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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicholson, Donald W -- Thornberry, Nancy A -- New York, N.Y. -- Science. 2003 Jan 10;299(5604):214-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Montreal, Quebec HLH 3LI, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12522239" target="_blank"〉PubMed〈/a〉
    Keywords: *Apoptosis ; Caspase 3 ; Caspase 9 ; Caspases/metabolism ; Cell Transformation, Neoplastic ; Enzyme Activation ; Humans ; Mitochondria/*metabolism ; Neoplasms/etiology/metabolism/pathology ; Protein Precursors/*metabolism ; Pyridines/*pharmacology ; RNA Interference ; Thymosin/*analogs & derivatives/*metabolism ; Tumor Suppressor Proteins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Nature Publishing Group (NPG)
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicholson, Donald W -- England -- Nature. 2009 Feb 19;457(7232):970-1. doi: 10.1038/457970a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225511" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/chemistry/*metabolism ; Animals ; Caspase 6/*metabolism ; Cell Death ; Mice ; Neurons/*cytology/*metabolism ; Peptide Fragments/chemistry/*metabolism ; Receptors, Tumor Necrosis Factor/*metabolism ; Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 98 (1993), S. 213-219 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary A model attributed to Dugdale provides a correction for plasticity effects at crack tips in Mode I, under the assumption of small-scale yielding. Similar models have been proposed for Modes II and III, the former fairly recently. In the present study, the Dugdale model is extended to cases combining Modes I, II and III, based on the von Mises yield criterion. The combined model provides an a posteriori estimate for plasticity effects, based only on the stress intensity factors from the elasticity solution. It also provides an estimate for the crack-opening displacement and theJ-integral value. In the limit of small loads, the corresponding elastic results are recovered.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 13 (1977), S. 279-287 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Résumé Des modèles qui décrivaient, pour de faibles flexions, le pelage d'une bande élastique hors d'un substrat rigide ont été étendus aux cas des grandes flexions. Des résultats de calcul obtenus par une méthode à valeur initiale sont présentés. L'une des observations est que l'analyse actuelle recourant à de grandes flexions et les modèles conventionnels basés sur des considérations d'énergie permettent de prédire la même dépendance des force de pelage avec l'angle de pelage.
    Notes: Abstract Previous small bending models for the peeling of an elastic strip from a rigid substrate are extended to large bending. Computational results obtained by an initial value method are presented. One finding is that the present large bending analysis and the conventional models based on energy considerations predict the same dependence of peel force on peel angle.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 16 (1981), S. 949-956 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A simple theoretical analysis has been developed for the force required to pull out an inextensible cord, or an array of cords, partly embedded in an elastic block. The analysis is based upon Griffith's fracture criterion: that energy supplied by the loading device as the cords are pulled out must be greater than the energy required to fracture the cord-block interface plus any increase in strain energy of the block itself. The pull-out force is obtained in this way as a function of cord diameter, the dimensions of the block, Young's modulus of the block material and the fracture energy per unit area of the interface. Measurements with brass-plated steel wire cords of various diameters, embedded to various depths in rubber blocks of varied dimensions, made of rubber having a wide range of Young's modulus, were all found to be in good agreement with the theoretical predictions. Moreover, the inferred value of the interfacial fracture energy is similar to a directly-measured value for rubber adhering to brass, about 20 kJ m−2. The theoretical treatment also predicts that the total pull-out force for an array of n cords will increase in proportion to n 1/2, until transverse fracture intervenes. Both the proportionality to n 1/2and the predicted transition to transverse fracture instead of cord pull-out have been observed. This broad agreement with the predictions of the theory suggests that the main factors governing cord pull-out have been taken into account.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 112 (1995), S. 187-201 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary In this study, using the VEC operator [1], compact expressions are formulated for the tangent modulus matrix of hyperelastic materials, in particular elastomers, using Lagrangian coordinates. Compressible, incompressible, and near-compressible materials are considered. Expressions are obtained for the corresponding finite element tangent stiffness matrices. It is observed that the incremental stress-strain relations should be considered anisotropic. Numerical procedures based on Newton iteration are sketched. The limiting case of small strain is developed. Finally, the tangent modulus matrix is presented for the Mooney-Rivlin material, with application to the rubber rod element.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 134 (1999), S. 199-215 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary The tangent modulus tensor, denoted as $$\mathfrak{D}$$ , plays a central role in finite element simulation of nonlinear applications such as metalforming. Using Kronecker product notation, compact expressions for $$\mathfrak{D}$$ have been derived in Refs. [1]–[3] for hyperelastic materials with reference to the Lagrangian configuration. In the current investigation, the corresponding expression is derived for materials experiencing finite strain due to plastic flow, starting from yield and flow relations referred to the current configuration. Issues posed by the decomposition into elastic and plastic strains and by the objective stress flux are addressed. Associated and non-associated models are accommodated, as is “plastic incompressibility”. A constitutive inequality with uniqueness implications is formulated which extends the condition for “stability in the small” to finite strain. Modifications of $$\mathfrak{D}$$ are presented which accommodate kinematic hardening. As an illustration, $$\mathfrak{D}$$ is presented for finite torsion of a shaft, comprised of a steel described by a von Mises yield function with isotropic hardening.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 34 (1979), S. 263-266 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 58 (1986), S. 113-122 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary A thermoviscoplastic constitutive model is used to treat uniaxial shock wave propagation in a material exhibiting rate-sensitive plasticity and thermal softening. Simple relations are obtained for the pressure jump as a function of the density jump, shock speed as a function of particle velocity, and pressure decay behind the shock front. Also, the model predicts a two-stage temperature rise, involving a jump at the shock front followed by a rise due to plastic dissipation (stress decay). The temperature rise and other quantities are predicted in the case of impact of titanium plates.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica 69 (1987), S. 167-175 
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Previously, stability inequalities in viscoplasticity appear to have been applied primarily to cases in which the associated flow rule is satisfied. Here, a stability inequality is formulated for a simple example of a non-associated viscoplastic constitutive model. The inequality ensures that a certain Jacobian matrix is Hurwitz. The main mathematical difficulty in non-associated models is the presence of a nonsymmetric vector dyadic product in the Jacobian matrix. In the current paper, to overcome this difficulty, general upper and lower bounds on the real parts of the eigenvalues of such products are derived and applied to the Jacobian matrix of interest. A relatively “sharp” stability inequality is first obtained in a complicated form. At some loss in sharpness, it is simplified to furnish a second inequality purely involving the condition number of a “flow compliance” matrix. Applications are given which correspond to an isotropic associated flow model and to a transversely isotropic non-associated model.
    Type of Medium: Electronic Resource
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