ISSN:
1432-1041
Keywords:
Key words Yohimbine
;
Salivary secretion
;
Anetholtrithi one; tricyclic antidepressants
;
α2 adrenoceptor anta gonists
;
dry mouth
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: The present study compares the effects of yohimbine, an alpha2 adrenoceptor antagonist, and anetholtrithione, a reference drug in the treatment of dry mouth, in patients treated with psychotropic drugs (tricyclic antidepressants or neuroleptics) and suffering from xerostomia. Methods: Ten patients were included in a randomized, double-blind, cross-over study, and receiving after yohimbine (3 × 6 mg per day) or anetholtrithione (3 × 25 mg per day) orally for 5 days. Salivary secretion was estimated under resting conditions, before any drug, and then on day 6, 1 h after the ingestion of yohimbine or anetholtrithione. Results: Compared with basal secretion, the increase in salivary flow was significantly more marked after yohimbine than after anetholtrithione. Conclusion: This study demonstrates the sialogenic effect of yohimbine in drug-induced dry mouth.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050298
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