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  • 1
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    Correlation between ground failure and soil conditions in Adapazar?, Turkey (2002)
    In:  Soil Dynamics and Earthquake Engineering, Basel, Inst. f. Geophys., Ruhr-Univ. Bochum, vol. 22, no. 9-12, pp. 1093-1102, pp. 1009, (ISSN: 1340-4202)
    Details
    Publication Date: 2002
    Keywords: Site amplification ; liquefaction ; Correlation ; basin ; Fault zone ; NAF ; noksp ; Oenalp ; Onalp ; SDEE
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Empirical attenuation relationship for Arias intensity (2003)
    In:  Earthquake Engineering and Structural Dynamics, Warszawa, EGS, vol. 32, no. 7, pp. 1133-1155, pp. L15S11, (ISSN: 1340-4202)
    Details
    Publication Date: 2003
    Keywords: Intensity ; Attenuation ; Earthquake engineering, engineering seismology ; noksp ; EESD
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    Nonlinear site response: Where we're at (A report from a SCEC/PEER seminar and workshop) (1998)
    In:  Seismological Research Letters, Tokyo, Terra Scientific Publishing Company, vol. 69, no. 3, pp. 230-235, pp. B12407, (ISBN: 0534351875, 2nd edition)
    Details
    Publication Date: 1998
    Keywords: Site amplification ; Non-linear effects ; Review article ; noksp ; SRL
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    BIBLIOGRAPHY SEISMOLOGY
  • 4
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    Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila (2015)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2015-12-10
    Description: Genetic and environmental factors influence complex disease in humans, such as metabolic syndrome, and Drosophila melanogaster serves as an excellent model in which to test these factors experimentally. Here we explore the modularity of endophenotypes with an in-depth reanalysis of a previous study by Reed et al . (2014) , where we raised 20 wild-type genetic lines of Drosophila larvae on four diets and measured gross phenotypes of body weight, total sugar, and total triglycerides, as well as the endophenotypes of metabolomic and whole-genome expression profiles. We then perform new gene expression experiments to test for conservation of phenotype-expression correlations across different diets and populations. We find that transcript levels correlated with gross phenotypes were enriched for puparial adhesion, metamorphosis, and central energy metabolism functions. The specific metabolites L-DOPA and N -arachidonoyl dopamine make physiological links between the gross phenotypes across diets, whereas leucine and isoleucine thus exhibit genotype-by-diet interactions. Between diets, we find low conservation of the endophenotypes that correlate with the gross phenotypes. Through the follow-up expression study, we found that transcript-trait correlations are well conserved across populations raised on a familiar diet, but on a novel diet, the transcript-trait correlations are no longer conserved. Thus, physiological canalization of metabolic phenotypes breaks down in a novel environment exposing cryptic variation. We cannot predict the physiological basis of disease in a perturbing environment from profiles observed in the ancestral environment. This study demonstrates that variation for disease traits within a population is acquired through a multitude of physiological mechanisms, some of which transcend genetic and environmental influences, and others that are specific to an individual’s genetic and environmental context.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 5
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    Evaluating Ammonia (NH3) Predictions in the NOAA NAQFC for Eastern North Carolina Using Ground Level and Satellite Measurements (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Ammonia (NH3) in the atmosphere contributes to the formation of airborne fine particulate matter (PM2.5), which is associated with adverse human health effects. The emission, transport, reactions, and deposition of NH3 in the atmosphere are modeled using the Community Multiscale Air Quality (CMAQ) model, within the U.S. National Air Quality Forecast Capability (NAQFC). The purpose of this current work is to evaluate the capability of the NAQFC CMAQ model and to identify potential improvements to NH3 emissions estimates and prediction methods. This study focuses on CMAQ predictions of atmospheric NH3 in North Carolina, including a region with intensive animal production and enhanced NH3 emissions. The CMAQ model is run for July 2011 using a version of the 2011 National Emissions Inventory in which agricultural NH3 emissions were adjusted to reflect the lower end of the range of estimates from the current process‐based emissions model. The NAQFC CMAQ model overpredicted atmospheric NH3 at a continuous monitor in Clinton, NC, within the region of intensive animal production. The average concentration measured by the monitor was 6.6 ppbv, while the average predicted by the model was 10.5 ppbv, a 60% overprediction. Outside of the region of intensive animal production, both measured and modeled NH3 concentrations were low, 1.3 ppbv or less. The model underpredicted wet deposition of NH4+ and dry deposition of NH3. It is believed that the overestimation of NH3 at Clinton is attributable at least in part to the underestimation of wet and dry deposition in North Carolina.
    Print ISSN: 2169-897X
    Electronic ISSN: 2169-8996
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    Genomics. Molecular prodigality (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bray, Dennis -- New York, N.Y. -- Science. 2003 Feb 21;299(5610):1189-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK. d.bray@zoo.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12595679" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Antibody Diversity ; Escherichia coli Proteins/chemistry/genetics/metabolism ; Evolution, Molecular ; Genetic Variation ; Genomics ; Histones/chemistry/genetics/metabolism ; Humans ; Methylation ; Phenotype ; Potassium Channels/chemistry/genetics/metabolism ; Protein Conformation ; Protein Isoforms/chemistry/metabolism ; Protein Processing, Post-Translational ; Proteins/*chemistry/genetics/*metabolism ; Proteomics ; RNA Splicing ; Receptors, Cell Surface/chemistry/genetics/metabolism ; Selection, Genetic ; Troponin T/chemistry/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    B cell ligand discrimination through a spreading and contraction response (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-05-06
    Description: B cells recognize foreign antigens by virtue of cell surface immunoglobulin receptors and are most effectively activated by membrane-bound ligands. Here, we show that in the early stages of this process, B cells exhibit a two-phase response in which they first spread over the antigen-bearing membrane and then contract, thereby collecting bound antigen into a central aggregate. The extent of this response, which is both signaling- and actin-dependent, determines the quantity of antigen accumulated and hence the degree of B cell activation. Brownian dynamic simulations reproduce essential features of the antigen collection process and suggest a possible basis for affinity discrimination. We propose that dynamic spreading is an important step of the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleire, S J -- Goldman, J P -- Carrasco, Y R -- Weber, M -- Bray, D -- Batista, F D -- G64713/PHS HHS/ -- New York, N.Y. -- Science. 2006 May 5;312(5774):738-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16675699" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Algorithms ; Animals ; Antibody Affinity ; Antigen Presentation ; Antigens, Surface/*immunology ; B-Lymphocytes/*immunology/*physiology ; Cell Shape ; Computer Simulation ; Flow Cytometry ; Ligands ; Lipid Bilayers ; *Lymphocyte Activation ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence ; Models, Immunological ; Muramidase/immunology ; Receptors, Antigen, B-Cell/*immunology/metabolism ; Recombinant Fusion Proteins/immunology ; Signal Transduction ; Stochastic Processes ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Molecular networks: the top-down view (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-09-27
    Description: Network theory can give a useful overview of how a biological system works. But to make testable predictions, we need the details.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bray, Dennis -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1864-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512614" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalysis ; *Cell Physiological Phenomena ; Enzymes/metabolism ; *Gene Expression Regulation ; Mathematics ; *Metabolism ; *Models, Biological ; Nerve Net/physiology ; Protein Binding ; Proteins/*metabolism ; *Signal Transduction ; Systems Theory
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines (2016)
    BioMed Central
    Details
    Publication Date: 2016-05-22
    Description: The major histocompatibility complex (MHC) plays a crucial role in the adaptive immune system and has been extensively studied across vertebrate taxa. Although the function of MHC genes appears to be conserved...
    Electronic ISSN: 1471-2148
    Topics: Biology
    Published by BioMed Central
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  • 10
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    Turing centenary: Is the brain a good model for machine intelligence? (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooks, Rodney -- Hassabis, Demis -- Bray, Dennis -- Shashua, Amnon -- England -- Nature. 2012 Feb 22;482(7386):462-3. doi: 10.1038/482462a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts Institute of Technology, USA〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22358812" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; *Artificial Intelligence ; Brain/cytology/*physiology ; Computers/history ; History, 20th Century ; Humans ; Intelligence/physiology ; *Models, Neurological ; Neurosciences/history/methods ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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