ISSN:
0025-116X
Schlagwort(e):
Chemistry
;
Polymer and Materials Science
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
,
Physik
Notizen:
Polypeptides can be prepared by stirring an amino acid solution in the presence of diphenylphosphoryl azide (DPPA) and an adequate tertiary amine. Generally, 1,3 mol of DPPA and 2,3 mol of triethylamine per mol of amino acid gave the best result. Polymerization of various amino acids (Gly, Ala, Leu, Phe, Met, Glu(OBzl), Glu(OMe), Cys(Bzl), Ser(Bzl), His(Bzl), Lys(Z), Arg(Tos), Arg(NO2), Arg(Mts), etc.; cf. Tab. 2) in dimethyl sulfoxide, N,N-dimethylformamide, 1,4-dioxane, pyridine, etc. gave the corresponding polypeptides with molecular weights as estimated from their intrinsic viscosities between 3 000 and 16 000, in reasonable yields. The purity of the resulting polypeptides was confirmed by IR, elemental analysis and optical rotation measurements of their acid total hydrolysates.
Zusätzliches Material:
3 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/macp.1991.021920813
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