ISSN:
0894-3230
Keywords:
Organic Chemistry
;
Physical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
The kinetics of the hydrolysis of benzohydroxamic acid have been investigated in hydrochloric, sulphuric and perchloric acids in 10% (v/v) dimethyl sulphoxide - water at 55 °C. Activation parameters were also determined. Rate correlation by the Cox - Yates excess acidity method shows an A-2 mechanism involving rapid pre-equilibrium protonation of the substrate followed by rate-limiting attack of water at the carbonyl carbon atom to form a tetrahedral intermediate which collapses, in a fast step, to the products.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/poc.610050106
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