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  • 1
    Publication Date: 2015-08-18
    Description: Lacustrine ecosystem history since the industrial revolution provides important evidence of natural versus anthropogenic effects on the environment. With high-resolution sedimentary core samples and organic–inorganic geochemical methods, we reconstruct the past ~150-year ecosystem evolution of Lake Wuliangsu in the upper reaches of the Yellow River, and probe factors controlling the ecological dynamics. In this study, ecological changes in Lake Wuliangsu over the past ~150 years were identified. After the lake formed in the 1850s, biological productivity of the lake was still under-developed until the 1950s. During the period of 1950s–1970s, submerged macrophytes became the dominant organisms in the lake because of lake area expansion and slight increases of nutrient input from agricultural development in the catchment. The domination of submerged macrophytes ceased after the 1970s, which was possibly induced by the shrinkage of the lake area. After the 1990s, the main contributor of sedimentary n -alkanes most likely shifted to reeds because of eutrophication caused by anthropogenic activities. The results clearly demonstrate that the ecosystem in Lake Wuliangsu before the 1950s strongly depended on the natural discharge, whereas at later stages, it was significantly influenced by human activities. During the period of 1950s–1990s, the human-monitored lake area seems to be the main factor in the lake ecosystem evolution. However, when the nutrient supply went beyond the tipping point after the 1990s, eutrophication took over and played a key role in the lake ecosystem evolution.
    Print ISSN: 0959-6836
    Electronic ISSN: 1477-0911
    Topics: Geography , Geosciences
    Published by Sage
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  • 2
    Publication Date: 2015-09-16
    Description: Natural photosynthesis harnesses solar energy to convert CO2 and water to value-added chemical products for sustaining life. We present a hybrid bioinorganic approach to solar-to-chemical conversion in which sustainable electrical and/or solar input drives production of hydrogen from water splitting using biocompatible inorganic catalysts. The hydrogen is then used by...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2013-09-25
    Description: Preceding antibody constant regions are switch (S) regions varying in length and repeat density that are targets of activation-induced cytidine deaminase. We asked how participating S regions influence each other to orchestrate rearrangements at the IgH locus by engineering mice in which the weakest S region, Sε, is replaced with...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2014-11-07
    Description: Motivation: A proper target or marker is essential in any diagnosis (e.g. an infection or cancer). An ideal diagnostic target should be both conserved in and unique to the pathogen. Currently, these targets can only be identified manually, which is time-consuming and usually error-prone. Because of the increasingly frequent occurrences of emerging epidemics and multidrug-resistant ‘superbugs’, a rapid diagnostic target identification process is needed. Results: A new method that can identify uniquely conserved regions (UCRs) as candidate diagnostic targets for a selected group of organisms solely from their genomic sequences has been developed and successfully tested. Using a sequence-indexing algorithm to identify UCRs and a k -mer integer-mapping model for computational efficiency, this method has successfully identified UCRs within the bacteria domain for 15 test groups, including pathogenic, probiotic, commensal and extremophilic bacterial species or strains. Based on the identified UCRs, new diagnostic primer sets were designed, and their specificity and efficiency were tested by polymerase chain reaction amplifications from both pure isolates and samples containing mixed cultures. Availability and implementation: The UCRs identified for the 15 bacterial species are now freely available at http://ucr.synblex.com . The source code of the programs used in this study is accessible at http://ucr.synblex.com/bacterialIdSourceCode.d.zip Contact: yazhousun@synblex.com Supplementary Information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 5
    Publication Date: 2019
    Description: 〈span〉〈div〉Abstract〈/div〉Traditional methods for imaging salt bodies seldom consider near-salt stress perturbations caused by salt, and the associated velocity perturbations of seismic waves in the sediments near the salt. To demonstrate the importance of stress changes caused by the salt on accurately imaging salt bodies, in this study we develop and apply a combined method of geomechanical stress modelling and salt imaging. We simulate the stress perturbations in sediments induced by a salt sphere using a static geomechanical model, and calculate the associated velocity changes of seismic waves in the sediments by using our model stress perturbations. We use the reverse time migration and imaging method to image the salt sphere, and then analyse the imaging results of two cases including and excluding the effects of stress perturbations by the salt sphere on velocity changes of seismic waves. The results show that the near-salt velocity changes of seismic waves induced by stress perturbations near salt bodies can have a significant impact on the salt imaging. We find that when the effects of near-salt stress perturbations are ignored, the imaging of the salt sphere is clearly distorted: the salt sphere is extended vertically and becomes a salt ellipse with a vertical major axis. In contrast, when we include the effects of near-salt stress perturbations, the imaging of this salt sphere accurately matches the salt geometry and position. Thus, the near-salt stress perturbations should not be ignored in salt imaging. This study provides scientific insights for petroleum geologists and exploration geophysicists on the relationship between near-salt stress perturbations and accurate imaging of salt structures.〈/span〉
    Print ISSN: 1354-0793
    Electronic ISSN: 2041-496X
    Topics: Geosciences
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  • 6
    Publication Date: 2016-05-28
    Description: This paper examines the Late Quaternary evolutionary history of the northern coast of the South China Sea by reviewing geological evidence from this coast. Results show that: (1) a lithostratigraphy with two marine sequences is observed in the deltaic basins of the Song Hong, Pearl and Han rivers, and these basins are all bounded by active faults; (2) whilst the upper marine sequence belongs to the present interglacial or the past 10.5 ka, the lower or older marine sequence was most likely deposited during the high sea level of the last interglacial period, c . 126–120 ka; (3) the burial depth of the older marine sequence is recorded at –15 m below modern sea level or deeper, implying localized subsidence of varying rates between these deltaic basins because the height of sea level during the last interglacial was close to that of the present; (4) this tectonic process is probably associated with the continuous long-term subsidence of the northern South China Sea continental shelf within the tectonic framework of southward continental extension of the Eurasian Plate during the Cenozoic; (5) fault activity has enhanced the localized subsidence of these deltaic basins, which led to marine inundation during interglacial high sea levels.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 7
    Publication Date: 2016-05-29
    Description: We present an approach that uses the huge fluid and thermal storage capacity of the subsurface, together with geologic carbon dioxide (CO 2 ) storage, to harvest, store, and dispatch energy from subsurface (geothermal) and surface (solar, nuclear, fossil) thermal resources, as well as excess energy on electric grids. Captured CO 2 is injected into saline aquifers to store pressure, generate artesian flow of brine, and provide a supplemental working fluid for efficient heat extraction and power conversion. Concentric rings of injection and production wells create a hydraulic mound to store pressure, CO 2 , and thermal energy. This energy storage can take excess power from the grid and excess and/or waste thermal energy and dispatch that energy when it is demanded, and thus enable higher penetration of variable renewable energy technologies (e.g., wind and solar). CO 2 stored in the subsurface functions as a cushion gas to provide enormous pressure storage capacity and displace large quantities of brine, some of which can be treated for a variety of beneficial uses. Geothermal power and energy-storage applications may generate enough revenues to compensate for CO 2 capture costs. While our approach can use nitrogen (N 2 ), in addition to CO 2 , as a supplemental fluid, and store thermal energy, this study focuses on using CO 2 for geothermal energy production and grid-scale energy storage. We conduct a techno-economic assessment to determine the levelized cost of electricity using this approach to generate geothermal power. We present a reservoir pressure management strategy that diverts a small portion of the produced brine for beneficial consumptive use to reduce the pumping cost of fluid recirculation, while reducing the risk of seismicity, caprock fracture, and CO 2 leakage.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
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  • 8
    Publication Date: 2015-09-12
    Description: Phospholipid transfer protein (PLTP) is a widely expressed lipid transfer protein participating in the transport of cholesterol and other lipids in the plasma and peripheral tissues. Recently, elevated amyloid β (Aβ) in young and aged PLTP-deficient brains had been reported. However, the role of PLTP in amyloid precursor protein (APP) processing and Alzheimer's disease (AD) pathology remains elusive. Here we first found that deficiency of PLTP accelerated memory dysfunction in APP/PS1E9 AD model mice at the age of 3 months. Further characterization showed that PLTP deficiency increased soluble Aβ peptides, and intracellular accumulation of Aβ was illustrated, which might be due to disrupted APP turnover and the enhanced amyloidogenic pathway. Besides, reduced brain-derived neurotrophic factor (BDNF) was found in PLTP-deficient APP/PS1E9 mice, and the BDNF level was negatively correlated with Aβ42 content, instead of Aβ40 content. In addition, autophagic dysfunction was found in the PLTP-deficient APP/PS1E9 mice. Our data presented a novel model to link phospholipid metabolism to APP processing and also suggested that PLTP played an important role in Aβ metabolism and would be useful to further elucidate functions of PLTP in AD susceptibility.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 9
    Publication Date: 2019
    Description: 〈span〉〈div〉Abstract〈/div〉Traditional methods for imaging salt bodies seldom consider near-salt stress perturbations caused by salt, and the associated velocity perturbations of seismic waves in the sediments near the salt. To demonstrate the importance of stress changes caused by the salt on accurately imaging salt bodies, in this study we develop and apply a combined method of geomechanical stress modelling and salt imaging. We simulate the stress perturbations in sediments induced by a salt sphere using a static geomechanical model, and calculate the associated velocity changes of seismic waves in the sediments by using our model stress perturbations. We use the reverse time migration and imaging method to image the salt sphere, and then analyse the imaging results of two cases including and excluding the effects of stress perturbations by the salt sphere on velocity changes of seismic waves. The results show that the near-salt velocity changes of seismic waves induced by stress perturbations near salt bodies can have a significant impact on the salt imaging. We find that when the effects of near-salt stress perturbations are ignored, the imaging of the salt sphere is clearly distorted: the salt sphere is extended vertically and becomes a salt ellipse with a vertical major axis. In contrast, when we include the effects of near-salt stress perturbations, the imaging of this salt sphere accurately matches the salt geometry and position. Thus, the near-salt stress perturbations should not be ignored in salt imaging. This study provides scientific insights for petroleum geologists and exploration geophysicists on the relationship between near-salt stress perturbations and accurate imaging of salt structures.〈/span〉
    Print ISSN: 1354-0793
    Electronic ISSN: 2041-496X
    Topics: Geosciences
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  • 10
    Publication Date: 2013-12-06
    Description: The dynamics of the high-inclination Plutinos is systematically studied. We first present the peculiar features of the 2:3 Neptune mean motion resonance (NMMR) for inclined orbits, especially for the correlation of resonant amplitude A with inclination i . Using the numerical integrations for the age of the Solar system, the dynamical structure of the 2:3 NMMR is mapped out on the plane of semimajor axis versus i for different eccentricities. We have shown that i of stable resonant orbits could be as high as 90°; and the stable region is roughly surrounded by the contours of A  = 120°. These new findings allow us to further explore the 2:3 NMMR capture and retention of planetesimals with initial inclinations i 0  ≤ 90° in the frame of the planet migration model. We find that the outward transportation of Plutinos is possible for any inclined or even perpendicular orbits. The role of i 0 in the formation of Plutinos during Neptune's migration is highlighted and interesting results are obtained: (1) the capture efficiency of the 2:3 NMMR decreases drastically first with the increase of i 0 , but it then raises instead when i 0 exceeds ~50°; (2) the magnitude of i -variation is limited to less than 5° for any i 0 , and moreover, for Plutinos with i   48°, their i are forced to decrease throughout the outward migration; (3) Plutinos with i   48° are certainly outside the Kozai mechanism, since an inclination increase is prohibited by the migrating 2:3 NMMR; (4) the 7:11 inclination-type NMMR could be responsible for nearly circular Plutinos, and a minimum i 0  ~ 15° is required to intrigue this mechanism.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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