ISSN:
1420-9071
Schlagwort(e):
1-(Substituted)-benzyl-5-aminoimidazole-4-carboxamide
;
T. cruzi
;
Chagas' disease
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Summary 1-(Substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors ofTrypanosoma cruzi infections in mice. The most active compounds are the 1-(4-chlorobenzyl)- and 1-(3,4-dichlorobenzyl)-analogs (L-153,094 [2] and L-153,153 [4], resp.) which are approximately 7-fold more potent upon oral administration than nifurtimox (Lampit) in suppressing parasite levels in the blood of mice with acuteTrypanosoma cruzi infections.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02041250
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