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  • 1
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    In:  Eos, Trans., Am. Geophys. Un., Warszawa, 1-3, vol. 84, no. 32, pp. 301, 304 & 305, pp. 1046, (ISSN: 1340-4202)
    Publication Date: 2003
    Keywords: Deep seismic sounding (espec. cont. crust) ; South ; America ; GFZ ; Andes ; Earthquake
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  • 2
    Publication Date: 2012-07-09
    Description: The Network Architecture of Cortical Processing in Visuo-spatial Reasoning Scientific Reports 2, 18052012 doi: 10.1038/srep00411 Ehsan Shokri-Kojori Michael A. Motes Bart Rypma Daniel C. Krawczyk Reasoning processes have been closely associated with prefrontal cortex (PFC), but specifically emerge from interactions among networks of brain regions. Yet it remains a challenge to integrate these brain-wide interactions in identifying the flow of processing emerging from sensory brain regions to abstract processing regions, particularly within PFC. Functional magnetic resonance imaging data were collected while participants performed a visuo-spatial reasoning task. We found increasing involvement of occipital and parietal regions together with caudal-rostral recruitment of PFC as stimulus dimensions increased. Brain-wide connectivity analysis revealed that interactions between primary visual and parietal regions predominantly influenced activity in frontal lobes. Caudal-to-rostral influences were found within left-PFC. Right-PFC showed evidence of rostral-to-caudal connectivity in addition to relatively independent influences from occipito-parietal cortices. In the context of hierarchical views of PFC organization, our results suggest that a caudal-to-rostral flow of processing may emerge within PFC in reasoning tasks with minimal top-down deductive requirements.
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 3
    Publication Date: 2001-09-22
    Description: The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffiths, E K -- Krawczyk, C -- Kong, Y Y -- Raab, M -- Hyduk, S J -- Bouchard, D -- Chan, V S -- Kozieradzki, I -- Oliveira-Dos-Santos, A J -- Wakeham, A -- Ohashi, P S -- Cybulsky, M I -- Rudd, C E -- Penninger, J M -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2260-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567140" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; *Adaptor Proteins, Signal Transducing ; Animals ; Antigens, CD/metabolism ; Antigens, CD3/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; B-Lymphocytes/immunology ; Carrier Proteins/genetics/*physiology ; Cell Adhesion ; Cell Adhesion Molecules/metabolism ; Chimera ; Gene Targeting ; Humans ; Immunization ; Immunoglobulin G/biosynthesis ; Integrins/*metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Interferon-gamma/biosynthesis ; Interleukin-2/biosynthesis/pharmacology ; Lectins, C-Type ; *Lymphocyte Activation ; Lymphocyte Function-Associated Antigen-1/metabolism ; Mice ; Phosphoproteins/genetics/*physiology ; Receptors, Antigen, T-Cell/immunology/metabolism ; Receptors, Interleukin-2/metabolism ; Recombinant Proteins/metabolism ; Signal Transduction ; T-Lymphocytes/immunology/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-11-17
    Description: High-velocity lower crust (HVLC) and seawarddipping reflector (SDR) sequences are typical features of volcanic rifted margins. However, the nature and origin of HVLC is under discussion. Here we provide a comprehensive analysis of deep crustal structures in the southern segment of the South Atlantic and an assessment of HVLC along the margins. Two new seismic refraction lines off South America fill a gap in the data coverage and together with five existing velocity models allow for a detailed investigation of the lower crustal properties on both margins. An important finding is the major asymmetry in volumes of HVLC on the conjugate margins. The seismic refraction lines across the South African margin reveal cross-sectional areas of HVLC 4 times larger than at the South American margin, a finding that is opposite to the asymmetric distribution of the flood basalts in the Paraná–Etendeka Large Igneous Province. Also, the position of the HVLC with respect to the SDR sequences varies consistently along both margins. Close to the Falkland–Agulhas Fracture Zone in the south, a small body of HVLC is not accompanied by SDRs. In the central portion of both margins, the HVLC is below the inner SDR wedges while in the northern area, closer to the Rio Grande Rise-Walvis Ridge, large volumes of HVLC extend far seaward of the inner SDRs. This challenges the concept of a simple extrusive/intrusive relationship between SDR sequences and HVLC, and it provides evidence for formation of the HVLC at different times during the rifting and breakup process. We suggest that the drastically different HVLC volumes are caused by asymmetric rifting in a simple-shear-dominated extension.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 5
    Publication Date: 2021-07-01
    Description: A passive seismic experiment using 25 broadband and 20 short‐period stations was conducted between September 2017 and September 2018 at Los Humeros geothermal field, an important natural laboratory for superhot geothermal systems in Mexico. From the recorded local seismicity, we derive a minimum 1‐D velocity model and obtain 3‐D Vp and Vp/Vs structures of Los Humeros. We improved the classical local earthquake tomography by using a postprocessing statistical approach. Several inversions were computed and averaged to reduce artifacts introduced by the model parametrization and to increase the resolution of the investigated region. Finally, the resulting Vp and Vp/Vs structures and associated seismicity were integrated with newly acquired geophysical and petrophysical data for comprehensive interpretation. The recorded seismicity is mainly grouped in three clusters, two of which seem directly related to exploitation activities. By combining new laboratory measurements and existing well data with our Vp model, we estimate possible geological unit boundaries. One large intrusion‐like body in the Vp model, together with neighboring high Vp/Vs anomalies, hints at a region of active resurgence or uplift due to the intrusion of new magma at the northern portion of the geothermal field. We interpret high Vp/Vs features as fluid bearing regions potentially favorable for further geothermal exploitation. Deep reaching permeable faults cutting the reservoir unit could explain fluid flow from a deeper local heat source in the area.
    Description: Key Points: High‐quality earthquake data were collected to image the Vp and Vp/Vs models for the first time at Los Humeros geothermal field (Mexico). Inversions were performed by extending the classical earthquake tomography using a postprocessing statistical approach. Geological unit boundaries and fluid and gas bearing zones were interpreted considering new geological, geophysical, and petrophysical data.
    Description: Consejo Nacional de Ciencia y Tecnología (CONACYT) http://dx.doi.org/10.13039/501100013704
    Description: EC | Horizon 2020 Framework Programme (H2020) http://dx.doi.org/10.13039/100011102
    Keywords: 551.22 ; Los Humeros ; geothermal exploration ; induced and local seismicity ; P and S velocity structure
    Type: article
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  • 6
    Publication Date: 2003-01-01
    Description: About 3 km of core material from 14 wells together with additional data from several hundred wells across the NE German Basin (NEGB), have been investigated in order to reconstruct the facies architecture and the evolution of the Upper Rotliegend II. Special attention has also been given to the verification of various controlling factors and their influence on sedimentation in an arid continental environment. The facies architecture within the logged profiles comprises five main environments, namely braided plain, ephemeral stream floodplain, sand flat, mudflat and playa lake. The evolution can be subdivided into four distinct basin-wide correlatable periods -- Parchim, Mirow, Dethlingen and Hannover formations -- with each of them being characterized by a specific basin geometry and interplay of controlling factors. The deposition of the basal Parchim Formation largely took place within a tectonically created basin, whereas the facies evolution displayed an initial less-arid climatic period and later shift to an arid climate. The succeeding Mirow Formation marks the beginning of thermally induced basin subsidence. However, sedimentation itself clearly reflects a period in which the climate was relatively less arid. The overlying Dethlingen Formation was largely controlled by the increasing thermal subsidence of the basin, leading to broad extension towards the south and east. Internally, the strata can show the effects of climatic variability, depending on their position within the basin. The uppermost Hannover Formation was the product of ongoing basin subsidence, a reduction in sediment supply and an increasingly peneplaned topography. In summary, evolution of the Upper Rotliegend II within the NEGB reveals a variety of factors which have a significant influence on sedimentation, such as climate variations, the creation rate and amount of accommodation space, wind direction, sediment budget and source area lithology. An understanding of how these various factors interlink in controlling basin infill is of great significance in understanding the complex depositional history of arid continental successions.
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  • 7
    Publication Date: 2011-11-15
    Description: Author(s): S. Neusser, H. G. Bauer, G. Duerr, R. Huber, S. Mamica, G. Woltersdorf, M. Krawczyk, C. H. Back, and D. Grundler [Phys. Rev. B 84, 184411] Published Mon Nov 14, 2011
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 8
    Publication Date: 2014-05-01
    Description: Various topological constraints at the ribosomal DNA (rDNA) locus impose an extra challenge for transcription and DNA replication, generating constant torsional DNA stress. The topoisomerase Top1 is known to release such torsion by single-strand nicking and re-ligation in a process involving transient covalent Top1 cleavage complexes (Top1cc) with the nicked DNA. Here we show that Top1ccs, despite their usually transient nature, are specifically targeted to and stabilized at the ribosomal replication fork barrier (rRFB) of budding yeast, establishing a link with previously reported Top1 controlled nicks. Using ectopically engineered rRFBs, we establish that the rRFB sequence itself is sufficient for induction of DNA strand-specific and replication-independent Top1ccs. These Top1ccs accumulate only in the presence of Fob1 and Tof2, they are reversible as they are not subject to repair by Tdp1- or Mus81-dependent processes, and their presence correlates with Top1 provided rDNA stability. Notably, the targeted formation of these Top1ccs accounts for the previously reported broken replication forks at the rRFB. These findings implicate a novel and physiologically regulated mode of Top1 action, suggesting a mechanism by which Top1 is recruited to the rRFB and stabilized in a reversible Top1cc configuration to preserve the integrity of the rDNA.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 9
    Publication Date: 2011-05-01
    Description: We propose a modified centroid method to compute the depth to the bottom of magnetic sources (DBMS) based on a fractal source distribution. This approach provides better estimates than the assumption of an uncorrelated source distribution. We apply our approach to a recently compiled homogeneous set of aeromagnetic data from Germany. The deepest DBMS values are found for some large basin areas, i.e., the Molasse basin and parts of the North German basin. Smaller DBMS were estimated for the Moldanubian region in southern Germany and the northern part of the North German basin. A comparison of DBMS with heat-flow data, crustal temperatures at 3-km depths, and Moho depth indicates that DBMS is controlled by the geothermal condition of the earth's crust in Germany and lithologic changes. Although the Upper Rhine graben and the Moldanubian region are characterized by small DBMS, a change in DBMS values in northern Germany seems to be related to the Elbe lineament.
    Print ISSN: 0016-8033
    Electronic ISSN: 1942-2156
    Topics: Geosciences , Physics
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  • 10
    Publication Date: 2013-03-15
    Description: Subsurface investigations in urban areas have to take sealed surfaces and densely built and populated areas into account. The shear-wave reflection seismic system developed at the Leibniz Institute for Applied Geophysics (LIAG) provides a solution for this acquisition technology problem using horizontally polarized shear waves (SH-waves) and noninvasive source and receiver designs.
    Print ISSN: 1070-485X
    Electronic ISSN: 1938-3789
    Topics: Geosciences
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