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  • 1
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    Migration of great earthquakes in Taiwan from 1898 to 1989 (1990)
    In:  Bull. of the Inst. of Earth Sciences Academia Sinica, Taipei, Elsevier, vol. 10, no. 9, pp. 66, pp. B09401, (ISBN: 0-12-018847-3)
    Details
    Publication Date: 1990
    Keywords: Seismology ; Migration of earthquakes ; Seismicity ; China
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Attenuation relations of Arias intensity based on the Chi-Chi Taiwan earthquake data (2004)
    In:  Soil Dynamics and Earthquake Engineering, Stuttgart, Schweizerbart'sche Verlagsbuchhandlung, vol. 24, no. 7, pp. 509-517, pp. 2077, (ISSN 0016-8548, ISBN 3-510-50045-8)
    Details
    Publication Date: 2004
    Description: This paper presents a derivation of attenuation relations of Arias intensity for various site conditions based on the strong-motion data recorded in the 1999 Chi-Chi Taiwan earthquake. The data are from the mainshock and three large aftershocks with stations in the footwall area and in the area away from the fault. At each station, Arias intensity is computed from two horizontal acceleration time histories. The Arias intensity data are separated into four groups according to site classes assigned to recording stations. For each site class, the attenuation relation of Arias intensity is derived using a two-step regression analysis method. The attenuation relations established in this study can be used to estimate Arias intensity from a rupture of a thrust fault for sites in the footwall area or in the area away from the fault
    Keywords: Horizontal to vertical spectral ratio ; Nakamura ; Spectrum ; NOISE ; Site amplification ; Attenuation ; Arias ; intensity ; Chi-Chi ; earthquake ; ground ; motion ; SDEE ; Site ; effect ; China ; SPAROLAI
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    An analysis of the nature and attenuation of Ls-3dgus0 waves
    Earth Resources Laboratory, Department of Earth, atmospheric, and Planetary Science, Massachusetts Institute of Technology
    In:  Cambridge, Earth Resources Laboratory, Department of Earth, atmospheric, and Planetary Science, Massachusetts Institute of Technology, vol. 13, no. 3, pp. 632 pp., (ISBN 0-8493-0068-1)
    Details
    Keywords: Seismology ; Surface waves ; Lg-waves ; Nuclear explosion ; Attenuation ; Toksoez ; Toksoz
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    BIBLIOGRAPHY SEISMOLOGY
  • 4
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    ASSIGN: context-specific genomic profiling of multiple heterogeneous biological pathways (2015)
    Oxford University Press
    Details
    Publication Date: 2015-05-27
    Description: Motivation: Although gene-expression signature-based biomarkers are often developed for clinical diagnosis, many promising signatures fail to replicate during validation. One major challenge is that biological samples used to generate and validate the signature are often from heterogeneous biological contexts—controlled or in vitro samples may be used to generate the signature, but patient samples may be used for validation. In addition, systematic technical biases from multiple genome-profiling platforms often mask true biological variation. Addressing such challenges will enable us to better elucidate disease mechanisms and provide improved guidance for personalized therapeutics. Results: Here, we present a pathway profiling toolkit, Adaptive Signature Selection and InteGratioN (ASSIGN), which enables robust and context-specific pathway analyses by efficiently capturing pathway activity in heterogeneous sets of samples and across profiling technologies. The ASSIGN framework is based on a flexible Bayesian factor analysis approach that allows for simultaneous profiling of multiple correlated pathways and for the adaptation of pathway signatures into specific disease. We demonstrate the robustness and versatility of ASSIGN in estimating pathway activity in simulated data, cell lines perturbed pathways and in primary tissues samples including The Cancer Genome Atlas breast carcinoma samples and liver samples exposed to genotoxic carcinogens. Availability and implementation: Software for our approach is available for download at: http://www.bioconductor.org/packages/release/bioc/html/ASSIGN.html and https://github.com/wevanjohnson/ASSIGN . Contact : andreab@genetics.utah.edu or wej@bu.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 5
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    Chitin Nanofibers as Reinforcing and Antimicrobial Agents in Carboxymethyl Cellulose Films: Influence of Partial Deacetylation (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-07-15
    Description: ACS Sustainable Chemistry & Engineering DOI: 10.1021/acssuschemeng.6b00981
    Electronic ISSN: 2168-0485
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 6
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    Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains (2013)
    Oxford University Press
    Details
    Publication Date: 2013-04-02
    Description: Single-cell genomics is revolutionizing basic genome research and clinical genetic diagnosis. However, none of the current research or clinical methods for single-cell analysis distinguishes between the analysis of a cell in G1-, S- or G2/M-phase of the cell cycle. Here, we demonstrate by means of array comparative genomic hybridization that charting the DNA copy number landscape of a cell in S-phase requires conceptually different approaches to that of a cell in G1- or G2/M-phase. Remarkably, despite single-cell whole-genome amplification artifacts, the log2 intensity ratios of single S-phase cells oscillate according to early and late replication domains, which in turn leads to the detection of significantly more DNA imbalances when compared with a cell in G1- or G2/M-phase. Although these DNA imbalances may, on the one hand, be falsely interpreted as genuine structural aberrations in the S-phase cell’s copy number profile and hence lead to misdiagnosis, on the other hand, the ability to detect replication domains genome wide in one cell has important applications in DNA-replication research. Genome-wide cell-type-specific early and late replicating domains have been identified by analyses of DNA from populations of cells, but cell-to-cell differences in DNA replication may be important in genome stability, disease aetiology and various other cellular processes.
    Keywords: Replication, Genomics
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    Na+-specific DNAzyme for intracellular sensing [Chemistry] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-05-13
    Description: Over the past two decades, enormous progress has been made in designing fluorescent sensors or probes for divalent metal ions. In contrast, the development of fluorescent sensors for monovalent metal ions, such as sodium (Na+), has remained underdeveloped, even though Na+ is one the most abundant metal ions in biological...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Coupling Analysis of Hydrometeorology and Erosive Landforms Evolution in Loess Plateau, China (2016)
    Hindawi
    Details
    Publication Date: 2016-01-01
    Description: The purpose of this study is to investigate hydrometeorology changing patterns impacts on erosive landforms evolution in Loess Plateau in the past 60 years (1950–2010). We firstly describe hydrometeorology changing patterns (rainfall-runoff-soil erosion response) at different time scales (daily, monthly, and yearly) in perspective of river basins and then further investigate hydrometeorology impacts on erosive landform through combined analysis of statistical quantification and proposed conceptual model of rainfall-runoff-soil erosion landform. Through the above investigations, the following findings are achieved. Firstly, it shows that annual runoff and sediment discharges decreased obviously although precipitation remained at the same level in the past 50 years (1960–2010). Discharges of annual runoff and sediment decreased by 30%–80% and 60%–90%, respectively. Secondly, contributors of soil erosion are determined by integrated factors such as precipitation, river network, and topography characteristics of river basins. The strong soil erosion area existed in the middle hilly-gully region, while the high precipitation was in southern mountains. Thirdly, erosion landform development was largely shaped by hydrometeorology characteristics in comparison with other contributors. It shows that there is strong positive relationship between precipitation and erosion.
    Print ISSN: 1687-9309
    Electronic ISSN: 1687-9317
    Topics: Geosciences , Physics
    Published by Hindawi
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  • 9
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    Protein mistranslation protects bacteria against oxidative stress (2015)
    Oxford University Press
    Details
    Publication Date: 2015-02-18
    Description: Accurate flow of genetic information from DNA to protein requires faithful translation. An increased level of translational errors (mistranslation) has therefore been widely considered harmful to cells. Here we demonstrate that surprisingly, moderate levels of mistranslation indeed increase tolerance to oxidative stress in Escherichia coli . Our RNA sequencing analyses revealed that two antioxidant genes katE and osmC , both controlled by the general stress response activator RpoS, were upregulated by a ribosomal error-prone mutation. Mistranslation-induced tolerance to hydrogen peroxide required rpoS, katE and osmC . We further show that both translational and post-translational regulation of RpoS contribute to peroxide tolerance in the error-prone strain, and a small RNA DsrA, which controls translation of RpoS, is critical for the improved tolerance to oxidative stress through mistranslation. Our work thus challenges the prevailing view that mistranslation is always detrimental, and provides a mechanism by which mistranslation benefits bacteria under stress conditions.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 10
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    Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy (2015)
    Oxford University Press
    Details
    Publication Date: 2015-11-06
    Description: Muscle weakness and exercise intolerance are hallmark symptoms in mitochondrial disorders. Little is known about the mechanisms leading to impaired skeletal muscle function and ultimately muscle weakness in these patients. In a mouse model of lethal mitochondrial myopathy, the muscle-specific Tfam knock-out (KO) mouse, we previously demonstrated an excessive mitochondrial Ca 2+ uptake in isolated muscle fibers that could be inhibited by the cyclophilin D (CypD) inhibitor, cyclosporine A (CsA). Here we show that the Tfam KO mice have increased CypD levels, and we demonstrate that this increase is a common feature in patients with mitochondrial myopathy. We tested the effect of CsA treatment on Tfam KO mice during the transition from a mild to terminal myopathy. CsA treatment counteracted the development of muscle weakness and improved muscle fiber Ca 2+ handling. Importantly, CsA treatment prolonged the lifespan of these muscle-specific Tfam KO mice. These results demonstrate that CsA treatment is an efficient therapeutic strategy to slow the development of severe mitochondrial myopathy.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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