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  • 1
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    The Natriuretic Hormones (2021)
    Frontiers Media SA
    Details
    Publikationsdatum: 2022-01-31
    Beschreibung: The title follows from the original demonstration by Dr. Hugh de Wardener in 1961 that a humoral agent is produced after extracellular volume expansion which results in a vigorous diuresis and natriuresis. Thus the name of "natriuretic hormone" was coined. In the years that followed several investigators pursued the search for the hormone. What resulted, however, was the discovery of several hormones with different characteristics, all of which were natriuretic. Initially it was found that the hormone was similar in action to ouabain or digoxin, hence the appelation of ouabain-like or digoxin-like. The hormone was found to be an inhibitor of Na-K-ATPase, which would fit with it being a cardiotonic steroid. On the other hand, neither ouabain or digoxin migrated on Sephadex gel filtration in the same locus as the hormone. Other investigators claim to have identified the hormone-initially as a vanadium-diascorbate, later as bufadienolides such as marinobufagenin, yet later as a macrocylic derivative of inorganic carbon suboxide with a molecular weight of 408 Da. Some support for the latter finding was derived from an earlier report that a semi-purified Sephadex-derived compound was found to have a molecular weight of about 12,000 Da but the active compound, when split from its carrier protein, had a molecular weight of exactly 408 Da. This compound had not been further identified. As further development was the demonstration by Bricker and colleagues that a natriuretic substance could be purified from uremic urine. This turned out to be a xathurenic acid derivative. Meanwhile the focus began to turn to natriuretic peptides derived from heart (ANF and BNP). These peptides have a shorter duration of action than the cardiotonic steroid-like hormone and ANF has proved to be most useful as a measure of heart failure. It should also be stressed that marinobufagenin, like ANF, is elevated in congestive heart failure, whereas the steroid-like hormone is depressed or absent in this state. This review will attempt to describe and contrast the properties of each of the proposed natriuretic hormones, including their locus on Sephadex separation, potency, duration of action, chemical structure (if known), behavior in hypertension, renal failure, heart failure, and brain disease. As most recent work has focussed on marinobufagenin, this hormone will be brought up to date by investigators in the field.
    Schlagwort(e): RC648-665 ; R5-920 ; Hypertension ; Volume expansion ; Natriuresis ; Hypothalamus ; hormone
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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    E-BOOK
  • 2
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    The existence of a thin low-viscosity layer beneath the lithosphere (1986)
    In:  Earth planet. Sci. Lett., Roma, Acad. Roy. des Sciences, vol. 78, no. 4, pp. 420-426, pp. B04102, (ISBN: 0-12-018847-3)
    Details
    Publikationsdatum: 1986
    Schlagwort(e): Inelastic ; Rheology ; Low viscosity zone ; EPSL
    Standort Signatur Erwartet Verfügbarkeit
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    BIBLIOGRAFIE SEISMOLOGIE
  • 3
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    Air quality impacts of increased use of ethanol under the United States’ Energy Independence and Security Act (2011)
    Elsevier
    Details
    Publikationsdatum: 2011-12-01
    Print ISSN: 1352-2310
    Digitale ISSN: 1873-2844
    Thema: Energietechnik , Geologie und Paläontologie , Physik
    Publiziert von Elsevier
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 4
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    Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus (2016)
    Molecular Diversity Preservation International
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    Publikationsdatum: 2016-09-27
    Digitale ISSN: 2079-6382
    Thema: Chemie und Pharmazie , Medizin
    Publiziert von Molecular Diversity Preservation International
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 5
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    The Economic Impact of Starting, Stopping, and Restarting an Antibiotic Stewardship Program: A 14-Year Experience (2013)
    Molecular Diversity Preservation International
    Details
    Publikationsdatum: 2013-04-24
    Digitale ISSN: 2079-6382
    Thema: Chemie und Pharmazie , Medizin
    Publiziert von Molecular Diversity Preservation International
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 6
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    An oxidation and stable mounting technique for geothermally altered Upper Devonian palynomorphs from western Venezuela (2001)
    Copernicus
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    Publikationsdatum: 2001-12-01
    Beschreibung: Upper Devonian sediments from western Venezuela have yielded palynomorphs that exhibit the palynomorph re-darkening and cracking phenomenon during post-oxidation mounting. A preparation technique has been developed, utilizing a diluted Schultze solution for prolonged periods, that appears not to affect substantially the structure of the palynomorphs, and thus prevents re-darkening. The use of PVA and Petropoxy 154 for mounting ensured the post-oxidative stability of the palynomorphs at room temperature. Conversely, the use of Elvacite 2044 as a mounting medium may cause cracking of the palynomorphs, related to shrinkage during solvent evaporation.
    Print ISSN: 0262-821X
    Digitale ISSN: 2041-4978
    Thema: Geologie und Paläontologie
    Publiziert von Copernicus im Namen von Micropalaeontological Society.
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 7
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    Habitats in Extreme Environments Senior Design Project (2011)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: No abstract available
    Schlagwort(e): Man/System Technology and Life Support
    Materialart: KSC-2011-176 , Third Annual ESMD Space Grant Faculty Senior Design Training; Jul 27, 2011 - Jul 28, 2011; Merritt Island, FL; United States
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 8
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    Decision Support for Emergency Operations Centers (2005)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-12
    Beschreibung: The Flood Disaster Mitigation Decision Support System (DSS) is a computerized information system that allows regional emergency-operations government officials to make decisions regarding the dispatch of resources in response to flooding. The DSS implements a real-time model of inundation utilizing recently acquired lidar elevation data as well as real-time data from flood gauges, and other instruments within and upstream of an area that is or could become flooded. The DSS information is updated as new data become available. The model generates realtime maps of flooded areas and predicts flood crests at specified locations. The inundation maps are overlaid with information on population densities, property values, hazardous materials, evacuation routes, official contact information, and other information needed for emergency response. The program maintains a database and a Web portal through which real-time data from instrumentation are gathered into the database. Also included in the database is a geographic information system, from which the program obtains the overlay data for areas of interest as needed. The portal makes some portions of the database accessible to the public. Access to other portions of the database is restricted to government officials according to various levels of authorization. The Flood Disaster Mitigation DSS has been integrated into a larger DSS named REACT (Real-time Emergency Action Coordination Tool), which also provides emergency operations managers with data for any type of impact area such as floods, fires, bomb
    Schlagwort(e): Man/System Technology and Life Support
    Materialart: SSC-00206-1 , NASA Tech Briefs, June 2005; 15
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    NASA TECHNICAL REPORTS
  • 9
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    CropEx Web-Based Agricultural Monitoring and Decision Support (2011)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-12
    Beschreibung: CropEx is a Web-based agricultural Decision Support System (DSS) that monitors changes in crop health over time. It is designed to be used by a wide range of both public and private organizations, including individual producers and regional government offices with a vested interest in tracking vegetation health. The database and data management system automatically retrieve and ingest data for the area of interest. Another stores results of the processing and supports the DSS. The processing engine will allow server-side analysis of imagery with support for image sub-setting and a set of core raster operations for image classification, creation of vegetation indices, and change detection. The system includes the Web-based (CropEx) interface, data ingestion system, server-side processing engine, and a database processing engine. It contains a Web-based interface that has multi-tiered security profiles for multiple users. The interface provides the ability to identify areas of interest to specific users, user profiles, and methods of processing and data types for selected or created areas of interest. A compilation of programs is used to ingest available data into the system, classify that data, profile that data for quality, and make data available for the processing engine immediately upon the data s availability to the system (near real time). The processing engine consists of methods and algorithms used to process the data in a real-time fashion without copying, storing, or moving the raw data. The engine makes results available to the database processing engine for storage and further manipulation. The database processing engine ingests data from the image processing engine, distills those results into numerical indices, and stores each index for an area of interest. This process happens each time new data is ingested and processed for the area of interest, and upon subsequent database entries, the database processing engine qualifies each value for each area of interest and conducts a logical processing of results indicating when and where thresholds are exceeded. Reports are provided at regular, operator-determined intervals that include variances from thresholds and links to view raw data for verification, if necessary. The technology and method of development allow the code base to easily be modified for varied use in the real-time and near-real-time processing environments. In addition, the final product will be demonstrated as a means for rapid draft assessment of imagery.
    Schlagwort(e): Man/System Technology and Life Support
    Materialart: SSC-00312 , NASA Tech Briefs, November 2011; 6
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 10
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    Software for Viewing Landsat Mosaic Images (2003)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-12
    Beschreibung: A Windows-based computer program has been written to enable novice users (especially educators and students) to view images of large areas of the Earth (e.g., the continental United States) generated from image data acquired in the Landsat observations performed circa the year 1990. The large-area images are constructed as mosaics from the original Landsat images, which were acquired in several wavelength bands and each of which spans an area (in effect, one tile of a mosaic) of .5 in latitude by .6 in longitude. Whereas the original Landsat data are registered on a universal transverse Mercator (UTM) grid, the program converts the UTM coordinates of a mouse pointer in the image to latitude and longitude, which are continuously updated and displayed as the pointer is moved. The mosaic image currently on display can be exported as a Windows bitmap file. Other images (e.g., of state boundaries or interstate highways) can be overlaid on Landsat mosaics. The program interacts with the user via standard toolbar, keyboard, and mouse user interfaces. The program is supplied on a compact disk along with tutorial and educational information.
    Schlagwort(e): Man/System Technology and Life Support
    Materialart: SSC-00148 , NASA Tech Briefs, April 2003; 15
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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