ISSN:
0306-042X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Quantitative selected ion monitoring methods for the determination of plasma concentrations of nabilone, a psychotropically active 9-ketocannabinoid, and two carbinol metabolites using deuterium labeled internal standards are described. These specific methods have a lower limit of sensitivity of about 2 pmol ml-1 with a coefficient of variation of less than 4%. The utility of these methods was demonstrated by in vivo studies of single dose and steady state pharmacokinetics of nabilone and its carbinol metabolites in the dog.
Additional Material:
12 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200050405
Permalink