ISSN:
1573-501X
Keywords:
adrenergic agonists and antagonists
;
ethanolamine library
;
ion exchange chromatography
;
parallel synthesis
;
reductive amination
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A library of potential agonists and antagonists for adrenergic receptors was prepared using high-throughput solution-phase parallel synthesis. Traditional solution-phase reductive amination reactions followed by rapid purification by ion exchange chromatography yielded products with near-analytical purity. An array of ketones and amines, arranged in an 8 × 12 matrix, were combined to form 96 individual compounds.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009602403514
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