Publication Date:
2015-05-27
Description:
Atorvastatin calcium (AC) spherical crystals were prepared by spherical agglomeration. CH 2 Cl 2 acting as bridging liquid was added together with the drug solution or after the antisolvent precipitation process. Polymorph transformation in antisolvent crystallization and agglomeration processes was observed by focused-beam reflectance measurement (FBRM). The results suggested the occurrence of an immediate agglomeration when CH 2 Cl 2 was added together with the drug solution. Size-controllable AC spherical crystals with improved flowability and compressibility can be obtained by adjusting the amount of CH 2 Cl 2 and the stirring speed. The improved compaction behavior of the AC particles can be applied for direct tableting. A higher stirring speed can reduce the amount of bridging liquid which is required for effective agglomeration. It was a prerequisite for fine particles to be wetted by the bridging liquid in the spherical agglomeration process. Spherical agglomeration is an effective method to improve the flowability and compressibility of Atorvastation calcium particles. A polymorph transformation occurred during the antisolvent precipitation and agglomeration process. The final size distribution of the particles is controllable by adjusting the amount of bridging liquid and stirring speed.
Print ISSN:
0930-7516
Electronic ISSN:
1521-4125
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
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