ALBERT

Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.

Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.

Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .

Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.

Description / Table of Contents: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.

Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.

Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. European pearl mussel: background information and literature review -- Chapter 3. Materials and methods -- Chapter 4. Results -- Chapter 5. Discussion -- Chapter 6. Conclusions.

Description / Table of Contents: Part I: Introduction -- Marine Population Genomics: Challenges and Opportunities -- Part II: Marine Microbes -- Part III: Genetic Diversity, Population Structure, and Biogeography -- Population Genomics of Marine Zooplankton -- Population Genomics of Early-Splitting Lineages of Metazoans -- Population Genomics and Biogeography of the Northern Acorn Barnacle (Semibalanus balanoides) Using Pooled Sequencing Approaches -- Part IV: Seascape Genomics -- Seascape Genomics: Contextualizing Adaptive and Neutral Genomic Variation in the Ocean Environment -- Part V: Adaptation, Acclimation, and Speciation -- Clinal Adaptation in the Marine Environment -- The Population Genomics of Parallel Adaptation: Lessons from Threespine Stickleback -- Mechanisms of Adaptive Divergence and Speciation in Littorina saxatilis: Integrating Knowledge from Ecology and Genetics with New Data Emerging from Genomic Studies -- Ecological Speciation in Corals -- Environmental Epigenomics and Its Applications in Marine Organisms -- Part VI: Protection, Conservation, and Management of Marine Organisms -- Marine Invasion Genomics: Revealing Ecological and Evolutionary Consequences of Biological Invasions -- Population Genomics Applied to Fishery Management and Conservation -- Marine Conservation and Marine Protected Areas -- Index.

Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.

Description / Table of Contents: Intro: Navigating Patagonian freshwaters- and this book -- 1: Are freshwaters wetlands? -- 2: Patagonian Andean lakes and climate change -- 3: Current state and recent changes of glaciers in the Patagonian Andes (35 °S to 55°S) -- 4: Biogeographical patterns of Patagonian freshwater microbiota -- 5: Extreme freshwater ecosystems from Patagonia: The Copahue-Agrio system -- 6: Mercury in aquatic systems of North Patagonia: sources, processes and trophic transfer -- 7: Diversity patterns across aquatic communities from peat bogs -- 8: Hydrologic Systems, water uses and emerging conflicts around freshwater availability in Patagonia -- 9: Land-use effects on aquatic ecosystems: An overview of environmental impacts and tools for ecological assessment -- 10: Patagonian wetlands: vertientes, vegas, mallines,turberas and lagunas -- 11: Fish and fisheries of the Patagonian steppe -- 12: Invasive species: The case of Didymosphenia geminata in Neuquén Province -- 13: Influence of the fish introduction in lakes of the arid Patagonia -- 14: Patagonian cultural limnology: knowledge and water management in Mapuche rural communities -- 15: Political Ecology, water valoration and Water Law deliberation in the Province of Tierra del Nacional de Tierra del Fuego -- 16: Freshwater systems in protected areas in Patagonia -- 17: Amphibians and waterbirds as bridges to conserve aquatic and terrestrial habitat in Patagonia -- 18: Integrated long term conservation strategies to recover the critically endangered Hooded Grebe (Podiceps gallardoi),an endemic waterbird of Austral Patagonia -- Conclusion: Reaching out for the UNDP Sustainable Development Goals in Patagonia.

Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.

Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.

Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.

Description / Table of Contents: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.

Description / Table of Contents: Antarctic Seaweeds: Biogeography, Adaptation and Ecosystem Services -- Diversity of Antarctic Seaweeds -- Biogeographic Processes Influencing Antarctic and Sub-Antarctic Seaweeds -- Detached Seaweeds as Important Dispersal Agents Across the Southern Ocean.-Biogeography of Antarctic Seaweeds Facing Climate Changes -- Comparative Phylogeography of Antarctic Seaweeds: Genetic Consequences of Historical Climatic Variations -- Underwater Light Environment of Antarctic Seaweeds -- Production and Biomass of Seaweeds in Newly Ice-Free Areas: Implications for Coastal Processes in a Changing Antarctic Environment -- Carbon Balance Under a Changing Light Environment -- Life History Strategies, Photosynthesis and Stress Tolerance in Propagules of Antarctic Seaweeds -- Form and Function in Antarctic Seaweeds: Photobiological Adaptations, Zonation Patterns and Ecosystem Feedbacks -- Successional Processes in Antarctic Benthic Algae -- Seaweed-Herbivore Interactions: Grazing as Biotic Filtering in Intertidal Antarctic Ecosystems -- Diversity and Functioning of Antarctic Seaweed Microbiomes -- Seaweeds in the Antarctic Marine Coastal Food Web -- Trophic Networks and Ecosystem Functioning -- Chemical Mediation of Antarctic Macroalgal-Grazer Interactions -- Brown Algal Phlorotannins: An Overview of their Functional Roles.

Description / Table of Contents: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.

Description / Table of Contents: 1. Pesticide and xenobiotic metabolism in aquatic organisms -- 2. Endocrine disrupting activity of xenobiotics in aquatic animals -- 3. Water contamination through xenobiotics and their toxic effects on aquatic animals -- 4. Cypermethrin induced reproductive toxicity in zebrafish: biochemical and molecular perspective -- 5. Impact of Pesticides Application on Aquatic Environments And Biodiversity -- 6. Impact of microplastics on reproductive and physiological aspects of aquatic inhabitants -- 7. The Impact of Xenobiotics in Development & Reproduction of fresh water Fishes -- 8. Mixtures and Reproduction in Aquatic Organisms – benefits and challenges -- 9. Phytoestrogens as Endocrine-Disrupting Agents In Aquaculture -- 10. A Proteomic Approach to Studying the Effects of Xenobiotics on Aquatic Living Organisms -- 11. Role of Cytochrome P450 in xenobiotic metabolism in fishes -- 12. Pharmacokinetic-Pharmacodynamic modelling of Xenobiotics: Fate and effect in Aquatic Animals -- 13. Occurrence of xenoestrogen alkylphenols (Octylphenols and Nonylphenol), and its impact on the aquatic ecosystem -- 14. Xenobiotics' effect on fish reproduction and development -- 15. Scientometric analysis of ecotoxicological investigations of xenobiotics in aquatic animals -- 16. Toxic effects of nanomaterials on aquatic animals and their future prospective -- 17. Microplastic Contamination in Aquatic organisms: An Ecotoxicological perspective -- 18. Effect of xenobiotics and their degradation in aquatic life -- 19. Transcriptome analysis of aquatic species exposed to endocrine disruptors -- 20. Fundamentals of genotoxicity and antiparasitic drugs associated with genotoxicity in fish -- 21. Endocrine disrupting compounds (EDCs) as emerging aquatic contaminants: Emphasis on Reproduction and Development.

Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.

Description / Table of Contents: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.

Description / Table of Contents: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.

Description / Table of Contents: Chapter 1. Introduction to cancer stem cells -- Chapter 2. Types of Cancer Stem Cells -- Chapter 3. Isolation and Characterization of Cancer Stem Cells (CSCs) -- Chapter 4. Lung and Prostate Cancer Stem Cells -- Chapter 5. A differential role of miRNAs in regulation of breast cancer stem cells -- Chapter 6. Skin stem cells in cancer -- Chapter 7. Ocular Cancer stem cells: Advances in therapeutic interventions -- Chapter 8. Cancer Stem Cells and Tumour Aggressiveness -- Chapter 9. Therapeutic Implication of Cancer Stem Cells.-Chapter 10. Glioblastoma stem cells as a therapeutic target -- Chapter 11. Cancer stem cells and therapeutic angiogenesis -- Chapter 12. Cancer stem cells as a seed for cancer metastasis -- Chapter 13. Functionality of intron specific genes and cancer stem cells in the progression of colorectal cancer -- Chapter 14. Technological advancement in Cancer Stem Cell Research -- Chapter 15. Controversies in Isolation and Characterization of Cancer Stem Cells -- Chapter 16. Targeting therapies for cancer stem cells -- Chapter 17. Targeting Cancer stem cells by nanoenabled drug delivery -- Chapter 18. Cancer Stem Cells in Patients Survival and Therapies in Cancer.-.

Description / Table of Contents: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.

Description / Table of Contents: Introduction: Christopher Clark and Ellen Garland -- Ch 1: Overview. Christopher Clark -- Ch. 2: Anatomy and physiology. Joy Reidenberg -- Ch. 3: Movement, Residency & Migration. Alex Zerbini and Sue Moore,- Ch. 4: Feeding strategies. Ari Friedlaender -- Ch. 5: Molecular genetics. Emma Carroll -- Ch. 6: Social organization. Peter Tyack -- Ch. 7: Ethological and bioacoustic variability. Christopher Clark -- Ch. 8: Baleen whale culture. Ellen Garland and Emma Carroll -- Ch. 9: Blue whale – Global diversity & behavioral variability in a specialist. Ana Sirovic -- Ch. 10: Humpback whale – Global diversity & behavioral plasticity in a court jester. Rebecca Dunlop -- Ch. 11: Humpback whale song - Global diversity & behavioral plasticity in a court jester. Danielle Cholewiak, Sal Cerchio and Ellen Garland -- Ch. 12: Bowhead whale – Acoustic variability in the almost-a-right whale that went north. Kate Stafford -- Ch. 13: Right whales - From north to south, what’s the big difference? Susan Parks -- Ch. 14: Minke Whale – Diversity and variability. Denise Risch -- Ch. 15: Omura’s Whale – An enigma. Sal Cerchio. .

Description / Table of Contents: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.

Description / Table of Contents: The Coral Tree at the End of the World: Introductory Notes to Coralline Mythology and Folklore from the Indian and Pacific oceans -- The Marine Animal Forests Of South Africa: Importance For Bioregionalisation And Marine Spatial Planning -- Coral and reef fish communities in the thermally extreme Persian/Arabian Gulf: Insights into potential climate change effects -- Marginal reefs in the Anthropocene: they are not Noah’s Ark -- Animal Forests in Submarine Caves -- The Tubeworm Forests of Hydrothermal Vents and Cold Seeps -- Bryozoans: the ‘forgotten’ bioconstructors -- Polychaetes as habitat former: structure and function -- Chemical war in marine animal forests: Natural products and chemical interactions -- The nursery role of marine animal forests -- From Trees To Octocorals: The Role Of Self-Thinning And Shading In Underwater Animal Forests -- Marine animal forests as Carbon immobilizers or why we should preserve these three-dimensional alive structures -- Invasive alien species and their effects on marine animal forests -- Plastics, an additional threat for coral ecosystems -- Visual methods for monitoring mesophotic-to-deep reefs and animal forests: finding a compromise between analytical effort and result quality -- Advances in the Marine Animal Forests Scientific Outreach and Citizen Science.

Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.

Description / Table of Contents: Chapter 1 Lake Alchichica: History of Human Settlements -- Chapter 2 Geological Evolution of the Alchichica Crater -- Chapter 3 Paleoenvironmental Change in Central Mexico During the Last 20,000 Years -- Chapter 4 Recent Climate of Serdán-Oriental Basin -- Chapter 5 Hydrogeology and Hydrochemistry of the Serdán-Oriental Basin and the Lake Alchichica -- Chapter 6 Meteorological Regime, Local Climate, and Hydrodynamics of Lake Alchichica -- Chapter 7 Physicochemical Characteristics -- Chapter 8 The Littoral Environment -- Chapter 9 Aquatic Vegetation -- Chapter 10 The Littoral Community -- Chapter 11 Bacterioplankton -- Chapter 12 -- Phytoplankton of Alchichica: A Unique Community for an Oligotrophic Lake -- Chapter 13 Protozooplankton -- Chapter 14 Metazooplankton: The Joys and Challenges of Living in a Saline, Oligotrophic, Warm Monomictic Lake -- Chapter 15 Alchichica Silverside -- Chapter 16 -- The Axolotl of Alchichica -- Chapter 17 The Deep Benthic Zone. - Chapter 18 Lake Metabolism. - Chapter 19 Lake Food Webs -- Chapter 20 Diversity and Endemisms -- Chapter 21 Conservation Actions -- Chapter 22 Microbialites: Diversity Hotspots in the Mexican Plateau -- Chapter 23 The Lake Alchichica from an Astrobiological Perspective -- Chapter 24 Lake Alchichica Traditions, Myths, and Legends: Interviews with Local Residents. .

Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.

Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.

Description / Table of Contents: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.

Description / Table of Contents: Evolution – Analisa Berta -- Sensory and cognition – Tentative Colleen Reichmuth and others -- Communication – Isabelle Charrier -- Physiology – Dan Crocker -- Movement – Luis Huckstadt and Ryan Reisinger -- Navigation – Patrick Robinson -- Foraging ecology and behavior – Don Bowen -- Reproductive behavior and lactation strategies – Dan Costa and Jen Maresh -- Breeding behavior – Paddy Pomeroy and Kelly Robinson -- Conservation – Samantha Simmons and others.

Description / Table of Contents: 1. Marine Biotechnology: A Frontier for the Discovery of Nutraceuticals, Energy, and Its Role in Meeting 21st Century Food Demands -- 2. Biotechnological Utilization of the Marine Environment for Food, Drugs and Energy -- 3. Grouper Hybridization: An Effective Biotechnological Tool for Food Security -- 4. The Application of Molecular Markers to Fish Breeding and Aquaculture -- 5. Aquaculture and Applications of Green Seaweeds of the Genus Caulerpa J.V. Lamouroux, 1809 -- 6. Potential and Challenges of Sea Cucumber Holothuria Scabra Mariculture in Sabah, Malaysia -- 7. Sea Cucumber (Echinodermata: Holothuroidea) Species Diversity on the West Coast of Sabah, Malaysia -- 8. Sea Cucumbers: Source of Nutritional, Medicinal, and Cosmeceutical Products -- 9. Marine Biotechnology and its Applications in Drug Discovery -- 10. Bacteriophage as Therapeutic Strategy Against Pathogenic Vibrio -- 11. Bacterial Diversity in the Marine Environment and the Cutting-edge Tools for Isolation, Identification, and Characterization of the Marine Microbiome -- 12. Biotechnological Applications of Jellyfish-Derived Products -- 13. Application of Biotechnology in White Syndrome Coral Disease Identification -- 14. The Synergy of Remote Sensing in Marine Invasion Science -- 15. The Utilization of Agro-based Wastes by Marine Phototrophic Microbes -- 16. Artificial Intelligence Methods in Marine Biotechnology.

Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.

Description / Table of Contents: Introduction -- Part I. Historical Perspectives -- Vertebrates of Upper Mesopotamia: Present Evidence and Archaeological Data -- Fishing Gears and Methods: A Comparison of Ancient Mesopotamia and Other Ancient Worlds -- Ichthyological Characteristics Available in the Fish Images Existed in the Art of the Ancient Mesopotamia -- The Effectiveness of Ancient Mesopotamian Medical Practices: The Example of šūšu-Licorice -- Part II. The Abiotic Aspects of the Tigris–Euphrates River System -- Management of Water Resources Using Storage Reservoirs -- Estimation of Irrigated Agricultural Area and Water Consumption in Iraq -- The Nature of Tigris–Euphrates Rivers Flow: Current Status and Future Prospective -- Streamflow Alteration Impacts with Particular Reference to the Lower Zab River, Tributary of the Tigris River -- Ecohydrology in Iraq: Challenges and its Future Pathways -- Oil Pollution in the Shatt Al-Arab River and its Estuary 1980–2018 -- Pesticides in the Waters, Sediments, and Biota of the Shatt Al-Arab River for the Period 1980–2017 -- Surface Water Salinity of the Euphrates, Tigris, and Shatt al-Arab Rivers -- Renewable Energy for Water–Energy Nexus in Euphrates and Tigris River Basin: A Literature Review -- Impacts of Dams on Aquatic Biodiversity, Fisheries, Fishes and Their Environment: Problems that Could Be Present in Iraq with Recommendations -- Water, Politics and Dams in the Mesopotamia Basin of the Northern Middle East: How Turkey Instrumentalises the South-Eastern Anatolia Project for Political, Military and Strategic Interests -- Dams and their Impacts on Fishes in Iran -- Part III. The Biotic Aspects of the Tigris–Euphrates River System -- Preliminary Review of the Aquatic Biodiversity in Al-Kahla River, Missan Province, Iraq -- Freshwater Fish Biodiversity in Iraq: Importance, Threats, Status, and Conservation Challenges -- Effect of Climate Changes on the Freshwater Biodiversity in the Mesopotamian Plain: Recommendations for Avoidance and Plans for the Future -- River Corridors as a Refuge for Freshwater Biodiversity: Basic Information and Recommendations to the Policymakers for Possible Implications in Iraq -- Biodiversity of Fungi in Aquatic Environment of Iraq -- Potability of Drinking Water in Basra-Iraq -- Algal Studies in Iraqi Inland Waters. A Review -- The Distribution of Epilitic Diatoms in the Turkish Part of the Tigris-Euphrates River Basin -- Plant Biodiversity in Shatt Al-Arab Estuary and Ecological Variations -- Medicinal Plants of Shatt al-Arab River and Adjacent Area -- The Role of Plants as a Canopy in the Inland Waters: Basic Information for Application in Iraq -- The Zooplankton Fauna of the Turkish Part of the Euphrates-Tigris River Basin -- Kinds and Distribution of Icthyoplankton in Shatt Al-Arab River -- Rotifer Diversity in Iranian Waters: A Review -- Biodiversity of the Freshwater Amphipods in Iran -- The Freshwater Molluscs of the Mesopotamian Plain -- Freshwater Annelida of Iraq -- A Critical Checklist of the Inland Fishes Native to the Euphrates and Tigris Drainages -- Fish Fauna of Shatt al-Arab River, Basrah, Iraq: A More than Quarter a Century of Changes -- The Common Carp, Cyprinus carpio: Effect on the Environment and the Indigenous Fish Species in Iraq -- The Good and the Bad in Releasing the Grass Carp Ctenopharyngodon idella in the Freshwater System: Recommendations for the Policymakers in Iraq -- The Avifauna of Tigris and Euphrates River Basin -- The Feasible Approaches to Assist Migratory Birds Visiting the Southern Reaches of Mesopotamia -- A Proposal for Establishing Bird Observatory Centre in the South of Iraq -- The Potential Role of Waterbirds as a Vector in Dispersing Invertebrates and Plants in the South of Iraq -- The Wild Mammals of the Tigris and Euphrates Rivers Basin -- The Amphibians and Reptiles of Euphrates and Tigris Basin -- A Preliminary Pictorial Guide to the Herpetofauna of Tigris and Euphrates River Basin -- Policy Guidance for Sustainable Aquaculture in the Inland Waters of Iraq -- How Possible to Use the Desert Area in Iraq for Aquaculture Industry: Basic Facts and Recommondations -- Aquaculture Industry in Iraq: Past, Present, and Future Perspectives -- Towards an Improved Tilapia Farming in Iraq: Recommendations for Future Application -- Information and Recommendations of Aquaculture Stress and its Source in Hatcheries: The Iraqi Aquaculture Industry Investors -- Exotic and Invasive Freshwater Fishes in the Tigris-Euphrates River System -- Part IV. Water Resources -- The Ecology and Modelling of the Freshwater Ecosystems in Iran -- Enhancing Rural Women’s Participation in Fisheries in Iraq -- The Impact of Destructive Fishing Gear on the Fish Biodiversity in the Inland Waters of Iraq -- Evaluating Variations in Fisheries by Means of Fishers’ Information: Suggested Methodology to Improve Small-Scale Fisheries in Rivers in Iraq -- A Possibility to Apply a Traditional Fisheries Enforcement Programme in the Inland Waters of Iraq -- Market-Resource Relations and Fish Seller Livelihood as Seen in Inland Waters of Iraq -- The Potential Impact of Deformities in Fishes upon Aquatic Production: Case of Iraq -- The Impact of some Social Taboos on Fisheries in Iraq -- Inland Water Fishes and Fisheries in Iran -- The Possibility of Introducing an Inland Fisheries Education in Iraq -- The Marine and Diadromous Fisheries of Iraq -- Part V. Stress of the Environment of the Two Rivers -- Fish Deformities in the Freshwater Fishes of Iraq: A Short Review and a Study Case on the Indian Catfish Heteropneustes fossilis -- The Phenomenon of Fluctuating Asymmetry: As Fish Welfare Indicator Represented by Case Study from the Freshwater Fishes of Iraq -- The Studies on Sediments Pollution by Different Types of Metals in Turkey -- Macroplastic and Microplastic in the Freshwater Environment of Southern Iraq: Evidences Obtained from Freshwater Fish Species -- Heavy Metals in Freshwater Invertebrates of Iran: A Review on the Bioaccumulation and Effects -- Fish Parasites of Tigris and Euphrates River Systems -- The Parasites of Fishes of the Euphrates and Tigris Rivers: Iraq and Turkey -- Ornamental Fishes: A Looming Danger for Inland Fish Diversity of Iraq -- Part VI. The Health of the Human Community Inhabiting Freshwater Zones -- Aquatic Snails as a Vector of Diseases to the Human in Iran -- Death by Drowning in Rivers in Iraq -- The Dangerous Catfish Species in the Freshwater System of Iraq: First Time Reports on Cases of Envenomation -- Fish Species of the Order Cypriniformes as a Source of Ichthyootoxin and Ichthyogallotoxin in Iraq: Cases Reports -- First Reports on Cases of Hallucinatory Fish Poisoning (Ichthyoallyeinotoxism) and Scombrotoxic Fish Poisoning in Iraq -- Part. VII. Conservation -- Freshwater Management and Conservation in Iran: Past, Present, and Future -- The Need of Biodiversity Conservation Strategies in Iraq: The State of Protected Areas -- Benthic Macroinvertebrates of the Tigris and Euphrates Rivers in Turkey -- Freshwater Ecosystem Conservation in Iraq: Recommendations for Management -- Utilising Phenotypic Difference to Regulate Protection Value: A Scheme for Application of a Novel Approach to the Inland Water of Iraq -- Hatchery-Reared Fish Stocks Released into the Wild: A Conservation Problem as Seen in a Case Study from Iraq -- Part VIII. Social Perspectives -- Is the Glass Half Empty or Half Full? An Appraisal of the Four Decades of Turkey’s Southeastern Anatolia Project (GAP) -- Part IX. Food Security -- How Possible to Build Rice–Fish Farming in Iraq in order to Support Food Security Plan: Positive and the Negative Aspects -- The Importance of Non-commercial and Small-Sized Fish Species: A Proposal for an Additional Revenue to Iraq -- Sociocultural Aspects Influence Food Consumption Habits in Iraq: Management of Food Security -- A Preliminary Investigation of Determinants of Food Security in Rural Areas of Basrah Province, Iraq.

Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.

Description / Table of Contents: Chapter 1_ Recent developments in Biosensor Technology for Fisheries and Aquaculture -- Chapter 2_Application of CRISPR-Cas9 Technology in Fish -- Chapter 3_ Nano-technological applications in Aquatic Health Management -- Chapter 4_Phenotypic plasticity and transgenerational immune priming: opportunities and potential in fisheries -- Chapter 5_Heat shock proteins in stress response: a promising tool for fish health management -- Chapter 6_Immunostimulants: Boon for disease management in Aquaculture -- Chapter 7_Molecular markers and their application in fisheries and aquaculture -- Chapter 8_Applications of Electronics in Fisheries and Aquaculture -- Chapter 9_Metatranscriptomics: A tool to study the host-microbe interactions and functional profile of fish intestinal microbiota under changing environmental conditions -- Chapter 10_Bioremediation and its application in aquaculture -- Chapter 11_Application of Probiotics in Aquaculture -- Chapter 12_Identifying novel antibiotic resistance genes (ARGs): Important aspect of metagenomic research.

Description / Table of Contents: Chapter 1_ An Introduction to the Functions and Ecosystems Services associated with aquatic macrophytes -- Chapter 2_ Factors structuring Aquatic Macrophytes -- Chapter 3_ Aquatic Macrophytes: Ecology, Function and Services in Niger Delta, Nigeria -- Chapter 4_ Environmental and Ecological Importance of Indian Aquatic Macrophytes -- Chapter 5_ Macrophytes used as complementary medicines for curing human ailments to facilitate livelihood opportunities -- Chapter 6_ Macrophytes and their role in wetland ecosystems -- Chapter 7_ Ecotoxicology of REEs in aquatic macrophytes and prospect for bioremediation of REEs -- Chapter 8_ Efficiency of Aquatic Plants for Remediation of Wastewater -- Chapter 9_ Phytoremediation of organic contaminants: An ecofriendly approach based application of aquatic macrophytes -- Chapter 10_ Remediation of heavy metals by different aquatic macrophytes -- Chapter 11_ Translocations of heavy metals in aquatic macrophytes naturally grown in the riverine ecosystem -- Chapter 12_ Enhanced Effluent Treatment and Bioelectricity Generation Using Coupled Constructed Wetland-Microbial Fuel Cell (CW-MFC) Technology: Challenges and Opportunities -- Chapter 13_ Role of microbial communities and aquatic macrophytes in constructed wetlands for tannery wastewater treatment: Challenges and opportunities -- Chapter 14_ Role of plant-bacteria association in constructed wetlands for the removal of iron (Fe) from contaminated water. .

Description / Table of Contents: Part I. Introduction -- Chapter 1. Insights from Cuban Coral Reefs -- Part II. History -- Chapter 2. Research History of Corals and Coral Reefs in Cuba -- Part III. Description -- Chapter 3. Physical-Geographic Characteristics of Cuban Reefs -- Chapter 4. Outline of the Geology, Geomorphology and Evolution of the Late Qua-ternary Shelf and Uplifted Marine Terraces of Cuba; Tectonic and Sea Level Control of Present Day Coral Reef Distribution -- Chapter 5. A Remote Sensing Appraisal of the Extent and Geomorphological Diversity of the Coral Reefs of Cuba -- Part IV. Biota -- Chapter 6. Macrophytes Associated with Cuban Coral Reefs -- Chapter 7. Sponges: Conspicuous Inhabitants of the Cuban Coral Reefs and Their Potential as Bioindicators of Contamination -- Chapter 8. Species List of Cuban Stony Corals: Class Anthozoa, Order Scleractinia; Class Hydrozoa, Suborders Capitata and Filifera -- Chapter 9. Octocoral Forests: Distribution, Abundance, and Species Richness in Cuban Coral Reefs -- Chapter 10. Current State of Knowledge of Reef Mollusks in Cuba -- Chapter 11. Herbivory on Cuban Coral Reefs -- Chapter 12. Chronology of the Lionfish Invasion in Cuba and Evaluation of Impacts on Native Reef Fishes -- Chapter 13. Sharks and Rays in Cuban Coral Reefs: Ecology, Fisheries, and Conservation -- Chapter 14. Mesophotic Coral Ecosystems of Cuba -- Part V. Ecology, Conservation and Management -- Chapter 15. Status of Cuban Coral Reefs -- Chapter 16. Population Genetics of Cuba’s Scleractinian Corals -- Chapter 17. Multiple Cumulative Effects on Coral Reefs of the Northwestern Cuban Region -- Chapter 18. Guanahacabibes National Park: Research, Monitoring and Man-Agement for the Conservation of Coral Reefs -- Chapter 19. Ciénaga de Zapata Biosphere Reserve: Integrating Science with the Management of Coral Reefs -- Chapter 20. Coral Reefs in Cuban Marine Protected Areas -- Part VI. Economic Valuation -- Chapter 21. Economic Valuation of the Coral Reefs of Jardines de la Reina and Punta Francés National Parks, Cuba -- Chapter 22. The Economic Value of Coral Reefs in the Context of Marine Protected Areas: Experiences of the South Cuban Archipelago Project -- Chapter 23. Fish Can Be More Valuable Alive Than Dead.

Description / Table of Contents: Chapter 1. A Global View of the Cold-Water Coral Reefs of the World -- Chapter 2. Biology, Ecology and Threats to Cold-Water Corals on Brazil’s Deep-Sea Margin -- Chapter 3. Cold-Water Corals of the World: Gulf of Mexico -- Chapter 4. Cold-Water Coral Reefs of the Southeastern United States -- Chapter 5. Norwegian Coral Reefs -- Chapter 6. Waters of Ireland and the UK -- Chapter 7. Life and Death of Cold-Water Corals across the Mediterranean Sea -- Chapter 8. Cold-Water Coral Reefs in the Oxygen Minimum Zones off West Africa -- Chapter 9. New Zealand: South West Pacific Region -- Chapter 10. Deep-Sea Corals of the North and Central Pacific Seamounts.

Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.

Description / Table of Contents: Part I. Fish Resources and Fishing Areas of the Western Balkans -- Chapter 1. Fish Resources of Inland Waters and Fisheries in Slovenia, Management, Sustainability and Conservation -- Chapter 2. Inland Fisheries in Croatia: Historical Aspects, Fish Resources, Management and Conservation -- Chapter 3. Fish Resources and Fisheries in Bosnia and Herzegovina – Overview, Sustainability, and Conservation -- Chapter 4. Inland Fisheries in Serbia: Historical Aspect, Fish Resources, Management and Conservation -- Chapter 5. The Freshwater Fish Resources and Freshwater Fisheries of Montenegro, Management, Sustainability and Conservation – With a Special Perspective on Lake Skadar -- Chapter 6. Fish and Fisheries of the Republic of North Macedonia, Current Situation and Its Perspective -- Chapter 7. Fish Resources of Inland Waters and Fisheries in Albania, Management, Sustainability and Conservation -- Part II. Some Fish Species of the Western Balkans Important for Fisheries and Conservation -- Chapter 8. Freshwater Crayfish of Western Balkan: Is It Possible to Use Them Sustainably or Do They Need Prompt Conservation Actions? -- Chapter 9. Salmonid Fish Species – Opportunities for Sustainable Use under Multiple Pressures and Current Climatic Change -- Chapter 10. Past and Future of Sturgeon Species (Acipenseridae) in Western Balkans – Case for Permanent Conservation or Sustainable Management -- Part III. Effects of Stressors on Inland Water Ecosystems and Fish Resources -- Chapter 11. Eutrophication of Fishing Waters and the Influence of Cyanobacterial Occurrence and Blooming on Fish Resources – Case Studies in Serbia -- Chapter 12. Pollution of Fishing Waters of the Western Balkan – Potentially Toxic Elements and Their Impact on the Ecological Sustainability of Fish Resources -- Chapter 13. Invasive Macroinvertebrate and Fish Species and Their Impact on Fish Resources: A Case Study on Fishing Waters of Serbia -- Part IV. Fish Stock Assessment Methods -- Chapter 14. A Brief Overview of the Development of the ES-HIPPO Model for Assessing the Sustainability and Conservation Priorities of Fish, Fish Resources, and Inland Water Habitats -- Part V. Conservation and Aquaculture -- Chapter 15. Тhe Role and Importance of Aquaculture for the Ecological Sustainability of Fish Resources in the Inland Water of Serbia -- Chapter 16. Huchen Hucho hucho (Linnaeus, 1758) in Croatia: Distribution, Genetic Diversity, Threats and Conservation -- Chapter 17. Future Perspective of Sustainable Development of Freshwater Fisheries and Conservation of Threatened Fish Species, Crustaceans and Molluscs -- Part VI. Social Aspect -- Chapter 18. Political and Socio-Economic aspects of Fisheries in Inland and Coastal Waters of the Western Balkan -- Chapter 19. Fish Resources of the Western Balkans, Sustainable Use and/or Conservation?.

Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .

Description / Table of Contents: Introduction. The Lake Charr: Biology, Ecology, Distribution, and Management -- Distribution -- Paleoecology -- Ecological Diversity -- Genetic Diversity -- Habitat -- Movement Ecology and Behavior -- Life History and Population Dynamics -- Trophic Ecology -- Reproduction -- Contaminants and Ecotoxicology -- A General, Life History Based Model for Sustainable Exploitation of Lake Charr across their Range -- Terminology Issues in Lake Charr Early Development.

Description / Table of Contents: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.

Description / Table of Contents: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.

Description / Table of Contents: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.

Description / Table of Contents: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.

Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.

Description / Table of Contents: Part I. Introduction -- Using the Concepts and Tools of Social Ecological Systems and Ecosystem Services to Advance the Practice of Ecosystem-Based Management -- Part II. Foundational Concepts -- Advancing Aquatic Ecosystem-Based Management with Full Consideration of the Social-Ecological System -- Ecosystem-Based Management: Moving from Concept to Practice -- From DPSIR the DAPSI(W)R(M) Emerges… a Butterfly – ‘protecting the natural stuff and delivering the human stuff’ -- The Promise and Pitfalls of Ecosystem Services Classification and Valuation -- Approaches for Estimating the Supply of Ecosystem Services: Concepts for Ecosystem-Based Management in Coastal and Marine Environments -- The Final Ecosystem Goods & Services (FEGS) Approach: A Beneficiary-Centric Method to Support Ecosystem-Based Management -- Part III. Tools and Techniques -- Ecosystem-Based Management and Natural Capital Accounting -- Establishing a Common Framework for Strategic Communications in Ecosystem-Based Management and the Natural Science -- Prioritizing Stakeholders, Beneficiaries, and Environmental Attributes: A Tool for Ecosystem-Based Management -- Linkage Frameworks: An Exploration Tool for Complex Systems in Ecosystem-Based Management -- Projecting Changes to Coastal and Estuarine Ecosystem Goods and Services – Models and Tools -- An Integrated Multi-Model Decision Support Framework for Evaluating Ecosystem-Based Management Options for Coupled Human-Natural Systems -- Mathematical Modeling for Ecosystem-Based Management (EBM) and Ecosystem Goods and Services (EGS) Assessment -- The Ecosystem Services Gradient: A Descriptive Model for Identifying Levels of Meaningful Change -- Rapid Benefit Indicator Tools -- Part IV. Governance -- The Ecosystem Approach in International Marine Environmental Law and Governance -- Ecosystem-Based Management (EBM) and Ecosystem Services in EU Law, Policy and Governance -- Ecosystem Services in U.S. Environmental Law and Governance for the Ecosystem-Based Management Practitioner -- Unravelling the Relationship between Ecosystem-Based Management, Integrated Coastal Zone Management And Marine Spatial Planning -- Part V. Case Studies -- Models and Mapping Tools to Inform Resilience Planning After Disasters: A Case Study of Hurricane Sandy and Long Island Ecosystem Services -- Ecosystem-Based Management to Support Conservation and Restoration Efforts in the Danube Basin -- Combining Methods to Establish Potential Management Measures for Invasive Species Elodea nutallii in Lough Erne Northern Ireland -- Mitigating Negative Unintended Impacts on Biodiversity in the Natura 2000 Vouga Estuary (Ria de Aveiro, Portugal) -- Ecosystem-Based Management for More Effective and Equitable Marine Protected Areas: A Case Study on the Faial-Pico Channel Marine Protected Area, Azores -- Using Stakeholder Engagement, Translational Science and Decision Support Tools for Ecosystem-Based Management in the Florida Everglades -- Remediation to Restoration to Revitalization: Engaging Communities to Support Ecosystem-Based Management and Improve Human Wellbeing at Clean-up Sites -- Predicting Future Vegetated Landscapes Under Climate Change: Application of the Environmental Stratification Methodology to Protected Areas in the Lower Mekong Basin.

Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.

Description / Table of Contents: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.

Description / Table of Contents: Diversity, Distribution, and Biology of Sea Cucumber -- Nutritional Components of Sea Cucumber and the Biochemical Characteristics of Autolytic Enzymes -- The Functional Components of Sea Cucumber and their Nutritional and Biological Activities -- Traditional Processing Technologies and Products of Sea Cucumber: Historical Review -- The Pretreatment Technology of Raw Sea Cucumber and New Processing Technology of Salted Sea Cucumber -- The New Processing Technology of Dried Sea Cucumber Products -- Ready-to-Eat Sea Cucumber Products and Collagen Stabilization Technology -- The Extraction, Separation Technology and New Product Development of Sulfated Polysaccharides from Sea Cucumber -- The Extraction, Separation Technology and New Product Development of Functional Lipids from Sea Cucumber -- The Extraction, Separation Technology and New Product Development of Collagen Peptides from Sea Cucumber -- The Quality Management Systems and Standards of Sea Cucumber Products -- Food Safety Issues and Regulatory Requirements of Sea Cucumber Products and Their Internationalization.

Description / Table of Contents: 1. Geological history and transition of the biota of Lake Biwa -- 2. Biodiversity of Lake Biwa -- 3. Ecological changes in Lake Biwa -- 4. History of the relationship between people and Lake Biwa -- 5.The use of Lake Biwa and people’s lifestyle -- 6. Evolving issues toward improvement of Lake Biwa – Yodo river basin governance -- 7. Environmental conservation of Lake Biwa.

Description / Table of Contents: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.

Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .

Description / Table of Contents: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.

Description / Table of Contents: Chance, Choice and Cichlids -- Frontiers in Cichlid Research: A History of Scientific Advancement -- Ecological Opportunity, Genetic Variation, and the Origins of African Cichlid Radiations -- Evolution in the Fast Lane: Diversity, Ecology, and Speciation of Cichlids in the lower Congo River -- Neotropical Riverine Cichlids: Adaptive Radiation and Macroevolution at Continental Scales -- Sympatric and Allopatric Diversification in the Adaptive Radiation of Midas Cichlids in Nicaraguan Lakes -- The Consequences of Anthropogenic Stressors on Cichlid Fish Communities: Revisiting Lakes Victoria, Kyoga, and Nabugabo -- Rapid Evolutionary Responses in Cichlids: Genetics of Adaptation, Morphology and Taxonomic Implications -- Identifying and Conserving Tilapiine Cichlid Species in the 21st Century -- Introduced Cichlids in the Americas: Distribution Patterns, Invasion Ecology, and Impacts -- The Evolutionary Ecology of Cichlid Vision -- The Mechanosensory Lateral Line System of Cichlid Fishes: From Anatomy to Behavior -- Sonic Cichlids -- The Evolution of Enhanced Cichlid Hearing: Functional Morphology and the Role of Ecoacoustical Factors -- Parental Care in Cichlid Fishes -- Cichlids as a model system for studying social behaviour and evolution -- Integrative Neurobiology of Social Behavior in Cichlid Fish -- Respiratory Ecology of Cichlids -- Feeding Ecology of Lake Tanganyika Cichlids -- Patterns of Trophic Evolution: Integration and Modularity of the Cichlid Skull -- An Evo-devo View of Post-genomic African Cichlid Biology: Enhanced Models for Evolution and Biomedicine.

Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.

Description / Table of Contents: Chapter 1. Role of selected transcription factors in pancreatic and colorectal cancer growth and metastasis -- Chapter 2. Adiponectin in gastrointestinal malignancies -- Chapter 3. Small molecule-targeted therapies for GI cancers: success and failures -- Chapter 4. Epigenetic biomarkers for the detection of Gastrointestinal Cancers -- Chapter 5. CD151: A Lateral organizer and modulator of Tumor microenvironment in gastrointestinal cancers -- Chapter 6. Targeting Pathways in GI Malignancies -- Chapter 7. Identification of Potential Key Genes Involved In Progression of Gastric Cancer Using Bioinformatics Analysis -- Chapter 8. Recent Development in the biomarkers for the gastric cancer -- Chapter 9. Gastric Cancer and it’s remedy -- Chapter 10. An intergenic variant rs4779584 between SCG5 and GREM1 contributes to the increased risk of colorectal cancer: A meta-analysis -- Chapter 11. Phytochemicals plus nanomaterial’s on colorectal cancer -- Chapter 12. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones? -- Chapter 13. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma -- Chapter 14. Immunotherapy in Gastrointestinal Malignancies -- Chapter 15. The Role of HIF-1α in Hepatocellular Carcinoma.

Description / Table of Contents: Standing up to Climate Change ̶ Creating Prospects for a Sustainable Future in Rural Iran -- Part I. Water and Land Use Challenges in Iran -- Water Resources and Water Security in the MENA Region -- Water Management in Iran: Appearance and Reality -- Contemporary Water Resource Management and Its Role in Tackling Land Degradation and Desertification in Iran -- Part II. Water and Land Use Challenges in the Zayandeh Rud Basin -- Zayandeh Rud River Basin: A Region of Economic and Social Relevance in the Central Plateau of Iran -- Returning Periods of Drought and Climate Change in the Zayandeh Rud River Basin -- Hydrological Modelling of Spatial and Temporal Changes of Blue and Green Water Resources in the Zayandeh Rud River Basin -- Part III. Water and Land Use Challenges in the Roodasht Region -- Realizing the Dynamic of Water Scarcity, Land Use Change and Environmental Degradation in Roodasht, Iran -- Structural Evolution of the Zayandeh Rud River Basin Based on Historical Climate Changes -- Evaluation of Lead and Cadmium Contamination in the Zayandeh Rud River -- Dust Production Crisis Following the Recent Droughts in the Eastern Part of the Zayandeh Rud River Basin -- Part IV. Possible Solutions for the Region -- Participatory Development of Strategies for the Transformation of Agriculture in the Zayandeh Rud River Basin -- Environmental Capacity Building Program for the Residents of the Zayandeh Rud Basin -- Adaptive Land and Water Management: A Regional Action Plan for Roodasht to Cope with Climate Change -- A Short Ecological History of Varzaneh: Adaptive Responses to and Resilience Against the Adversity of Drought -- Determination of Net Water Requirement of Crops and Gardens in Order to Optimize the Management of Water Demand in Agricultural Sector -- Increasing Water and Energy Productivity via Replacing Abiotic Stress Tolerant Forages in East of Zayandeh Rud River Basin.

Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.

Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.

Description / Table of Contents: Preface -- The Bahía Blanca Estuary in a regional context -- Geography of the Bahía Blanca Estuary -- Physical Oceanography of the Bahía Blanca Estuary -- Bahía Blanca Estuary: a chemical oceanographic approach -- Plankton ecology and biodiversity in the Bahía Blanca Estuary -- Biology and ecology of the benthic algae -- The intertidal meiobenthos of the Bahía Blanca Estuary -- The intertidal soft-bottom macrobenthic invertebrates -- Taxonomic and functional approach of subtidal macrobenthic communities in the Bahía Blanca Estuary (Argentina) -- Shrimps and prawns -- Ecology and biology of the fish assemblages -- The Bahia Blanca Estuary and importance of the wetlands for the conservation of see turtles -- Shorebirds and Seabirds’ Ecology and Conservation -- Marine mammals: is the Bahía Blanca Estuary and its area of influence important for their conservation? -- Use of coastal area habitats by land mammals -- Coastal wetlands of the Bahía Blanca Estuary. Landscape structure and plant associations -- Environmental diagnosis of the protected coastal areas of the Bahía Blanca Estuary -- Small-scale artisanal fishers and socio-environmental conflicts in estuarine and coastal wetlands -- Estuarine environmental monitoring programs: long term studies -- Environmental education: mud and salt classrooms -- Index.

Description / Table of Contents: Introduction -- Source and Screening of Probiotic Microorganisms -- Application Methods of Probiotics and Options -- Use of Probiotics in Finfish -- Use of Probiotics in Shellfish -- Paraprobiotics in Aquaculture -- Probiotics for Controlling Infectious Diseases -- Probiotics for Biofloc System and Water Quality -- Probiotics as Vaccine Adjuvants -- Modes of Action of Probiotics -- Factors Influencing the Efficacy of Probiotics -- Quality, Safety and Regulatory Issues of Probiotics -- Methods Used for Selecting and Evaluating Probiotics -- Conclusions.

Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.

Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.

Description / Table of Contents: Habitat: Sunlit Rocky Grounds -- Habitat: Shady Rocky Grounds -- Habitat: Dark Caves -- Habitat: Intertidal Zone -- Habitat: Sandy Grounds -- Habitat: Seagrass -- Habitat: Muddy Grounds -- Habitat: Open Waters -- Humans and the Sea.

Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.

Description / Table of Contents: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).

Description / Table of Contents: The Ecology of Plant Litter Decomposition in Stream Ecosystems: An Overview -- Multi-scale Biophysical Factors Driving Plant Litter Dynamics in Streams -- Stoichiometry of Plant Litter Decomposition in Stream Ecosystems -- Global Patterns of Plant Litter Decomposition in Streams -- Plant Litter Decomposition in Intermittent Rivers and Ephemeral Streams -- Plant Litter Decomposition in Terrestrial Ecosystems Compared to Streams -- Biodiversity and Plant Litter Decomposition in Streams -- The Role of Key Plant Species on Litter Decomposition in Streams: Alder as Experimental Model -- Linking Microbial Decomposer Diversity to Plant Litter Decomposition and Associated Processes in Streams -- The Role of Macro Invertebrates on Plant Litter Decomposition in Streams -- The role of Microscopically Small Invertebrates in Plant Litter Decomposition in Streams -- Individual and Interacting Effects of Elevated CO2, Warming, and Hydrologic Intensification on Plant Litter Decomposition in Streams -- Causes and Consequences of Changes in Riparian Vegetation for Plant Litter Decomposition Throughout River Networks -- Effects of Exotic Tree Plantations on Plant Litter Decomposition in Streams -- Salt Modulates Plant Litter Decomposition in Stream Ecosystems -- Pathways, Mechanisms and Consequences of Nutrient-stimulated Plant Litter Decomposition in Streams -- How Toxicants Influence Plant Litter Decomposition in Streams -- Effects of Engineered Nanoparticles on Plant Litter Decomposition in Streams -- The Construction of Plant Litter Decomposition Curves -- Design and Analysis of Laboratory Experiments on Aquatic Plant Litter Decomposition -- Plant Litter Decomposition as a Tool for Stream Ecosystem Assessment -- Plant Litter Decomposition as a Contributor to Stream Ecosystem Service Provision.

Description / Table of Contents: Neuroethological background of marine mammal complexity -- Social extremes and their relation to anthropogenic stress -- Lone, sociable marine mammals and their influence on human attitudes -- Efforts of conserving marine mammals (spaces excluded) -- Conserving marine mammal spaces and habitats -- Conservation relevance of marine mammal social learning and culture -- Marine mammal migrations.

Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Processing method of the original data -- Chapter 3 Grey correlation analysis -- Chapter 4 Grey Clustering Analysis -- Chapter 5 Grey System Modeling -- Chapter 6 Grey Prediction -- Chapter 7 Grey decision-making -- Chapter 8 Grey Linear Programming -- Chapter 9 Grey Dynamic Control.

Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.

Description / Table of Contents: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.

Description / Table of Contents: 1 Aquaculture Productivity Enhancement through Advanced Technologies -- 2 Indigenous fishes as valued genetic resources -- 3 Applications of Next Generation Sequencing in Aquaculture and Fisheries -- 4 Genome Sequencing in Fishes -- 5 Omics in Aquaculture -- 6 Gowth Hormone Transgenesis in Aquaculture -- 7 Genome Editing in Fish Reproduction -- 8 Metabolomics: a Novel Technology for Health Management in Aquaculture -- 9 Epigenetics: Perspectives and Potential in Aquaculture -- 10 Application of Stem Cell Based Technologies in Management of Fisheries Resources -- 11 Molecular Markers in Fisheries and Aquaculture -- 12 Microsatellite Markers for Fish Conservation -- 13 Cryopreservation in Aquaculture -- 14 Nanobiotechnology: Prospects and Applications in Aquaculture -- 15 Application of Nanotechnology for Abiotic Stress Management in Aquaculture -- 16 Nutritional biotechnology to augment aquaculture production -- 17 Colour enhancement in ornamental fishes -- 18 Immunoprophylactic Measures in Aquaculture -- 19 DNA Vaccines for Fish -- 20 Bacteriophage Therapy in Aquaculture: An Overview -- 21 Disease Diagnostic Tools for Health Management in Aquaculture -- 22 Prospect and Challenges of Biofloc Technology for Sustainable Aquaculture Development -- 23 Biofilm in Aquaculture Production -- 24 Bioremediation of Aquatic Environment -- 25 Effects of Pharmaceutical Waste in Aquatic Life -- 26 Biosafety and Biosecurity for Sustainable Aquaculture Development -- 27 Specific Pathogen Free (SPF) Shrimps in Aquaculture -- 28 Enzymes from Aquatic Resources and their Application in Food and Cosmetic Industry -- 29 Biotechnological approaches to valorization of aquaculture bio-wastes and their biomedical applications. .

Description / Table of Contents: Chapter 1. Phenology of photosynthesis in a deciduous broadleaf forest: implications for the carbon cycle in a changing environment -- Chapter 2. Ecological significance of throughfall and stemflow to the carbon cycle in forest ecosystems -- Chapter 3.Forest carbon sequestration in mountainous region in Japan under ongoing climate change: implication for future research -- Chapter 4. Woody biomass change monitoring in temperate montane forests by airborne LiDAR analysis -- Chapter 5. Semi-natural grasslands maintained by controlled burning in Japan - Air and soil temperature and plant diversity -- Chapter 6. Detection and Identification of Phytophthora Pathogens That are Threatening Forest Ecosystems Worldwide -- Chapter 7. Water quality safety and security - from evaluation to control -- Chapter 8. Energy Recovery from Wastewater -- Chapter 9. Management of on-site household wastewater treatment systems (Johkasou) in Japan -- Chapter 10. Predicting fine sediment deposition rate in low-land river channel: Comparison of two adjacent rivers -- Chapter 11. Relationship between forest stand condition and water balance in a forested basin -- Chapter 12. Plant pathogenic oomycetes inhabiting river water are a potential source of infestation in agricultural areas -- Chapter 13. Soil contamination and conservation -- Chapter 14. Evaporation in arid regions -- Chapter 15. Feature Extraction and Analysis of Earthquake Motion -- Chapter 16. Involving the community to manage natural disasters: A study of Japanese disaster risk reduction practices.

Description / Table of Contents: Part 1: Fundamentals -- Chapter 1: Introduction -- Chapter 2: Diatom Classifications: What Purpose Do They Serve? -- Chapter 3: Diatom Taxonomy And Identification Keys -- Chapter 4: Teratologies/Life Cycle/Ecotoxicology -- Part 2: Sensing -- Chapter 5: Microscope Lighting Techniques -- Chapter 6: Microscope Filtering Techniques -- Chapter 7: Automatization Techniques. Slide Scanning -- Part 3: Analysis -- Chapter 8: Segmentation -- Chapter 9: Feature Extraction And Classification -- Chapter 10: Multifocus And Hdr -- Chapter 11: 3d Imaging -- Chapter 12: Morphometrics -- Part 4: Applications -- Chapter 13: Water Quality Assessment -- Chapter 14: Diatoms In Forensic Analysis -- Chapter 15: Benthic Foraminifera And Diatoms As Ecological Indicators.

Description / Table of Contents: 1. An Introduction to the Brazilian Deep-Sea biodiversity -- 2. Water masses and oceanic circulation of the Brazilian continental margin and adjacent abyssal plain -- 3. Continental slope and submarine canyons: benthic biodiversity and human impacts -- 4. Brazilian deep-sea corals -- 5. Chemosynthetic ecosystems on the Brazilian deep-sea margin -- 6. Deep-sea microbes in the Southwestern Atlantic -- 7. The scientific explorations of the deep-sea fishes in Brazil: the known knowns, the known unknowns, and the unknown unknowns -- 8. Living and non-living resources in Brazilian deep waters -- Index -- .

Description / Table of Contents: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.

Description / Table of Contents: Chapter 1. Chemoprevention of Cancer - Past,Present, and Future -- Chapter 2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities -- Chapter 3. Pterostilbene as a Potent Chemopreventive Agent in Cancer -- Chapter 4. Pharmacokinetics and Bioavailability Enhancement of Natural Products -- Chapter 5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention -- Chapter 6. Anti-cancer Effects of Silibinin – The Current Status in Cancer Chemoprevention -- Chapter 7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management -- Chapter 8. Cancer Prevention by Tea Polyphenols -- Chapter 9. The Chemopreventive Power of Isothiocyanates -- Chapter 10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control -- Chapter 11. Anthocyanins and Cancer Prevention -- Chapter 12. Grape ChemopreventiveAgents AgainstAngiogenesis and Metastasis -- Chapter 13. Punicagranatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment -- Chapter 14. Cancer ChemopreventivePotential of Epidermal Growth Factor Receptor Inhibitors from Natural Products -- Chapter 15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-dependent Kinases -- Chapter 16. Pro-apoptotic Properties of Chemopreventive Agents -- Chapter 17. The Use of Anti-inflammatory Agents for Cancer Chemoprevention -- Chapter 18. Combination Chemoprevention by Targeting the Epigenome -- Chapter 19. Perspective – a positive cocktail effect of the bioactive components in the diet.

Description / Table of Contents: Introduction -- Molecular and cellular functions of CTLA-4 pathway -- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond -- Discovery of new immune checkpoints: family grows up -- Mechanisms of resistance to checkpoint blockade therapy -- Molecular events behind adverse effects -- Rational discovery of response biomarkers -- Spatiotemporal changes in checkpoint molecule expression -- Functions of checkpoint molecules beyond immune evasion -- Genetic alterations and checkpoint expression -- Regulations on messenger RNA: wires and nodes -- Folded or degraded in endoplasmic reticulum -- Mono- and poly-ubiquitination: tags for fates -- Lysosome as the black hole for checkpoint molecules -- Phosphorylation: a fast switch for checkpoint signalling -- Palmitoylation as a signal for delivery -- Checkpoints under traffic control: from and to organelles -- Exosome and secretion: action on? -- Macromolecules and antibody-based drugs -- Mechanisms inspired targeting peptides -- Small molecular inhibitors -- Therapeutic development of immune checkpoint blockers -- Concluding remarks.

Description / Table of Contents: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.

Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.

Description / Table of Contents: 1. The Perspective of climate change on aquatic environment and fish production -- 2. Climate Change: Stressor on Marine Buffer System -- 3. Climate Change: Impact on Fauna and Fishing Activity 0f River -- 4. Possible Impact of Climate Change on Fisheries -- 5. Impact of global warming on changing pattern of biodiversity and fish production in inland open waters -- 6. Climate Change and Coral Reef Ecosystem: Impacts and Management Strategies -- 7. Implications of Climate Change on Fisheries and Food Security -- 8. Nexus of climate change with fish production and its implications on livelihood and nutritional security -- 9. Gut microbes and its physiological role in fish: adaptive strategies for climatic variability -- 10. Metabolic adaptation of fishes under different consequences of climate change -- 11. Argulus Parasitism in Aquaculture: An Elevated Temperature Scenario -- 12. Effect of environmental variability on the pigmentation of Fishes -- 13. Climate Change and stress Response in Teleost. 14. Impact of Climate Change on Emergence of Biotoxin in Fish and Shellfish -- 15. Metabolomic response to high temperature stress in murrel Channa striatus and insights for designer feeds -- 16. Feed and feeding management for sustainable growth and health of fish in varying climatic condition -- 17. Vulnerability and Mitigation Approach to Nutritional Pathology for Sustainable Fish Growth in Changing Climatic Conditions -- 18. Technology Prioritization For Climate-Resilient Nutritive Fish -- 19. Role of Dietary supplements in stress amelioration of teleost fishes -- 20. Dealing the hardship in aquaculture nutrition in a changing climatic condition -- 21. Strategies to mitigate climate change-imposed challenges in fish nutrition -- 22. Duckweed-based circular aquaculture for climate resilience and carbon foot-print reduction of fed Aquaculture -- 23. Nutraceuticals in aquaculture: a prospective climate change adaptation strategy -- 24. Broodstock development, induced breeding, and seed production of climbing perch Anabas testudineus: An alternative aquaculture species for changing environment -- 25. Effect of changing environmental factors on reproductive cycle and endocrinology of fishes -- 26. Impact of climate change on fish reproduction and climate-resilient broodstock management -- 27. Nutrition and environment interactions in aquaculture -- 28. Reproductive and maternal nutrition in changing climatic conditions.

Description / Table of Contents: 1 – Presentation and introduction -- 2 – Dedication (to Genevieve Corwin) -- 3 – Comprehensive Italian annotated bibliography on bluefin tuna, Thunnus thynnus (Linnaeus, 1758) -- 4 – Comprehensive Italian annotated bibliography on albacore tuna, Thunnus alalunga (Bonnaterre, 1788) -- 5 – Comprehensive Italian annotated bibliography on small tunas (or: on small tunas species, tbd) -- 6 – Comprehensive Italian annotated blibliography on tropical tunas species -- 7 – Comprehensive Italian annotated bibliography on swordfish, Xiphias gladius, Linnaeus, 1758 -- 8 – Comprehensive Italian annotated bibliography on Mediterranean spearfish, Tetrapturus belone, Rafinesque, 1810, and other Istiophoridae.

Description / Table of Contents: Chapter 1: Water Development, Consumptive Water Uses, and Great Salt Lake -- Chapter 2:Climate Change and Great Salt Lake -- Chapter 3: Relationships between Humans and Great Salt Lake: Dynamics of Change -- Chapter 4: Microbialites of Great Salt Lake -- Chapter 5: Unexpected complexity at salinity saturation: microbial diversity of the north arm of Great Salt Lake -- Chapter 6: Invertebrates and phytoplankton: is salinity the driving factor? -- Chapter 7: Great Salt Lake Artemia: Ecosystem Functions and Services with a Global Reach -- Chapter 8: Importance of Great Salt Lake to Pelagic Birds: Eared Grebes, Phalaropes, Gulls, Ducks, and White Pelicans -- Chapter 9: Great Salt Lake Shorebirds, Their Habitats and Food Base -- Chapter 10: American White Pelicans of Gunnison Island, Great Salt Lake, Utah -- Chapter 11: Amphibians and Reptiles of Antelope Island, Great Salt Lake, Utah -- Chapter 12: Shoreline Plants of Great Salt Lake -- Chapter 13: Invasive plants of Great Salt Lake wetlands: what, where, how, and why? -- Chapter 14: Mercury Bioaccumulation and Biomagnification in Great Salt Lake Ecosystems -- Chapter 15: The Rozel Point Tar Seeps and Their Impact on the Local Biology -- Chapter 16: Great Salt Lake as an astrobiology analogue for ancient Martian hypersaline aqueous systems.

Description / Table of Contents: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.

Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.

Description / Table of Contents: Part I: Introduction And Context -- Chapter 1: Introduction And Context -- Part II: Case Studies -- Chapter 2: Kenya Case Study One -- Chapter 3: Guatemala Case Study -- Chapter 4: Ghana Case Study One -- Chapter 5: Pacific Island Case Study -- Chapter 6: Saudi Arabia Case Study -- Chapter 7: Philippines Case Study One -- Chapter 8: Kenya Case Study Two -- Chapter 9: Tanzania Case Study -- Chapter 10: Indonesia Case Study -- Chapter 11: Panama Case Study -- Chapter 12: Philippines Case Study Two -- Chapter 13: Bangladesh Case Study -- Chapter 14: Ghana Case Study Two -- Chapter 15: Ecuador Case Study -- Chapter 16: Thailand Case Study -- Chapter 17: Peru Case Study -- Part III: Evaluation And Synopsis -- Chapter 18: Evaluation And Synopsis.

Description / Table of Contents: Introduction -- Physical Geography -- Pollution in the Pearl River Estuary -- Trace Metals in the Water Column and Sediments -- Trace Metals in Pearl River Estuary Organisms -- Trace Metal Contamination of Seafood from the Pearl River Estuary -- Trace Metals and Ecotoxicological Effects in the Pearl River Estuary -- Future needs.

Description / Table of Contents: Eosinophils in the tumor microenvironment -- Dendritic cells in the tumor microenvironment -- Resident memory T cells in the tumor microenvironment -- NK cells in the tumor microenvironment -- γδ T cells in tumor microenvironment -- Regulatory T Cells in the Tumor Microenvironment -- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche) -- Langerhans cells in the tumor microenvironment -- Mast cells in the tumor microenvironment -- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine? -- Microglia in the Brain Tumor Microenvironment -- Index.