Publication Date:
1991-12-13
Description:
The targeting of proteins to mitochondria involves the recognition of the precursor proteins by receptors on the mitochondrial surface followed by insertion of the precursors into the outer membrane at the general insertion site GIP. Most mitochondrial proteins analyzed so far use a mitochondrial outer membrane protein of 19 kilodaltons (MOM19) as an import receptor. The gene encoding MOM19 has now been isolated. The deduced amino acid sequence predicts that MOM19 is anchored in the outer membrane by an NH2-terminal hydrophobic sequence, while the rest of the protein forms a hydrophilic domain exposed to the cytosol. MOM19 was targeted to the mitochondria via a pathway that is independent of protease-accessible surface receptors and controlled by direct assembly of the MOM19 precursor with GIP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneider, H -- Sollner, T -- Dietmeier, K -- Eckerskorn, C -- Lottspeich, F -- Trulzsch, B -- Neupert, W -- Pfanner, N -- New York, N.Y. -- Science. 1991 Dec 13;254(5038):1659-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Physiologische Chemie, Universitat Munchen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1661031" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Cell Compartmentation
;
DNA/genetics
;
Fungal Proteins/chemistry/genetics
;
Genes, Fungal
;
Intracellular Membranes/metabolism
;
Macromolecular Substances
;
Membrane Proteins/*metabolism
;
Mitochondria/*metabolism
;
Molecular Sequence Data
;
Protein Precursors/metabolism
;
Receptors, Cell Surface/*genetics/*metabolism
;
*Receptors, Cytoplasmic and Nuclear
;
Recombinant Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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