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Combined treatment with calcitonin and 1,25-dihydroxyvitamin D3 for osteoporosis in women (1993)

Eriksson, Staffan A. V. ; Lindgren, J. Urban

Springer

Calcified tissue international 53 (1993), S. 26-28

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ISSN: 1432-0827

Keywords: Calcitonin ; Calcitriol ; Calcium ; Densitometry ; Osteoporosis

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary Twenty-two middle-aged women with severe osteoporosis were treated for 2 years with either 0.5 mg of synthetic human calcitonin subcutaneously three times per week combined with 0.5 μg of calcitriol and 0.5 g of calcium per day orally or calcium only. The treatment with calcitonin plus calcitriol (12 patients) resulted in a significantly increased calcium absorption rate. The mean values for serum phosphate did not change during the treatment period and the mean values did not differ between the treatment groups, but the serum calcium and urinary Ca/Cr ratio increased somewhat in the group given the combined treatment. There was no evidence that the combined treatment improved the bone density in this study. It is possible that calcitriol, instead of increasing the effect of calcitonin by suppression of the parathyroid, might have counteracted its effect by increasing the bone resorption.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01352011

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Studies of the calcium accretion rate of bone during immobilization in intact and thyroparathyroidectomized adult rats (1977)

Lindgren, J. Urban

Springer

Calcified tissue international 22 (1977), S. 41-47

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ISSN: 1432-0827

Keywords: 45Calcium ; Immobilization ; Osteoporosis ; Parathyroid glands ; Thyroparathyroidectomy

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Abstract In order to study the role played by the thyroid and the parathyroid glands in the development of osteoporosis induced by immobilization, 153 male adult Sprague-Dawley rats allocated in two groups were used. The animals of one group were thyroparathyroidectomized; those of the other group were left intact. Each group was then divided into two subgroups; in one the right hind leg of the animals were immobilized by an elastic adhesive bandage. The animals were observed for varying periods of time up to 16 weeks. Studies of bone mass and45Ca accretion rate of the right and left femur and tibia were performed in all animals. The results indicate that disuse osteoporosis occurs in rats in the virtual absence of the thyroid and parathyroid glands. The bone loss of the immobilized femur and tibia was less pronounced in thyroparathyroidectomized rats compared to intact rats. The uptake of45Ca in bone treated by immobilization as compared to the non-immobilized bone was found to be increased to the same proportion in thyroparathyroidectomized and in intact rats. The calcium-accretion rate of non-immobilized bone was lower in thyroparathyroidectomized than in intact rats. The observations indicate that in the rat the parathyroid and thyroid hormones influence the rate of bone turnover and thereby the rate of development of disuse osteoporosis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02010345

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