Publication Date:
2016-05-21
Description:
3BNC117 is a broad and potent neutralizing antibody to HIV-1 that targets the CD4 binding site on the viral envelope spike. When administered passively, this antibody can prevent infection in animal models and suppress viremia in HIV-1-infected individuals. Here we report that HIV-1 immunotherapy with a single injection of 3BNC117 affects host antibody responses in viremic individuals. In comparison to untreated controls that showed little change in their neutralizing activity over a 6-month period, 3BNC117 infusion significantly improved neutralizing responses to heterologous tier 2 viruses in nearly all study participants. We conclude that 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schoofs, Till -- Klein, Florian -- Braunschweig, Malte -- Kreider, Edward F -- Feldmann, Anna -- Nogueira, Lilian -- Oliveira, Thiago -- Lorenzi, Julio C C -- Parrish, Erica H -- Learn, Gerald H -- West, Anthony P Jr -- Bjorkman, Pamela J -- Schlesinger, Sarah J -- Seaman, Michael S -- Czartoski, Julie -- McElrath, M Juliana -- Pfeifer, Nico -- Hahn, Beatrice H -- Caskey, Marina -- Nussenzweig, Michel C -- 1UM1 AI00645/AI/NIAID NIH HHS/ -- 1UM1 AI100663-01/AI/NIAID NIH HHS/ -- AI045008/AI/NIAID NIH HHS/ -- F30 AI112426/AI/NIAID NIH HHS/ -- P01 AI100148/AI/NIAID NIH HHS/ -- UM1AI068618/AI/NIAID NIH HHS/ -- UM1AI069481/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 May 20;352(6288):997-1001. doi: 10.1126/science.aaf0972. Epub 2016 May 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. ; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. Laboratory of Experimental Immunology, Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Department of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, 50937 Cologne, Germany. ; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. Albert Ludwigs University of Freiburg, Freiburg, Germany. ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E14, 66123 Saarbrucken, Germany. ; Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. ; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27199429" target="_blank"〉PubMed〈/a〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
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Chemistry and Pharmacology
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Computer Science
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Medicine
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Natural Sciences in General
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Physics
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