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  • 1
    Online Resource
    Online Resource
    Immunotherapy for Gastrointestinal Malignancies (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.
    Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .
    Abstract: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .
    Type of Medium: Online Resource
    Pages: XII, 251 p. 34 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564871
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-6487-1
    DOI: 10.1007/978-981-15-6487-1
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Lipid Metabolism in Tumor Immunity (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    URL: https://doi.org/10.1007/978-981-33-6785-2
    DOI: 10.1007/978-981-33-6785-2
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Autophagy in tumor and tumor microenvironment (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    URL: https://doi.org/10.1007/978-981-15-6930-2
    DOI: 10.1007/978-981-15-6930-2
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Obesity and Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    URL: https://doi.org/10.1007/978-981-16-1846-8
    DOI: 10.1007/978-981-16-1846-8
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    New Nanomaterials and Techniques for Tumor-targeted Systems (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Nanotechnology. ; Biomedical Research.
    Description / Table of Contents: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.
    Abstract: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.
    Type of Medium: Online Resource
    Pages: VI, 463 p. 72 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551598
    URL: https://doi.org/10.1007/978-981-15-5159-8
    DOI: 10.1007/978-981-15-5159-8
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cancer Stem Cells: New Horizons in Cancer Therapies (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Stem cells. ; Oncology. ; Medical microbiology. ; Cancer Biology. ; Stem Cell Biology. ; Oncology. ; Medical Microbiology.
    Description / Table of Contents: Chapter 1. Introduction to cancer stem cells -- Chapter 2. Types of Cancer Stem Cells -- Chapter 3. Isolation and Characterization of Cancer Stem Cells (CSCs) -- Chapter 4. Lung and Prostate Cancer Stem Cells -- Chapter 5. A differential role of miRNAs in regulation of breast cancer stem cells -- Chapter 6. Skin stem cells in cancer -- Chapter 7. Ocular Cancer stem cells: Advances in therapeutic interventions -- Chapter 8. Cancer Stem Cells and Tumour Aggressiveness -- Chapter 9. Therapeutic Implication of Cancer Stem Cells.-Chapter 10. Glioblastoma stem cells as a therapeutic target -- Chapter 11. Cancer stem cells and therapeutic angiogenesis -- Chapter 12. Cancer stem cells as a seed for cancer metastasis -- Chapter 13. Functionality of intron specific genes and cancer stem cells in the progression of colorectal cancer -- Chapter 14. Technological advancement in Cancer Stem Cell Research -- Chapter 15. Controversies in Isolation and Characterization of Cancer Stem Cells -- Chapter 16. Targeting therapies for cancer stem cells -- Chapter 17. Targeting Cancer stem cells by nanoenabled drug delivery -- Chapter 18. Cancer Stem Cells in Patients Survival and Therapies in Cancer.-.
    Abstract: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.
    Type of Medium: Online Resource
    Pages: VII, 369 p. 65 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551208
    URL: https://doi.org/10.1007/978-981-15-5120-8
    DOI: 10.1007/978-981-15-5120-8
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Skin Cancer: Pathogenesis and Diagnosis (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biomedical engineering. ; Biochemical markers. ; Nanomedicine. ; Cancers. ; Biomedical Engineering and Bioengineering. ; Biomarkers. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.
    Abstract: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 27 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811603648
    URL: https://doi.org/10.1007/978-981-16-0364-8
    DOI: 10.1007/978-981-16-0364-8
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Genetic Polymorphism and cancer susceptibility (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Genetics. ; Medical genetics. ; Cancers. ; Genetics and Genomics. ; Medical Genetics. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.
    Abstract: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
    Type of Medium: Online Resource
    Pages: XXI, 339 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813366992
    URL: https://doi.org/10.1007/978-981-33-6699-2
    DOI: 10.1007/978-981-33-6699-2
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Immuno-Oncology Crosstalk and Metabolism (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.
    Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
    Abstract: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
    Type of Medium: Online Resource
    Pages: X, 218 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811662263
    URL: https://doi.org/10.1007/978-981-16-6226-3
    DOI: 10.1007/978-981-16-6226-3
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Dietary Research and Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.
    Abstract: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.
    Type of Medium: Online Resource
    Pages: XX, 197 p. 57 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811660504
    URL: https://doi.org/10.1007/978-981-16-6050-4
    DOI: 10.1007/978-981-16-6050-4
    DDC: 571.978
    Language: English
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  • 11
    Online Resource
    Online Resource
    'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Oncology. ; Medical genetics. ; Bioinformatics. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Oncology. ; Medical Genetics. ; Bioinformatics. ; Microsystems and MEMS.
    Description / Table of Contents: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.
    Abstract: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
    Type of Medium: Online Resource
    Pages: XVIII, 499 p. 59 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510670
    URL: https://doi.org/10.1007/978-981-15-1067-0
    DOI: 10.1007/978-981-15-1067-0
    DDC: 571.978
    Language: English
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  • 12
    Online Resource
    Online Resource
    Novel therapeutic approaches for gastrointestinal malignancies (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Nanotechnology. ; Radiology. ; Molecular genetics. ; Cancer Biology. ; Nanotechnology. ; Radiology. ; Molecular Genetics.
    Description / Table of Contents: Chapter 1. Role of selected transcription factors in pancreatic and colorectal cancer growth and metastasis -- Chapter 2. Adiponectin in gastrointestinal malignancies -- Chapter 3. Small molecule-targeted therapies for GI cancers: success and failures -- Chapter 4. Epigenetic biomarkers for the detection of Gastrointestinal Cancers -- Chapter 5. CD151: A Lateral organizer and modulator of Tumor microenvironment in gastrointestinal cancers -- Chapter 6. Targeting Pathways in GI Malignancies -- Chapter 7. Identification of Potential Key Genes Involved In Progression of Gastric Cancer Using Bioinformatics Analysis -- Chapter 8. Recent Development in the biomarkers for the gastric cancer -- Chapter 9. Gastric Cancer and it’s remedy -- Chapter 10. An intergenic variant rs4779584 between SCG5 and GREM1 contributes to the increased risk of colorectal cancer: A meta-analysis -- Chapter 11. Phytochemicals plus nanomaterial’s on colorectal cancer -- Chapter 12. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones? -- Chapter 13. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma -- Chapter 14. Immunotherapy in Gastrointestinal Malignancies -- Chapter 15. The Role of HIF-1α in Hepatocellular Carcinoma.
    Abstract: This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.
    Type of Medium: Online Resource
    Pages: XII, 259 p. 53 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811554711
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-5471-1
    DOI: 10.1007/978-981-15-5471-1
    DDC: 571.978
    Language: English
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  • 13
    Online Resource
    Online Resource
    Therapeutic potential of Cell Cycle Kinases in Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    URL: https://doi.org/10.1007/978-981-19-8911-7
    DOI: 10.1007/978-981-19-8911-7
    DDC: 571.978
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  • 14
    Online Resource
    Online Resource
    Breast Cancer: From Bench to Personalized Medicine (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.
    Abstract: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
    Type of Medium: Online Resource
    Pages: XVII, 536 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811901973
    URL: https://doi.org/10.1007/978-981-19-0197-3
    DOI: 10.1007/978-981-19-0197-3
    DDC: 571.978
    Language: English
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  • 15
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    Online Resource
    Oncology: Genomics, Precision Medicine and Therapeutic Targets (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.
    Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.
    Abstract: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.
    Type of Medium: Online Resource
    Pages: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819915293
    URL: https://doi.org/10.1007/978-981-99-1529-3
    DOI: 10.1007/978-981-99-1529-3
    DDC: 571.978
    Language: English
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  • 16
    Online Resource
    Online Resource
    Polarization Remote Sensing Physics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Atmospheric science. ; Environment. ; Physics. ; Geographical Information System. ; Atmospheric Science. ; Environmental Sciences. ; Applied and Technical Physics.
    Description / Table of Contents: Physical rationale of polarized remote sensing -- Remote sensing of ground objects 1: physical characteristics of multi-angle polarized reflectance -- Remote sensing of ground objects 2: multispectral chemical characteristics of surface polarization reflection -- Remote sensing of ground objects 3: Surface roughness and density structure of polarization reflectance -- Remote sensing of land surfaces 4: Signal-to-background high contrast ratio filtering of polarimetric reflections -- Remote sensing of land surfaces 5: Characteristics of radiative transfer on surface polarization -- Atmospheric remote sensing 1: the nature and physical characteristics of the full-sky polarization pattern -- Atmospheric remote sensing 2: Neutral point areas of atmospheric polarization and land-atmosphere parameter separation -- Atmospheric remote sensing 3: atmospheric polarization characteristics and multi-angular three-dimensional chromatography -- New areas in polarization 1: bionic polarization for automatic navigation using the Earth’s polarization vector field -- New areas in polarization 2: remote sensing for advanced space exploration and global change research.
    Abstract: This book elaborates on the physical principles of polarization remote sensing. It explains the reflective characteristics of surface objects and atmosphere separately, including theory, experiment, instrument and application. In addition, it introduces how polarization remote sensing works in advanced research programs as it can be used in aviation, astronomy, disaster risk prevention and navigation fields. This book serves as a fundamental and comprehensive reference for researchers and students.
    Type of Medium: Online Resource
    Pages: XXVII, 337 p. 305 illus., 196 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811528866
    Series Statement: Springer Remote Sensing/Photogrammetry,
    URL: https://doi.org/10.1007/978-981-15-2886-6
    DOI: 10.1007/978-981-15-2886-6
    DDC: 910.285
    Language: English
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  • 17
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    Online Resource
    Patterns in Past Settlements: Geospatial Analysis of Imprints of Cultural Heritage on Landscapes (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Geography. ; Cultural property. ; Archaeology. ; Geographical Information System. ; Regional Geography. ; Archaeology and Heritage.
    Description / Table of Contents: Landscape archaeology: role of remote sensing and GIS -- Landscape morphology and spatial patterning of archaeological signatures when viewed from above -- The science and technology of remote sensing in context of archaeology -- GIS: an array of exceptional tools for archaeology -- RS and GIS for preservation, conservation and management.
    Abstract: This book is an introduction to a new branch of archaeology that scrutinises landscapes to find evidence of past human activity. Such evidence can be hard to detect at ground-level, but may be visible in remote sensing (RS) imagery from aerial platforms and satellites. Drawing on examples from around the world as well as from her own research work on archaeological sites in India (including Nalanda, Agra, Srirangapatna, Talakadu, and Mahabalipuram), the author presents a systematic process for integrating this information with historical spatial records such as old maps, paintings, and field surveys using Geographic Information Systems (GIS) to gain new insights into our past. Further, the book highlights several instances where these insights are actionable -- they have been used to identify, understand, conserve, and protect the fragile remnants of our past. This book will be of particular interest not only to researchers in archaeology, history, art history, and allied fields, but to governmental and non-governmental professionals working in cultural heritage protection and conservation.
    Type of Medium: Online Resource
    Pages: XXIII, 168 p. 86 illus., 81 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811574665
    Series Statement: Springer Remote Sensing/Photogrammetry,
    URL: https://doi.org/10.1007/978-981-15-7466-5
    DOI: 10.1007/978-981-15-7466-5
    DDC: 910.285
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  • 18
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    Online Resource
    Theory and Practice of GNSS Reflectometry (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Telecommunication. ; Oceanography. ; Signal processing. ; Aerospace engineering. ; Astronautics. ; Geographical Information System. ; Communications Engineering, Networks. ; Ocean Sciences. ; Signal, Speech and Image Processing . ; Aerospace Technology and Astronautics.
    Description / Table of Contents: Introduction -- GNSS Signal -- Multipath Propagation -- Modeling and Simulation of GNSS Multipath Signals -- GNSS-R Receiver -- Data Processing for GNSS Reflectometry -- Wind Speed and Direction Retrieval -- Sea Surface Altimetry and Wave Height Estimation -- Sea Ice Detection -- Tsunami Detection and Parameter Estimation -- Snow Depth and Snow Water Equivalent Estimation -- Soil Moisture Retrieval.
    Abstract: This is the first authored English book completely focused on global navigation satellite system reflectometry (GNSS-R). It consists of two main parts: the fundamental theory; and major applications, which include ocean altimetry, sea surface wind speed retrieval, snow depth measurement, soil moisture measurement, tsunami detection and sea ice detection. Striking a healthy balance between theory and practice, and featuring in-depth studies and extensive experimental results, the book introduces beginners to the fundamentals, while preparing experienced researchers to pursue advanced investigations and applications in GNSS-R. .
    Type of Medium: Online Resource
    Pages: XI, 369 p. 257 illus., 244 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811604119
    Series Statement: Navigation: Science and Technology, 9
    URL: https://doi.org/10.1007/978-981-16-0411-9
    DOI: 10.1007/978-981-16-0411-9
    DDC: 910.285
    Language: English
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  • 19
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    Online Resource
    A New GeoComputation Pattern and Its Application in Dual-Evaluation (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Image processing Digital techniques. ; Computer vision. ; Geography. ; Geographical Information System. ; Computer Imaging, Vision, Pattern Recognition and Graphics. ; Geography.
    Description / Table of Contents: Foreword -- Preface -- Part I The Theory of a New GC Pattern -- Research background -- Relevant Research -- The New GC Pattern -- GeoComputation Language -- Part II The Practice of the New GC Pattern -- Implementation of G language -- Dual evaluation system of Territorial and Spatial planning -- Part III The Dual-evaluation geocomputation model -- Individual Evaluation -- Integrated Evaluation -- Optional Evaluations -- Comparative Analysis -- Map Analysis -- Appendix Layer Style of Thematic Map.
    Abstract: This book introduces Document As System (DAS), a new GeoComputation pattern, which is also a new GIS application pattern. It uses the GeoComputation language (G language) to describe and execute complex spatial analysis model in the MS Word environment, which solves the bottleneck problem of GIS application, makes GIS become a popular tool for spatial data analysis from the spatial data visualization tool, and plays an important role in the wide application of GIS technology. This book systematically introduces the theory related to the new GeoComputation pattern and the application example in the “dual-evaluation” of territorial and spatial planning, which can be used as a learning and reference manual for GIS related professionals and business personnel engaged in the “dual-evaluation” of territorial and spatial planning.
    Type of Medium: Online Resource
    Pages: XIX, 277 p. 155 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813364325
    URL: https://doi.org/10.1007/978-981-33-6432-5
    DOI: 10.1007/978-981-33-6432-5
    DDC: 910.285
    Language: English
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  • 20
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    Online Resource
    Geospatial Data Science in Healthcare for Society 5.0 (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Quantitative research. ; Artificial intelligence. ; Medical care. ; Geographical Information System. ; Data Analysis and Big Data. ; Artificial Intelligence. ; Health Care.
    Description / Table of Contents: Potential of Geospatial Data in Healthcare for Society 5.0 -- Geospatial Health Data Analytics for Society 5.0 -- Relevance of spatio-temporal data visualisation techniques in healthcare system -- GIS and Remote Sensing for public health -- Infectious diseases and their tracking in GIS.
    Abstract: The book introduces a variety of latest techniques designed to represent, enhance, and empower multi-disciplinary approaches of geographic information system (GIS), artificial intelligence (AI), deep learning (DL), machine learning, and cloud computing research in healthcare. It provides a unique compendium of the current and emerging use of geospatial data for healthcare and reflects the diversity, complexity, and depth and breadth of this multi-disciplinary area. This book addresses various aspects of how smart healthcare devices can be used to detect and analyze diseases. Further, it describes various tools and techniques to evaluate the efficacy, suitability, and efficiency of geospatial data for health-related applications. It features illustrative case studies, including future applications and healthcare challenges. This book is beneficial for computer science and engineering students and researchers, medical professionals, and anyone interested in using geospatial data in healthcare. It is also intended for experts, offering them a valuable retrospective and a global vision for the future, as well as for non-experts who are curious to learn about this important subject. The book presents an effort to draw how we can build health-related applications using geospatial big data and their subsequent analysis.
    Type of Medium: Online Resource
    Pages: VIII, 318 p. 116 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811694769
    Series Statement: Disruptive Technologies and Digital Transformations for Society 5.0,
    URL: https://doi.org/10.1007/978-981-16-9476-9
    DOI: 10.1007/978-981-16-9476-9
    DDC: 910.285
    Language: English
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  • 21
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    Online Resource
    Remote Sensing of Urban Green Space (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Sustainability. ; Environmental monitoring. ; Geography. ; Geographical Information System. ; Sustainability. ; Environmental Monitoring. ; Regional Geography.
    Description / Table of Contents: Introduction -- Remote Sensing Data Preprocessing Technology -- Remote Sensing Extraction Technology of Urban Vegetation Information -- Measurement Technology of Two-Dimensional Urban Green Space -- Measurement Technology of Three-Dimensional Urban Green Space -- Construction Technology of Multi-Scale Perception Model of Urban Green Space -- Evaluation Technology of Remote Sensing in Urban Green Space.
    Abstract: This book presents a systematic study of urban green space remote sensing from multi-dimensional and multi-scale technologies. On the basis of introducing the connotation, science and application value of urban green space, this book focuses on the two-dimensional and three-dimensional information extraction technology of urban vegetation, two-dimensional and three-dimensional measurement technology of urban green space and multi-scale perception technology and discusses the remote sensing evaluation method of urban green space. By exploring the technical advantages of ‘satellite remote sensing + aerial remote sensing + near-ground remote sensing’, urban green space remote sensing promotes the development of urban vegetation research from two-dimensional to three-dimensional observation, so that the quantity, quality and human perception of urban vegetation can be measured. In each chapter, an individual technology/method is introduced, and several cases are cited to demonstrate its practical application. This book offers a valuable reference guide for practitioners in urban planning, landscape greening, environmental protection and urban management, as well as teachers and graduate students engaged in urban remote sensing research.
    Type of Medium: Online Resource
    Pages: XVI, 240 p. 164 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819907038
    URL: https://doi.org/10.1007/978-981-99-0703-8
    DOI: 10.1007/978-981-99-0703-8
    DDC: 910.285
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  • 22
    Online Resource
    Online Resource
    Earth Data Analytics for Planetary Health (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Environmental health. ; Public health. ; Sustainability. ; Geographical Information System. ; Environmental Health. ; Public Health. ; Sustainability.
    Description / Table of Contents: Topic 1. Environmental Quality Monitoring -- Chap1: Applications of Remote Sensing for Air Pollution Monitoring in Thailand: An Early Warning for Public Health -- Chap2: A novel evaluation of air pollution impact from stationary emission sources to ambient air quality via time-series Granger causality -- Chap3: Groundwater Recharge, Monitoring and Finding Suitable Areas for Groundwater Recharge in Northeast Thailand -- Topic 2. Environmental Changes and Health -- Chap4: Health benefits of air pollution reduction during the COVID-19 lockdown period in Thailand using a machine learning algorithm -- Chap5: Satellite-Derived Vegetation Indices as A Criterion for Assessing Green Exposure that is Related to Human Health Burdens -- Chap6: Five common myths about land use change and infectious disease -- Topic 3. Data and Methodological Issues for Health Studies -- Chap7: Geospatial Environmental Data for Planetary Health Applications -- Chap8: Delineating zones of disease diffusion from the amenity-sharing network in Peninsular Malaysia -- Chap9: Approaches for spatial and temporal-spatial clustering analysis in avian influenza outbreaks -- Chap10: Detecting urban form using remote sensing: spatiotemporal research gaps for sustainable environment and human health.
    Abstract: Planetary health involves complex spatial–temporal interactions among agents, hosts, and earth environment. Due to rapid technical development of geomatics, including geographic information systems (GIS) and remote sensing (RS) in the era of big data analytics, therefore, earth data analytics has become one of the important approaches for monitoring earth surface process and measuring of the effects of environment changes on all humans and other living organisms on earth. Various methods in earth data analytics, including spatial–temporal statistics, spatial evolutionary algorithms, remote sensing image analysis, wireless geo-sensors, and location-based analytics, are an emerging discipline in understanding complex interactions in planetary health. This edited book provides a broad focus on methodological theories of earth data analytics and their applications to measuring the process of planetary health, with the goal to build scientific understanding on how geospatial analytics can provide valuable insights in measuring environmental risks in Southeast Asian regions. It is collection of selected papers covering both theoretical and empirical studies focusing on topics relevant to spatial perspectives on planetary health and environmental exposure studies. The book is written for senior undergraduates, graduate students, lecturers, and researchers in applications of geospatial technologies for public health and environmental studies.
    Type of Medium: Online Resource
    Pages: IX, 217 p. 60 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811987656
    Series Statement: Atmosphere, Earth, Ocean & Space,
    URL: https://doi.org/10.1007/978-981-19-8765-6
    DOI: 10.1007/978-981-19-8765-6
    DDC: 910.285
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  • 23
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    Online Resource
    Remote Sensing Intelligent Interpretation for Mine Geological Environment : From Land Use and Land Cover Perspective (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Machine learning. ; Signal processing. ; Geology. ; Environmental monitoring. ; Geographical Information System. ; Machine Learning. ; Signal, Speech and Image Processing . ; Geology. ; Environmental Monitoring.
    Description / Table of Contents: Preface.-Mine geological environment: An overview.-Multimodal remote sensing science and technology.-Deep learning technology for remote sensing intelligent interpretation.-Remote sensing interpretation signs of mine land occupation type -- Mine remote sensing dataset construction for multi-level tasks -- Mine target detection by remote sensing and deep learning -- Mine remote sensing scene classification by deep learning -- Mine land occupation classification based on machine learning and remote sensing images -- Mine land occupation classification based on deep learning and remote sensing images -- Concluding remarks.
    Abstract: This book examines the theory and methods of remote sensing intelligent interpretation based on deep learning. Based on geological and environmental effects on mines, this book constructs a set of systematic mine remote sensing datasets focusing on the multi-level task with the system of “target detection→scene classification→semantic segmentation." Taking China’s Hubei Province as an example, this book focuses on the following four aspects: 1. Development of a multiscale remote sensing dataset of the mining area, including mine target remote sensing dataset, mine (including non-mine areas) remote sensing scene dataset, and semantic segmentation remote sensing dataset of mining land cover. The three datasets are the basis of intelligent interpretation based on deep learning. 2. Research on mine target remote sensing detection method based on deep learning. 3. Research on remote sensing scene classification method of mine and non-mine areas based on deep learning. 4. Research on the fine-scale classification method of mining land cover based on semantic segmentation. The book is a valuable reference both for scholars, practitioners and as well as graduate students who are interested in mining environment research.
    Type of Medium: Online Resource
    Pages: XII, 246 p. 110 illus., 89 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811937392
    URL: https://doi.org/10.1007/978-981-19-3739-2
    DOI: 10.1007/978-981-19-3739-2
    DDC: 910.285
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  • 24
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    Online Resource
    Temporal and Spatial Environmental Impact of the COVID-19 Pandemic (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Natural disasters. ; Environmental sciences Social aspects. ; Atmospheric science. ; Geographical Information System. ; Natural Hazards. ; Environmental Social Sciences. ; Atmospheric Science.
    Description / Table of Contents: Overview Of Geospatial Science And Technology -- Geospatial Appraisal Of Vegetation Health And Air Quality Of Delhi During Pre And Post Lockdown Phase Through Multi-Criteria Decision Model -- Pandemic Effect Of Covid-19: Identification, Present Scenario And Preventive Measures -- Impact Of Lockdown (Covid-19) On Air Pollution In India -- Impact Of Covid-19 Pandemic On Environmental Awareness: A Case Study Of Hyderabad City -- Examination Of Radiation Distribution And Its Relation With Stress Degree Day Index In Some Crops Of Yamne River Catchment In Arunachal Pradesh During Pre And Post Covid Times -- Covid 19 And Its Impact On Urban Health Care System -- Impact Of Covid-19 Pandemic On Education Sector Of Kashmir Valley Its Challenges And Future Prospects -- A Study On Socio-Economic Impact Of Covid 19 Pandemic On Tour Operators Of Vishakhapatnam City, Andhra Pradesh -- A Study On Problems Faced By The Street Vendors In Hyderabad City Post Covid-19 Pandemic.
    Abstract: This book identifies, evaluates and reports the impacts of the COVID-19 pandemic on the physical, biological and socioeconomic environment, using the science and technology of geoinformatics. It encourages the environmental considerations in the future city and policy planning and decision-making. For example, according to the World Health Organization, 80% of people living in cities are exposed to polluted air that exceeds healthy levels. City planners have applied the developing concepts of sustainability to modern debates over how cities and regions should be reviewed, regenerated and reformed since the introduction of the concept in developmental science. During the COVID-19 pandemic, a remarkable drop in air pollution has been observed in India and other countries, which has accelerated the shift to green and sustainable development. Geoinformatics can provide solutions and resources for local, sustainable activities in education, health, sustainable agriculture, resource management and related fields. This book serves researchers in a variety of areas, including hazards, land surveys, remote sensing, cartography, geophysics, geology, natural resources, environment and geography.
    Type of Medium: Online Resource
    Pages: X, 155 p. 68 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819919345
    Series Statement: Advances in Geographical and Environmental Sciences,
    URL: https://doi.org/10.1007/978-981-99-1934-5
    DOI: 10.1007/978-981-99-1934-5
    DDC: 910.285
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  • 25
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    Online Resource
    Regulation of Cancer Immune Checkpoints : Molecular and Cellular Mechanisms and Therapy (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Immunology. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Molecular and cellular functions of CTLA-4 pathway -- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond -- Discovery of new immune checkpoints: family grows up -- Mechanisms of resistance to checkpoint blockade therapy -- Molecular events behind adverse effects -- Rational discovery of response biomarkers -- Spatiotemporal changes in checkpoint molecule expression -- Functions of checkpoint molecules beyond immune evasion -- Genetic alterations and checkpoint expression -- Regulations on messenger RNA: wires and nodes -- Folded or degraded in endoplasmic reticulum -- Mono- and poly-ubiquitination: tags for fates -- Lysosome as the black hole for checkpoint molecules -- Phosphorylation: a fast switch for checkpoint signalling -- Palmitoylation as a signal for delivery -- Checkpoints under traffic control: from and to organelles -- Exosome and secretion: action on? -- Macromolecules and antibody-based drugs -- Mechanisms inspired targeting peptides -- Small molecular inhibitors -- Therapeutic development of immune checkpoint blockers -- Concluding remarks.
    Abstract: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
    Type of Medium: Online Resource
    Pages: X, 653 p. 105 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532665
    Series Statement: Advances in Experimental Medicine and Biology, 1248
    URL: https://doi.org/10.1007/978-981-15-3266-5
    DOI: 10.1007/978-981-15-3266-5
    DDC: 571.978
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  • 26
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    Online Resource
    Histone Mutations and Cancer (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Molecular genetics. ; Proteins . ; Cancer Biology. ; Molecular Genetics. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
    Abstract: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
    Type of Medium: Online Resource
    Pages: VII, 96 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581045
    Series Statement: Advances in Experimental Medicine and Biology, 1283
    URL: https://doi.org/10.1007/978-981-15-8104-5
    DOI: 10.1007/978-981-15-8104-5
    DDC: 571.978
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  • 27
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    Online Resource
    Pharmacotherapeutic Botanicals for Cancer Chemoprevention (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Medical genetics. ; Pharmaceutical chemistry. ; Bioinformatics. ; Cancer Biology. ; Medical Genetics. ; Pharmaceutics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.
    Abstract: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 120 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811559990
    URL: https://doi.org/10.1007/978-981-15-5999-0
    DOI: 10.1007/978-981-15-5999-0
    DDC: 571.978
    Language: English
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    Online Resource
    Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.
    Abstract: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544316
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-4431-6
    DOI: 10.1007/978-981-15-4431-6
    DDC: 571.978
    Language: English
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  • 29
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    Online Resource
    Role of Exosomes in Biological Communication Systems (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Human physiology. ; Diseases. ; Oncology. ; Regenerative medicine. ; Cancer Biology. ; Human Physiology. ; Diseases. ; Oncology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches -- Chapter 2. Characterization and fine structure of exosomes -- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication -- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes -- Chapter 5. The interplay between exosomes and spermatozoa -- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine -- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes -- Chapter 8. Exosomes in Neurodegenerative Disorders -- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases -- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers -- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease -- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases -- Chapter 13. Cancer cells-derived Exosomes and Metastasis -- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression -- Chapter 15. Exosomes: the crucial element in the prostate cancer -- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis -- Chapter 17. Exosomes in drug delivery -- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.
    Abstract: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 373 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811565991
    URL: https://doi.org/10.1007/978-981-15-6599-1
    DOI: 10.1007/978-981-15-6599-1
    DDC: 571.978
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  • 30
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    Online Resource
    Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Immunology. ; Cytology. ; Cancer Biology. ; Immunology. ; Cell Biology.
    Description / Table of Contents: Chapter 1. History of oncotherapies in cancer biology -- Chapter 2. Electrochemical Sensors and Biosensors for the Detection of Cancer Biomarkers and Drugs -- Chapter 3. Cell cycle arrest: An impending therapeutic strategy to curb cancer -- Chapter 4. Apoptotic cell death: important cellular process as chemotherapeutic target -- Chapter 5. Regulatory roles of autophagy in cancer -- Chapter 6. ROS and Oxidative Stress in Cancer: Recent Advances -- Chapter 7. Inflammatory mediators: Potential drug targets in cancer -- Chapter 8. Pharmacologic modulation of the immune response against tumours in the elderly. Chapter 9. Angiogenesis: A Therapeutic Target for Cancer -- Chapter 10. Metastasis: A major driver of cancer pathogenesis -- Chapter 11. Designing Personalized and Innovative Novel Drug Therapies For Cancer Treatment.
    Abstract: This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.
    Type of Medium: Online Resource
    Pages: XIII, 228 p. 28 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811575860
    URL: https://doi.org/10.1007/978-981-15-7586-0
    DOI: 10.1007/978-981-15-7586-0
    DDC: 571.978
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  • 31
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    Online Resource
    Emerging Trends in Nanomedicine (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Microsystems and MEMS.
    Description / Table of Contents: Chapter 1. Strategies to improve oral delivery of natural anticancer molecules -- Chapter 2. Nanoparticles catalyzing enzymatic reactions: recent developments and future prospects -- Chapter 3. Biogenic silver nanoparticles: A potent therapeutic agent -- Chapter 4. Translational studies of nanofibers-based scaffold for skin and bone tissue regeneration -- Chapter 5. Functional Dendritic Coatings for Biomedical Implants -- Chapter 6. Application of nanotherapeutics for combating human protozoan parasitic infections.
    Abstract: This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.
    Type of Medium: Online Resource
    Pages: XIV, 240 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599200
    URL: https://doi.org/10.1007/978-981-15-9920-0
    DOI: 10.1007/978-981-15-9920-0
    DDC: 571.978
    Language: English
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  • 32
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    Online Resource
    Biomarkers and Biosensors for Cervical Cancer Diagnosis (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumor markers. ; Medical screening. ; Materials. ; Detectors. ; Cancer Biology. ; Tumour Biomarkers. ; Cancer Screening. ; Sensors and biosensors.
    Description / Table of Contents: Chapter 1. An Introduction to Cancer Biomarkers -- Chapter 2. Cervical Cancer -- Chapter 3. Potential Biomarkers for Early Diagnosis of Cervical Cancer -- Chapter 4. Methods for Screening of Cervical Cancer: State of Art -- Chapter 5. Electrochemical DNA Biosensors for Cervical Cancers -- Chapter 6. Optical DNA based Sensors for Cervical Cancers -- Chapter 7. Other Biosensors for Cervical Cancer Detection.
    Abstract: This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.
    Type of Medium: Online Resource
    Pages: IX, 115 p. 18 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811625862
    URL: https://doi.org/10.1007/978-981-16-2586-2
    DOI: 10.1007/978-981-16-2586-2
    DDC: 571.978
    Language: English
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  • 33
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    Online Resource
    Methods in Cancer Stem Cell Biology (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biology Technique. ; Stem cells. ; Cancer Biology. ; Biological Techniques. ; Cancer Stem Cells. ; Stem Cell Biology.
    Description / Table of Contents: 1. On the origin of cancer -- 2. Culture of Cells: Basic Principles -- 3. Stem cell culture from embryos -- 4. Reprogramming of normal cells -- 5. Maintenance of human Pluripotent Stem Cells -- 6. Identification of cancer stem cells by different molecular markers -- 7. Enrichment of Cancer Stem Cell from malignant tumor -- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line -- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells -- 10. Quick method to assess non-mutagenic carcinogens with iPS cells -- 11. Self-renewal potential of caner stem cells -- 12. Differentiation potential of cancer stem cells in vitro -- 13. Tumor Angiogenesis by cancer stem cells in vivo -- 14. Invasion and Metastatic potential of cancer stem cells in vitro -- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro -- 17. Tumorigenic potential of cancer stem cells in vivo -- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells -- 19. In-vitro evaluation of anti-cancer stem cell drugs -- 20. In vitro Tumoroid Model Using Cancer Stem Cells.
    Abstract: This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters if this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. .
    Type of Medium: Online Resource
    Pages: XVII, 243 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819913312
    URL: https://doi.org/10.1007/978-981-99-1331-2
    DOI: 10.1007/978-981-99-1331-2
    DDC: 571.978
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    Online Resource
    Hypoxia in Cancer: Significance and Impact on Cancer Therapy (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Cancers. ; Cancer Therapy. ; Cancer Biology. ; Tumour Immunology.
    Description / Table of Contents: Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy – Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance.
    Abstract: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
    Type of Medium: Online Resource
    Pages: XV, 447 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903139
    URL: https://doi.org/10.1007/978-981-99-0313-9
    DOI: 10.1007/978-981-99-0313-9
    DDC: 571.978
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    Online Resource
    Theranostics Approaches to Gastric and Colon Cancer (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Gastroenterology. ; Oncology. ; Genetics. ; Cancer Biology. ; Gastroenterology. ; Oncology. ; Genetics and Genomics.
    Description / Table of Contents: Chapter 1. Therapeutic role of Phytochemicals in Colorectal cancer -- Chapter 2. Adiponectin Signaling In Colorectal Cancer -- Chapter 3. Role of Matrix Metalloproteinases in Colorectal Cancer -- Chapter 4. The Role of Hypoxia-Inducible Factor 1- Alpha in Colorectal Cancer -- Chapter 5. Mechanisms and pathways of metabolic reprogramming of colorectal cancer -- Chapter 6. Targeting metabolic reprogramming of colorectal cancer -- Chapter 7. Understanding colorectal cancer: the basics -- Chapter 8. Molecular signaling pathways involved in gastric cancer chemoresistance -- Chapter 9. Meta-analysis reveals no significant association of EPHX1 Tyr113His and His139Arg polymorphisms with the colorectal cancer risk -- Chapter 10. Meta-analysis of genetic variants in alcohol metabolizing enzymes and their association with colorectal cancer risk -- Chapter 11. Gut microbiota as signatures in non-communicable diseases and mucosal immunity -- Chapter 12. Immunotherapy for Colon Cancer: Recent Perspectives -- Chapter 13. Nanotechnology Applications in Gastric cancer. .
    Abstract: This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.
    Type of Medium: Online Resource
    Pages: XIII, 250 p. 26 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811520174
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-2017-4
    DOI: 10.1007/978-981-15-2017-4
    DDC: 571.978
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  • 36
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    Online Resource
    Genetics and Epigenetics of Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    URL: https://doi.org/10.1007/978-981-19-9925-3
    DOI: 10.1007/978-981-19-9925-3
    DDC: 571.978
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  • 37
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    Online Resource
    Cancer Cell Metabolism: A Potential Target for Cancer Therapy (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Chapter 1: Cancer cell metabolism: Solid tumor vs non-solid tumor -- Chapter 2: Reprogramming of cancer cell metabolism: Warburg and Reverse Warburg hypothesis -- Chapter 3: Molecular aspects of cancer cell metabolism: Altered glycolysis and lipid metabolism -- Chapter 4: Understanding the metabolic cross-talk between cancer cells and cancer-associated fibroblasts -- Chapter 5: Metabolic cross-talk between cancer cells and tumor microenvironment -- Chapter 6: Role of autophagy in cancer cell metabolism -- Chapter 7: Role of c-Met/HGF axis in altered cancer metabolism -- Chapter 8: Recent advances in drug development targeting cancer metabolism -- Chapter 9: Clinical relevance of “Diagnostic markers” in cancer metabolism -- Chapter 10: Alterations in Metabolite-driven Gene Regulation in Cancer Metabolism -- Chapter 11: Role of Phytochemicals in Cancer Cell Metabolism Regulation.
    Abstract: This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.
    Type of Medium: Online Resource
    Pages: XIII, 184 p. 29 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811519918
    URL: https://doi.org/10.1007/978-981-15-1991-8
    DOI: 10.1007/978-981-15-1991-8
    DDC: 571.978
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  • 38
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    Online Resource
    Cancer Biomarkers in Diagnosis and Therapeutics (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Tumor markers. ; Cancer. ; Cancer Treatment. ; Nanomedicine. ; Tumour Biomarkers. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Introduction to cancer biomarkers -- Chapter 2.Technologies for identification and validation of cancer biomarkers -- Chapter 3. BIOMARKERS FOR CANCER DRUG DEVELOPMENT -- Chapter 4. Clinical proteomics: diagnostics and prognostic markers of Cancer -- Chapter 5.Microbiome as cancer biomarkers -- Chapter 6. Predictive biomarkers for anticancer drugs -- Chapter 7. Biomarkers in Cancer Survival and Drug Resistance -- Chapter 8. Biomarkers in tumor recurrence and metastasis -- Chapter 9. Biomarkers for Cancer Immunotherapy -- Chapter 10. Role of Biomarkers in Personalized Medicine -- Chapter 11.Development of Novel Cancer Biomarkers for Diagnosis and Prognosis -- Chapter 12. Nanotechnology for Cancer Biomarkers.
    Abstract: This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
    Type of Medium: Online Resource
    Pages: XII, 365 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811657597
    URL: https://doi.org/10.1007/978-981-16-5759-7
    DOI: 10.1007/978-981-16-5759-7
    DDC: 571.978
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  • 39
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    Online Resource
    Cancer Stem Cells: Basic Concept and Therapeutic Implications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
    Abstract: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
    Type of Medium: Online Resource
    Pages: XVI, 372 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931859
    URL: https://doi.org/10.1007/978-981-99-3185-9
    DOI: 10.1007/978-981-99-3185-9
    DDC: 571.978
    Language: English
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    Online Resource
    Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Molecular genetics. ; Medical genetics. ; Biomaterials. ; Nucleic acids. ; Cancer Biology. ; Molecular Genetics. ; Medical Genetics. ; Nucleic Acid.
    Description / Table of Contents: Chapter 1_Epigenetic modifying enzymes. -Chapter 2_Epigenetic modifying enzymes implicated in cancer. -Chapter 3_Classification of histone deacetylases (HDACs). -Chapter 4_Implications of 18 HDAC isoforms in therapeutically monotonous cancers. –Chapter 5_Possible Mechanisms of HDACs in Cancer development -- Chapter 6_Different strategies employed for circumventing cancer resistance (chemo and radio) and mitigating toxicity. -Chapter 7_Limitations of conventional therapeutic regimens in treating cancer. -Chapter 8_Overview of epidrugs with special emphasis on HDAC inhibitors (HDACi) -- Chapter 9_HDAC inhibitors as promising epidrugs for treating cancer. -Chapter 10_ HDAC inhibitors in anticancer monotherapy. -Chapter 11_Distinct groups of histone deacetylase inhibitors (HDACi) based on the structural distinction, HDACs targeted. -Chapter 12_Limited efficacy of HDAC inhibitor-based monotherapy. -Chapter 13_Resistance mechanisms generated by cancer cells against HDACi based monotherapy. -Chapter 14_ Toxicity issue of HDAC inhibitor based monotherapy. -Chapter 15_Combinatorial therapeutic strategies of HDACi. -Chapter 16_Designing Selective HDACi using computational and medicinal chemistry approach. -Chapter 17. Current therapeutic challenges and future directions. .
    Abstract: This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.
    Type of Medium: Online Resource
    Pages: XVII, 258 p. 27 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811581793
    URL: https://doi.org/10.1007/978-981-15-8179-3
    DOI: 10.1007/978-981-15-8179-3
    DDC: 571.978
    Language: English
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    Online Resource
    Translational Research in Breast Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Cancer Biology. ; Biomedical Research. ; Medical Biochemistry.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Translational Research in Surgical Oncology: Introduction and My Own Experience as a Surgeon-Scientist -- Part II. Breast Cancer Biology and Cell Signaling Pathways -- Chapter 2. Phospholipase Signaling in Breast Cancer -- Chapter 3. HER2 Signaling in Breast Cancer -- Chapter 4. Ras Signaling in Breast Cancer -- Chapter 5. Epigenetic Regulation in Breast Cancer -- Chapter 6. Role of tRNAs in Breast Cancer Regulation -- Chapter 7. Fusion Genes in Breast Cancer -- Chapter 8. DNA Damage Repair Inhibitor for Breast Cancer Treatment -- Part III. Cancer Stem Cell and Tumor Heterogeneity in Breast Cancer -- Chapter 9. Breast Cancer Metastasis -- Chapter 10. Single Cell Genomics for Tumor Heterogeneity -- Chapter 11. Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics -- Chapter 12. Cancer Stem Cell in Immune Microenvironment -- Chapter 13. Theranostics for Breast Cancer Stem Cells -- Chapter 14. Patient-Derived Xenograft Models in Breast Cancer Research -- Part IV Biomarkers for Precision Medicine in Breast Cancer Patients -- Chapter 15. Proteomic Interrogation in Cancer Biomarker -- Chapter 16. Next-Generation Sequencing-Based Biomarkers in Breast Cancer -- Chapter 17. Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA -- Chapter 18. Current Biomarkers for Precision Medicine in Breast Cancer -- Chapter 19. The Potential Predictors in Chemotherapy Sensitivity -- Chapter 20. Hormone Resistance -- Part V. Managing High Risk Women -- Chapter 21. High-Risk Population Based on BC Risk Factors -- Chapter 22. Breast Cancer-Related Low Penetrance Genes -- Chapter 23. Rare Coding Variants Associated with Breast Cancer -- Chapter 24. Multigene Panel Testing for Hereditary Cancer and Genetic Counseling -- Chapter 25. BRCA and Breast Cancer-Related High-Penetrance Genes -- Part VI. Next Generation Clinical Research -- Chapter 26. Clinical Databases for Breast Cancer Research -- Chapter 27. Care for Breast Cancer Survivors -- Chapter 28. Considerations in Oncoplastic Surgery -- Chapter 29. Diet Before and After Breast Cancer -- Chapter 30. Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer -- Chapter 31. Minimal Invasive and Individualizing Management of the Axillary Nodes -- Chapter 32. Malignant Phyllodes of Breast -- Chapter 33. Next-Generation Clinical Trials and Research with Successful Collaborations -- Part VII. Epilogue -- Chapter 34. Transformation of the Patient and Society: A Patient Survivors’ Group and Breast Cancer Awareness Campaign.
    Abstract: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
    Type of Medium: Online Resource
    Pages: IX, 630 p. 122 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813296206
    Series Statement: Advances in Experimental Medicine and Biology, 1187
    URL: https://doi.org/10.1007/978-981-32-9620-6
    DOI: 10.1007/978-981-32-9620-6
    DDC: 571.978
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    Online Resource
    Polyphenols-based Nanotherapeutics for Cancer Management (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Nanomedicine. ; Immunology. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology. ; Immunology. ; Cancer Stem Cells.
    Description / Table of Contents: Chapter 1_Introduction and classification of natural polyphenols -- Chapter 2_Polyphenol intakes and risk of cancer: An epidemiological scenario -- Chapter 3_Polyphenols-based prevention and therapeutics in different cancers -- Chapter 4_Effect of polyphenols on signaling pathways -- Chapter 5_Role of polyphenols in modulating gene expression in different cancers -- Chapter 6_Effect of polyphenols on Inflammation and immune response in cancer -- Chapter 7_Epigenetic basis of polyphenols in cancer prevention and therapy -- Chapter 8_Polyphenols and cancer stem cells (CSCs) -- Chapter 9_Polyphenols as modulator of oxidative stress in cancer disease -- Chapter 10_Development of novel therapeutics for enhanced polyphenol delivery -- Chapter 11_Toxicological concern of different bioactive polyphenols as anticancer agents.
    Abstract: This book reviews the applications of polyphenols in cancer treatment. The initial chapter of the book classifies different polyphenols and discusses their biological and chemical properties. The subsequent chapters then explore the diverse role of polyphenols in modulating signal transduction pathways in cancer including, cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. This book highlights the usefulness of polyphenol enriched seafood in modulating the anti-tumor and anti-inflammatory cytokine IFN-γ. The book also presents nanoformulation of polyphenol as a promising strategy for their enhanced bioavailability and targeted delivery. Lastly, the book examines the toxicity and safety evaluations of polyphenols as anticancer agents.
    Type of Medium: Online Resource
    Pages: XIII, 437 p. 85 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811649356
    URL: https://doi.org/10.1007/978-981-16-4935-6
    DOI: 10.1007/978-981-16-4935-6
    DDC: 571.978
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  • 43
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    Online Resource
    Cancer Diagnostics and Therapeutics : Current Trends, Challenges, and Future Perspectives (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumors Blood-vessels. ; Blood-vessels Growth. ; Cancer Imaging. ; Cancer Genetic aspects. ; Cancer Biology. ; Tumour Angiogenesis. ; Cancer Imaging. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Part I: Basic Background -- Chapter 1. Fighting with Cancer: A Common Man’s Dilemma -- Chapter 2. Introduction to Cell Biology and Cell Behavior in Cancer -- Chapter 3. Tumor Biology: An Introduction -- Chapter 4. Role of Angiogenesis in Tumours -- Chapter 5. Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis -- Part II: Diagnostics and Theory -- Chapter 6. MRI, CT and PETSCAN: Engineer’s Perspective -- Chapter 7. Diffusion, MRI and Cancer Diagnosis: Physicist’s Outlook -- Chapter 8. Oncology: Radiation Oncologist’s View -- Chapter 9. Oncology: Biochemists’ Perspective -- Chapter 10. Oncology: Pathologist’s View -- Part III: Cancer Therapeutics -- Chapter 11. Surgical Oncology: An Overview -- Chapter 12. Medical Oncology in Cancer Treatment -- Chapter 13. Chemotherapy Effects on Immune System -- Chapter 14. Telomerase and its therapeutic implications in Cancer -- Chapter 15. Pain Management in Oncology -- Part IV: Emerging Trends in Cancer Research -- Chapter 16. New Approaches in Cancer Research: Stem-cell research, Translational Research, Immuno-therapy, and others -- Chapter 17. Cancer Cell Lines: Its Implication for Therapeutic Use -- Chapter 18. Genomics of Cancer -- Chapter 19. Chapter 19: Diabetes and Cancer -- Chapter 20. Oncology Informatics, AI, and Drug Discovery -- Chapter 21. Radiomics: Cropping More from the Images -- Part V: Epidemiology and Statistics of Cancer -- Chapter 22. Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies -- Chapter 23. Epidemiology of Cancer: Asian Perspective -- Chapter 24. Cancer Genomics and Diagnostics: Northeast Indian Scenario.
    Abstract: This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.
    Type of Medium: Online Resource
    Pages: XIX, 529 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647529
    URL: https://doi.org/10.1007/978-981-16-4752-9
    DOI: 10.1007/978-981-16-4752-9
    DDC: 571.978
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    Cytokine and Chemokine Networks in Cancer (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Tumors Immunological aspects. ; Therapeutics. ; Cancers. ; Tumour Immunology. ; Therapeutics.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Expression pattern of Chemokines in Cancer -- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer -- Chapter 4_Cytokine and chemokines networks in cancer stemness -- Chapter 5_Cytokine and chemokines networks in angiogeneis -- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition -- Chapter 7_Role of Chemokines in establishment of Metastatic Niche -- Chapter 8_CXCL12-CXCR4 axis in Metastasis -- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment -- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation -- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases -- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance -- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer -- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer -- Chapter 15_Chemokines in cancer therapy.
    Abstract: Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
    Type of Medium: Online Resource
    Pages: XVII, 440 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819946570
    URL: https://doi.org/10.1007/978-981-99-4657-0
    DOI: 10.1007/978-981-99-4657-0
    DDC: 571.978
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    Redox Regulation and Therapeutic Approaches in Cancer (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.
    Description / Table of Contents: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.
    Abstract: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
    Type of Medium: Online Resource
    Pages: XI, 431 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819973422
    URL: https://doi.org/10.1007/978-981-99-7342-2
    DOI: 10.1007/978-981-99-7342-2
    DDC: 571.978
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    Spatial Observation of Giant Panda Habitat : Techniques and Methods (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Human ecology Study and teaching. ; Environment. ; Geographical Information System. ; Environmental Studies. ; Environmental Sciences.
    Description / Table of Contents: Chapter 1. Natural heritage sites and space observation -- Chapter 2. Space monitoring technology and method of natural heritage sites -- Chapter 3. Technology and method of fine information extraction of animal habitat elements -- Chapter 4. Analysis of changes of key environmental parameters of land surface characteristics of giant panda habitat -- Chapter 5. Spatial observation and assessment of ecological environment change of giant panda habitat -- Chapter 6. The evaluation model of long-term monitoring and restoration of ecological environment by remote sensing after earthquake -- Chapter 7. Fine-Scale Evaluation of Giant Panda Habitats and Countermeasures against the Future Impacts of Climate Change -- Chapter 8. Suggestions for sustainable development of giant panda habitat.
    Abstract: This book evaluates the past, present, and future habitat suitability of giant pandas based on spatial observation technology involving optical remote sensing, microwave remote sensing, and LiDAR to discover the mysterious ecological environment of giant panda habitat. Considering the problems faced by the world natural heritage site protection, it takes the world natural heritage site “Sichuan Giant Panda Sanctuaries – Wolong, Mt Siguniang and Jiajin Mountains” as the research area, exemplifies systematically the various techniques and methodologies of spatial information technology for monitoring, evaluation, and prediction of rare and endangered species habitats, and provides scientific suggestions for sustainable development of giant panda habitat based on a series of comprehensive case analysis at Wolong national nature reserve and Ya'an prefecture, Sichuan province, China. The book serves both as a textbook in the field of natural heritage protection, remote sensing, and GIS application, as well as a reference for managing natural heritage sites.
    Type of Medium: Online Resource
    Pages: XVII, 378 p. 167 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811987946
    URL: https://doi.org/10.1007/978-981-19-8794-6
    DOI: 10.1007/978-981-19-8794-6
    DDC: 910.285
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    New Thinking in GIScience (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Geographic information systems. ; Artificial intelligence. ; Machine learning. ; Geographical Information System. ; Artificial Intelligence. ; Machine Learning.
    Description / Table of Contents: From Representation to Geocomputation: Some Theoretical Accounts of Geographic Information Science -- On Holo-Spatial Information System -- The Virtual Geographic Environment—More than the Digital Twin of the Physical Geographical Environments -- Big Remote Sensing Data as Curves -- GIScience from the Viewpoint of Information Science -- Towards Place-based GIS -- The Bottom-up Approach and De-mapping Direction of GIS -- The Geography of Geography -- Classification and Description of Geographic Information: a Comprehensive Expression Framework -- On the Third Law of Geography -- Human Mobility and the Neighborhood Effect Averaging Problem (NEAP) -- How to Form and Answer the So What Question in GIScience -- Prospects on Causal Inferences in GIS -- Bayesian Methods for Geospatial Data Analysis.
    Abstract: This book is a collection of seminal position essays by leading researchers on new development in Geographic Information Sciences (GIScience), covering a wide range of topics and representing a variety of perspectives. The authors propose enrichments and extensions to the conceptual framework of GIScience; discuss a series of transformational methodologies and technologies for analysis and modeling; elaborate on key issues in innovative approaches to data acquisition and integration, across earth sensing to social sensing; and outline frontiers in application domains, spanning from natural science to humanities and social science, e.g., urban science, land use and planning, social governance, transportation, crime, and public health, just name a few. The book provides an overview of the strategic directions on GIScience research and development. It will benefit researchers and practitioners in the field who are seeking a high-level reference regarding those directions.
    Type of Medium: Online Resource
    Pages: X, 381 p. 69 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811938160
    URL: https://doi.org/10.1007/978-981-19-3816-0
    DOI: 10.1007/978-981-19-3816-0
    DDC: 910.285
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    Environmental Remote Sensing in Flooding Areas : A Case Study of Ayutthaya, Thailand (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Environmental monitoring. ; Environmental health. ; Epidemiology. ; Geographical Information System. ; Environmental Monitoring. ; Environmental Health. ; Epidemiology.
    Description / Table of Contents: Geographical characteristics of Study area -- Datasets and data preparation -- Flooding identification by vegetation index -- Flood identification by Support Vector Machine (SVM) -- Improved support vector machine classifier by Particle filter algorithm -- Flood related parameters affecting waterborne diseases -- Measure of Disease Risk -- Modeling Outbreak Risk based on Back Propagation Neural Network (BPNN) algorithm -- Application of surveillance communicable diseases risk using Expert system -- Conclusions.
    Abstract: This book introduces flood inundation area and flood risks assessment based on a comprehensive monitoring system using remote sensing and geographic information system technologies. Taking the 2011 flood disaster of Ayutthaya in Thailand as an example, it presents a flood intrusion zone identification method based on remote sensing technology, spatial information technology and geographic information system for flood disaster monitoring and early warning system. It introduces the study area and data, vegetation index, improved support vector machine and flood intrusion zone identification method. It also analyzes the flood remote sensing parameters and waterborne diseases, method of risk assessment of waterborne disease outbreak, waterborne disease outbreak risk monitoring based on backpropagation neural network and its expert system. It not only promotes a new interdisciplinary approach both in public health and space information technology, but also greatly supports decision makers in disaster reduction.
    Type of Medium: Online Resource
    Pages: XI, 148 p. 55 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811582028
    URL: https://doi.org/10.1007/978-981-15-8202-8
    DOI: 10.1007/978-981-15-8202-8
    DDC: 910.285
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    The Geography and Remote Sensing Analysis of Sri Lanka (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Geographic information systems. ; Physical geography. ; Environmental monitoring. ; Geographical Information System. ; Physical Geography. ; Environmental Monitoring.
    Description / Table of Contents: Introduction -- The location of Sri Lanka in "One Belt And One Road -- National Geography -- Remote Sensing Analysis of Resources and Environment -- Remote Sensing Analysis of Socioeconomic Development.
    Abstract: This book presents a survey, dynamic monitoring and comprehensive analysis of Sri Lanka’s land, vegetation, surface water, ocean and other environmental resources, as well as its economic, transportation, urban, agricultural and tourism development. It offers readers accurate, systematic and comprehensive information on Sri Lanka’s ecological setting and socio-economic development. It also sheds light on policies for the protection of the environment and biodiversity.
    Type of Medium: Online Resource
    Pages: XIII, 263 p. 314 illus., 312 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813346277
    URL: https://doi.org/10.1007/978-981-33-4627-7
    DOI: 10.1007/978-981-33-4627-7
    DDC: 910.285
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    High Accuracy Surface Modeling Method: The Robustness (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Geographic information systems. ; Climatology. ; Planetary science. ; Bioclimatology. ; Geographical Information System. ; Climate Sciences. ; Planetary Science. ; Climate Change Ecology.
    Description / Table of Contents: Chapter1 Research Process of the surface modeling method -- Chapter 2 Modern method of high accuracy surface modeling -- Chapter 3 Sensitivity analysis of HASM -- Chapter 4 Effect of sampling information on HASM -- Chapter 5 Efficient computation methods for HASM -- Chapter 6 Different implementations of HASM in simulating climate variables.
    Abstract: This book focuses on the robustness analysis of high accuracy surface modeling method (HASM) to yield good performance of it. Understanding the sensitivity and uncertainty is important in model applications. The book aims to advance an integral framework for assessing model error that can demonstrate robustness across sets of possible controls, variable definitions, standard error, algorithm structure, and functional forms. It is an essential reference to the most promising numerical models. In areas where there is less certainty about models, but also high expectations of transparency, robustness analysis should aspire to be as broad as possible. This book also contains a chapter at the end featuring applications in climate simulation illustrating different implementations of HASM in surface modeling. The book is helpful for people involved in geographical information science, ecological informatics, geography, earth observation, and planetary surface modeling.
    Type of Medium: Online Resource
    Pages: XVIII, 187 p. 108 illus., 75 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811640278
    URL: https://doi.org/10.1007/978-981-16-4027-8
    DOI: 10.1007/978-981-16-4027-8
    DDC: 910.285
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    Spatially Explicit Hyperparameter Optimization for Neural Networks (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Geographic information systems. ; Artificial intelligence. ; Environmental sciences Social aspects. ; Economic geography. ; Geographical Information System. ; Artificial Intelligence. ; Environmental Social Sciences. ; Economic Geography.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Literature Review -- Chapter 3: Methodology -- Chapter 4: Study I. Hyperparameter optimization of neural network-driven spatial models accelerated using cyber-enabled high-performance computing -- Chapter 5: Study II. Spatially explicit hyperparameter optimization of neural networks accelerated using high-performance computing -- Chapter 6: Study III. An integration of spatially explicit hyperparameter optimization with convolutional neural networks-based spatial models.
    Abstract: Neural networks as the commonly used machine learning algorithms, such as artificial neural networks (ANNs) and convolutional neural networks (CNNs), have been extensively used in the GIScience domain to explore the nonlinear and complex geographic phenomena. However, there are a few studies that investigate the parameter settings of neural networks in GIScience. Moreover, the model performance of neural networks often depends on the parameter setting for a given dataset. Meanwhile, adjusting the parameter configuration of neural networks will increase the overall running time. Therefore, an automated approach is necessary for addressing these limitations in current studies. This book proposes an automated spatially explicit hyperparameter optimization approach to identify optimal or near-optimal parameter settings for neural networks in the GIScience field. Also, the approach improves the computing performance at both model and computing levels. This book is written for researchers of the GIScience field as well as social science subjects.
    Type of Medium: Online Resource
    Pages: XIX, 108 p. 45 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811653995
    URL: https://doi.org/10.1007/978-981-16-5399-5
    DOI: 10.1007/978-981-16-5399-5
    DDC: 910.285
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    Dynamic and Precise Engineering Surveying (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Geographic information systems. ; Surveying. ; Cartography. ; Geotechnical engineering. ; Geographical Information System. ; Surveying. ; Cartography. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Introduction -- Structural state surveying for transportation infrastructure -- Dynamic surveying in autonomous driving -- Indoor and underground space measurement -- UAV 3D measurement -- Coastal zone survey -- Outlook. .
    Abstract: Driven by the increasingly expanding needs of infrastructure construction, operation and maintenance, as well as the rapid developments of intelligent sensing and information technology, precise engineering surveying has been transformed from static, discrete, and manual into dynamic, continuous, and intelligent ways. This transformation leads to an advanced multidisciplinary field, dynamic and precise engineering surveying, on which the author has worked for over two decades. This book systematically summarizes the fundamentals, methods, and applications in dynamic and precise engineering surveying. The contents mainly include two parts: the first part introduces principles and methods of dynamic and precise engineering surveying; the second part presents representative applications in which innovative methods and advanced equipment are applied in the construction, operation and maintenance of mega and complex infrastructures. Readers engaged in surveying and mapping, civil engineering, water conservancy engineering, railway engineering, electronic information, and computer science, including undergraduates, graduates, researchers and engineers, will find it an informative reference.
    Type of Medium: Online Resource
    Pages: XXVIII, 498 p. 394 illus., 352 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819959426
    URL: https://doi.org/10.1007/978-981-99-5942-6
    DOI: 10.1007/978-981-99-5942-6
    DDC: 910.285
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    Online Resource
    Manual of Digital Earth (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Physical geography. ; Computer networks . ; Big data. ; Sustainability. ; Climatology. ; Geographical Information System. ; Earth System Sciences. ; Computer Communication Networks. ; Big Data. ; Sustainability. ; Climate Sciences.
    Description / Table of Contents: Understanding Digital Earth -- Part I Digital Earth Technologies -- Digital Earth Platforms -- Remote Sensing -- Satellites for Digital Earth -- Satellite Navigation for Digital Earth -- Geospatial Information Infrastructures -- Geospatial Information Processing Technologies -- Geospatial Information Visualization and Extended Reality Displays -- Transformation in Scale for Continuous Zooming -- Big Data and Cloud Computing -- Artificial Intelligence -- Internet of Things -- Social Media and Social Awareness -- Part II Digital Earth for Multi-domain Applications -- Digital Earth for Sustainable Development Goals -- Digital Earth for Climate Change Research -- Digital Earth for Disaster Mitigation Research -- Digital City: An Urban Perspective on Digital Earth -- Digital Heritage -- Citizen Science in Support of Digital Earth -- The Economic Value of Digital Earth -- Part III Digital Earth Regional & National Development -- Digital Earth in Europe -- Digital Earth in Australia -- Digital Earth in China -- Digital Earth in Russia -- Part IV Digital Earth Education and Ethics -- Digital Earth Education -- Digital Earth Ethics.
    Abstract: This open access book offers a summary of the development of Digital Earth over the past twenty years. By reviewing the initial vision of Digital Earth, the evolution of that vision, the relevant key technologies, and the role of Digital Earth in helping people respond to global challenges, this publication reveals how and why Digital Earth is becoming vital for acquiring, processing, analysing and mining the rapidly growing volume of global data sets about the Earth. The main aspects of Digital Earth covered here include: Digital Earth platforms, remote sensing and navigation satellites, processing and visualizing geospatial information, geospatial information infrastructures, big data and cloud computing, transformation and zooming, artificial intelligence, Internet of Things, and social media. Moreover, the book covers in detail the multi-layered/multi-faceted roles of Digital Earth in response to sustainable development goals, climate changes, and mitigating disasters, the applications of Digital Earth (such as digital city and digital heritage), the citizen science in support of Digital Earth, the economic value of Digital Earth, and so on. This book also reviews the regional and national development of Digital Earth around the world, and discusses the role and effect of education and ethics. Lastly, it concludes with a summary of the challenges and forecasts the future trends of Digital Earth. By sharing case studies and a broad range of general and scientific insights into the science and technology of Digital Earth, this book offers an essential introduction for an ever-growing international audience.
    Type of Medium: Online Resource
    Pages: XIX, 852 p. 422 illus., 255 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813299153
    URL: https://doi.org/10.1007/978-981-32-9915-3
    DOI: 10.1007/978-981-32-9915-3
    DDC: 910.285
    Language: English
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  • 54
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    Online Resource
    Monitoring of Desert Locust in Africa and Asia (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Agriculture. ; Environmental sciences Social aspects. ; Geographical Information System. ; Agriculture. ; Environmental Social Sciences.
    Description / Table of Contents: Foreword -- Preface -- Chapter 1 Introduction -- Chapter 2 Desert Locust Breeding Area and Migration Path in Africa and Asia -- Chapter 3 Monitoring of Desert Locusts in East Africa -- Chpater 4 Monitoring of Desert Locusts in West and South Asia -- Chapter 5 Remote Sensing Monitoring System of Desert Locust and its Application -- References.
    Abstract: This book deals with the topic on remote sensing monitoring of desert locust in Africa and Asia. Remote sensing monitoring of the occurrence and damage of desert locust is conducted by integrating cutting-edge technologies and methods in cross-disciplinary fields in remote sensing science, geographic information science, agronomy, plant protection, agricultural meteorology, mathematics, and computer science. The main contents include spatio-temporal data analysis and processing, desert locust breeding areas monitoring, pest migration path analysis and damage monitoring. Moreover, a desert locust remote sensing monitoring system is constructed and applied in the region of Africa and Asia countries. This book not only provides technical reference for remote sensing monitoring and application of desert locust but also serves as a research reference for scholars and graduate students engaged in agricultural remote sensing, agricultural information technology, plant protection and other related field. It will help to improve remote sensing monitoring and application of desert locust.
    Type of Medium: Online Resource
    Pages: XIV, 126 p. 116 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811972386
    URL: https://doi.org/10.1007/978-981-19-7238-6
    DOI: 10.1007/978-981-19-7238-6
    DDC: 910.285
    Language: English
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  • 55
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    Online Resource
    Geographic Information Systems in Urban Planning and Management (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Geography. ; Human geography. ; Environmental sciences Social aspects. ; Geographical Information System. ; Regional Geography. ; Human Geography. ; Environmental Social Sciences.
    Description / Table of Contents: Introduction of Geographic Information System -- Referencing and Coordinate Systems in GIS -- GIS Data Models -- Data Input in GIS -- Data Visualization and Output -- Spatial Data Analysis -- Non-spatial Data Management -- Applications of GIS in Urban Policy/Planning/Management -- Monitoring and Modelling of Urban Land Use Changes -- Simulating Future Urban Growth using Cellular Automata-Markov Chain Models -- Identification of Potential Sites for Housing Development Using GIS Based Multi-Criteria Evaluation Technique -- Urban Green Space Analysis and Potential Site Selection for Green Space Expansion -- A Multi-Criteria Decision Making for Alternative Landfill Site Selections Using Fuzzy TOPSIS Approach -- Urban Flood Susceptibility Modelling of Srinagar using Novel Fuzzy Multi-Layer Perceptron Neural Network (Fuzzy MLPNN) -- Assessment, Mapping and prediction of Urban Heat Island. .
    Abstract: Geographic Information Systems (GIS) play a pivotal role in the field of urban planning and management and provide better solutions for numerous urban problems. With GIS, one has the ability to better understand existing requirements of a city and its design to fulfill those needs. This book contributes to developing scientific knowledge based on geospatial technologies among planners, researchers, scientists, professionals, students, and laymen and providing them with better understanding for urban planning and management at various levels. The book manifests the importance of GIS in better understanding of current urban challenges and provides new insights on how to apply GIS in urban planning. It also encourages the various stakeholders of society to participate in the decision-making process and assists planners and authorities to formulate suitable plans for sustainable urban growth of a region. The book is divided into two parts. The first part describes the fundamental concepts of GIS and also deals with the advanced techniques of spatial planning. The second part addresses real-world case studies using various applications of GIS. The case studies include urban land-use changes, simulation of future urban growth, urban heat island, alternate landfill site selection and urban flood susceptibility mapping, among others. This book shows how to integrate GIS with remote sensing, geostatistics, artificial intelligence-machine learning techniques, and other cutting-edge technologies. Readers find this book to be an invaluable resource for understanding and solving problems relating to sustainable urban planning and management.
    Type of Medium: Online Resource
    Pages: XVII, 252 p. 115 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811978555
    Series Statement: Advances in Geographical and Environmental Sciences,
    URL: https://doi.org/10.1007/978-981-19-7855-5
    DOI: 10.1007/978-981-19-7855-5
    DDC: 910.285
    Language: English
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  • 56
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    Online Resource
    Geospatial Data Analytics and Urban Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Quantitative research. ; System theory. ; Public health. ; Urban economics. ; Geographical Information System. ; Data Analysis and Big Data. ; Complex Systems. ; Public Health. ; Urban Economics.
    Description / Table of Contents: Introduction: Spatial Big Data and Urban Analytics -- Preferential Home Search in Urban Settings -- Air Quality Dynamics and Urban Heat Island effects during COVID-19 -- Mass Rapid Transit and Population Dynamics during Covid-19 in Singapore -- A Geospatial analysis of Tweets during Post-Circuit Breaker in Singapore -- Space-Time Analytics of New York City Shooting Incidents -- Spatial and Temporal patterns of Tourist Source Market Emissiveness: A Study of Shanghai, China -- Spatial Perspective of Crime Patterns in Chicago amid Covid-19 -- Geospatial analysis of Grab Trips in Singapore -- Ecological Vulnerability of Nyingchi, Tibet.
    Abstract: This book highlights advanced applications of geospatial data analytics to address real-world issues in urban society. With a connected world, we are generating spatial at unprecedented rates which can be harnessed for insightful analytics which define the way we analyze past events and define the future directions. This book is an anthology of applications of spatial data and analytics performed on them for gaining insights which can be used for problem solving in an urban setting. Each chapter is contributed by spatially aware data scientists in the making who present spatial perspectives drawn on spatial big data. The book shall benefit mature researchers and student alike to discourse a variety of urban applications which display the use of machine learning algorithms on spatial big data for real-world problem solving.
    Type of Medium: Online Resource
    Pages: XVIII, 187 p. 106 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811676499
    Series Statement: Advances in 21st Century Human Settlements,
    URL: https://doi.org/10.1007/978-981-16-7649-9
    DOI: 10.1007/978-981-16-7649-9
    DDC: 910.285
    Language: English
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  • 57
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    Online Resource
    Geospatial Technology for Landscape and Environmental Management : Sustainable Assessment and Planning (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Environmental management. ; Climatology. ; Natural disasters. ; Database management. ; Geographical Information System. ; Environmental Management. ; Climate Sciences. ; Natural Hazards. ; Database Management.
    Description / Table of Contents: Spatio-temporal variability of channel planform dynamics in response to spatial expansion of brick kilns: a case study of the downstream course of Ichamati River, West Bengal, India -- Assessment of replenishable groundwater resource and integrated water resource planning for sustainable agriculture -- Spatial prediction of flood frequency analysis in a semi-arid zone: A case study from the Seyad basin (Guelmim Region, Morocco) -- Geospatial modeling in the assessment of environmental resources for sustainable water resource management in a Gondia district, India -- Hydrochemical characteristics of groundwater-assessment of saltwater intrusion along Krishna Godavari Delta Region, Andhra Pradesh, India -- Micro level planning for integrated natural resources management and sustainable development: an approach through a micro watershed using geospatial technology -- Ecohydrological perspective for environmental degradation of lakes and wetlands in Delhi -- Prioritization and quantitative assessment of Dhundsir Gad using RS and GIS: implications for watershed management, planning and conservation, Garhwal Himalaya, Uttarakhand -- Assessment of groundwater potential zones and resource sustainability through Geospatial Techniques: a case study of Kamina sub-watershed of Bhima River Basin, Maharashtra, India -- Morphometric analysis of Damodar River sub-watershed, Jharkhand, India, using remote sensing and GIS techniques -- The increasing inevitability of IOT in remote disaster monitoring applications -- Countering challenges of smart cities mission through participatory approach -- Urban growth modelling and prediction of land use land cover change over Nagpur city, India using Cellular automata approach -- Slum categorization for efficient development plan - a case study of Udhampur city, J&K using Remote sensing and GIS -- Urban growth trend analysis using Shannon Entropy approach – A case study of Dehradun City of Uttarakhand, India -- Geospatial approach for mapping of significant land use / land cover changes in Andhra Pradesh -- Assessing the impact of Delhi metro network towards urbanization of Delhi-NCR -- Analysis of urban heat island effect in the Rajkot city using Geospatial Techniques -- Multi spectral remote sensing for urban planning and development -- Analysis Of urban green spaces using geospatial techniques-a case study of Vijayawada urban local body Andhra Pradesh, India -- Magnetic susceptibility and heavy metals contamination in agricultural soil of Kopargaon Area, Ahmadnagar District, Maharashtra, India.
    Abstract: Geospatial technology is a combination of state-of-the-art remote sensing and technology for geographic information systems (GIS) and global navigation satellite systems (GNSS) for the mapping and monitoring of landscapes and environment. The main thrust of using geospatial technology is to understand the causes, mechanisms, and consequences of spatial heterogeneity, while its ultimate objective is to provide a scientific basis for developing and maintaining ecologically, economically, and socially sustainable landscapes. This book presents new research on the interdisciplinary applications of geospatial technology for identification, assessment, monitoring, and modelling issues related to landscape, natural resources, and environmental management. The book specifically focuses on the creation, collection, storage, processing, modelling, interpretation, display, and dissemination of spatio-temporal data, which help to resolve environmental management issues including ecosystem change, resource utilization, land use management, and environmental pollution. The positive environmental impacts of information technology advancements with regard to global environmental and climate change are also discussed. The book addresses the interests of a wide spectrum of readers who have a common interest in geospatial science, geology, water resource management, database management, planning and policy making, and resource management.
    Type of Medium: Online Resource
    Pages: XVII, 430 p. 203 illus., 193 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811673733
    Series Statement: Advances in Geographical and Environmental Sciences,
    URL: https://doi.org/10.1007/978-981-16-7373-3
    DOI: 10.1007/978-981-16-7373-3
    DDC: 910.285
    Language: English
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  • 58
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    Optical and SAR Remote Sensing of Urban Areas : A Practical Guide (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Cartography. ; Human geography. ; Geographical Information System. ; Cartography. ; Human Geography.
    Description / Table of Contents: - Geospatial Machine Learning in Urban Areas: Challenges and Prospects -- Exploratory Analysis and Transformation for Remotely-Sensed Imagery -- Mapping Urban Land Cover using Multi-seasonal Sentinel-2 Imagery, Spectral and Texture Indices -- Mapping Urban Land Cover using Multi-seasonal Sentinel-1 Imagery and Texture Indices -- Improving Urban Land Cover Mapping -- Land Cover Classification Accuracy Assessment -- Appendix.
    Abstract: This book introduces remotely sensed image processing for urban areas using optical and synthetic aperture radar (SAR) data and assists students, researchers, and remote sensing practitioners who are interested in land cover mapping using such data. There are many introductory and advanced books on optical and SAR remote sensing image processing, but most of them do not serve as good practical guides. However, this book is designed as a practical guide and a hands-on workbook, where users can explore data and methods to improve their land cover mapping skills for urban areas. Although there are many freely available earth observation data, the focus is on land cover mapping using Sentinel-1 C-band SAR and Sentinel-2 data. All remotely sensed image processing and classification procedures are based on open-source software applications such QGIS and R as well as cloud-based platforms such as Google Earth Engine (GEE). The book is organized into six chapters. Chapter 1 introduces geospatial machine learning, and Chapter 2 covers exploratory image analysis and transformation. Chapters 3 and 4 focus on mapping urban land cover using multi-seasonal Sentinel-2 imagery and multi-seasonal Sentinel-1 imagery, respectively. Chapter 5 discusses mapping urban land cover using multi-seasonal Sentinel-1 and Sentinel-2 imagery as well as other derived data such as spectral and texture indices. Chapter 6 concludes the book with land cover classification accuracy assessment.
    Type of Medium: Online Resource
    Pages: XI, 119 p. 103 illus., 90 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811651496
    Series Statement: Springer Geography,
    URL: https://doi.org/10.1007/978-981-16-5149-6
    DOI: 10.1007/978-981-16-5149-6
    DDC: 910.285
    Language: English
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  • 59
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    Online Resource
    Advanced Remote Sensing for Urban and Landscape Ecology (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Geographic information systems. ; Cartography. ; Urban ecology (Biology). ; Human geography. ; Geographical Information System. ; Cartography. ; Urban Ecology. ; Human Geography.
    Description / Table of Contents: Data And Urban Poverty: Detecting And Characterising Slums And Deprived Urban Areas In Low-And Middle-Income Countries -- Investigation Of Ecological Sustainability Through The Landscape Approach Of Geospatial Technology: Study From New Town Project In Eastern India -- Advanced Remote Sensing For Sustainable Decent Housing For The Economically Challenged Urban Households -- Impact Of Uncontrolled Tourism Development On Landscape Ecology Of Purba Medinipur Coastal Region, West Bengal: A 4-C Framework And Swoc Analysis -- Impact Of Urban Heat Island: A Local-Level Urban Climate Phenomenon On Urban Ecology And Human Health -- Identification Of Environmental Epidemiology Through Advanced Remote Sensing Based On Ndvi -- Assessment Of Land Utilization Pattern And Their Relationship With Surface Temperature And Vegetation In Sikkim, India -- Monitoring Land Use And Land Cover Change Over Bhiwani District Using Google Earth Engine -- Image And Perception Of Royal Heritage And Eco-Space Of The Medium Towns In India: Reflection From Burdwan Royal Heritage Site -- Governance And Floodplain Extent Changes Of Yamuna River Floodplain In Megacity Delhi -- Assessing Urban Compactness Using Machine Learning And Earth Observation Datasets: A Case Study Of Kolkata City -- Analysis Of Ecological Vulnerability Behind The Land Conversion From Agriculture To Aquaculture Of Purba Medinipur District In West Bengal, India -- Environmental Change Analysis Using Remote Sensing And Gis: A Study Of Upper Baitarani Basin, Odisha -- Mapping Urban Footprint Using Machine Learning And Public Domain Datasets.
    Abstract: This book introduces the use of various remote sensing data such as microwave, hyperspectral and very high-resolution (VHR) satellite imagery; mapping techniques including pixel and object-based machine learning; and geostatistical modelling techniques including cellular automation, entropy and land fragmentation. Remote sensing plays a vital role in solving urban and environmental challenges at the landscape level. Globally, more than half of the urban population is facing severe environmental and social challenges, especially those relating to climate change, agricultural land encroachment, green infrastructure and environmental degradation, mobility due to rapid rural–urban transformation and anthropogenic interventions. Mapping and quantification of such threats at the landscape level are challenging for experts using traditional techniques; however, remote sensing technology provides diverse spatial data at a varying scale, volume and accessibility for mapping and modelling, and it also analyses challenges at urban and landscape levels. Together, they address challenges at urban and landscape levels to support the Sustainable Development Goals (SDGs).
    Type of Medium: Online Resource
    Pages: XIII, 317 p. 153 illus., 129 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819930067
    Series Statement: Advances in Geographical and Environmental Sciences,
    URL: https://doi.org/10.1007/978-981-99-3006-7
    DOI: 10.1007/978-981-99-3006-7
    DDC: 910.285
    Language: English
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