step input ; Critical response ; Long-duration ground motion ; double impulse ; forward-directivity input ; triple impulse ; robustness ; Near-fault ground motion ; Ground motion ; Ductility factor ; uncertainty ; resonance ; Structural parameter ; Earthquake Response ; Elastic-plastic response ; Interval analysis ; Multiple impulse ; Earthquake input energy ; redundancy ; Upper bound of input energy ; earthquake engineering ; critical excitation method ; Energy transfer function ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 49
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Catalysis, in the industrial production of chemicals, fuels, and materials, accounts for more than half of gross material production worldwide. Heterogeneous catalysis enables fast and selective chemical transformations, resulting in superior product yield and facilitating catalyst separation and recovery. The synthesis of novel catalysts has emerged as a hot topic for process and product development with numerous research publications and patents. Hence, development of efficient catalysts and their applications is important for sustainable energy production and use, green chemicals production and use, and economic growth. This Special Issue discusses recent developments related to catalysis for the production of sustainable fuels and chemicals and traverses many new frontiers of catalysis including synthesis, characterization, catalytic performances, reaction kinetics and modelling, as well as applications of catalysts for the production of biofuels, synthesis gas, and other green products. This covers the current state-of-the-art catalysis research applied to bioenergy, organic transformation, carbon–carbon and carbon–heteroatoms, reforming, hydrogenation, hydrodesulfurization, hydrodenitrogenation, hydrodemetalization, Fischer–Tropsch synthesis, to name a few. This book highlights new avenues in catalysis including catalyst preparation methods, analytical tools for catalyst characterization, and techno-economic assessment to enhance a chemical or biological transformation process using catalysts for a betterment of industry, academia and society.
    Keywords: HDO ; sulfide catalyst ; NiMo/Al2O3 ; phospholipid ; fatty acid ; choline ; oxidative desulfurization ; oxidative denitrogenation ; hydrotreating ; XPS ; activated carbon ; tert-butyl hydroperoxide ; biofuel ; biodiesel ; hydrocarbon ; waste ; glycerol hydrogenolysis ; in situ hydrogen ; methanol steam reforming ; Ni/Cu/ZnO/Al2O3 catalysts ; chilean natural zeolite ; Brønsted acid sites ; bio-oil upgrade ; catalytic pyrolysis ; nitrogen-doping ; iron nitrides ; light olefins ; CO hydrogenation ; KMnO4 pretreatment ; dry reforming methane (DRM) ; methane ; carbon dioxide ; microwave ; conversion ; catalyst ; selectivity ; thermal integration ; catalyst support ; CoMo sulfided catalyst ; deoxygenation ; cracking and polymerization ; hydrogenation and dehydrogenation ; waste cooking oil ; artificial neural network ; kinetic modeling ; cobalt-praseodymium (III) oxide ; CO-rich hydrogen ; methane dry reforming ; hydrodeoxygenation ; Ni/KIT-6 ; ethyl acetate ; CO2 activation ; methanol synthesis ; atomic layer deposition ; copper nanoparticles ; zinc oxide atomic layer ; hydroprocessing ; FeCu catalysts ; jet fuel ; oleic acid ; catalytic conversion ; catalyst acidity and basicity ; product distribution ; reaction pathways ; molybdenum phosphide ; methyl palmitate ; isomerization ; carboxylic acids upgrading ; ketonization ; deuterated acetic acid ; acetone D-isotopomers distribution ; H/D exchange ; inverse deuterium kinetic isotope effect ; kinetic parameters ; activation energy ; catalytic pyrolysis of biomass ; bio-oil ; sustainable fuels and chemicals ; hydrogenolysis ; desulfurization and denitrogenation ; CO2 utilization ; pyrolysis and cracking ; syngas and hydrogen ; biomass and bio-oil ; catalysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 50
    facet.materialart.
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Energy is an important material basis that can promote the development of human society. Despite the increasing use of renewable energy, the overall energy supply is dominated by fossil fuels. For a long period of time, the main consumption proportion of fossil energy will not change. With the perspective of fossil fuels such as coal, oil, natural gas, shale oil, shale gas, and combustible ice, energy exploration, reservoir reconstruction, and intelligent applications in energy exploitation and energy occurrence geology are currently explored from the perspectives of exploration and exploitation technology. This reprint summarizes the intelligent unmanned mining and its development trends and conducts various research studies, including the stratigraphic correlation of sandy conglomerate in the Yellow River Delta Sag of the Bohai Bay basin, the growth and distribution of coal-measured hydrocarbon source rocks in a mixed platform, the physical and mechanical properties of sandstone, mudstone and granite in the geological environment of deep energy reservoirs, the formation mechanism of energy reservoirs and gas reservoirs, the two-phase flow experiment and numerical simulation in energy mining, the evolution law of cracks in the surrounding rock and the reinforcement principle of gradient support, and the comparison of particle pickup by axial flow and swirling flow in horizontal pneumatic conveying.
    Keywords: intelligent mine ; smart mining ; intelligent working face ; intelligent control ; adaptive ; robotic technology ; seismic rock physics ; sandstone and mudstone ; P-wave and S-wave velocity ; pressure ; temperature ; sandy conglomerate ; Huanghekou Sag ; stratigraphic correlation ; calcite U-Pb dating ; detrital zircon ; pressure-controlled pyrolysis ; oil–water separation ; centrifugal force ; two-phase vapor separation ; cyclone separation ; Tarim Basin ; mixed platform ; delta ; coal-measure distribution ; coal-measure logging response ; axial flow ; swirling flow ; pickup behavior ; coefficient of variation ; tight sandstone gas reservoir ; nuclear magnetic resonance ; fracture ; water blocking ; n/a ; rock mechanical properties ; MMTS ; geothermal development ; geothermal reservoir ; different depth of occurrence ; gas storage ; injection production simulation ; effective permeability ; seepage law ; two-dimensional simulation experiment ; fracture evolution law ; fractured seepage zone ; gradient failure support ; hierarchical control mechanism ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 51
    facet.materialart.
    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Robotics and control are both research and application domains that have been frequently engineered through the use of interdisciplinary approaches like cybernetics. Cognition is a particular concept of this approach, abstracted from the context of living organisms to that of artificial devices, and is concerned with knowledge acquisition and understanding through thought, experience, and the senses. Cognitive robotics and control refer to knowledge processing as much as knowledge generation from problem understanding, leading to special forms of architectures that enable systems to behave in an autonomous way. The main aim of this book is to highlight emerging applications and address recent breakthroughs in the domain of cognitive robotics and control and related areas. Procedures, algorithms, architectures, and implementations for reasoning, problem solving, or decision making are considered in the domain of robotics and control.
    Keywords: initial trajectory ; trajectory optimization ; Bézier surface ; robotics ; open FPGAs ; robot control ; surgical robotics ; human–machine interaction ; autonomous guidance ; low-cost platform ; FPGA ; S-curve ; motion control ; SoC ; telemanipulation ; haptics ; machine learning ; gesture recognition ; upper limb rehabilitation robot ; particle swam optimization (PSO) ; artificial bee colony (ABC) ; Ziegler Nichols ; Maximum sensitivity ; ontology ; robot task planning ; knowledge base ; knowledge representation ; industrial collaborative robots ; shared robotic tasks ; physical human–robot interaction ; human intention recognition ; time series classification ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 52
    facet.materialart.
    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 53
    facet.materialart.
    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the implementation of sustainable concrete systems has been a topic of great interest in the field of construction engineering worldwide, as a result of the large and rapid increase in carbon emissions and environmental problems resulting from traditional concrete production and industry. For example, the uses of supplementary cementitious materials, geopolymer binder, recycled aggregate and industrial/agricultural wastes in concrete are all approaches to building a sustainable concrete system. However, such materials have inherent flaws due to their variety of sources, and exhibit very different properties compared with traditional concrete. Therefore, they require specific modifications in preprocessing, design, and evaluation before use in concrete. This reprint, entitled “Advances in Sustainable Concrete System”, covers a broad range of advanced concrete research in environmentally friendly concretes, cost-effective admixtures, and waste recycling, specifically including the design methods, mechanical properties, durability, microstructure, various models, hydration mechanisms, and practical applications of solid wastes in concrete systems.
    Keywords: high-strength concrete ; energy evolution ; elastic strain energy ; brittleness evaluation index ; concrete ; humidity ; moisture absorption ; moisture desorption ; numerical simulation ; acoustic emission ; AE rate process theory ; corrosion rate ; damage evolution ; axial load ; precast concrete structure ; lattice girder semi-precast slabs ; bending resistance ; FE modelling ; concrete damage ; GSP ; high strength ; hydration ; strength ; penetrability ; rice husk ash ; sustainable concrete ; artificial neural networks ; multiple linear regression ; eco-friendly concrete ; green concrete ; sustainable development ; artificial intelligence ; data science ; machine learning ; bagasse ash ; mechanical properties ; natural coarse aggregate ; recycled coarse aggregate ; two-stage concrete ; materials design ; recycled concrete ; crumb rubber concrete ; crumb rubber ; NaOH treatment ; lime treatment ; water treatment ; detergent treatment ; compressive strength ; materials ; adhesively-bonded joint ; temperature aging ; residual strength ; mechanical behavior ; failure criterion ; steel slag powder ; compound activator ; mortar strength ; orthogonal experiment ; GM (0, N) model ; ultrafine metakaolin ; silica fume ; durability ; fiber-reinforced concrete ; damage mechanism ; uniaxial tension ; cracked concrete ; crack width ; crack depth ; tortuosity ; sustainability ; concrete composites ; sulfate and acid attacks ; WPFT fibers ; coal gangue ; gradation ; cement content ; unconfined compressive strength ; freeze–thaw cycle ; minimum energy dissipation principle ; three-shear energy yield criterion ; damage variable ; constitutive model ; phosphorus slag ; limestone ; sulphate-corrosion resistance ; volume deformation ; blast furnace ferronickel slag ; alkali-activated material ; dosage of activator ; reactive powder concrete ; beam-column joint ; FE modeling ; crack ; cementitious gravel ; fly ash ; age ; optimal dosage ; bamboo ; sawdust ; pretreatment ; bio-based material ; mechanical property ; self-compacting concrete ; supplementary cementitious materials ; hydration mechanisms ; microstructure ; fresh properties ; synthetic polymer ; high temperature ; bentonite-free drilling fluid ; rheology ; filtration ; FRP reinforced concrete slab ; punching shear strength ; SHAP ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKX Conservation of buildings and building materials
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  • 54
    facet.materialart.
    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book is a collection of recent publications from researchers all over the globe in the broad area of high-voltage engineering. The presented research papers cover both experimental and simulation studies, with a focus on topics related to insulation monitoring using state-of-the-art sensors and advanced machine learning algorithms. Special attention was given in the Special Issue to partial discharge monitoring as one of the most important techniques in insulation condition assessment. Moreover, this Special Issue contains several articles which focus on different modeling techniques that help researchers to better evaluate the condition of insulation systems. Different power system assets are addressed in this book, including transformers, outdoor insulators, underground cables, and gas-insulated substations.
    Keywords: TA1-2040 ; T1-995 ; artificial neural network ; simulation ; high-frequency ; artificial flashover tests ; wide bandgap power modules ; tracking ; electrical field strength ; fast-rise square wave voltages ; FDTD simulation ; cable joint ; corona discharge ; feature selection ; post insulator ; earthing systems ; wind speed ; surface discharge ; oil/paper insulation ; oil-paper insulation ; high-magnitude currents and impulse polarity ; UFVM ; Tettex 9520 ; electrical tree ; flashover characteristics ; composite insulator ; partial discharge ; numerical modeling ; saline mechanism ; thermal parameters ; space charge density ; seasonal ; ion flow field ; denoising ; DDX 9121b ; temperature ; transformer asset management ; cavity discharge ; space/interface charge ; insulation health index ; heat transfer model ; leakage current ; machine learning ; partial discharges (PD) ; RF signal ; flashover ; high impulse conditions ; grounding electrodes ; generalized finite difference time domain ; curve fitting ; grounding ; plasma discharge ; outdoor insulators ; flashover dynamic model ; wavelet transform ; degradation ; thermal properties ; bipolar charge transport model ; UHF sensor ; cable ; random walk theory ; tracking test setup ; GIL ; pressure ; modelling ; non-uniform pollution between windward and leeward sides ; calibrator ; secondary arc ; polymeric insulation ; optical-UHF integrated detection ; shoreline ; dry band arcing ; photoelectric fusion pattern ; DDX 8003 ; XLPE ; silicone gel ; partial discharge modeling ; electric field analysis ; NSCT ; electrode’s geometry ; gas ; Comsol Multiphysics ; fast-impulses ; laying modes ; ageing ; cable ampacity ; residual resistance formulation ; finite element analysis ; thermal effect ; hydrophobicity ; soil resistivity ; charge simulation method ; short-circuit discharge ; dry band formation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 55
    Publication Date: 2024-04-11
    Description: Energy systems worldwide are undergoing major transformation as a consequence of the transition towards the widespread use of clean and sustainable energy sources. Basically, this involves massive changes in technical and organizational levels together with tremendous technological upgrades in different sectors ranging from energy generation and transmission systems down to distribution systems. These actions generate huge science and engineering challenges and demands for expert knowledge in the field to create solutions for a sustainable energy system that is economically, environmentally, and socially viable while meeting high security requirements. This book covers these promising and dynamic areas of research and development, and presents contributions in sustainable energy systems planning, integration, and management. Moreover, the book elaborates on a variety of topics, ranging from design and planning of small- to large-scale energy systems to the operation and control of energy networks in different sectors, namely electricity, heat, ?and transport.
    Keywords: TA1-2040 ; T1-995 ; n/a ; Romanian coastal environment ; neural networks ; intermittent heating ; wind velocities ; time-space network ; optimal chiller loading (OCL) ; renewable energy ; pure electric buses ; mixed-integer non-linear programming problem (MINLP) ; control system ; FANP ; energy consumption ; load regulation ; energy ; smart box ; novel method ; smart logistics system ; multiple uncertainties ; non-intrusive load monitoring ; wind speed forecasting ; solid waste to energy plant ; uncertain cooling demand ; dual robust optimization ; Black Sea ; field test and numerical simulation ; electric power ; sustainable development ; multi-type bus operating organization ; cuckoo search algorithm ; vehicular emissions ; SWAN ; public transport ; product quality model ; MCDM ; TOPSIS ; heat transfer ; solar energy ; forecasting validity ; information gap decision theory (IGDT) ; photovoltaic systems ; configurations of internal wall ; ensemble empirical mode decomposition ; agricultural pruning ; hot summer and cold winter climate zone ; energy and environmental systems ; feature extraction ; information platform ; pruning biomass ; smart grid ; product usability testing ; meteorological variables ; fuzzy logic ; performance evaluation ; rural residential building ; threshold value of daily operation hours ; datacenter ; wave energy ; thermal comfort ; heat storage and release ; resampling ; risk aversion ; environment ; support vector machine ; internal coverings ; numerical models ; gradient descent ; renewable biomass energy ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 56
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
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  • 57
    facet.materialart.
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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  • 59
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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  • 60
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The last few decades have seen rapid development in the field of surface engineering and its applications in almost all industrial sectors. Tribological coatings, which are an important aspect of surface engineering, are today applied on machine component surfaces for a diverse range of moving machine components to control (mostly to minimize) friction and wear in order to conserve energy and materials. This reprint book is a compilation of 11 research papers contributed by experts in the field of surface engineering and tribology. These papers have dealt with the synthesis of various types of coatings, characterization and applications under different operating conditions. It is hoped that this reprint book will be of interest, not only to researchers, but also to practicing engineers and technologists in the industry.
    Keywords: Cr-Ti-B-N films ; magnetron sputtering ; microstructure ; friction and wear ; GH4169 alloy ; Ag–Mo co-implantation ; ion-beam-assisted bombardment technology (IBAB) ; wear mechanism ; polymer coating ; graphene ; tribological properties ; elevated temperature ; VCN–Cu films ; mechanical ; friction property ; wear property ; high-entropy alloy (HEA) matrix coating ; plasma spraying ; wear resistance ; microhardness ; bonding strength ; Cu/MoS2 coatings ; Cu-Al/MoS2 coatings ; annealing treatment ; γ2-Cu9Al4 phase ; scratch test ; acoustic emission ; thin films ; silicon carbide ; multilayered AlCrN coating ; Raman spectroscopy ; tribo-corrosion ; sliding wear ; DLC ; MoS2 ; coating ; elastomer ; seals ; TiB2 ; ZrB2 ; coating blade ; anti-wear ; stainless steel coating ; sputtering ; wear ; adhesion ; friction ; structure ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 61
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 62
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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  • 64
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In impulse-based manufacturing technologies, the energy required to form, join or cut components acts on the workpiece in a very short time and suddenly accelerates workpiece areas to very high velocities. The correspondingly high strain rates, together with inertia effects, affect the behavior of many materials, resulting in technological benefits such as improved formability, reduced localizing and springback, extended possibilities to produce high-quality multi material joints and burr-free cutting. This Special Issue of JMMP presents the current research findings, which focus on exploiting the full potential of these processes by providing a deeper understanding of the technology and the material behavior and detailed knowledge about the sophisticated process and equipment design. The range of processes that are considered covers electromagnetic forming, electrohydraulic forming, adiabatic cutting, forming by vaporizing foil actuators and other impulse-based manufacturing technologies. Papers show significant improvements in the aforementioned processes with regard to: Processes analysis; Measurement technique; Technology development; Materials and modelling; Tools and equipment; Industrial implementation.
    Keywords: magnetic pulse welding ; spot welds ; linear coils ; shear lap test ; automotive alloys ; numerical analysis ; LS-DYNA ; impact deformation ; vaporizing foil actuator ; powder compaction ; spallation ; inclined collision welding ; dissimilar material combinations ; impact velocity ; impact angle ; collision velocity ; impulse forming ; bulge forming ; permeability ; conductivity ; adiabatic blanking ; adiabatic shear band ; high velocity ; clearance ; blanked surface ; stress triaxiality ; FE simulation ; electromagnetic forming ; proximity effect ; Lorentz forces ; coil windings ; electro-hydraulic ; pulsed forming ; numerical simulation ; preforming ; collision welding ; impact welding ; welding window ; aluminum and copper ; high-speed imaging ; jet ; cloud of particles ; energy balance ; energy extraction ; melting ; material properties ; interface morphology ; magnetic pulse welding (MPW) ; AA6016 ; aluminum ; 22MnB5 ; press-hardening steel ; interface characterization ; mechanical characterization ; tribological characterization ; high strain rate ; elevated temperature ; additive manufacturing ; 18Ni300 maraging steel ; constitutive modelling ; damage modelling ; machining simulation ; magnetic pulse forming ; electro-hydraulic forming ; high strain rates ; lightweight ; high pulsed power ; formability ; simulation ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 65
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book presents the results of the successful Sensors Special Issue on Intelligent Vehicles that received submissions between March 2019 and May 2020. The Guest Editors of this Special Issue are Dr. David Fernández-Llorca, Dr. Ignacio Parra-Alonso, Dr. Iván García-Daza and Dr. Noelia Parra-Alonso, all from the Computer Engineering Department at the University of Alcalá (Madrid, Spain). A total of 32 manuscripts were finally accepted between 2019 and 2020, presented by top researchers from all over the world. The reader will find a well-representative set of current research and developments related to sensors and sensing for intelligent vehicles. The topics of the published manuscripts can be grouped into seven main categories: (1) assistance systems and automatic vehicle operation, (2) vehicle positioning and localization, (3) fault diagnosis and fail-x systems, (4) perception and scene understanding, (5) smart regenerative braking systems for electric vehicles, (6) driver behavior modeling and (7) intelligent sensing. We, the Guest Editors, hope that the readers will find this book to contain interesting papers for their research, papers that they will enjoy reading as much as we have enjoyed organizing this Special Issue
    Keywords: tracking-by-detection ; multi-vehicle tracking ; Siamese network ; data association ; Markov decision process ; driving behavior ; real-time monitoring ; driver distraction ; mobile application ; portable system ; simulation test ; dynamic driving behavior ; traffic scene augmentation ; corridor model ; IMU ; vision ; classification networks ; Hough transform ; lane markings detection ; semantic segmentation ; transfer learning ; autonomous ; off-road driving ; tire-road forces estimation ; slip angle estimation ; gauge sensors ; fuzzy logic system ; load transfer estimation ; simulation results ; normalization ; lateral force empirical model ; driver monitor ; lane departure ; statistical process control ; fault detection ; sensor fault ; signal restoration ; intelligent vehicle ; autonomous vehicle ; kinematic model ; visual SLAM ; sparse direct method ; photometric calibration ; corner detection and filtering ; loop closure detection ; road friction coefficient ; tire model ; nonlinear observer ; self-aligning torque ; lateral displacement ; Lyapunov method ; automatic parking system (APS) ; end-to-end parking ; reinforcement learning ; parking slot tracking ; deceleration planning ; multi-layer perceptron ; smart regenerative braking ; electric vehicles ; vehicle speed prediction ; driver behavior modeling ; electric vehicle control ; driver characteristics online learning ; objects’ edge detection ; stixel histograms accumulate ; point cloud segmentation ; autonomous vehicles ; scene understanding ; occlusion reasoning ; road detection ; advanced driver assistance system ; trajectory prediction ; risk assessment ; collision warning ; connected vehicles ; vehicular communications ; vulnerable road users ; fail-operational systems ; fall-back strategy ; automated driving ; advanced driving assistance systems ; illumination ; shadow detection ; shadow edge ; image processing ; traffic light detection ; intelligent transportation system ; lane-changing ; merging maneuvers ; game theory ; decision-making ; intelligent vehicles ; model predictive controller ; automatic train operation ; softness factor ; fusion velocity ; online obtaining ; hardware-in-the-loop simulation ; driving assistant ; driving diagnosis ; accident risk maps ; driving safety ; intelligent driving ; virtual test environment ; millimeter wave radar ; lane-change decision ; risk perception ; mixed traffic ; minimum safe deceleration ; automated driving system (ADS) ; sensor fusion ; multi-lane detection ; particle filter ; self-driving car ; unscented Kalman filter ; vehicle model ; Monte Carlo localization ; millimeter-wave radar ; square-root cubature Kalman filter ; Sage-Husa algorithm ; target tracking ; stationary and moving object classification ; localization ; LiDAR ; GNSS ; Global Positioning System (GPS) ; monte carlo ; autonomous driving ; robot motion ; path planning ; piecewise linear approximation ; multiple-target path planning ; autonomous mobile robot ; homotopy based path planning ; LiDAR signal processing ; sensor and information fusion ; advanced driver assistance systems ; autonomous racing ; high-speed camera ; real-time systems ; LiDAR odometry ; fail-aware ; sensors ; sensing ; percepction ; object detection and tracking ; scene segmentation ; vehicle positioning ; fail-x systems ; driver behavior modelling ; automatic operation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 66
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 67
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Physical processes are keys for the status of a lake. In this Special Issue, the emphasis is on dissolved oxygen and on exchange of gases, energy and momentum between atmosphere and further mixing and consumption within the water. The studies presented relate to ice-free as well as ice-covered lakes. Field measurements are combined with theoretical approaches.
    Keywords: hydrodynamic model ; bubble plume ; artificial mixing ; GLM ; Si3D ; dissolved gas ; Henry law ; total gas pressure ; ebullition ; greenhouse gases ; lacustrine waters ; diurnal variation ; hourly model ; water temperature ; dissolved oxygen ; shallow lakes ; and sediment heat flux ; water quality ; chlorophyll-a ; phosphorus ; phosphorus release ; full set of turbulent stresses ; Acoustic Doppler current profilers ; interbeam velocity correlations ; ice-covered lakes ; convectively-mixed layer ; anisotropic turbulence ; shallow lake ; ice-covered period ; ice phenology ; snow-ice cover thickness ; under-ice irradiance ; radiatively driven convection ; climate change ; 3D modelling ; stratification ; bubble plumes ; fractal ; lakes ; mixing ; multi-scale ; turbulence ; energy fluxes ; energy content ; reservoirs ; internal waves ; surface waves ; biogenic turbulence ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 68
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
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  • 69
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Unconventional reservoirs are usually complex and highly heterogeneous, such as shale, coal, and tight sandstone reservoirs. The strong physical and chemical interactions between fluids and pore surfaces lead to the inapplicability of conventional approaches for characterizing fluid flow in these low-porosity and ultralow-permeability reservoir systems. Therefore, new theories and techniques are urgently needed to characterize petrophysical properties, fluid transport, and their relationships at multiple scales for improving production efficiency from unconventional reservoirs. This book presents fundamental innovations gathered from 21 recent works on novel applications of new techniques and theories in unconventional reservoirs, covering the fields of petrophysical characterization, hydraulic fracturing, fluid transport physics, enhanced oil recovery, and geothermal energy. Clearly, the research covered in this book is helpful to understand and master the latest techniques and theories for unconventional reservoirs, which have important practical significance for the economic and effective development of unconventional oil and gas resources.
    Keywords: TA1-2040 ; T1-995 ; shale gas ; permeability ; prediction by NMR logs ; matrix–fracture interaction ; faults ; remaining oil distributions ; unconventional reservoirs ; coal deformation ; reservoir depletion ; carbonate reservoir ; nanopore ; fracturing fluid ; pseudo-potential model ; shale reservoirs ; matrix-fracture interactions ; multi-scale fracture ; succession pseudo-steady state (SPSS) method ; fluid transport physics ; integrated methods ; chelating agent ; dissolved gas ; non-equilibrium permeability ; effective stress ; fractal ; fracture network ; spontaneous imbibition ; tight oil ; porous media ; 0-1 programming ; the average flow velocity ; geothermal water ; micro-fracture ; pore types ; pore network model ; petrophysical characterization ; nitrogen adsorption ; analysis of influencing factors ; mudstone ; rheology ; velocity profile ; shale permeability ; flow resistance ; global effect ; tight sandstones ; fractal dimension ; contact angle ; temperature-resistance ; fractured well transient productivity ; reservoir classifications ; deep circulation groundwater ; viscosity ; NMR ; fractional diffusion ; lattice Boltzmann method ; multiporosity and multiscale ; fractal geometry ; imbibition front ; productivity contribution degree of multimedium ; wetting angle ; pH of formation water ; enhanced oil recovery ; isotopes ; tight sandstone ; fracture diversion ; shale ; SRV-fractured horizontal well ; low-salinity water flooding ; shale gas reservoir ; tight reservoirs ; fracture continuum method ; tight oil reservoir ; Lucaogou Formation ; hydraulic fracturing ; clean fracturing fluid ; recovery factor ; flow regimes ; local effect ; complex fracture network ; pore structure ; gas adsorption capacity ; polymer ; non-linear flow ; conformable derivative ; production simulation ; analytical model ; enhanced geothermal system ; multi-scale flow ; experimental evaluation ; extended finite element method ; fluid-solid interaction ; groundwater flow ; well-placement optimization ; thickener ; imbibition recovery ; equilibrium permeability ; slip length ; large density ratio ; clay mineral composition ; finite volume method ; volume fracturing ; influential factors ; sulfonate gemini surfactant ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 70
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint focuses on basic and applied research on fatigue and fracture processes in engineering of materials and composites. Special attention is given to understanding fracture processes from the point of view of micro and nano damage mechanisms related to material microstructure. Advanced experimental methods such as tomography, digital image correlation, high resolution electron microscopy and fractography are applied in combination with theoretical multiscale models based on finite element methods and fracture mechanics to reveal the fundamental causes of material failure.
    Keywords: cyclic indentation ; Vickers hardness ; inverse analysis ; numerical simulations ; cyclic material properties ; fatigue life ; advanced high-strength steels ; hydrogen embrittlement ; in-situ testing ; scanning electron microscopy ; plasma charging ; coarse-grained Ni-based superalloys ; crystal plasticity ; notch effect ; strain concentration factor ; hull fracture ; inspection manholes ; bulk carrier ; cracks ; corrosion fatigue ; steel quality ; cleavage fracture ; finite element analysis ; local approach ; Weibull stress ; synchrotron tomography ; short fatigue crack growth ; residual stress ; very high cycle fatigue ; silicon carbide ; ceramic matrix composites ; creep properties ; high-temperature strength ; molecular dynamics ; artificial neural network ; forged titanium alloy ; low-cycle fatigue ; cycle wave form ; durability ; crack meso-tunneling ; fractography ; crack growth duration ; ultrasonic fatigue ; frequency effect ; strain rate effect ; environmental effect ; size effect ; high cycle fatigue ; underload cycles ; crack closure ; threshold ; fatigue crack growth ; oxidation ; EA4T steel ; fracture ; gigacycle fatigue ; surface morphology ; kinetic equation ; laminated metallic composites ; toughening mechanisms ; interfaces ; fatigue crack propagation ; large chamber SEM ; ultra-high steel grades ; tensile characteristics ; fracture toughness ; temperature dependence ; modelling fracture ; ductile-to-brittle transition ; local approach to fracture ; ferritic steel ; synchrotron radiation X-ray imaging ; fatigue performance ; fatigue crack ; FGH96 alloy ; microstructure ; micro-indentation ; mechanical and fracture properties identification ; optimisation analysis ; 316L stainless steel ; selective laser melting ; fatigue damage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 71
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Recently, new wide-band energy gap semiconductors can be grown by ALD, PLD, sputtering, or MOCVD. They have great potential for the fabrication and application to TFTs. Inorganic semiconductors have good stability against environmental degradation over their organic counterparts, whereas organic materials are usually flexible, transparent, and when solution-processed at low temperatures, are prone to degradation when exposed to heat, moisture, and oxygen. For this Special Issue, we invited researchers to submit papers discussing the development of new functional and smart materials, and inorganic as well as organic semiconductor materials, such as ZnO, InZnO, GaO, AlGaO, AnGaO, AlN/GaN, conducting polymers, molecular semiconductors, perovskite-based materials, carbon nanotubes, carbon nanotubes/polymer composites, and 2D materials (e.g., graphene, MoS2) and their potential applications in display drivers, radio frequency identification tags, e-paper, gas, chemical and biosensors, to name but a few.
    Keywords: TA1-2040 ; TK1-9971 ; T1-995 ; charge transport and injection mechanisms ; optical synaptic devices ; flat panel displays ; simulation ; persistent photoconductivity ; hydrogen ; interdigitated ; interface state trap density ; technology computer aided design (TCAD) ; oxygen defects ; Corbino ; transistor model evaluation ; metal-halide lamp ; InGaZnOx ; contact resistances ; chemical treatment ; colour difference ; organic transistor ; equivalent circuit ; channel-length dependence ; just noticeable difference ; oxide semiconductor ; OTFT ; chromaticity ; modeling contact effects ; oxygen deficiency ; dual-threshold inverter ; surface treated ; charge-carrier-mobility extraction ; optical detecting ; thin film transistor ; green ; photo-sensors ; modelling ; capacitor ; TFT-LCD ; organic thin-film transistor ; spectrum ; hydrogen effect ; organic film growth ; transparent conducting oxides ; quartz-halogen lamp ; optical ; blue LED ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: We invite you to read the Special Issue on innovation for sustainable business. It is a collection of 7 articles published in a Special Issue of Sustainability MDPI in 2021-2022. Many of the articles in this reprint are related to leadership. In the context of sustainable development, issues such as dynamic capabilities, CSR, succession management and innovative projects were addressed. Sustainable innovation is also considered from other perspectives. One of them is the topic of introducing sustainable innovations to new ventures. In addition, drivers and impacts of eco-innovation were also examined. There was also research in the area of ​​live commerce, which includes the perspective of consumer behavior.
    Keywords: dynamic capabilities ; eco-innovation ; leadership ; corporate social responsibility ; the attitude of future managers towards CSR ; ethical aspects of companies’ operations ; sustainability ; green technologies ; environmental innovation ; industry ; Brazil ; capability ; organization ; survival ; workforce ; live commerce ; hunger marketing ; perceived trust ; perceived value ; impulse buying behavior ; Sustainable Industry 4.0 ; innovative projects ; interdisciplinarity ; project team competencies ; sustainable innovation ; knowledge search ; organizational learning ; strategic flexibility ; new ventures ; QCA ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 74
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint focuses on the position of sustainability in engineering and points to the multidimensionality of the issue. Architecture, civil and engineering issues are main themes of discussion, with special attention to research and design. Attention is focused on four thematic groups: energy (including energy harvesting), economy (including building circularity), pro-health activities, and design.
    Keywords: CFD ; mechanical ventilation ; industrial buildings ; thermal comfort ; air quality ; natural environment ; construction sector ; steel ; sustainable development ; cradle-to-gate with options ; Life Cycle Assessment ; life cycle costs ; maintenance costs ; warranty period ; number of use cycles ; building circularity assessment ; material flow model ; building circularity material passport ; building circularity calculation method ; adaption ; landscape pattern ; local microclimate ; comprehensive analysis ; morphological parameters ; space syntax ; façade configuration ; visual perception ; built heritage ; Kaunas ; cultural sustainability ; PV system ; social acceptability ; system dynamics ; CO2 emissions ; feed-in-tariffs ; subsidy policy ; water management ; housing environment quality ; multi-family settlements ; Bio-Morpheme ; greenery ; automated design ; plant selector ; sustainability ; algorithmic design ; landscape design ; BIM ; green BIM ; city breathability ; urban ventilation ; urban air quality management ; blue-green infrastructure ; integrated urban planning ; economic analysis ; marketplace regeneration ; optimisation ; spatial analysis ; urban design ; vibration ; energy harvesting ; green gardens ; multifunctionality ; plus-energy building ; thermal stack ; solar energy ; integrated design ; prefabricated rural housing ; PEST ; entropy weighted TOPSIS ; implementation potential ; Chongqing ; n/a ; urban planning ; building layout ; energy demand ; climate ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Numerous efforts have been devoted to using biomass as a feedstock for the production of bio-based materials, biochemicals, and biofuels that reduce greenhouse gas emissions and dependence on conventional fossil resources. Conversion strategies for the production of platform chemicals, building blocks, fine chemicals, and biofuels include a wide range of processes such as chemical and mechanical pretreatment for improved carbohydrate production, fractionation of biomass into carbohydrates and lignin and their further conversions, microbial and enzymatic conversion of biomass into valuable products, and direct catalytic conversion of biomass or its components into chemicals and fuels. This Special Issue introduces recent innovative research results in the area of bioenergy and value-added chemicals from various feedstocks through chemical and biological catalytic processes.
    Keywords: biomass ; xylan ; lignin ; cellulose ; pretreatment ; solid superacid catalyst ; sulfated tin(IV) oxide ; α-pinene partial coupling ; renewable high-density fuel ; biofuel ; biorefinery ; sugar-decomposed ; enzymatic hydrolysis ; waste biomass ; kinetics ; biomass pre-treatment ; green diesel ; renewable diesel ; Ni catalyst ; hydrodeoxygenation ; Cu-promotion effect ; catalysts ; solvents ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 76
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
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    Ledizioni
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue covers a wide range of areas—including building orientation, service life, use of photocatalytically active structures and PV facades, implications of transportation system, building types (i.e., high rise, multilevel, commercial, residential), life cycle assessment, and structural engineering—that need to be considered in the environmental impact assessment of buildings, and the chapters include case studies across the globe. Consideration of these strategies would help reduce energy and material consumption, environmental emissions, and waste generation associated with all phases of a building’s life cycle. Chapter 1 demonstrates that green star concrete exhibits the same structural properties as conventional concrete in Australia. Chapter 2 showed that the use of TiO2 as a photocatalyst on the surface of construction materials with a suitable stable binding agent, such as aggregates, would enable building walls to absorb NOx from air. This study found that TiO2 has the potential to reduce ambient concentrations of NOx from areas where this pollutant becomes concentrated under solar irradiation. Chapter 3 presents the life cycle assessment of architecturally integrated glass–glass photovoltaics in building facades to find the appropriate material composition for a multicolored PV façade offering improved environmental performance. Chapter 4 shows that urban office buildings lacking appropriate orientation experienced indoor overheating. Chapter 5 details four modeling approaches that were implemented to estimate buildings’ response towards load shedding. Chapter 6 covers the life cycle GHG emissions of high-rise residential housing block to discover opportunities for environmental improvement. Chapter 7 discusses an LCA framework that took into account variation in the service life of buildings associated with the use of different types of materials. Chapter 8 presents a useful data mining algorithm to conduct life cycle asset management in residential developments built on transport systems.
    Keywords: TA1-2040 ; T1-995 ; wash water ; greenhouse gases ; environmental life cycle assessment ; sustainable-development ; transit-policy ; public-engagement ; Multilevel buildings ; building integrated photovoltaic ; slag ; operational energy ; life-cycle social analysis ; building ; travel-satisfaction ; TEASER ; BIPV ; photocatalytic construction materials ; functionalized aggregate ; green star concrete ; work-commute ; shallow plan forms ; life cycle assessment ; recycled aggregate ; environmental remediation ; block of buildings ; rain cladding ; LCA ; sustainability ; peak shaving ; residential building ; indoor overheating ; LCI ; air pollution ; environmental performance ; service life ; nitric oxides ; thermal model ; coloured glass ; demand response ; modal-variability ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book derives from the Special Issue of the Manufacturing Engineering Society 2019 (SIMES-2019) that has been launched as a joint issue of the journals Materials and Applied Sciences. The 29 contributions published in this Special Issue of Materials present cutting-edge advances in the field of manufacturing engineering focusing on additive manufacturing and 3D printing; advances and innovations in manufacturing processes; sustainable and green manufacturing; manufacturing of new materials; metrology and quality in manufacturing; industry 4.0; design, modeling, and simulation in manufacturing engineering; and manufacturing engineering and society. Among them, the topic "Additive Manufacturing and 3D Printing" has attracted a large number of contributions in this journal due to its widespread popularity and potential.
    Keywords: Bayesian inference ; control chart ; dynamic methodology ; hidden Markov chain ; occupational accident ; risk assessment ; risk control ; risk management ; Fused Deposition Modeling ; roughness ; Polylactic Acid ; print orientation angle ; build angle ; titanium alloys ; sustainable lubrication ; cryogenic lubrication ; MQL ; OD grinding ; CBN ; dressing ; rotary dresser ; wear ; CVD diamond ; additive manufacturing ; 3D printing ; fused filament fabrication ; flexural properties ; fatigue ; PLA ; cements ; ballast waste ; cornubianite ; mechanical properties ; Spain ; joining ; forming ; sheet–tube connections ; experimentation ; modelling and simulation ; quality enhancement ; process parameters ; design optimization ; calibration artifact ; kinematic support ; dimensional metrology ; machine tool ; length measurement ; rapid prototyping ; efficiency ; printing time ; experimental model ; prepeg ; carbon fiber ; Raman spectroscopy ; AWJM ; waterjet ; CFRP ; kerf taper ; surface quality ; metal forming ; bi-metallic ; cylinders ; compression ; finite elements ; microscopy ; cold expansion ; mandrel ; cold-forming ; swaging ; shipbuilding ; LARG paradigm ; supply chain ; coordinate metrology ; confocal microscopy ; measurement ; calibration ; traceability ; uncertainty ; quality assessment ; digital image correlation ; indentation process ; incremental forming ; finite element method ; material flow ; AWJM (Abrasive waterjet machining) ; CFRTP (Carbon fiber-reinforced thermoplastics) ; RSM (response surface methodology) ; ANOVA (Analysis of variance) ; C/TPU (carbon/polyurethane) ; image processing ; position control ; accuracy ; micromachines ; position compensation ; inverse conical perspective ; micromanufacturing ; manufacturing systems ; mechatronics ; FDM ; bimodulus materials ; standards ; finite element analysis (FEA) ; ABS ; anisotropy ; infill density ; layer orientation ; ASTM D638–14:2014 ; ISO 527–2:2012 ; grounding electrodes in two-layered soils ; step and touch potentials ; step potentials upper bound ; orthoses ; prostheses ; fused deposition modeling ; laminated object manufacturing ; selective laser sintering ; laser tracker ; Monte Carlo method ; verification ; green manufacturing ; sustainability metrics ; cleaner product life cycle ; material removal processes ; hybrid components ; light alloys ; magnesium ; aluminum ; drilling ; dry machining ; cold compressed air ; lubrication and cooling systems ; arithmetical mean roughness ; Ra ; average maximum height ; Rz ; repair and maintenance operations ; fused deposition modelling ; composites ; polymer injection moulding ; polyamide ; metal matrix composite ; Al-SiC ; microstructure ; machining ; cooling compressed air ; thrust force ; energy ; material removed rate ; PEEK-GF30 ; multi-response optimization ; sustainable manufacturing ; metrology ; industry 4.0 ; modeling and simulation ; quality in manufacturing ; technological and industrial heritage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
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  • 82
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
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    SciELO Books - Editora FIOCRUZ
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The world’s energy demand is still growing, partly due to the rising population, partly to increasing personal needs. This growing demand has to be met without increasing (or preferably, by decreasing) the environmental impact. One of the ways to do so is the use of existing low-temperature heat sources for producing electricity, such as using power plants based on the organic Rankine cycle (ORC) . In ORC power plants, instead of the traditional steam, the vapor of organic materials (with low boiling points) is used to turn heat to work and subsequently to electricity. These units are usually less efficient than steam-based plants; therefore, they should be optimized to be technically and economically feasible. The selection of working fluid for a given heat source is crucial; a particular working fluid might be suitable to harvest energy from a 90 ℃ geothermal well but would show disappointing performance for well with a 80 ℃ head temperature. The ORC working fluid for a given heat source is usually selected from a handful of existing fluids by trial-and-error methods; in this collection, we demonstrate a more systematic method based on physical and chemical criteria.
    Keywords: adiabatic expansion ; isentropic expansion ; T-s diagram ; working fluid classification ; optimization ; single-screw expander ; vapor–liquid two-phase expansion ; thermal efficiency ; net work output ; heat exchange load of condenser ; cis-butene ; HFO-1234ze(E) ; ORC working fluids ; temperature–entropy saturation curve ; saturation properties ; wet and dry fluids ; ideal-gas heat capacity ; Rankine cycle ; ORC ; biomass ; fluid mixtures ; hydrocarbons ; working fluid ; selection method ; volumetric expander ; thermodynamic analysis ; wet zeotropic mixture ; single screw expander ; organic Rankine cycle ; R441A ; R436B ; R432A ; T–s diagram ; molecular degree of freedom ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: By the late 1940s, and since then, the continuous development of dislocation theories have provided the basis for correlating the macroscopic time-dependent deformation of metals and alloys—known as creep—to the time-dependent processes taking place within the metals and alloys. High-temperature deformation and stress relaxation effects have also been explained and modeled on similar bases. The knowledge of high-temperature deformation as well as its modeling in conventional or unconventional situations is becoming clearer year by year, with new contemporary and better performing high-temperature materials being constantly produced and investigated.This book includes recent contributions covering relevant topics and materials in the field in an innovative way. In the first section, contributions are related to the general description of creep deformation, damage, and ductility, while in the second section, innovative testing techniques of creep deformation are presented. The third section deals with creep in the presence of complex loading/temperature changes and environmental effects, while the last section focuses on material microstructure–creep correlations for specific material classes. The quality and potential of specific materials and microstructures, testing conditions, and modeling as addressed by specific contributions will surely inspire scientists and technicians in their own innovative approaches and studies on creep and high-temperature deformation.
    Keywords: TA1-2040 ; T1-995 ; TN1-997 ; Larson–Miller parameter ; n/a ; visualization ; bond coat ; hydrogen ; poly-crystal ; Gibbs free energy principle ; constitutive equations ; creep damage ; DFT ; finite element method ; austenitic stainless steel ; strain rate sensitivity ; MCrAlY ; excess volume ; superalloy ; scanning electron microscopy ; creep buckling ; dislocation dynamics ; creep ; elevated temperature ; modelling ; size effect ; residual stress ; superalloy VAT 32 ; water vapor ; activation energy ; small angle neutron scattering ; superalloy VAT 36 ; metallic glass ; iron aluminides ; Gr.91 ; internal stress ; relaxation fatigue ; multiaxiality ; creep grain boundary ; grain boundary cavitation ; cavitation ; solute atom ; stress exponent ; external pressure ; P92 ; TMA ; low cycle fatigue ; nanoindentation ; high temperature ; FEM ; intrinsic ductility ; normalizing ; creep ductility ; creep rupture mechanism ; microstructural features ; simulate HAZ ; P92 steel ; glide ; ferritic–martensitic steel ; creep rupture ; cyclic softening ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
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  • 88
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: With increasing power levels and power densities in electronics systems, thermal issues are becoming more and more critical. The elevated temperatures result in changing electrical system parameters, changing the operation of devices, and sometimes even the destruction of devices. To prevent this, the thermal behavior has to be considered in the design phase. This can be done with thermal end electro-thermal design and simulation tools. This Special Issue of Energies, edited by two well-known experts of the field, Prof. Marta Rencz, Budapest University of Technology and Economics, and by Prof. Lorenzo Codecasa, Politecnico di Milano, collects twelve papers carefully selected for the representation of the latest results in thermal and electro-thermal system simulation. These contributions present a good survey of the latest results in one of the most topical areas in the field of electronics: The thermal and electro-thermal simulation of electronic components and systems. Several papers of this issue are extended versions of papers presented at the THERMINIC 2018 Workshop, held in Stockholm in the fall of 2018. The papers presented here deal with modeling and simulation of state-of-the-art applications that are highly critical from the thermal point of view, and around which there is great research activity in both industry and academia. Contributions covered the thermal simulation of electronic packages, electro-thermal advanced modeling in power electronics, multi-physics modeling and simulation of LEDs, and the characterization of interface materials, among other subjects.
    Keywords: TA1-2040 ; T1-995 ; thermal interface material ; thermal aging ; modeling ; LED compact thermal models ; niobium pentoxide ; model-order reduction ; ferromagnetic cores ; LED digital twin ; Cauer RC ladder ; in-situ characterization ; electronic packages ; time domain thermoreflectance ; multi-domain compact model ; power LEDs ; DC–DC converters ; structure function ; boundary condition independent ; electric aircraft ; multi-LED ; modelling ; light emitting diodes ; thin film ; JEDEC metrics ; tool agnostic ; power losses ; switching ; dynamic thermal compact model ; thermal transient testing ; reliability ; thermal transient analysis ; thermal simulation ; non-destructive testing ; IGBT ; carbon nanotubes ; compact thermal model ; power semiconductor devices ; SPICE ; phosphor light conversion ; thermal management ; LED luminaire design ; design flow ; thermal characterization ; motor cooling ; thermal phenomena ; silicone dome ; LED ; secondary heat path ; multi-domain modelling ; heating and optical power ; transient analysis ; thermal testability ; thermal conductivity ; multiple heat source ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
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  • 91
    Publication Date: 2024-03-30
    Description: Nuclear Engineering; Environmental Science and Engineering; Social Sciences, general
    Keywords: Nuclear Engineering ; Environmental Science and Engineering ; Social Sciences, general ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNR Natural disasters ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKX Conservation of buildings and building materials
    Language: English
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book presents an interesting sample of the latest advances in optimization techniques applied to electrical power engineering. It covers a variety of topics from various fields, ranging from classical optimization such as Linear and Nonlinear Programming and Integer and Mixed-Integer Programming to the most modern methods based on bio-inspired metaheuristics. The featured papers invite readers to delve further into emerging optimization techniques and their real application to case studies such as conventional and renewable energy generation, distributed generation, transport and distribution of electrical energy, electrical machines and power electronics, network optimization, intelligent systems, advances in electric mobility, etc.
    Keywords: TA1-2040 ; T1-995 ; n/a ; Stackelberg game ; MILP ; optimal congestion threshold ; magnetic field mitigation ; simulation ; multi-objective particle swarm optimization ; virtual power plant ; internal defect ; day-ahead load forecasting ; neural network ; modular predictor ; multi-objective particle swarm optimization algorithm ; stochastic optimization ; dragonfly algorithm ; unit commitment ; metaheuristic ; multi-population method (MP) ; optimization ; tabu search ; considerable decomposition ; loss minimization ; active distribution system ; islanded microgrid ; dynamic solving framework ; feature selection ; electric energy costs ; power factor compensation ; dependability ; interactive load ; overhead ; energy internet ; evolutionary computation ; wind power ; developed grew wolf optimizer ; underground ; ETAP ; fuzzy algorithm ; electric vehicles ; Schwarz’s equation ; evolutionary algorithms ; electric power contracts ; congestion management ; optimizing-scenarios method ; building energy management system ; particle encoding method ; ringdown detection ; HOMER software ; DC optimal power flow ; prosumer ; constrained parameter estimation ; distributed generations (DGs) ; strong track filter (STF) ; transient stability ; calibration ; cost minimization ; radiance ; decentralized and collaborative optimization ; hybrid renewable energy system ; renewable energy sources ; rural electrification ; distribution network reconfiguration ; interval variables ; optimization methods ; particle swarm optimization ; hierarchical scheduling ; micro grid ; AC/DC hybrid active distribution ; consensus ; artificial bee colony ; CCHP system ; data center ; support vector machine ; affinity propagation clustering ; extended Kalman filter ; affine arithmetic ; linear discriminant analysis (LDA) ; current margins ; heterogeneous networks ; Cameroon ; hybrid method ; distributed heat-electricity energy management ; discrete wind driven optimization ; fitness function ; cross-entropy ; GenOpt ; wind energy ; demand uncertainty ; UC ; off-design performance ; genetic algorithm ; energy storage ; the biomimetic membrane computing ; power system optimization ; electric vehicle ; power architectures ; economic load dispatch problem (ELD) ; runner-root algorithm (RRA) ; Cable joint ; battery energy storage system ; load curtailment ; integration assessment ; power system unit commitment ; artificial lighting ; power flow ; hybrid membrane computing ; two-point estimation method ; low-voltage networks ; demand bidding ; non-sinusoidal circuits ; energy flow model ; power transfer distribution factors ; sustainability ; HVAC system ; voltage deviation ; street light points ; radial basis function ; energy storage system ; charging/discharging ; power systems ; intelligent scatter search ; MV/LV substation ; optimal power flow ; stochastic state estimation ; eight searching sub-regions ; chaos optimization algorithm (COA) ; mutual information theory ; inter-turn shorted-circuit fault (ISCF) ; C&I particle swarm optimization ; multiobjective optimization ; passive shielding ; sub-Saharan Africa ; micro-phasor measurement unit ; geometric algebra ; bio-inspired algorithms ; adaptive consensus algorithm ; energy management ; PCS efficiency ; multi-stakeholders ; generalized generation distribution factors ; the genetic algorithm based P system ; JAYA algorithm ; thermal probability density ; power optimization ; pumped-hydro energy storage ; smart grid ; two-stage feature selection ; piecewise linear techniques ; photovoltaic ; SOCP relaxations ; switched reluctance machine (SRM) ; optimal reactive power dispatch ; optimal operation ; controllable response ; off-grid ; active shielding ; transformer-fault diagnosis ; IEEE Std. 80-2000 ; principal component analysis ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mountains encompass more than 30% of all land and 23% of the Earth’s forests, with high levels of biodiversity and endemism, and they support diverse habitats and refuges for approximately 85% of amphibian, bird, and mammal species. More than 1/4 of the global human population inhabits mountain environments, many of whom are among the world’s poorest people. The climate and anthropogenic changes have had a tremendous impact on biodiversity and ecosystems around the world. On the Qinghai–Xizang Plateau, which is characterized by a low temperature, short growing season, and diverse ecosystems, global changes such as the warming climate might reduce biodiversity and alter ecosystem functions. This reprint contains studies with a focus on the Qinghai–Xizang Plateau and the south-west mountainous areas of China. The topic deals with the application of multiscale methods and approaches in the context of biodiversity, from the scale of genes and individuals to ecosystems and landscapes, including the adaptations of organisms, like plants, birds, and micro-organisms, spatial–temporal variations in vegetation patterns and land use statuses, and the possible driving factors of the functional adaptation of organisms to climate and anthropogenic changes.
    Keywords: adaptation ; biogeography ; ecosystem functions ; functional traits ; genetic and species diversity ; global change ; landscape heterogeneity ; mountain environment ; NDVI ; sustainable development&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 94
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    The MIT Press | The MIT Press
    Publication Date: 2024-04-14
    Description: How Bulgaria transformed the computer industry behind the Iron Curtain—and the consequences of that transformation for a society that dreamt of a brighter future.Bulgaria in 1963 was a communist country led by a centralized party trying to navigate a multinational Cold War. The state needed money, and it sought prestige. By cultivating a burgeoning computer industry, Bulgaria achieved both but at great cost to the established order. In Balkan Cyberia, Victor Petrov elevates a deeply researched, local story of ambition into an essential history of global innovation, ideological conflict, and exchange. Granted tremendous freedom by the Politburo and backed by a concerted state secret intelligence effort, a new, privileged class of technical intellectuals and managers rose to prominence in Bulgaria in the 1960s. Plugged in to transnational business and professional networks, they strove to realize the party's radical dreams of utopian automation, and Bulgaria would come to manufacture up to half of the Eastern Bloc's electronics. Yet, as Petrov shows, the export-oriented nature of the industry also led to the disruption of party rule. Technicians, now thinking with and through computers, began to recast the dominant intellectual discourse within a framework of reform, while technocratic managers translated their newfound political clout into economic power that served them well before and after the revolutions of 1989.Balkan Cyberia reveals the extension of economic and political networks of influence far past the reputed fall of communism, along with the pivotal role small countries played in geopolitical games at the time. Through the prism of the Bulgarian computer industry, the true nature of the socialist international economy, and indeed the links between capitalism and communism, emerge.
    Keywords: Computer Science/History of Computing ; Science, Technology & Society/History of Technology ; Economics/Economic History ; Business/Business Technology ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 95
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The Special Issue, “Architectural Structure,” aims to gather general advances in human-made constructions which simultaneously are driven by aesthetic and structural engineering considerations. This Special Issue brings together twelve contributions covering the following topics: analysis of architectural typologies; the study of the mechanical performance of structural materials, structural systems and components; and the proposal of techniques to evaluate the mechanical performance in existing structures and new construction techniques.
    Keywords: recycled aggregate concrete ; block masonry ; compressive strength ; carbon emission ; stress–strain curves ; outrigger wall ; multiple openings ; deep beam ; stiffness ; shear strength ; tall building ; inverted multi tee ; prestressed concrete ; precast concrete ; structural performance ; flexural analysis ; self-compacting concrete ; non-destructive test methods ; ultrasonic pulse velocity test ; surface hardness test ; pull-out test ; maturity test ; within-test variability ; normal vibrated concrete ; concrete structures ; beams &amp ; girders ; torsion ; high-strength concrete ; prestressing ; traditional slabs ; ceramic-reinforced slabs ; shear response ; cyclic loading ; natural fiber-reinforced polymers ; NFRP ; computational design ; tailored fiber placement ; coreless filament winding ; rapid prototyping ; industry 4.0 ; lightweight structure ; Geopolymer ; Alkali activated ; tensile strength ; deformability ; experimental study ; analytical model ; reinforced concrete ; beams ; fly ash alkali activated ; bending ; thin-walled I-section ; continuous beam ; local buckling ; longitudinal stress variation ; design ultimate resistance of the cross-section ; Rudolf Steiner ; anthroposophy ; architecture ; Goetheanum ; double-steel-concrete composite shear walls ; axial and bending capacity ; failure characteristic ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 98
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue on Antimicrobial Resistance in Environmental Waters features 11 articles on the monitoring and surveillance of antimicrobial resistance (AMR) in natural aquatic systems (i.e., reservoirs, rivers), and effluent discharge from water treatment plants to assess the effectiveness of AMR removal and resulting loads in treated waters. Some of the key elements of AMR studies presented in this Special Issue highlight the underlying drivers of AMR contamination in the environment and the evaluation of the hazard imposed on aquatic organisms in receiving environments through ecological risk assessments. As described in this Issue, screening antimicrobial peptide (AMP) libraries for biofilm disruption and antimicrobial candidates are promising avenues for the development of new treatment options to eradicate resistance.
    Keywords: TA1-2040 ; T1-995 ; TA170-171 ; risk assessment ; reuse water ; Acinetobacter junii ; Escherichia coli ; co-occurrence pattern ; EPS ; wastewater treatment plant ; UV-disinfection ; biofilm ; estuary reservoir ; Environmental Waters ; antibiotic resistance genes ; antimicrobial peptide (AMP) ; wastewater ; tertiary media filtration ; Psl ; antibiotic-resistant strains ; drinking water treatment plants ; water ; sediment ; surface water ; gastrointestinal infections ; Acinetobacter baumannii ; metal resistance genes ; metagenomics ; water reuse ; bacterial community ; antibiotics ; ERIC-PCR ; river-reservoir system ; the Yellow River ; ecological risk assessment ; aquatic environment ; wastewater treatment ; sand settling reservoirs ; antibiotic resistance gene ; environmental ecology ; antibiotic resistance ; ESBL ; water treatment plants ; Pseudomonas aeruginosa ; chlorination ; irrigation water ; exopolysaccharide ; fecal indicator bacteria ; Antimicrobial Resistance ; persistence ; Qingcaosha reservoir ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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