ISSN:
1432-1041
Keywords:
Diphemanil methylsulphate
;
pharmacokinetics
;
healthy subjects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax=2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00265939
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