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  • 1
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    Scanning probe evolution in biology (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-11-08
    Description: Twenty years ago the first scanning probe instrument, the scanning tunneling microscope, opened up new realms for our perception of the world. Atoms that had been abstract entities were now real objects, clearly seen as distinguishable individuals at particular positions in space. A whole family of scanning probe instruments has been developed, extending our sense of touching to the scale of atoms and molecules. Such instruments are especially useful for imaging of biomolecular structures because they can produce topographic images with submolecular resolution in aqueous environments. Instruments with increased imaging rates, lower probe-specimen force interactions, and probe configurations not constrained to planar surfaces are being developed, with the goal of imaging processes at the single-molecule level-not only at surfaces but also within three-dimensional volumes-in real time.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horber, J K H -- Miles, M J -- New York, N.Y. -- Science. 2003 Nov 7;302(5647):1002-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Wayne State University School of Medicine, 5229 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14605360" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/instrumentation/*methods ; Cellular Structures/physiology/*ultrasonography ; Crystallization ; Electrochemistry ; *Microscopy, Atomic Force/instrumentation/methods ; *Microscopy, Scanning Probe/instrumentation/methods ; Nanotechnology ; Optics and Photonics ; Protein Conformation ; Proteins/*chemistry/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Self-assembling cages from coiled-coil peptide modules (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-13
    Description: An ability to mimic the boundaries of biological compartments would improve our understanding of self-assembly and provide routes to new materials for the delivery of drugs and biologicals and the development of protocells. We show that short designed peptides can be combined to form unilamellar spheres approximately 100 nanometers in diameter. The design comprises two, noncovalent, heterodimeric and homotrimeric coiled-coil bundles. These are joined back to back to render two complementary hubs, which when mixed form hexagonal networks that close to form cages. This design strategy offers control over chemistry, self-assembly, reversibility, and size of such particles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fletcher, Jordan M -- Harniman, Robert L -- Barnes, Frederick R H -- Boyle, Aimee L -- Collins, Andrew -- Mantell, Judith -- Sharp, Thomas H -- Antognozzi, Massimo -- Booth, Paula J -- Linden, Noah -- Miles, Mervyn J -- Sessions, Richard B -- Verkade, Paul -- Woolfson, Derek N -- BB/G008833/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 May 3;340(6132):595-9. doi: 10.1126/science.1233936. Epub 2013 Apr 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23579496" target="_blank"〉PubMed〈/a〉
    Keywords: Circular Dichroism ; Microscopy, Electron, Scanning ; Models, Molecular ; Molecular Dynamics Simulation ; *Nanostructures ; Peptides/*chemistry ; Protein Conformation ; Protein Folding ; Protein Multimerization ; Protein Structure, Secondary ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Uniform patchy and hollow rectangular platelet micelles from crystallizable polymer blends (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-05-07
    Description: The preparation of colloidally stable, self-assembled materials with tailorable solid or hollow two-dimensional (2D) structures represents a major challenge. We describe the formation of uniform, monodisperse rectangular platelet micelles of controlled size by means of seeded-growth methods that involve the addition of blends of crystalline-coil block copolymers and the corresponding crystalline homopolymer to cylindrical micelle seeds. Sequential addition of different blends yields solid platelet block comicelles with concentric rectangular patches with distinct coronal chemistries. These complex nano-objects can be subject to spatially selective processing that allows their disassembly to form perforated platelets, such as well-defined hollow rectangular rings. The solid and hollow 2D micelles provide a tunable platform for further functionalization and potential for a variety of applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Qiu, Huibin -- Gao, Yang -- Boott, Charlotte E -- Gould, Oliver E C -- Harniman, Robert L -- Miles, Mervyn J -- Webb, Stephen E D -- Winnik, Mitchell A -- Manners, Ian -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2016 May 6;352(6286):697-701. doi: 10.1126/science.aad9521.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Chemistry, University of Bristol, Bristol BS8 1TS, UK. ; School of Physics, University of Bristol, Bristol BS8 1TL, UK. ; Central Laser Facility, Science and Technology Facilities Council, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0QX, UK. ; Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6, Canada. ; School of Chemistry, University of Bristol, Bristol BS8 1TS, UK. ian.manners@bristol.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27151866" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Observation of phase transitions in an antiferroelectric liquid crystal investigated by scanning tunneling microscopy (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 77 (1995), S. 122-126 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Here, we present scanning tunneling microscopy images of antiferroelectric liquid-crystalline (AFELC) molecules observed at different elevated temperatures corresponding to different bulk mesophases of the material. These images show evidence for a commensurate changing of the molecular arrangement on the graphite substrate as a function of temperature. Furthermore, a nontrivial angular relationship between the graphite substrate and the AFELC domains was obtained, indicating that there may be a stronger, polar (electrostatic) interaction between the AFELC molecules than between the adsorbate and the substrate. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.359378
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  • 5
    Electronic Resource
    Electronic Resource
    Studying topography and sub-surface structure of 8CB liquid crystal films with shear-force microscopy (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 3143-3146 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Scanning shear-force microscopy, which is usually employed to track scanning near-field optical microscopy probes across samples, was used to observe the sub-surface smectic layer structure through the thickness of a film of the alkyl cyanobiphenyl liquid crystal 8CB on a highly oriented pyrolytic graphite substrate from force-distance measurements. With the noncontact imaging shear-force microscopy supplies, it was possible to follow, in the topography, the movement of a monolayer of the 8CB molecules. This has enabled the diffusion of molecules in a precursor film of 8CB to be observed without significantly disrupting the free liquid surface. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363252
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  • 6
    Electronic Resource
    Electronic Resource
    Melt-drawn scanning near-field optical microscopy probe profiles (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 4804-4812 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Consistently obtaining super-resolution with scanning near-field optical microscopy depends almost entirely on the ability to manufacture reproducibly probes with aperture sizes smaller than 100 nm. The probe fabrication process usually involves heating an optical fiber using a CO2 laser and melt-drawing the glass to produce a taper. A number of variables ultimately define the taper shape but the actual effects these parameters have are still not clear. In this work, the physics behind the taper formation is examined in detail for the first time and equations describing the initial taper profile and the final aperture size are derived in terms of the experimental conditions. It is shown that the taper shape is primarily determined by the laser spot size. The pulling force, although important, has a lower significance. Continuum mechanics and Stefan's law are used to show that the aperture size is closely related to the radius of the fiber at the start of the hard pull and the fiber temperature at that time. Further comparisons of experimental data with the expected taper profile exposes the heating effect of the CO2 laser. Further analysis is given using a form of Mie theory which describes the interaction of electromagnetic fields with cylindrical structures. These results give many significant insights into the fabrication process and the formation of the aperture. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363521
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  • 7
    Electronic Resource
    Electronic Resource
    Carob gum-κ-carrageenan mixed gels: mechanical properties and x-ray fiber diffraction studies (1984)
    s.l. : American Chemical Society
    Macromolecules 17 (1984), S. 2443-2445 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00141a041
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  • 8
    Electronic Resource
    Electronic Resource
    A new method to measure the oscillation of a cylindrical cantilever: "The laser reflection detection system" (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 1689-1694 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new optical detection system for measuring the oscillation of cylindrical cantilevers has been designed. A laser beam is directed perpendicularly to the oscillating plane and is focused on the curved surface of the vibrating probe. The surface reflects the light and a second lens refocuses it onto a two-segment photodiode. The sensitivity of this method lies in the fact that a small displacement of the probe produces a large angular deflection of the reflected laser. Applications of this new system are presented in order to demonstrate its reliability, accuracy, sensitivity, and the possible use in a shear force microscope. All the results are finally analyzed by modeling the motion of the cantilevers using harmonic oscillator theory and the continuous model for oscillating bars. The agreement between experimental data and models is well inside the experimental errors confirming the possibility of using this system to accurately study the dynamics of cylindrical cantilevers. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150520
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  • 9
    Electronic Resource
    Electronic Resource
    Gravimetric Determination of Zirconium in Titanium (1959)
    s.l. : American Chemical Society
    Analytical chemistry 31 (1959), S. 252-254 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60146a029
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  • 10
    Electronic Resource
    Electronic Resource
    Determination of Beryllium in Titanium Alloys (1956)
    s.l. : American Chemical Society
    Analytical chemistry 28 (1956), S. 1728-1730 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60119a024
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