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  • 1
    Publication Date: 2023-01-13
    Keywords: AGE; Principal component 1; Principal component 2
    Type: Dataset
    Format: text/tab-separated-values, 2340 data points
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  • 2
    Publication Date: 2024-03-02
    Description: Regional stacks of benthic carbon isotopes from previously published data for the shallow North Atlantic (〈 2000 m), deep North Atlantic (〉 2000 m), and the South Atlantic for the last 800 kyr. Gradients between the shallow and deep North Atlantic, and between the deep North Atlantic and the South Atlantic.
    Type: Dataset
    Format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 92.3 kBytes
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  • 3
    Publication Date: 2024-03-02
    Description: Data compilation of sea-surface temperature, benthic carbon isotope, and multiple dust proxies interpolated to a time step of 2-kyr for the last 800-kyr.
    Type: Dataset
    Format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 270.4 kBytes
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  • 4
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    In:  Supplement to: Barth, Aaron M; Clark, Peter U; Bill, Nicholas S; He, Feng; Pisias, Nicklas G (2018): Climate evolution across the Mid-Brunhes Transition. Climate of the Past, 14(12), 2071-2087, https://doi.org/10.5194/cp-14-2071-2018
    Publication Date: 2024-03-02
    Description: The Mid-Brunhes Transition (MBT) began ∼430ka with an increase in the amplitude of the 100-kyr climate cycles of the past 800,000 years. The MBT has been identified in ice-core records, which indicate interglaciations became warmer with higher atmospheric CO2 levels after the MBT, and benthic oxygen isotope (δ18O) records, which suggest that post-MBT interglaciations had higher sea levels than pre-MBT interglaciations. It remains unclear, however, whether the MBT was a globally synchronous phenomenon that included other components of the climate system. Here we further characterize changes in the climate system across the MBT through statistical analyses of ice-core and δ18O records as well as sea-surface temperature, benthic carbon isotope, and dust accumulation records. Our results demonstrate that the MBT was a global event with a significant increase in climate variance in most components of the climate system assessed here. However, our results indicate that the onset of high-amplitude variability in temperature, atmospheric CO2, and sea level at ∼430ka was preceded by changes in the carbon cycle, ice sheets, and monsoon strength during MIS 14 and 13.
    Type: Dataset
    Format: application/zip, 3 datasets
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 468-471 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper presents a simulation analysis of stress and strain of an underground railelastic bar using the commercial finite-element simulator ANSYS-10. Under constant compressiondisplacement of 10.4 mm or the fixed-plug-in displacement of 84 mm, the stress distributions areexamined by varying the boundary condition of the corresponding fixed-plug-in displacement or thecompression displacement. Results show that the maximum stress which is 1,490 Mpa occurs as thecompression displacement is 10.4 mm while the fixed-plug-in displacement is 84 mm. In addition,in both group of scenarios the maximum stress is at the end of the arc of the elastic bar and exceedsthe strength limit of 60Si2Mn. While both the compression displacement and the fixed-plug-indisplacement affect the stress distribution and the maximum stress, it appears that the effect due tocompression displacement is much more significant
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Attachment to host cells by enterohaemorrhagic Escherichia coli (EHEC) is associated with the formation of a highly organized cytoskeletal structure containing filamentous actin, termed an attaching and effacing (AE) lesion. Intimin, an outer membrane protein of EHEC, is required for the formation of AE lesions, as is Tir, a bacterial protein that is translocated into the host cell to function as a receptor for intimin. We established a yeast two-hybrid assay for intimin–Tir interaction and, after random mutagenesis, isolated 24 point mutants in intimin, which disrupted Tir recognition in this system. Analysis of 11 point mutants revealed a correlation between recognition of recombinant Tir and the ability to trigger AE lesions. Many of the mutations fell within a 50-residue region near the C-terminus of intimin. Alanine-scanning mutagenesis of this region revealed four residues (Ser890, Thr909, Asn916 and Asn927) that are critical for Tir recognition. Mapping the sequences of EHEC intimin and Tir onto the crystal structure of the intimin–Tir complex of enteropathogenic E. coli predicts that each of these four intimin residues lies at the intimin–Tir interface and contributes to a pocket that interacts with Ile298 of EHEC Tir. Thus, this genetic approach to intimin function both identified residues critical for Tir binding and demonstrated a correlation between the ability to bind Tir and the ability to trigger actin focusing.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Microchimica acta 100 (1990), S. 293-297 
    ISSN: 1436-5073
    Keywords: determination of sulfite ; piezoelectric detector ; microdetermination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A piezoelectric method is proposed for the determination of sulfite in concentration range 1 × 10−7−1 × 10−5 mol/1. The method is based on the redox reaction of sulfite with iodine followed by measuring frequency change of the piezoelectric crystal caused by the unreacted iodine. The method is applied to the determination of sulfite in liquor.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0983
    Keywords: Yarrowia lipolytica ; 7SL RNA ; Essential genes ; Yeast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Cells containing a deletion of either the SCR1 or SCR2 genes, which code for the 7SL RNA component of the signal recognition particle (SRP) homologue, were found to be viable. Two independent approaches demonstrated that cells containing deletions of both genes were inviale. Therefore, Yarrowia lipolytica contains two (and only two) functional 7SL RNA genes.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 297-300 (Nov. 2005), p. 1968-1972 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Metal materials especially steel or cast iron are used extensively in many types ofconstruction such as buildings, bridges, cranes, vehicles and so on, so detection or prediction of metal failure is very important, but deformation of metal material often deliveries heat energy which can be detected by infrared imager. The test specimen is installed between the two grips of the testing machine and then loaded in tension and in compression. The IR913A infrared imager is used to observe the deformation of metal specimen. The high-sensitive infrared thermal images of metal specimen in the different phase of deformation are obtained. The paper theoretically analyzes thereason from the thermodynamics and plastic mechanics, the conclusions are drawn as follows: 1) When applying loads, temperature field on the surface of metal specimen is changing, the local rise of temperature is remarkable, this can be observed from the infrared thermal images. 2) From the infrared thermal images, rising temperatures are found in the regions of stress concentrations. 3) When the test specimen approaches to failure or appears fracture, there is a remarkable change that can be shown from the infrared thermal images with remarkable colors
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1423-0127
    Keywords: Promoter ; Transcription factor ; Transactivation ; Signal transduction ; Phorbol ester ; Protein kinase A ; Protein kinase C ; DNA repair enzyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract That mammalian DNA polymerase-β (β-pol) gene transcription is upregulated by activatedras and also by phorbol ester (TPA) treatment suggests the involvement of protein kinase C in the gene expression control for this DNA repair enzyme. Yet, the core promoters of the human, bovine and rodent β-pol genes do not have a TPA response element or other binding site for the transcriptional activator AP-1. Instead, these β-pol promoters appear to be regulated mainly by proteins binding to the cAMP response element (CRE) centered within 50 bp 5′ of the transcriptional start site. In this study, the CRE in the human β-pol promoter was found to mediate TPA upregulation of the cloned promoter in HeLa cell transient expression experiments. To further examine the role of this CRE in TPA stimulation, we used several mutated promoters that were either deficient in protein binding to the CRE or contained extra CRE sites arranged as tandem repeats. All constructs with at least one functional CRE were upregulated by TPA, whereas mutants lacking CRE protein-binding function were not TPA upregulated. Analyses of HeLa nuclear extract DNA-binding proteins indicated that the β-pol CRE was bound by CRE-binding protein (CREB) family members CREB-1 and activating transcription factor-1, but not by AP-1 or complexes containg AP-1 subunits. These results suggest that CREB, rather than AP-1 proteins, are required for the CRE-mediated TPA activation of the β-pol promoter.
    Type of Medium: Electronic Resource
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